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Entry version 152 (16 Jan 2019)
Sequence version 1 (01 May 2000)
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Protein

SLAM family member 5

Gene

CD84

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592).By similarityCurated7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Autophagy, Cell adhesion, Immunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SLAM family member 5
Alternative name(s):
Cell surface antigen MAX.3
Hly9-beta
Leukocyte differentiation antigen CD84
Signaling lymphocytic activation molecule 5
CD_antigen: CD84
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD84
Synonyms:SLAMF5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000066294.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1704 CD84

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604513 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UIB8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 225ExtracellularSequence analysisAdd BLAST204
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 345CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi55T → A: Loss of dimerization. 1 Publication1
Mutagenesisi62Y → A: No effect. 1 Publication1
Mutagenesisi62Y → D: Loss of dimerization. 1 Publication1
Mutagenesisi77T → A: Loss of dimerization. 1 Publication1
Mutagenesisi78H → A: Loss of dimerization. 1 Publication1
Mutagenesisi110D → A: Loss of dimerization. 1 Publication1
Mutagenesisi112N → A: Loss of dimerization. 1 Publication1
Mutagenesisi119T → A: Loss of dimerization. 1 Publication1
Mutagenesisi279Y → F: Reduced tyrosine phosphorylation, reduced binding of SH2D1B and loss of binding of SH2D1A. 1 Publication1
Mutagenesisi316Y → F: Reduced tyrosine phosphorylation and reduced binding of SH2D1B. Loss of phosphorylation and loss of binding of SH2D1A and SH2D1B; when associated with F-279. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8832

Open Targets

More...
OpenTargetsi
ENSG00000066294

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26242

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CD84

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762772

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025202922 – 345SLAM family member 5Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi155 ↔ 193PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei279Phosphotyrosine1 Publication1
Modified residuei296Phosphotyrosine; by LYN2 Publications1
Modified residuei316Phosphotyrosine1 Publication1 Publication1
Modified residuei341Phosphotyrosine; by FES1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A is dependent of tyrosine phosphorylation of its cytoplasmic domain. Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation. Phosphorylated on tyrosine residues upon high affinity immunoglobulin epsilon receptor aggregation in mast cells.5 Publications
N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UIB8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UIB8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UIB8

PeptideAtlas

More...
PeptideAtlasi
Q9UIB8

PRoteomics IDEntifications database

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PRIDEi
Q9UIB8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84484
84485 [Q9UIB8-2]
84486 [Q9UIB8-3]
84487 [Q9UIB8-4]
84488 [Q9UIB8-5]
84489 [Q9UIB8-6]
84490 [Q9UIB8-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UIB8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UIB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast cells.7 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is slightly increased in naive B-cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000066294 Expressed in 187 organ(s), highest expression level in visceral pleura

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UIB8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA070502

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/EAT-2. Interacts with tyrosine-protein phosphatases PTPN6/SHP-1 and PTPN11//SHP-2 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A. Interacts (via phosphorylated ITSM 1 and 2) with INPP5D/SHIP1.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114359, 6 interactors

Database of interacting proteins

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DIPi
DIP-60957N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9UIB8

Protein interaction database and analysis system

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IntActi
Q9UIB8, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9UIB8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000312367

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PKDX-ray2.04A/B/C/D/E/F22-131[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UIB8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UIB8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UIB8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 129Ig-like V-typeAdd BLAST104
Domaini135 – 207Ig-like C2-typeAdd BLAST73

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi277 – 282ITSM 1By similarity6
Motifi314 – 319ITSM 2By similarity6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).By similarity1 Publication

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IVV0 Eukaryota
ENOG410Z5M6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154401

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG093961

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UIB8

KEGG Orthology (KO)

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KOi
K06511

Identification of Orthologs from Complete Genome Data

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OMAi
ITQSLMT

Database of Orthologous Groups

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OrthoDBi
990343at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UIB8

