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UniProtKB - Q9UIF7 (MUTYH_HUMAN)

>sp|Q9UIF7|MUTYH_HUMAN Adenine DNA glycosylase OS=Homo sapiens OX=9606 GN=MUTYH PE=1 SV=1
MTPLVSRLSRLWAIMRKPRAAVGSGHRKQAASQEGRQKHAKNNSQAKPSACDGMIAECPG
APAGLARQPEEVVLQASVSSYHLFRDVAEVTAFRGSLLSWYDQEKRDLPWRRRAEDEMDL
DRRAYAVWVSEVMLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRG
RRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQATGVVDGNVARVL
CRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQAAMELGATVCTPQRPLCSQCPVE
SLCRARQRVEQEQLLASGSLSGSPDVEECAPNTGQCHLCLPPSEPWDQTLGVVNFPRKAS
RKPPREESSATCVLEQPGALGAQILLVQRPNSGLLAGLWEFPSVTWEPSEQLQRKALLQE
LQRWAGPLPATHLRHLGEVVHTFSHIKLTYQVYGLALEGQTPVTTVPPGARWLTQEEFHT
AAVSTAMKKVFRVYQGQQPGTCMGSKRSQVSSPCSRKKPRMGQQVLDNFFRSHISTDAHS
LNSAAQ

Entry version 198 (25 May 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss

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Protein

Adenine DNA glycosylase

Gene

MUTYH

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.

5 Publications

Manual assertion based on experiment inⁱ

Ref.2
"Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria."
Ohtsubo T., Nishioka K., Imaiso Y., Iwai S., Shimokawa H., Oda H., Fujikawa T., Nakabeppu Y.
Nucleic Acids Res. 28:1355-1364(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-1; ALPHA-2; ALPHA-3; BETA-1; GAMMA-2 AND GAMMA-3), FUNCTION.
Ref.20
"Functional analysis of MUTYH mutated proteins associated with familial adenomatous polyposis."
D'Agostino V.G., Minoprio A., Torreri P., Marinoni I., Bossa C., Petrucci T.C., Albertini A.M., Ranzani G.N., Bignami M., Mazzei F.
DNA Repair 9:700-707(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANTS FAP2 ILE-TRP-148 INS; CYS-176; TRP-182; ASP-393 AND GLU-477 DEL, FUNCTION, CATALYTIC ACTIVITY.
Ref.22
"Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer."
Goto M., Shinmura K., Nakabeppu Y., Tao H., Yamada H., Tsuneyoshi T., Sugimura H.
Hum. Mutat. 31:E1861-E1874(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANTS FAP2 CYS-176; HIS-179; VAL-220; VAL-280; CYS-306; PRO-385; ASP-393; LEU-402 AND GLU-477 DEL, CHARACTERIZATION OF VARIANTS GLU-72; VAL-370 AND PHE-512, FUNCTION, MUTAGENESIS OF ASP-233.
Ref.23
"Functional complementation assay for 47 MUTYH variants in a MutY-disrupted Escherichia coli strain."
Komine K., Shimodaira H., Takao M., Soeda H., Zhang X., Takahashi M., Ishioka C.
Hum. Mutat. 36:704-711(2015) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANTS FAP2 LEU-18; HIS-125; ARG-128; LEU-154; CYS-176; CYS-179; HIS-179; GLN-182; GLU-186; VAL-220; TRP-238; HIS-242; TRP-271; GLU-283; LEU-292; CYS-306; THR-377; PRO-385; ASP-393; LEU-402; MET-417; CYS-423; ASP-470; THR-470; GLU-477 DEL; THR-486 AND PHE-490, CHARACTERIZATION OF VARIANTS GASC SER-402 AND ARG-411, CHARACTERIZATION OF VARIANTS MET-22; ASP-25; ARG-100; ASN-102; VAL-224; MET-231; CYS-242; PHE-243; TRP-287; HIS-335; ARG-335; GLN-434; PRO-434; GLU-500; PHE-512; LEU-513; MET-526 AND GLN-531, FUNCTION, SUBCELLULAR LOCATION.
Ref.24
"Functional evaluation of nine missense-type variants of the human DNA glycosylase enzyme MUTYH in the Japanese population."
Shinmura K., Kato H., Goto M., Yamada H., Tao H., Nakamura S., Sugimura H.
Hum. Mutat. 37:350-353(2016) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANT FAP2 SER-235, CHARACTERIZATION OF VARIANT ASN-102; GLY-121; MET-231; GLY-244; ASN-319; HIS-520 AND ALA-536, FUNCTION.

Catalytic activityⁱ

Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.20
  "Functional analysis of MUTYH mutated proteins associated with familial adenomatous polyposis."
  D'Agostino V.G., Minoprio A., Torreri P., Marinoni I., Bossa C., Petrucci T.C., Albertini A.M., Ranzani G.N., Bignami M., Mazzei F.
  DNA Repair 9:700-707(2010) [PubMed] [Europe PMC] [Abstract]
  Cited for: CHARACTERIZATION OF VARIANTS FAP2 ILE-TRP-148 INS; CYS-176; TRP-182; ASP-393 AND GLU-477 DEL, FUNCTION, CATALYTIC ACTIVITY.
EC:3.2.2.31

Cofactorⁱ

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	131	Proton donor/acceptorBy similarity	1
Siteⁱ	233	Transition state stabilizerBy similarity	1
Metal bindingⁱ	287	Iron-sulfur (4Fe-4S)By similarity	1
Metal bindingⁱ	294	Iron-sulfur (4Fe-4S)By similarity	1
Metal bindingⁱ	297	Iron-sulfur (4Fe-4S)By similarity	1
Metal bindingⁱ	303	Iron-sulfur (4Fe-4S)By similarity	1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase
Biological process	DNA damage, DNA repair
Ligand	4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

PathwayCommonsⁱ	Q9UIF7
Reactomeⁱ	R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110331, Cleavage of the damaged purine R-HSA-110357, Displacement of DNA glycosylase by APEX1 R-HSA-9608287, Defective MUTYH substrate binding [Q9UIF7-3] R-HSA-9608290, Defective MUTYH substrate processing
SignaLinkⁱ	Q9UIF7
SIGNORⁱ	Q9UIF7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Adenine DNA glycosylase (EC:3.2.2.311 Publication) Alternative name(s): MutY homolog Short name: hMYH
Gene namesⁱ	Name:MUTYH Synonyms:MYH
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7527, MUTYH
MIMⁱ	604933, gene
neXtProtⁱ	NX_Q9UIF7
VEuPathDBⁱ	HostDB:ENSG00000132781

