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UniProtKB - Q9UIC8 (LCMT1_HUMAN)

Entry version 166 (17 Jun 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Leucine carboxyl methyltransferase 1

Gene

LCMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.1 µM for PP2AD1 Publication
  2. KM=1.3 µM for AdoMet1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei37S-adenosyl-L-methionineCombined sources1 Publication1
    Binding sitei73S-adenosyl-L-methionineCombined sources1 Publication1
    Binding sitei98S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1 Publication1
    Binding sitei122S-adenosyl-L-methionineCombined sources1 Publication1
    Binding sitei198S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMethyltransferase, Transferase
    LigandS-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:MONOMER-16510

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q9UIC8

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Leucine carboxyl methyltransferase 1 (EC:2.1.1.2332 Publications)
    Alternative name(s):
    Protein-leucine O-methyltransferase
    [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:LCMT1
    Synonyms:LCMT
    ORF Names:CGI-68
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000205629.11

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:17557 LCMT1

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		610286 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q9UIC8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		51451

    Open Targets

    More...    OpenTargetsi    		ENSG00000205629

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA134928443

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q9UIC8 Tbio

    Chemistry databases

    Drug and drug target database

    More...    DrugBanki    		DB00149 Leucine

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		LCMT1

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		12643251

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002044221 – 334Leucine carboxyl methyltransferase 1Add BLAST334

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q9UIC8

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q9UIC8

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q9UIC8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9UIC8

    PeptideAtlas

    More...    PeptideAtlasi    		Q9UIC8

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9UIC8

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		84491 [Q9UIC8-1]
    84492 [Q9UIC8-2]
    84493 [Q9UIC8-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9UIC8

    MetOSite database of methionine sulfoxide sites

    More...    MetOSitei    		Q9UIC8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9UIC8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000205629 Expressed in testis and 224 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q9UIC8 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q9UIC8 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000205629 Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		119549, 10 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q9UIC8, 6 interactors

    Molecular INTeraction database

    More...    MINTi    		Q9UIC8

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000382021

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q9UIC8 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1334
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q9UIC8

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		Q9UIC8

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni171 – 172S-adenosyl-L-methionine bindingCombined sources1 Publication2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the methyltransferase superfamily. LCMT family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG2918 Eukaryota
    ENOG410YB9K LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000156372

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_031312_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9UIC8

    KEGG Orthology (KO)

    More...    KOi    		K18203

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		NMSDRFG

    Database of Orthologous Groups

    More...    OrthoDBi    		1094856at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9UIC8

    TreeFam database of animal gene trees

    More...    TreeFami    		TF315087

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR016651 PPM1
    IPR007213 Ppm1/Ppm2/Tcmp
    IPR029063 SAM-dependent_MTases

    The PANTHER Classification System

    More...    PANTHERi    		PTHR13600 PTHR13600, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF04072 LCM, 1 hit

    PIRSF; a whole-protein classification database

    More...    PIRSFi    		PIRSF016305 LCM_mtfrase, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF53335 SSF53335, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9UIC8-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MATRQRESSI TSCCSTSSCD ADDEGVRGTC EDASLCKRFA VSIGYWHDPY 
            60         70         80         90        100
    IQHFVRLSKE RKAPEINRGY FARVHGVSQL IKAFLRKTEC HCQIVNLGAG 
           110        120        130        140        150
    MDTTFWRLKD EDLLPSKYFE VDFPMIVTRK LHSIKCKPPL SSPILELHSE 
           160        170        180        190        200
    DTLQMDGHIL DSKRYAVIGA DLRDLSELEE KLKKCNMNTQ LPTLLIAECV 
           210        220        230        240        250
    LVYMTPEQSA NLLKWAANSF ERAMFINYEQ VNMGDRFGQI MIENLRRRQC 
           260        270        280        290        300
    DLAGVETCKS LESQKERLLS NGWETASAVD MMELYNRLPR AEVSRIESLE 
           310        320        330 
    FLDEMELLEQ LMRHYCLCWA TKGGNELGLK EITY
    Length:334
    Mass (Da):38,379
    Last modified:December 1, 2000 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8D200118E6F353D
    GO
    Isoform 2 (identifier: Q9UIC8-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-37: MATRQRESSI...GTCEDASLCK → MLPCARELPS...CSHLGLRSGR

    Show »
    Length:357
    Mass (Da):41,106
    Checksum:iFBC25BB4C0B61057
    GO
    Isoform 3 (identifier: Q9UIC8-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         136-190: Missing.

