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UniProtKB - Q9UIC8 (LCMT1_HUMAN)

Entry version 175 (25 May 2022)
Sequence version 2 (01 Dec 2000)
Previous versions | rss
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Protein

Leucine carboxyl methyltransferase 1

Gene

LCMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.1 µM for PP2AD1 Publication
  2. KM=1.3 µM for AdoMet1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei37S-adenosyl-L-methionineCombined sources1 Publication1
Binding sitei73S-adenosyl-L-methionineCombined sources1 Publication1
Binding sitei98S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1 Publication1
Binding sitei122S-adenosyl-L-methionineCombined sources1 Publication1
Binding sitei198S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.233, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UIC8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q9UIC8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UIC8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UIC8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine carboxyl methyltransferase 1 (EC:2.1.1.2332 Publications)
Alternative name(s):
Protein-leucine O-methyltransferase
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LCMT1
Synonyms:LCMT
ORF Names:CGI-68
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17557, LCMT1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610286, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UIC8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000205629

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51451

Open Targets

More...OpenTargetsi		ENSG00000205629

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134928443

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UIC8, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00149, Leucine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LCMT1

Domain mapping of disease mutations (DMDM)

More...DMDMi		12643251

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002044221 – 334Leucine carboxyl methyltransferase 1Add BLAST334

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UIC8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UIC8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UIC8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UIC8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UIC8

PeptideAtlas

More...PeptideAtlasi		Q9UIC8

PRoteomics IDEntifications database

More...PRIDEi		Q9UIC8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84491 [Q9UIC8-1]
84492 [Q9UIC8-2]
84493 [Q9UIC8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UIC8

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9UIC8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UIC8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000205629, Expressed in testis and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UIC8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UIC8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000205629, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119549, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q9UIC8, 6 interactors

Molecular INTeraction database

More...MINTi		Q9UIC8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000382021

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UIC8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9UIC8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UIC8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UIC8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni171 – 172S-adenosyl-L-methionine bindingCombined sources1 Publication2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the methyltransferase superfamily. LCMT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2918, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156372

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_031312_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UIC8

Identification of Orthologs from Complete Genome Data

More...OMAi		IIYEPIR

Database of Orthologous Groups

More...OrthoDBi		1094856at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UIC8

TreeFam database of animal gene trees

More...TreeFami		TF315087

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016651, PPM1
IPR007213, Ppm1/Ppm2/Tcmp
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...PANTHERi		PTHR13600, PTHR13600, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04072, LCM, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF016305, LCM_mtfrase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UIC8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATRQRESSI TSCCSTSSCD ADDEGVRGTC EDASLCKRFA VSIGYWHDPY 
        60         70         80         90        100
IQHFVRLSKE RKAPEINRGY FARVHGVSQL IKAFLRKTEC HCQIVNLGAG 
       110        120        130        140        150
MDTTFWRLKD EDLLPSKYFE VDFPMIVTRK LHSIKCKPPL SSPILELHSE 
       160        170        180        190        200
DTLQMDGHIL DSKRYAVIGA DLRDLSELEE KLKKCNMNTQ LPTLLIAECV 
       210        220        230        240        250
LVYMTPEQSA NLLKWAANSF ERAMFINYEQ VNMGDRFGQI MIENLRRRQC 
       260        270        280        290        300
DLAGVETCKS LESQKERLLS NGWETASAVD MMELYNRLPR AEVSRIESLE 
       310        320        330 
FLDEMELLEQ LMRHYCLCWA TKGGNELGLK EITY
Length:334
Mass (Da):38,379
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8D200118E6F353D
GO
Isoform 2 (identifier: Q9UIC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MATRQRESSI...GTCEDASLCK → MLPCARELPS...CSHLGLRSGR

Show »
Length:357
Mass (Da):41,106
Checksum:iFBC25BB4C0B61057
GO
Isoform 3 (identifier: Q9UIC8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-190: Missing.

Show »
Length:279
Mass (Da):32,172
Checksum:i6573F21B2405F64B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2Q8I3L2Q8_HUMAN
[Phosphatase 2A protein]-leucine-ca...
LCMT1
119Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2E3I3L2E3_HUMAN
[Phosphatase 2A protein]-leucine-ca...
LCMT1
93Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4A2I3L4A2_HUMAN
[Phosphatase 2A protein]-leucine-ca...
LCMT1
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L537I3L537_HUMAN
Leucine carboxyl methyltransferase ...
LCMT1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUP7H3BUP7_HUMAN
Leucine carboxyl methyltransferase ...
LCMT1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYF0H7BYF0_HUMAN
Leucine carboxyl methyltransferase ...
LCMT1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49P → S in BAD97084 (Ref. 4) Curated1
Sequence conflicti114L → P in BAB15270 (PubMed:14702039).Curated1
Sequence conflicti248 – 249RQ → PS in AAD34063 (PubMed:10810093).Curated2
Sequence conflicti251D → E in AAF18267 (PubMed:10600115).Curated1
Sequence conflicti301F → L in BAB15270 (PubMed:14702039).Curated1
Sequence conflicti306 – 307EL → DV in AAF18267 (PubMed:10600115).Curated2
Sequence conflicti312 – 313MR → NA in AAF18267 (PubMed:10600115).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0174281 – 37MATRQ…ASLCK → MLPCARELPSAAPDSTLLLT AQHWVANLFILATLIGWTVR SFFLGRMETCCSHLGLRSGR in isoform 2. 3 PublicationsAdd BLAST37
Alternative sequenceiVSP_041416136 – 190Missing in isoform 3. CuratedAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF037601 mRNA Translation: AAF18267.1
AF151826 mRNA Translation: AAD34063.1
AK025884 mRNA Translation: BAB15270.1
AK223364 mRNA Translation: BAD97084.1
AK291885 mRNA Translation: BAF84574.1
AK314409 mRNA Translation: BAG37031.1
AC008741 Genomic DNA No translation available.
AC133552 Genomic DNA No translation available.
BC001214 mRNA Translation: AAH01214.1
BC014217 mRNA Translation: AAH14217.1
AL137283 mRNA Translation: CAB70677.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45445.1 [Q9UIC8-1]
CCDS45446.1 [Q9UIC8-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T46352