Keywords - Cellular componentⁱ

Mitochondrion, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Familial adenomatous polyposis 2 (FAP2)15 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_077640	18	P → L in FAP2; also found in multiple polyposis, colorectal and lung cancer cases; unknown pathological significance; decreased function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs79777494Ensembl.	1
Natural variantⁱVAR_026045	125	Y → H in FAP2; decreased function in DNA repair. 2 Publications	1
Natural variantⁱVAR_026046	128	W → R in FAP2; loss of function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs730881832Ensembl.	1
Natural variantⁱVAR_064938	148	G → GIW in FAP2; reduced DNA glycosylase activity; decreased DNA binding; loss of function in DNA repair. 3 Publications	1
Natural variantⁱVAR_077646	154	P → L in FAP2; decreased function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs777184451Ensembl.	1
Natural variantⁱVAR_018873	176	Y → C in FAP2; loss of DNA glycosylase activity; decreased DNA binding; loss of function in DNA repair. 12 PublicationsCorresponds to variant dbSNP:rs34612342Ensembl.	1
Natural variantⁱVAR_077647	177	Y → S in FAP2. 1 Publication	1
Natural variantⁱVAR_064939	179	R → C in FAP2; also found in multiple polyposis and colorectal cancer cases; loss of function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs747993448Ensembl.	1
Natural variantⁱVAR_026047	179	R → H in FAP2; loss of DNA glycosylase activity; loss of function in DNA repair. 4 PublicationsCorresponds to variant dbSNP:rs143353451Ensembl.	1
Natural variantⁱVAR_077648	182	R → Q in FAP2; loss of function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs533899702Ensembl.	1
Natural variantⁱVAR_064940	182	R → W in FAP2; loss of DNA glycosylase activity; loss of DNA binding; loss of function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs750592289Ensembl.	1
Natural variantⁱVAR_077649	186	G → E in FAP2; decreased function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs754155145Ensembl.	1
Natural variantⁱVAR_077650	213	G → E in FAP2. 1 PublicationCorresponds to variant dbSNP:rs768553551Ensembl.	1
Natural variantⁱVAR_077651	220	I → V in FAP2; also found in multiple polyposis case; unknown pathological significance; reduced DNA glycosylase activity; no effect on function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs200872702Ensembl.	1
Natural variantⁱVAR_077654	235	N → S in FAP2; loss of DNA glycosylase activity; loss of function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs1057517765Ensembl.	1
Natural variantⁱVAR_026048	238	R → W in FAP2; also found in a case of sporadic colorectal cancer; unknown pathological significance; decreased function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs34126013Ensembl.	1
Natural variantⁱVAR_077656	242	R → H in FAP2; loss of function in DNA repair. 4 PublicationsCorresponds to variant dbSNP:rs140342925Ensembl.	1
Natural variantⁱVAR_077659	271	R → W in FAP2; loss of function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs769237459Ensembl.	1
Natural variantⁱVAR_077660	280	M → V in FAP2; reduced DNA glycosylase activity. 2 PublicationsCorresponds to variant dbSNP:rs876659676Ensembl.	1
Natural variantⁱVAR_077661	283	G → E in FAP2; also found in a patient with multiple polyps; unknown pathological significance; does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs730881833Ensembl.	1
Natural variantⁱVAR_077663	292	P → L in FAP2; also found in multiple polyposis cases; loss of function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs374950566Ensembl.	1
Natural variantⁱVAR_077664	306	R → C in FAP2; also found in multiple polyposis cases; unknown pathological significance; does not affect DNA glycosylase activity; slightly decreased function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs138089183Ensembl.	1
Natural variantⁱVAR_077667	377	P → T in FAP2; decreased function in DNA repair. 1 Publication	1
Natural variantⁱVAR_077668	385	L → P in FAP2; also found in multiple polyposis cases; loss of DNA glycosylase activity; loss of function in DNA repair. 4 PublicationsCorresponds to variant dbSNP:rs1060501335Ensembl.	1
Natural variantⁱVAR_018875	393	G → D in FAP2; reduced DNA glycosylase activity; decreased DNA binding; decreased function in DNA repair. 12 PublicationsCorresponds to variant dbSNP:rs36053993Ensembl.	1
Natural variantⁱVAR_077669	402	P → L in FAP2; also found in multiple polyposis and colorectal cancer cases; loss of DNA glycosylase activity; loss of function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs529008617Ensembl.	1
Natural variantⁱVAR_077670	417	L → M in FAP2; also found in patient with multiple polyps and in a family with non-polyposis colorectal cancer-like syndrome; unknown pathological significance; does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs144079536Ensembl.	1
Natural variantⁱVAR_077671	423	R → C in FAP2; unknown pathological significance; does not affect function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs150792276Ensembl.	1
Natural variantⁱVAR_077674	470	A → D in FAP2; loss of function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs200844166Ensembl.	1
Natural variantⁱVAR_077676	474	T → M in FAP2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767747402Ensembl.	1
Natural variantⁱVAR_064941	477	Missing in FAP2; also found in a case of sporadic colorectal cancer; loss of DNA glycosylase activity; loss of DNA binding; loss of function in DNA repair. 6 Publications	1
Natural variantⁱVAR_077677	486	A → T in FAP2; decreased function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs587782263Ensembl.	1
Natural variantⁱVAR_077678	490	V → F in FAP2; found also in sporadic colorectal cancer cases; unknown pathological significance; decreased function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs587782228Ensembl.	1

Gastric cancer (GASC)2 Publications

The gene represented in this entry may be involved in disease pathogenesis. Somatic mutations contribute to the development of a sub-set of sporadic gastric cancers in carriers of Helicobacter pylori (PubMed:15273732).1 Publication

Disease descriptionA malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_026049	402	P → S in GASC; sporadic; decreased function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs121908382Ensembl.		1
Natural variantⁱVAR_026050	411	Q → R in GASC; sporadic; unknown pathological significance; does not affect function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs121908383Ensembl.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	233	D → N: Loss of DNA glycosylase activity. 1 Publication		1

Keywords - Diseaseⁱ

Disease variant, Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4595
GeneReviewsⁱ	MUTYH
MalaCards human disease database More...MalaCardsⁱ	MUTYH
MIMⁱ	608456, phenotype 613659, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000132781
Orphanetⁱ	247798, MUTYH-related attenuated familial adenomatous polyposis
PharmGKBⁱ	PA31328

Miscellaneous databases

Pharosⁱ	Q9UIF7, Tbio

Pharosⁱ

Q9UIF7, Tbio

Genetic variation databases

BioMutaⁱ	MUTYH
DMDMⁱ	48428272

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000102239	1 – 546	Adenine DNA glycosylaseAdd BLAST		546

Proteomic databases

EPDⁱ	Q9UIF7
jPOSTⁱ	Q9UIF7
MassIVEⁱ	Q9UIF7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UIF7
PaxDbⁱ	Q9UIF7
PeptideAtlas More...PeptideAtlasⁱ	Q9UIF7
PRIDEⁱ	Q9UIF7
ProteomicsDBⁱ	84500 [Q9UIF7-1] 84501 [Q9UIF7-2] 84502 [Q9UIF7-3] 84503 [Q9UIF7-4] 84504 [Q9UIF7-5] 84505 [Q9UIF7-6]

PTM databases

iPTMnetⁱ	Q9UIF7
PhosphoSitePlusⁱ	Q9UIF7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000132781, Expressed in right hemisphere of cerebellum and 225 other tissues
ExpressionAtlasⁱ	Q9UIF7, baseline and differential
Genevisibleⁱ	Q9UIF7, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000132781, Low tissue specificity

HPAⁱ

ENSG00000132781, Low tissue specificity

Interactionⁱ

Binary interactionsⁱ

Isoform Alpha-3 [Q9UIF7-3]