    Show »
    Length:279
    Mass (Da):32,172
    Checksum:i6573F21B2405F64B
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    I3L2E3I3L2E3_HUMAN
    Leucine carboxyl methyltransferase ...
    LCMT1
    		93Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L2Q8I3L2Q8_HUMAN
    Leucine carboxyl methyltransferase ...
    LCMT1
    		119Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L4A2I3L4A2_HUMAN
    Leucine carboxyl methyltransferase ...
    LCMT1
    		158Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L537I3L537_HUMAN
    Leucine carboxyl methyltransferase ...
    LCMT1
    		138Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BUP7H3BUP7_HUMAN
    Leucine carboxyl methyltransferase ...
    LCMT1
    		111Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7BYF0H7BYF0_HUMAN
    Leucine carboxyl methyltransferase ...
    LCMT1
    		101Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49P → S in BAD97084 (Ref. 4) Curated1
    Sequence conflicti114L → P in BAB15270 (PubMed:14702039).Curated1
    Sequence conflicti248 – 249RQ → PS in AAD34063 (PubMed:10810093).Curated2
    Sequence conflicti251D → E in AAF18267 (PubMed:10600115).Curated1
    Sequence conflicti301F → L in BAB15270 (PubMed:14702039).Curated1
    Sequence conflicti306 – 307EL → DV in AAF18267 (PubMed:10600115).Curated2
    Sequence conflicti312 – 313MR → NA in AAF18267 (PubMed:10600115).Curated2

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0174281 – 37MATRQ…ASLCK → MLPCARELPSAAPDSTLLLT AQHWVANLFILATLIGWTVR SFFLGRMETCCSHLGLRSGR in isoform 2. 3 PublicationsAdd BLAST37
    Alternative sequenceiVSP_041416136 – 190Missing in isoform 3. CuratedAdd BLAST55

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF037601 mRNA Translation: AAF18267.1
    AF151826 mRNA Translation: AAD34063.1
    AK025884 mRNA Translation: BAB15270.1
    AK223364 mRNA Translation: BAD97084.1
    AK291885 mRNA Translation: BAF84574.1
    AK314409 mRNA Translation: BAG37031.1
    AC008741 Genomic DNA No translation available.
    AC133552 Genomic DNA No translation available.
    BC001214 mRNA Translation: AAH01214.1
    BC014217 mRNA Translation: AAH14217.1
    AL137283 mRNA Translation: CAB70677.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS45445.1 [Q9UIC8-1]
    CCDS45446.1 [Q9UIC8-3]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		T46352

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001027563.1, NM_001032391.1 [Q9UIC8-3]
    NP_057393.2, NM_016309.2 [Q9UIC8-1]
    XP_011544166.1, XM_011545864.1 [Q9UIC8-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000380966; ENSP00000370353; ENSG00000205629 [Q9UIC8-3]
    ENST00000399069; ENSP00000382021; ENSG00000205629 [Q9UIC8-1]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		51451