TreeFam database of animal gene trees

More...
TreeFami
TF334964

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UIB8-1) [UniParc]FASTAAdd to basket
Also known as: CD84a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQHHLWILL LCLQTWPEAA GKDSEIFTVN GILGESVTFP VNIQEPRQVK
60 70 80 90 100
IIAWTSKTSV AYVTPGDSET APVVTVTHRN YYERIHALGP NYNLVISDLR
110 120 130 140 150
MEDAGDYKAD INTQADPYTT TKRYNLQIYR RLGKPKITQS LMASVNSTCN
160 170 180 190 200
VTLTCSVEKE EKNVTYNWSP LGEEGNVLQI FQTPEDQELT YTCTAQNPVS
210 220 230 240 250
NNSDSISARQ LCADIAMGFR THHTGLLSVL AMFFLLVLIL SSVFLFRLFK
260 270 280 290 300
RRQGRIFPEG SCLNTFTKNP YAASKKTIYT YIMASRNTQP AESRIYDEIL
310 320 330 340
QSKVLPSKEE PVNTVYSEVQ FADKMGKAST QDSKPPGTSS YEIVI
Length:345
Mass (Da):38,782
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA06BC5A682E62DE
GO
Isoform 2 (identifier: Q9UIB8-2) [UniParc]FASTAAdd to basket
Also known as: CD84b

The sequence of this isoform differs from the canonical sequence as follows:
     254-259: Missing.

Show »
Length:339
Mass (Da):38,082
Checksum:iE78D6D5CAC8D3604
GO
Isoform 3 (identifier: Q9UIB8-3) [UniParc]FASTAAdd to basket
Also known as: CD84c

The sequence of this isoform differs from the canonical sequence as follows:
     254-271: GRIFPEGSCLNTFTKNPY → D

Show »
Length:328
Mass (Da):36,871
Checksum:i6C9A89206A6D0344
GO
Isoform 4 (identifier: Q9UIB8-4) [UniParc]FASTAAdd to basket
Also known as: CD84e

The sequence of this isoform differs from the canonical sequence as follows:
     261-280: SCLNTFTKNPYAASKKTIYT → KMWKLTFSPPGTEAIYPRFS
     281-345: Missing.

Show »
Length:280
Mass (Da):31,651
Checksum:iA043E048E762A718
GO
Isoform 5 (identifier: Q9UIB8-5) [UniParc]FASTAAdd to basket
Also known as: CD84d

The sequence of this isoform differs from the canonical sequence as follows:
     255-272: RIFPEGSCLNTFTKNPYA → ASLQGRASEHSLFRSAVC
     273-345: Missing.

Show »
Length:272
Mass (Da):30,514
Checksum:i6A2E13AA4E22E13E
GO
Isoform 6 (identifier: Q9UIB8-6) [UniParc]FASTAAdd to basket
Also known as: CD84s

The sequence of this isoform differs from the canonical sequence as follows:
     214-241: DIAMGFRTHHTGLLSVLAMFFLLVLILS → GNQLCPSLLVSLRDHSEELQGLNVGHIL
     242-345: Missing.

Show »
Length:241
Mass (Da):26,902
Checksum:iF0121BC1609B6C52
GO
Isoform 7 (identifier: Q9UIB8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-130: WPEAAGKDSE...TKRYNLQIYR → C
     254-271: GRIFPEGSCLNTFTKNPY → D

Show »
Length:214
Mass (Da):24,025
Checksum:iF6E403CF77EB2D2A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti311P → S in CAG46645 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02084816 – 130WPEAA…LQIYR → C in isoform 7. 2 PublicationsAdd BLAST115
Alternative sequenceiVSP_020849214 – 241DIAMG…VLILS → GNQLCPSLLVSLRDHSEELQ GLNVGHIL in isoform 6. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_020850242 – 345Missing in isoform 6. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_020851254 – 271GRIFP…TKNPY → D in isoform 3 and isoform 7. 7 PublicationsAdd BLAST18
Alternative sequenceiVSP_020852254 – 259Missing in isoform 2. 1 Publication6
Alternative sequenceiVSP_020853255 – 272RIFPE…KNPYA → ASLQGRASEHSLFRSAVC in isoform 5. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_020854261 – 280SCLNT…KTIYT → KMWKLTFSPPGTEAIYPRFS in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_020855273 – 345Missing in isoform 5. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_020856281 – 345Missing in isoform 4. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U82988 mRNA Translation: AAB84364.1
AJ223324 mRNA Translation: CAA11264.1
AF054815 mRNA Translation: AAF21721.1
AF054816 mRNA Translation: AAF21722.1
AF054817 mRNA Translation: AAF21723.1
AF054818 mRNA Translation: AAF21724.1
AF081189 Genomic DNA Translation: AAD13155.1
AH008972 Genomic DNA Translation: AAF21784.1
AH008376 Genomic DNA Translation: AAF06840.1
U96627 mRNA Translation: AAD04232.1
Y12632 mRNA Translation: CAA73181.1
AK296290 mRNA Translation: BAH12304.1
AK313496 mRNA Translation: BAG36278.1
CR541847 mRNA Translation: CAG46645.1
CR933666 mRNA Translation: CAI45963.1
AL138930 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52707.1
BC020063 mRNA Translation: AAH20063.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1206.1 [Q9UIB8-3]
CCDS53395.1 [Q9UIB8-7]
CCDS53396.1 [Q9UIB8-1]
CCDS53397.1 [Q9UIB8-5]
CCDS81388.1 [Q9UIB8-2]