With	#Exp.	IntAct
AGTRAP [Q6RW13]	3	EBI-10321956,EBI-741181

Protein-protein interaction databases

BioGRIDⁱ	110681, 27 interactors
Database of interacting proteins More...DIPⁱ	DIP-41972N
IntActⁱ	Q9UIF7, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q9UIF7
STRINGⁱ	9606.ENSP00000361170

Miscellaneous databases

RNActⁱ	Q9UIF7, protein

RNActⁱ

Q9UIF7, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	87 – 104	Combined sources	18
Helixⁱ	109 – 116	Combined sources	8
Helixⁱ	120 – 135	Combined sources	16
Helixⁱ	139 – 152	Combined sources	14
Helixⁱ	156 – 160	Combined sources	5
Helixⁱ	164 – 171	Combined sources	8
Helixⁱ	177 – 193	Combined sources	17
Helixⁱ	202 – 208	Combined sources	7
Helixⁱ	214 – 224	Combined sources	11
Helixⁱ	234 – 243	Combined sources	10
Helixⁱ	253 – 266	Combined sources	14
Helixⁱ	272 – 285	Combined sources	14
Beta strandⁱ	289 – 291	Combined sources	3
Helixⁱ	300 – 302	Combined sources	3
Helixⁱ	304 – 316	Combined sources	13
Helixⁱ	330 – 332	Combined sources	3
Beta strandⁱ	358 – 360	Combined sources	3
Beta strandⁱ	366 – 377	Combined sources	12
Beta strandⁱ	379 – 388	Combined sources	10
Beta strandⁱ	403 – 405	Combined sources	3
Helixⁱ	410 – 424	Combined sources	15
Beta strandⁱ	447 – 456	Combined sources	10
Beta strandⁱ	470 – 474	Combined sources	5
Helixⁱ	475 – 480	Combined sources	6
Helixⁱ	485 – 495	Combined sources	11

Show more details

3D structure databases

AlphaFoldDBⁱ	Q9UIF7
SMRⁱ	Q9UIF7
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UIF7

EvolutionaryTraceⁱ

Q9UIF7

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	364 – 495	Nudix hydrolasePROSITE-ProRule annotationAdd BLAST		132

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	19 – 51	DisorderedSequence analysisAdd BLAST		33

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	404 – 426	Nudix boxAdd BLAST		23

Sequence similaritiesⁱ

Belongs to the Nth/MutY family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2457, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047220
HOGENOMⁱ	CLU_012862_0_0_1
InParanoidⁱ	Q9UIF7
OMAⁱ	THIRLKM
Database of Orthologous Groups More...OrthoDBⁱ	616758at2759
PhylomeDBⁱ	Q9UIF7
TreeFamⁱ	TF328549

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03431, DNA_Glycosylase_C, 1 hit cd00056, ENDO3c, 1 hit
Gene3Dⁱ	1.10.1670.10, 1 hit
InterProⁱ	View protein in InterPro IPR011257, DNA_glycosylase IPR004036, Endonuclease-III-like_CS2 IPR003651, Endonuclease3_FeS-loop_motif IPR004035, Endouclease-III_FeS-bd_BS IPR003265, HhH-GPD_domain IPR023170, HhH_base_excis_C IPR000445, HhH_motif IPR044298, MIG/MutY IPR029119, MutY_C IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom
PANTHERⁱ	PTHR42944, PTHR42944, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00633, HHH, 1 hit PF00730, HhH-GPD, 1 hit PF14815, NUDIX_4, 1 hit
SMARTⁱ	View protein in SMART SM00478, ENDO3c, 1 hit SM00525, FES, 1 hit
SUPFAMⁱ	SSF48150, SSF48150, 1 hit SSF55811, SSF55811, 1 hit
PROSITEⁱ	View protein in PROSITE PS00764, ENDONUCLEASE_III_1, 1 hit PS01155, ENDONUCLEASE_III_2, 1 hit PS51462, NUDIX, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 20 potential isoforms that are computationally mapped.Show all Align All

Isoform Alpha-1 (identifier: Q9UIF7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPLVSRLSR LWAIMRKPRA AVGSGHRKQA ASQEGRQKHA KNNSQAKPSA 
        60         70         80         90        100
CDGMIAECPG APAGLARQPE EVVLQASVSS YHLFRDVAEV TAFRGSLLSW 
       110        120        130        140        150
YDQEKRDLPW RRRAEDEMDL DRRAYAVWVS EVMLQQTQVA TVINYYTGWM 
       160        170        180        190        200
QKWPTLQDLA SASLEEVNQL WAGLGYYSRG RRLQEGARKV VEELGGHMPR 
       210        220        230        240        250
TAETLQQLLP GVGRYTAGAI ASIAFGQATG VVDGNVARVL CRVRAIGADP 
       260        270        280        290        300
SSTLVSQQLW GLAQQLVDPA RPGDFNQAAM ELGATVCTPQ RPLCSQCPVE 
       310        320        330        340        350
SLCRARQRVE QEQLLASGSL SGSPDVEECA PNTGQCHLCL PPSEPWDQTL 
       360        370        380        390        400
GVVNFPRKAS RKPPREESSA TCVLEQPGAL GAQILLVQRP NSGLLAGLWE 
       410        420        430        440        450
FPSVTWEPSE QLQRKALLQE LQRWAGPLPA THLRHLGEVV HTFSHIKLTY 
       460        470        480        490        500
QVYGLALEGQ TPVTTVPPGA RWLTQEEFHT AAVSTAMKKV FRVYQGQQPG 
       510        520        530        540 
TCMGSKRSQV SSPCSRKKPR MGQQVLDNFF RSHISTDAHS LNSAAQ

Length:546

Mass (Da):60,069

Last modified:May 1, 2000 - v1

Checksum:ⁱ6C79BDB34345DD10

Isoform Alpha-2 (identifier: Q9UIF7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
53-62: Missing.

« Hide

        10         20         30         40         50
MTPLVSRLSR LWAIMRKPRA AVGSGHRKQA ASQEGRQKHA KNNSQAKPSA 
        60         70         80         90        100
CDAGLARQPE EVVLQASVSS YHLFRDVAEV TAFRGSLLSW YDQEKRDLPW 
       110        120        130        140        150
RRRAEDEMDL DRRAYAVWVS EVMLQQTQVA TVINYYTGWM QKWPTLQDLA 
       160        170        180        190        200
SASLEEVNQL WAGLGYYSRG RRLQEGARKV VEELGGHMPR TAETLQQLLP 
       210        220        230        240        250
GVGRYTAGAI ASIAFGQATG VVDGNVARVL CRVRAIGADP SSTLVSQQLW 
       260        270        280        290        300
GLAQQLVDPA RPGDFNQAAM ELGATVCTPQ RPLCSQCPVE SLCRARQRVE 
       310        320        330        340        350
QEQLLASGSL SGSPDVEECA PNTGQCHLCL PPSEPWDQTL GVVNFPRKAS 
       360        370        380        390        400
RKPPREESSA TCVLEQPGAL GAQILLVQRP NSGLLAGLWE FPSVTWEPSE 
       410        420        430        440        450
QLQRKALLQE LQRWAGPLPA THLRHLGEVV HTFSHIKLTY QVYGLALEGQ 
       460        470        480        490        500
TPVTTVPPGA RWLTQEEFHT AAVSTAMKKV FRVYQGQQPG TCMGSKRSQV 
       510        520        530 
SSPCSRKKPR MGQQVLDNFF RSHISTDAHS LNSAAQ

Show »

Length:536

Mass (Da):59,142

Checksum:ⁱ09F58E89627B124D

Isoform Alpha-3 (identifier: Q9UIF7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
53-63: Missing.