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:51451

    UCSC genome browser

    More...    UCSCi    		uc002dnx.2 human [Q9UIC8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF037601 mRNA Translation: AAF18267.1
    AF151826 mRNA Translation: AAD34063.1
    AK025884 mRNA Translation: BAB15270.1
    AK223364 mRNA Translation: BAD97084.1
    AK291885 mRNA Translation: BAF84574.1
    AK314409 mRNA Translation: BAG37031.1
    AC008741 Genomic DNA No translation available.
    AC133552 Genomic DNA No translation available.
    BC001214 mRNA Translation: AAH01214.1
    BC014217 mRNA Translation: AAH14217.1
    AL137283 mRNA Translation: CAB70677.1
    CCDSiCCDS45445.1 [Q9UIC8-1]
    CCDS45446.1 [Q9UIC8-3]
    PIRiT46352
    RefSeqiNP_001027563.1, NM_001032391.1 [Q9UIC8-3]
    NP_057393.2, NM_016309.2 [Q9UIC8-1]
    XP_011544166.1, XM_011545864.1 [Q9UIC8-2]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3IEIX-ray1.90A/B/C/D/E/F/G/H1-334[»]
    3O7WX-ray2.00A23-232[»]
    A259-334[»]
    3P71X-ray2.70T1-334[»]
    SMRiQ9UIC8
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi119549, 10 interactors
    IntActiQ9UIC8, 6 interactors
    MINTiQ9UIC8
    STRINGi9606.ENSP00000382021

    Chemistry databases

    DrugBankiDB00149 Leucine

    PTM databases

    iPTMnetiQ9UIC8
    MetOSiteiQ9UIC8
    PhosphoSitePlusiQ9UIC8

    Polymorphism and mutation databases

    BioMutaiLCMT1
    DMDMi12643251

    Proteomic databases

    EPDiQ9UIC8
    jPOSTiQ9UIC8
    MassIVEiQ9UIC8
    PaxDbiQ9UIC8
    PeptideAtlasiQ9UIC8
    PRIDEiQ9UIC8
    ProteomicsDBi84491 [Q9UIC8-1]
    84492 [Q9UIC8-2]
    84493 [Q9UIC8-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		26192 229 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		51451

    Genome annotation databases

    EnsembliENST00000380966; ENSP00000370353; ENSG00000205629 [Q9UIC8-3]
    ENST00000399069; ENSP00000382021; ENSG00000205629 [Q9UIC8-1]
    GeneIDi51451
    KEGGihsa:51451
    UCSCiuc002dnx.2 human [Q9UIC8-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		51451
    DisGeNETi51451
    EuPathDBiHostDB:ENSG00000205629.11

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		LCMT1
    HGNCiHGNC:17557 LCMT1
    HPAiENSG00000205629 Low tissue specificity
    MIMi610286 gene
    neXtProtiNX_Q9UIC8
    OpenTargetsiENSG00000205629
    PharmGKBiPA134928443

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG2918 Eukaryota
    ENOG410YB9K LUCA
    GeneTreeiENSGT00940000156372
    HOGENOMiCLU_031312_0_0_1
    InParanoidiQ9UIC8
    KOiK18203
    OMAiNMSDRFG
    OrthoDBi1094856at2759
    PhylomeDBiQ9UIC8
    TreeFamiTF315087

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-16510
    ReactomeiR-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
    SABIO-RKiQ9UIC8

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		51451 217 hits in 794 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		LCMT1 human
    EvolutionaryTraceiQ9UIC8

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		Leucine_carboxyl_methyltransferase_1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		51451
    PharosiQ9UIC8 Tbio

    Protein Ontology

    More...    PROi    		PR:Q9UIC8
    RNActiQ9UIC8 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000205629 Expressed in testis and 224 other tissues
    ExpressionAtlasiQ9UIC8 baseline and differential
    GenevisibleiQ9UIC8 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR016651 PPM1
    IPR007213 Ppm1/Ppm2/Tcmp
    IPR029063 SAM-dependent_MTases
    PANTHERiPTHR13600 PTHR13600, 1 hit
    PfamiView protein in Pfam
    PF04072 LCM, 1 hit
    PIRSFiPIRSF016305 LCM_mtfrase, 1 hit
    SUPFAMiSSF53335 SSF53335, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCMT1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIC8
    Secondary accession number(s): A6NL89
    , A8K770, Q53FC5, Q96CI5, Q9H6I9, Q9NTG4, Q9Y378
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: June 17, 2020
    This is version 166 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
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