NCBI Reference Sequences

More...RefSeqi		NP_001027563.1, NM_001032391.1 [Q9UIC8-3]
NP_057393.2, NM_016309.2 [Q9UIC8-1]
XP_011544166.1, XM_011545864.1 [Q9UIC8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000380966.8; ENSP00000370353.4; ENSG00000205629.12 [Q9UIC8-3]
ENST00000399069.8; ENSP00000382021.3; ENSG00000205629.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51451

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51451

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000399069.8; ENSP00000382021.3; NM_016309.3; NP_057393.2

UCSC genome browser

More...UCSCi		uc002dnx.2, human [Q9UIC8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037601 mRNA Translation: AAF18267.1
AF151826 mRNA Translation: AAD34063.1
AK025884 mRNA Translation: BAB15270.1
AK223364 mRNA Translation: BAD97084.1
AK291885 mRNA Translation: BAF84574.1
AK314409 mRNA Translation: BAG37031.1
AC008741 Genomic DNA No translation available.
AC133552 Genomic DNA No translation available.
BC001214 mRNA Translation: AAH01214.1
BC014217 mRNA Translation: AAH14217.1
AL137283 mRNA Translation: CAB70677.1
CCDSiCCDS45445.1 [Q9UIC8-1]
CCDS45446.1 [Q9UIC8-3]
PIRiT46352
RefSeqiNP_001027563.1, NM_001032391.1 [Q9UIC8-3]
NP_057393.2, NM_016309.2 [Q9UIC8-1]
XP_011544166.1, XM_011545864.1 [Q9UIC8-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IEIX-ray1.90A/B/C/D/E/F/G/H1-334[»]
3O7WX-ray2.00A23-232[»]
A259-334[»]
3P71X-ray2.70T1-334[»]
AlphaFoldDBiQ9UIC8
SMRiQ9UIC8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119549, 21 interactors
IntActiQ9UIC8, 6 interactors
MINTiQ9UIC8
STRINGi9606.ENSP00000382021

Chemistry databases

DrugBankiDB00149, Leucine

PTM databases

iPTMnetiQ9UIC8
MetOSiteiQ9UIC8
PhosphoSitePlusiQ9UIC8

Genetic variation databases

BioMutaiLCMT1
DMDMi12643251

Proteomic databases

EPDiQ9UIC8
jPOSTiQ9UIC8
MassIVEiQ9UIC8
MaxQBiQ9UIC8
PaxDbiQ9UIC8
PeptideAtlasiQ9UIC8
PRIDEiQ9UIC8
ProteomicsDBi84491 [Q9UIC8-1]
84492 [Q9UIC8-2]
84493 [Q9UIC8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26192, 239 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		51451

Genome annotation databases

EnsembliENST00000380966.8; ENSP00000370353.4; ENSG00000205629.12 [Q9UIC8-3]
ENST00000399069.8; ENSP00000382021.3; ENSG00000205629.12
GeneIDi51451
KEGGihsa:51451
MANE-SelectiENST00000399069.8; ENSP00000382021.3; NM_016309.3; NP_057393.2
UCSCiuc002dnx.2, human [Q9UIC8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51451
DisGeNETi51451

GeneCards: human genes, protein and diseases

More...GeneCardsi		LCMT1
HGNCiHGNC:17557, LCMT1
HPAiENSG00000205629, Low tissue specificity
MIMi610286, gene
neXtProtiNX_Q9UIC8
OpenTargetsiENSG00000205629
PharmGKBiPA134928443
VEuPathDBiHostDB:ENSG00000205629

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2918, Eukaryota
GeneTreeiENSGT00940000156372
HOGENOMiCLU_031312_0_0_1
InParanoidiQ9UIC8
OMAiIIYEPIR
OrthoDBi1094856at2759
PhylomeDBiQ9UIC8
TreeFamiTF315087

Enzyme and pathway databases

BRENDAi2.1.1.233, 2681
PathwayCommonsiQ9UIC8
ReactomeiR-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition
SABIO-RKiQ9UIC8
SignaLinkiQ9UIC8
SIGNORiQ9UIC8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51451, 250 hits in 1090 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LCMT1, human
EvolutionaryTraceiQ9UIC8

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Leucine_carboxyl_methyltransferase_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51451
PharosiQ9UIC8, Tbio

Protein Ontology

More...PROi		PR:Q9UIC8
RNActiQ9UIC8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000205629, Expressed in testis and 238 other tissues
ExpressionAtlasiQ9UIC8, baseline and differential
GenevisibleiQ9UIC8, HS

Family and domain databases

Gene3Di3.40.50.150, 1 hit
InterProiView protein in InterPro
IPR016651, PPM1
IPR007213, Ppm1/Ppm2/Tcmp
IPR029063, SAM-dependent_MTases
PANTHERiPTHR13600, PTHR13600, 1 hit
PfamiView protein in Pfam
PF04072, LCM, 1 hit
PIRSFiPIRSF016305, LCM_mtfrase, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCMT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIC8
Secondary accession number(s): A6NL89
, A8K770, Q53FC5, Q96CI5, Q9H6I9, Q9NTG4, Q9Y378
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 25, 2022
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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