« Hide

        10         20         30         40         50
MTPLVSRLSR LWAIMRKPRA AVGSGHRKQA ASQEGRQKHA KNNSQAKPSA 
        60         70         80         90        100
CDGLARQPEE VVLQASVSSY HLFRDVAEVT AFRGSLLSWY DQEKRDLPWR 
       110        120        130        140        150
RRAEDEMDLD RRAYAVWVSE VMLQQTQVAT VINYYTGWMQ KWPTLQDLAS 
       160        170        180        190        200
ASLEEVNQLW AGLGYYSRGR RLQEGARKVV EELGGHMPRT AETLQQLLPG 
       210        220        230        240        250
VGRYTAGAIA SIAFGQATGV VDGNVARVLC RVRAIGADPS STLVSQQLWG 
       260        270        280        290        300
LAQQLVDPAR PGDFNQAAME LGATVCTPQR PLCSQCPVES LCRARQRVEQ 
       310        320        330        340        350
EQLLASGSLS GSPDVEECAP NTGQCHLCLP PSEPWDQTLG VVNFPRKASR 
       360        370        380        390        400
KPPREESSAT CVLEQPGALG AQILLVQRPN SGLLAGLWEF PSVTWEPSEQ 
       410        420        430        440        450
LQRKALLQEL QRWAGPLPAT HLRHLGEVVH TFSHIKLTYQ VYGLALEGQT 
       460        470        480        490        500
PVTTVPPGAR WLTQEEFHTA AVSTAMKKVF RVYQGQQPGT CMGSKRSQVS 
       510        520        530 
SPCSRKKPRM GQQVLDNFFR SHISTDAHSL NSAAQ

Show »

Length:535

Mass (Da):59,071

Checksum:ⁱB035F73FE7E5EC88

Isoform Beta-1 (identifier: Q9UIF7-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-14: Missing.

« Hide

        10         20         30         40         50
MRKPRAAVGS GHRKQAASQE GRQKHAKNNS QAKPSACDGM IAECPGAPAG 
        60         70         80         90        100
LARQPEEVVL QASVSSYHLF RDVAEVTAFR GSLLSWYDQE KRDLPWRRRA 
       110        120        130        140        150
EDEMDLDRRA YAVWVSEVML QQTQVATVIN YYTGWMQKWP TLQDLASASL 
       160        170        180        190        200
EEVNQLWAGL GYYSRGRRLQ EGARKVVEEL GGHMPRTAET LQQLLPGVGR 
       210        220        230        240        250
YTAGAIASIA FGQATGVVDG NVARVLCRVR AIGADPSSTL VSQQLWGLAQ 
       260        270        280        290        300
QLVDPARPGD FNQAAMELGA TVCTPQRPLC SQCPVESLCR ARQRVEQEQL 
       310        320        330        340        350
LASGSLSGSP DVEECAPNTG QCHLCLPPSE PWDQTLGVVN FPRKASRKPP 
       360        370        380        390        400
REESSATCVL EQPGALGAQI LLVQRPNSGL LAGLWEFPSV TWEPSEQLQR 
       410        420        430        440        450
KALLQELQRW AGPLPATHLR HLGEVVHTFS HIKLTYQVYG LALEGQTPVT 
       460        470        480        490        500
TVPPGARWLT QEEFHTAAVS TAMKKVFRVY QGQQPGTCMG SKRSQVSSPC 
       510        520        530 
SRKKPRMGQQ VLDNFFRSHI STDAHSLNSA AQ

Show »

Length:532

Mass (Da):58,444

Checksum:ⁱ51845EFF75321F12

Isoform Gamma-2 (identifier: Q9UIF7-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-14: Missing.
53-62: Missing.

« Hide

        10         20         30         40         50
MRKPRAAVGS GHRKQAASQE GRQKHAKNNS QAKPSACDAG LARQPEEVVL 
        60         70         80         90        100
QASVSSYHLF RDVAEVTAFR GSLLSWYDQE KRDLPWRRRA EDEMDLDRRA 
       110        120        130        140        150
YAVWVSEVML QQTQVATVIN YYTGWMQKWP TLQDLASASL EEVNQLWAGL 
       160        170        180        190        200
GYYSRGRRLQ EGARKVVEEL GGHMPRTAET LQQLLPGVGR YTAGAIASIA 
       210        220        230        240        250
FGQATGVVDG NVARVLCRVR AIGADPSSTL VSQQLWGLAQ QLVDPARPGD 
       260        270        280        290        300
FNQAAMELGA TVCTPQRPLC SQCPVESLCR ARQRVEQEQL LASGSLSGSP 
       310        320        330        340        350
DVEECAPNTG QCHLCLPPSE PWDQTLGVVN FPRKASRKPP REESSATCVL 
       360        370        380        390        400
EQPGALGAQI LLVQRPNSGL LAGLWEFPSV TWEPSEQLQR KALLQELQRW 
       410        420        430        440        450
AGPLPATHLR HLGEVVHTFS HIKLTYQVYG LALEGQTPVT TVPPGARWLT 
       460        470        480        490        500
QEEFHTAAVS TAMKKVFRVY QGQQPGTCMG SKRSQVSSPC SRKKPRMGQQ 
       510        520 
VLDNFFRSHI STDAHSLNSA AQ

Show »

Length:522

Mass (Da):57,517

Checksum:ⁱ8E913C90D72DF87E

Isoform Gamma-3 (identifier: Q9UIF7-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-14: Missing.
53-63: Missing.

« Hide

        10         20         30         40         50
MRKPRAAVGS GHRKQAASQE GRQKHAKNNS QAKPSACDGL ARQPEEVVLQ 
        60         70         80         90        100
ASVSSYHLFR DVAEVTAFRG SLLSWYDQEK RDLPWRRRAE DEMDLDRRAY 
       110        120        130        140        150
AVWVSEVMLQ QTQVATVINY YTGWMQKWPT LQDLASASLE EVNQLWAGLG 
       160        170        180        190        200
YYSRGRRLQE GARKVVEELG GHMPRTAETL QQLLPGVGRY TAGAIASIAF 
       210        220        230        240        250
GQATGVVDGN VARVLCRVRA IGADPSSTLV SQQLWGLAQQ LVDPARPGDF 
       260        270        280        290        300
NQAAMELGAT VCTPQRPLCS QCPVESLCRA RQRVEQEQLL ASGSLSGSPD 
       310        320        330        340        350
VEECAPNTGQ CHLCLPPSEP WDQTLGVVNF PRKASRKPPR EESSATCVLE 
       360        370        380        390        400
QPGALGAQIL LVQRPNSGLL AGLWEFPSVT WEPSEQLQRK ALLQELQRWA 
       410        420        430        440        450
GPLPATHLRH LGEVVHTFSH IKLTYQVYGL ALEGQTPVTT VPPGARWLTQ 
       460        470        480        490        500
EEFHTAAVST AMKKVFRVYQ GQQPGTCMGS KRSQVSSPCS RKKPRMGQQV 
       510        520 
LDNFFRSHIS TDAHSLNSAA Q

Show »

Length:521

Mass (Da):57,446

Checksum:ⁱ7487EE8AB10FDF6E

Computationally mapped potential isoform sequencesⁱ

There are 20 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A5F9ZI14	A0A5F9ZI14_HUMAN	Adenine DNA glycosylase Adenine DNA glycosylase, EC 3.2.2.31	MUTYH	466	Annotation score:
	E9PM53	E9PM53_HUMAN	Adenine DNA glycosylase Adenine DNA glycosylase, EC 3.2.2.31	MUTYH	535	Annotation score:
	E9PNY0	E9PNY0_HUMAN	Adenine DNA glycosylase Adenine DNA glycosylase, EC 3.2.2.31	MUTYH	216	Annotation score:
	H0YCY5	H0YCY5_HUMAN	Adenine DNA glycosylase Adenine DNA glycosylase, EC 3.2.2.31	MUTYH	213	Annotation score:
	Q5T418	Q5T418_HUMAN	Adenine DNA glycosylase Adenine DNA glycosylase, EC 3.2.2.31	MUTYH	215	Annotation score:
	Q5T413	Q5T413_HUMAN	Adenine DNA glycosylase Adenine DNA glycosylase, EC 3.2.2.31	MUTYH	291	Annotation score:
	H0YEI2	H0YEI2_HUMAN	Adenine DNA glycosylase Adenine DNA glycosylase	MUTYH	184	Annotation score:
	E9PP34	E9PP34_HUMAN	Adenine DNA glycosylase Adenine DNA glycosylase	MUTYH	94	Annotation score:
	E9PLT4	E9PLT4_HUMAN	Adenine DNA glycosylase Adenine DNA glycosylase	MUTYH	62	Annotation score:
	A0A5F9ZHI2	A0A5F9ZHI2_HUMAN	Adenine DNA glycosylase Adenine DNA glycosylase	MUTYH	212	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence BAA89339 differs from that shown. Probable cloning artifact.Curated

The sequence BAA89339 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

The sequence BAA89345 differs from that shown. Probable cloning artifact.Curated

The sequence BAA89345 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_077640	18	P → L in FAP2; also found in multiple polyposis, colorectal and lung cancer cases; unknown pathological significance; decreased function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs79777494Ensembl.	1
Natural variantⁱVAR_018872	22	V → M Does not affect function in DNA repair. 6 PublicationsCorresponds to variant dbSNP:rs3219484Ensembl.	1
Natural variantⁱVAR_077641	25	G → D Does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs75321043Ensembl.	1
Natural variantⁱVAR_077642	72	V → E Likely benign variant; does not affect DNA glycosylase activity. 1 Publication	1
Natural variantⁱVAR_077643	100	W → R Found in sporadic hepatocellular carcinoma; unknown pathological significance; loss of function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs1140507Ensembl.	1
Natural variantⁱVAR_077644	102	D → N Found in multiple polyposis and sporadic colorectal cancer cases; unknown pathological significance; does not affect DNA glycosylase activity; does not affect function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs587780746Ensembl.	1
Natural variantⁱVAR_077645	121	D → G Likely benign variant; does not affect DNA glycosylase activity; does not affect function in DNA repair. 1 Publication	1
Natural variantⁱVAR_026045	125	Y → H in FAP2; decreased function in DNA repair. 2 Publications	1
Natural variantⁱVAR_026046	128	W → R in FAP2; loss of function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs730881832Ensembl.	1
Natural variantⁱVAR_064938	148	G → GIW in FAP2; reduced DNA glycosylase activity; decreased DNA binding; loss of function in DNA repair. 3 Publications	1
Natural variantⁱVAR_077646	154	P → L in FAP2; decreased function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs777184451Ensembl.	1
Natural variantⁱVAR_018873	176	Y → C in FAP2; loss of DNA glycosylase activity; decreased DNA binding; loss of function in DNA repair. 12 PublicationsCorresponds to variant dbSNP:rs34612342Ensembl.	1
Natural variantⁱVAR_077647	177	Y → S in FAP2. 1 Publication	1
Natural variantⁱVAR_064939	179	R → C in FAP2; also found in multiple polyposis and colorectal cancer cases; loss of function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs747993448Ensembl.	1
Natural variantⁱVAR_026047	179	R → H in FAP2; loss of DNA glycosylase activity; loss of function in DNA repair. 4 PublicationsCorresponds to variant dbSNP:rs143353451Ensembl.	1
Natural variantⁱVAR_077648	182	R → Q in FAP2; loss of function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs533899702Ensembl.	1
Natural variantⁱVAR_064940	182	R → W in FAP2; loss of DNA glycosylase activity; loss of DNA binding; loss of function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs750592289Ensembl.	1
Natural variantⁱVAR_077649	186	G → E in FAP2; decreased function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs754155145Ensembl.	1
Natural variantⁱVAR_077650	213	G → E in FAP2. 1 PublicationCorresponds to variant dbSNP:rs768553551Ensembl.	1
Natural variantⁱVAR_077651	220	I → V in FAP2; also found in multiple polyposis case; unknown pathological significance; reduced DNA glycosylase activity; no effect on function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs200872702Ensembl.	1
Natural variantⁱVAR_077652	224	A → V Decreased function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs11545695Ensembl.	1
Natural variantⁱVAR_077653	231	V → M Probable disease-associated variant found in a case of familial colorectal cancer; no significant effect on DNA glycosylase activity; slightly decreased function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs200165598Ensembl.	1
Natural variantⁱVAR_077654	235	N → S in FAP2; loss of DNA glycosylase activity; loss of function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs1057517765Ensembl.	1
Natural variantⁱVAR_026048	238	R → W in FAP2; also found in a case of sporadic colorectal cancer; unknown pathological significance; decreased function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs34126013Ensembl.	1
Natural variantⁱVAR_077655	242	R → C Probable disease-associated variant found in multiple polyposis cases; decreased function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs200495564Ensembl.	1
Natural variantⁱVAR_077656	242	R → H in FAP2; loss of function in DNA repair. 4 PublicationsCorresponds to variant dbSNP:rs140342925Ensembl.	1
Natural variantⁱVAR_077657	243	V → F Does not affect function. 1 PublicationCorresponds to variant dbSNP:rs587780749Ensembl.	1
Natural variantⁱVAR_077658	244	R → G Reduced DNA glycosylase activity; decreased function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs587782885Ensembl.	1
Natural variantⁱVAR_077659	271	R → W in FAP2; loss of function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs769237459Ensembl.	1
Natural variantⁱVAR_077660	280	M → V in FAP2; reduced DNA glycosylase activity. 2 PublicationsCorresponds to variant dbSNP:rs876659676Ensembl.	1
Natural variantⁱVAR_077661	283	G → E in FAP2; also found in a patient with multiple polyps; unknown pathological significance; does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs730881833Ensembl.	1
Natural variantⁱVAR_077662	287	C → W Found in a case of sporadic lung cancer; unknown pathological significance; loss of function in DNA repair. 1 Publication	1
Natural variantⁱVAR_077663	292	P → L in FAP2; also found in multiple polyposis cases; loss of function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs374950566Ensembl.	1
Natural variantⁱVAR_077664	306	R → C in FAP2; also found in multiple polyposis cases; unknown pathological significance; does not affect DNA glycosylase activity; slightly decreased function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs138089183Ensembl.	1
Natural variantⁱVAR_077665	319	S → N Does not affect DNA glycosylase activity; does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs587781810Ensembl.	1
Natural variantⁱVAR_018874	335	Q → H Does not affect function in DNA repair. 6 PublicationsCorresponds to variant dbSNP:rs3219489Ensembl.	1
Natural variantⁱVAR_077666	335	Q → R Found in a family with non-polyposis colorectal cancer-like syndrome; unknown pathological significance; does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs199742231Ensembl.	1
Natural variantⁱVAR_048262	370	A → V Does not affect DNA glycosylase activity. 1 PublicationCorresponds to variant dbSNP:rs35352891Ensembl.	1
Natural variantⁱVAR_077667	377	P → T in FAP2; decreased function in DNA repair. 1 Publication	1
Natural variantⁱVAR_077668	385	L → P in FAP2; also found in multiple polyposis cases; loss of DNA glycosylase activity; loss of function in DNA repair. 4 PublicationsCorresponds to variant dbSNP:rs1060501335Ensembl.	1
Natural variantⁱVAR_018875	393	G → D in FAP2; reduced DNA glycosylase activity; decreased DNA binding; decreased function in DNA repair. 12 PublicationsCorresponds to variant dbSNP:rs36053993Ensembl.	1
Natural variantⁱVAR_077669	402	P → L in FAP2; also found in multiple polyposis and colorectal cancer cases; loss of DNA glycosylase activity; loss of function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs529008617Ensembl.	1
Natural variantⁱVAR_026049	402	P → S in GASC; sporadic; decreased function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs121908382Ensembl.	1
Natural variantⁱVAR_026050	411	Q → R in GASC; sporadic; unknown pathological significance; does not affect function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs121908383Ensembl.	1
Natural variantⁱVAR_077670	417	L → M in FAP2; also found in patient with multiple polyps and in a family with non-polyposis colorectal cancer-like syndrome; unknown pathological significance; does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs144079536Ensembl.	1
Natural variantⁱVAR_077671	423	R → C in FAP2; unknown pathological significance; does not affect function in DNA repair. 3 PublicationsCorresponds to variant dbSNP:rs150792276Ensembl.	1
Natural variantⁱVAR_077672	434	R → P Found in sporadic colorectal cancer cases; unknown pathological significance; decreased function in DNA repair. 1 Publication	1
Natural variantⁱVAR_077673	434	R → Q Does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs587782120Ensembl.	1
Natural variantⁱVAR_077674	470	A → D in FAP2; loss of function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs200844166Ensembl.	1
Natural variantⁱVAR_077675	470	A → T Found in patient with multiple polyposis; unknown pathological significance; does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs192816572Ensembl.	1
Natural variantⁱVAR_077676	474	T → M in FAP2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767747402Ensembl.	1
Natural variantⁱVAR_064941	477	Missing in FAP2; also found in a case of sporadic colorectal cancer; loss of DNA glycosylase activity; loss of DNA binding; loss of function in DNA repair. 6 Publications	1
Natural variantⁱVAR_077677	486	A → T in FAP2; decreased function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs587782263Ensembl.	1
Natural variantⁱVAR_077678	490	V → F in FAP2; found also in sporadic colorectal cancer cases; unknown pathological significance; decreased function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs587782228Ensembl.	1
Natural variantⁱVAR_018876	500	G → E Decreased function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs3219494Ensembl.	1
Natural variantⁱVAR_026051	512	S → F Does not affect DNA glycosylase activity; does not affect function in DNA repair. 4 PublicationsCorresponds to variant dbSNP:rs140118273Ensembl.	1
Natural variantⁱVAR_077679	513	P → L Does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs587778542Ensembl.	1
Natural variantⁱVAR_077680	520	R → H Does not affect DNA glycosylase activity; does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs374655042Ensembl.	1
Natural variantⁱVAR_018877	526	L → M Does not affect function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs3219496Ensembl.	1
Natural variantⁱVAR_018878	531	R → Q Does not affect function in DNA repair. 2 PublicationsCorresponds to variant dbSNP:rs3219497Ensembl.	1
Natural variantⁱVAR_077681	536	T → A Does not affect DNA glycosylase activity; does not affect function in DNA repair. 1 PublicationCorresponds to variant dbSNP:rs151196169Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_010548	1 – 14	Missing in isoform Beta-1, isoform Gamma-2 and isoform Gamma-3. 1 PublicationAdd BLAST	14
Alternative sequenceⁱVSP_010550	53 – 63	Missing in isoform Alpha-3 and isoform Gamma-3. 2 PublicationsAdd BLAST	11
Alternative sequenceⁱVSP_010549	53 – 62	Missing in isoform Alpha-2 and isoform Gamma-2. 1 Publication	10

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U63329 Genomic DNA Translation: AAC50618.1 AB032920 mRNA Translation: BAA89336.1 AB032921 mRNA Translation: BAA89337.1 AB032922 mRNA Translation: BAA89338.1 AB032923 mRNA Translation: BAA89339.1 Sequence problems. AB032924 mRNA Translation: BAA89340.1 AB032925 mRNA Translation: BAA89341.1 AB032926 mRNA Translation: BAA89342.1 AB032927 mRNA Translation: BAA89343.1 AB032928 mRNA Translation: BAA89344.1 AB032929 mRNA Translation: BAA89345.1 Sequence problems. HQ205466 Genomic DNA Translation: ADP90937.1 HQ205468 Genomic DNA Translation: ADP90947.1 HQ205469 Genomic DNA Translation: ADP90952.1 HQ205470 Genomic DNA Translation: ADP90957.1 HQ205472 Genomic DNA Translation: ADP90967.1 HQ205473 Genomic DNA Translation: ADP90972.1 HQ205474 Genomic DNA Translation: ADP90977.1 HQ205475 Genomic DNA Translation: ADP90982.1 HQ205476 Genomic DNA Translation: ADP90987.1 HQ205477 Genomic DNA Translation: ADP90992.1 HQ205479 Genomic DNA Translation: ADP91002.1 HQ205480 Genomic DNA Translation: ADP91007.1 HQ205481 Genomic DNA Translation: ADP91012.1 HQ205482 Genomic DNA Translation: ADP91017.1 HQ205483 Genomic DNA Translation: ADP91022.1 HQ205484 Genomic DNA Translation: ADP91027.1 HQ205485 Genomic DNA Translation: ADP91032.1 HQ205486 Genomic DNA Translation: ADP91037.1 HQ205487 Genomic DNA Translation: ADP91042.1 HQ205488 Genomic DNA Translation: ADP91047.1 HQ205489 Genomic DNA Translation: ADP91052.1 HQ205490 Genomic DNA Translation: ADP91057.1 HQ205491 Genomic DNA Translation: ADP91062.1 HQ205492 Genomic DNA Translation: ADP91067.1 HQ205493 Genomic DNA Translation: ADP91072.1 HQ205494 Genomic DNA Translation: ADP91077.1 HQ205495 Genomic DNA Translation: ADP91082.1 HQ205496 Genomic DNA Translation: ADP91087.1 HQ205497 Genomic DNA Translation: ADP91092.1 HQ205498 Genomic DNA Translation: ADP91097.1 HQ205499 Genomic DNA Translation: ADP91102.1 HQ205500 Genomic DNA Translation: ADP91107.1 HQ205501 Genomic DNA Translation: ADP91112.1 HQ205502 Genomic DNA Translation: ADP91117.1 HQ205503 Genomic DNA Translation: ADP91122.1 HQ205505 Genomic DNA Translation: ADP91132.1 AF527839 Genomic DNA Translation: AAM78555.1 AL359540 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06993.1 CH471059 Genomic DNA Translation: EAX06996.1 CH471059 Genomic DNA Translation: EAX06997.1 BC003178 mRNA Translation: AAH03178.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41320.1 [Q9UIF7-6] CCDS41321.1 [Q9UIF7-5] CCDS41322.1 [Q9UIF7-6] CCDS520.1 [Q9UIF7-1] CCDS72776.1 [Q9UIF7-4] CCDS72777.1 [Q9UIF7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001041636.1, NM_001048171.1 [Q9UIF7-6] NP_001041637.1, NM_001048172.1 [Q9UIF7-5] NP_001041638.1, NM_001048173.1 [Q9UIF7-6] NP_001041639.1, NM_001048174.1 [Q9UIF7-6] NP_001121897.1, NM_001128425.1 NP_001280119.1, NM_001293190.1 [Q9UIF7-2] NP_001280120.1, NM_001293191.1 [Q9UIF7-4] NP_001280121.1, NM_001293192.1 NP_001280124.1, NM_001293195.1 [Q9UIF7-6] NP_001280125.1, NM_001293196.1 NP_036354.1, NM_012222.2 [Q9UIF7-1] XP_011539806.1, XM_011541504.2 [Q9UIF7-4] XP_016856823.1, XM_017001334.1 [Q9UIF7-5] XP_016856824.1, XM_017001335.1

Genome annotation databases

Ensemblⁱ	ENST00000354383.10; ENSP00000346354.6; ENSG00000132781.20 [Q9UIF7-5] ENST00000355498.6; ENSP00000347685.2; ENSG00000132781.20 [Q9UIF7-6] ENST00000372098.7; ENSP00000361170.3; ENSG00000132781.20 ENST00000372104.5; ENSP00000361176.1; ENSG00000132781.20 [Q9UIF7-6] ENST00000372110.7; ENSP00000361182.3; ENSG00000132781.20 [Q9UIF7-2] ENST00000372115.7; ENSP00000361187.3; ENSG00000132781.20 [Q9UIF7-3] ENST00000448481.5; ENSP00000409718.1; ENSG00000132781.20 [Q9UIF7-4] ENST00000456914.7; ENSP00000407590.2; ENSG00000132781.20 [Q9UIF7-6] ENST00000672818.3; ENSP00000500891.1; ENSG00000132781.20
GeneIDⁱ	4595
KEGGⁱ	hsa:4595
MANE-Selectⁱ	ENST00000456914.7; ENSP00000407590.2; NM_001048174.2; NP_001041639.1 [Q9UIF7-6]
UCSC genome browser More...UCSCⁱ	uc001cnf.4, human [Q9UIF7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UIF7	Adenine DNA glycosylase		HUMAN		546	UniRef100_Q9UIF7
Isoform Beta-1 of Adenine DNA glycosylase		HUMAN		532
Adenine DNA glycosylase (Fragment)		HUMAN		291
Q9UIF7-2	Adenine DNA glycosylase		HUMAN		522	UniRef100_Q9UIF7-2
Isoform Gamma-2 of Adenine DNA glycosylase		HUMAN		522
Q9UIF7-3	Adenine DNA glycosylase		HUMAN		535	UniRef100_E5KP27
Isoform Gamma-3 of Adenine DNA glycosylase		HUMAN		521
Adenine DNA glycosylase (Fragment)		HUMAN		466

Protein	Similar proteins		Species	Score	Length	Source
Q9UIF7	Adenine DNA glycosylase		HUMAN		546	UniRef90_Q9UIF7
Adenine DNA glycosylase		PANTR		615
Adenine DNA glycosylase		PANPA		521
Adenine DNA glycosylase		NOMLE		591
Adenine DNA glycosylase		GORGO		556
+93

Protein	Similar proteins		Species	Score	Length	Source
Q9UIF7	Adenine DNA glycosylase		HUMAN		546	UniRef50_Q9UIF7
Adenine DNA glycosylase		PANTR		615
Adenine DNA glycosylase		PANPA		521
Adenine DNA glycosylase		NOMLE		591
Adenine DNA glycosylase		GORGO		556
+375

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U63329 Genomic DNA Translation: AAC50618.1 AB032920 mRNA Translation: BAA89336.1 AB032921 mRNA Translation: BAA89337.1 AB032922 mRNA Translation: BAA89338.1 AB032923 mRNA Translation: BAA89339.1 Sequence problems. AB032924 mRNA Translation: BAA89340.1 AB032925 mRNA Translation: BAA89341.1 AB032926 mRNA Translation: BAA89342.1 AB032927 mRNA Translation: BAA89343.1 AB032928 mRNA Translation: BAA89344.1 AB032929 mRNA Translation: BAA89345.1 Sequence problems. HQ205466 Genomic DNA Translation: ADP90937.1 HQ205468 Genomic DNA Translation: ADP90947.1 HQ205469 Genomic DNA Translation: ADP90952.1 HQ205470 Genomic DNA Translation: ADP90957.1 HQ205472 Genomic DNA Translation: ADP90967.1 HQ205473 Genomic DNA Translation: ADP90972.1 HQ205474 Genomic DNA Translation: ADP90977.1 HQ205475 Genomic DNA Translation: ADP90982.1 HQ205476 Genomic DNA Translation: ADP90987.1 HQ205477 Genomic DNA Translation: ADP90992.1 HQ205479 Genomic DNA Translation: ADP91002.1 HQ205480 Genomic DNA Translation: ADP91007.1 HQ205481 Genomic DNA Translation: ADP91012.1 HQ205482 Genomic DNA Translation: ADP91017.1 HQ205483 Genomic DNA Translation: ADP91022.1 HQ205484 Genomic DNA Translation: ADP91027.1 HQ205485 Genomic DNA Translation: ADP91032.1 HQ205486 Genomic DNA Translation: ADP91037.1 HQ205487 Genomic DNA Translation: ADP91042.1 HQ205488 Genomic DNA Translation: ADP91047.1 HQ205489 Genomic DNA Translation: ADP91052.1 HQ205490 Genomic DNA Translation: ADP91057.1 HQ205491 Genomic DNA Translation: ADP91062.1 HQ205492 Genomic DNA Translation: ADP91067.1 HQ205493 Genomic DNA Translation: ADP91072.1 HQ205494 Genomic DNA Translation: ADP91077.1 HQ205495 Genomic DNA Translation: ADP91082.1 HQ205496 Genomic DNA Translation: ADP91087.1 HQ205497 Genomic DNA Translation: ADP91092.1 HQ205498 Genomic DNA Translation: ADP91097.1 HQ205499 Genomic DNA Translation: ADP91102.1 HQ205500 Genomic DNA Translation: ADP91107.1 HQ205501 Genomic DNA Translation: ADP91112.1 HQ205502 Genomic DNA Translation: ADP91117.1 HQ205503 Genomic DNA Translation: ADP91122.1 HQ205505 Genomic DNA Translation: ADP91132.1 AF527839 Genomic DNA Translation: AAM78555.1 AL359540 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06993.1 CH471059 Genomic DNA Translation: EAX06996.1 CH471059 Genomic DNA Translation: EAX06997.1 BC003178 mRNA Translation: AAH03178.1
CCDSⁱ	CCDS41320.1 [Q9UIF7-6] CCDS41321.1 [Q9UIF7-5] CCDS41322.1 [Q9UIF7-6] CCDS520.1 [Q9UIF7-1] CCDS72776.1 [Q9UIF7-4] CCDS72777.1 [Q9UIF7-2]
RefSeqⁱ	NP_001041636.1, NM_001048171.1 [Q9UIF7-6] NP_001041637.1, NM_001048172.1 [Q9UIF7-5] NP_001041638.1, NM_001048173.1 [Q9UIF7-6] NP_001041639.1, NM_001048174.1 [Q9UIF7-6] NP_001121897.1, NM_001128425.1 NP_001280119.1, NM_001293190.1 [Q9UIF7-2] NP_001280120.1, NM_001293191.1 [Q9UIF7-4] NP_001280121.1, NM_001293192.1 NP_001280124.1, NM_001293195.1 [Q9UIF7-6] NP_001280125.1, NM_001293196.1 NP_036354.1, NM_012222.2 [Q9UIF7-1] XP_011539806.1, XM_011541504.2 [Q9UIF7-4] XP_016856823.1, XM_017001334.1 [Q9UIF7-5] XP_016856824.1, XM_017001335.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X51	NMR	-	A	356-497	[»]
	3N5N	X-ray	2.30	X/Y	76-362	[»]
AlphaFoldDBⁱ	Q9UIF7
SMRⁱ	Q9UIF7
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	110681, 27 interactors
DIPⁱ	DIP-41972N
IntActⁱ	Q9UIF7, 16 interactors
MINTⁱ	Q9UIF7
STRINGⁱ	9606.ENSP00000361170

PTM databases

iPTMnetⁱ	Q9UIF7
PhosphoSitePlusⁱ	Q9UIF7

Genetic variation databases

BioMutaⁱ	MUTYH
DMDMⁱ	48428272

Proteomic databases

EPDⁱ	Q9UIF7
jPOSTⁱ	Q9UIF7
MassIVEⁱ	Q9UIF7
MaxQBⁱ	Q9UIF7
PaxDbⁱ	Q9UIF7
PeptideAtlasⁱ	Q9UIF7
PRIDEⁱ	Q9UIF7
ProteomicsDBⁱ	84500 [Q9UIF7-1] 84501 [Q9UIF7-2] 84502 [Q9UIF7-3] 84503 [Q9UIF7-4] 84504 [Q9UIF7-5] 84505 [Q9UIF7-6]

Protocols and materials databases

Antibodypediaⁱ	1869, 334 antibodies from 41 providers
The CPTC Antibody Portal More...CPTCⁱ	Q9UIF7, 1 antibody
The DNASU plasmid repository More...DNASUⁱ	4595

Genome annotation databases

Organism-specific databases

CTDⁱ	4595
DisGeNETⁱ	4595
GeneCardsⁱ	MUTYH
GeneReviewsⁱ	MUTYH
HGNCⁱ	HGNC:7527, MUTYH
HPAⁱ	ENSG00000132781, Low tissue specificity
MalaCardsⁱ	MUTYH
MIMⁱ	604933, gene 608456, phenotype 613659, phenotype
neXtProtⁱ	NX_Q9UIF7
OpenTargetsⁱ	ENSG00000132781
Orphanetⁱ	247798, MUTYH-related attenuated familial adenomatous polyposis
PharmGKBⁱ	PA31328
VEuPathDBⁱ	HostDB:ENSG00000132781
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2457, Eukaryota
GeneTreeⁱ	ENSGT00510000047220
HOGENOMⁱ	CLU_012862_0_0_1
InParanoidⁱ	Q9UIF7
OMAⁱ	THIRLKM
OrthoDBⁱ	616758at2759
PhylomeDBⁱ	Q9UIF7
TreeFamⁱ	TF328549

Enzyme and pathway databases

PathwayCommonsⁱ	Q9UIF7
Reactomeⁱ	R-HSA-110330, Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110331, Cleavage of the damaged purine R-HSA-110357, Displacement of DNA glycosylase by APEX1 R-HSA-9608287, Defective MUTYH substrate binding [Q9UIF7-3] R-HSA-9608290, Defective MUTYH substrate processing
SignaLinkⁱ	Q9UIF7
SIGNORⁱ	Q9UIF7

Miscellaneous databases

BioGRID-ORCSⁱ	4595, 17 hits in 1080 CRISPR screens
EvolutionaryTraceⁱ	Q9UIF7
GeneWikiⁱ	MUTYH
GenomeRNAiⁱ	4595
Pharosⁱ	Q9UIF7, Tbio
Protein Ontology More...PROⁱ	PR:Q9UIF7
RNActⁱ	Q9UIF7, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000132781, Expressed in right hemisphere of cerebellum and 225 other tissues
ExpressionAtlasⁱ	Q9UIF7, baseline and differential
Genevisibleⁱ	Q9UIF7, HS

Family and domain databases

CDDⁱ	cd03431, DNA_Glycosylase_C, 1 hit cd00056, ENDO3c, 1 hit
Gene3Dⁱ	1.10.1670.10, 1 hit
InterProⁱ	View protein in InterPro IPR011257, DNA_glycosylase IPR004036, Endonuclease-III-like_CS2 IPR003651, Endonuclease3_FeS-loop_motif IPR004035, Endouclease-III_FeS-bd_BS IPR003265, HhH-GPD_domain IPR023170, HhH_base_excis_C IPR000445, HhH_motif IPR044298, MIG/MutY IPR029119, MutY_C IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom
PANTHERⁱ	PTHR42944, PTHR42944, 1 hit
Pfamⁱ	View protein in Pfam PF00633, HHH, 1 hit PF00730, HhH-GPD, 1 hit PF14815, NUDIX_4, 1 hit
SMARTⁱ	View protein in SMART SM00478, ENDO3c, 1 hit SM00525, FES, 1 hit
SUPFAMⁱ	SSF48150, SSF48150, 1 hit SSF55811, SSF55811, 1 hit
PROSITEⁱ	View protein in PROSITE PS00764, ENDONUCLEASE_III_1, 1 hit PS01155, ENDONUCLEASE_III_2, 1 hit PS51462, NUDIX, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MUTYH_HUMAN
Accessionⁱ	Q9UIF7Primary (citable) accession number: Q9UIF7 Secondary accession number(s): D3DPZ4 Q9UIF6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
	Last sequence update:	May 1, 2000
	Last modified:	May 25, 2022
	This is version 198 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q9UIF7 (MUTYH_HUMAN)

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Adenine DNA glycosylase

MUTYH

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Isoform Alpha-3 [Q9UIF7-3]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