NCBI Reference Sequences

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RefSeqi
NP_001171808.1, NM_001184879.1 [Q9UIB8-1]
NP_001171810.1, NM_001184881.1 [Q9UIB8-5]
NP_001171811.1, NM_001184882.1 [Q9UIB8-7]
NP_001317671.1, NM_001330742.1 [Q9UIB8-2]
NP_003865.1, NM_003874.3 [Q9UIB8-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.398093

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000311224; ENSP00000312367; ENSG00000066294 [Q9UIB8-1]
ENST00000368048; ENSP00000357027; ENSG00000066294 [Q9UIB8-2]
ENST00000368051; ENSP00000357030; ENSG00000066294 [Q9UIB8-5]
ENST00000368054; ENSP00000357033; ENSG00000066294 [Q9UIB8-3]
ENST00000534968; ENSP00000442845; ENSG00000066294 [Q9UIB8-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8832

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8832

UCSC genome browser

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UCSCi
uc001fwf.5 human [Q9UIB8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82988 mRNA Translation: AAB84364.1
AJ223324 mRNA Translation: CAA11264.1
AF054815 mRNA Translation: AAF21721.1
AF054816 mRNA Translation: AAF21722.1
AF054817 mRNA Translation: AAF21723.1
AF054818 mRNA Translation: AAF21724.1
AF081189 Genomic DNA Translation: AAD13155.1
AH008972 Genomic DNA Translation: AAF21784.1
AH008376 Genomic DNA Translation: AAF06840.1
U96627 mRNA Translation: AAD04232.1
Y12632 mRNA Translation: CAA73181.1
AK296290 mRNA Translation: BAH12304.1
AK313496 mRNA Translation: BAG36278.1
CR541847 mRNA Translation: CAG46645.1
CR933666 mRNA Translation: CAI45963.1
AL138930 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52707.1
BC020063 mRNA Translation: AAH20063.1
CCDSiCCDS1206.1 [Q9UIB8-3]
CCDS53395.1 [Q9UIB8-7]
CCDS53396.1 [Q9UIB8-1]
CCDS53397.1 [Q9UIB8-5]
CCDS81388.1 [Q9UIB8-2]
RefSeqiNP_001171808.1, NM_001184879.1 [Q9UIB8-1]
NP_001171810.1, NM_001184881.1 [Q9UIB8-5]
NP_001171811.1, NM_001184882.1 [Q9UIB8-7]
NP_001317671.1, NM_001330742.1 [Q9UIB8-2]
NP_003865.1, NM_003874.3 [Q9UIB8-3]
UniGeneiHs.398093

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PKDX-ray2.04A/B/C/D/E/F22-131[»]
ProteinModelPortaliQ9UIB8
SMRiQ9UIB8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114359, 6 interactors
DIPiDIP-60957N
ELMiQ9UIB8
IntActiQ9UIB8, 3 interactors
MINTiQ9UIB8
STRINGi9606.ENSP00000312367

PTM databases

iPTMnetiQ9UIB8
PhosphoSitePlusiQ9UIB8

Polymorphism and mutation databases

BioMutaiCD84
DMDMi74762772

Proteomic databases

EPDiQ9UIB8
jPOSTiQ9UIB8
PaxDbiQ9UIB8
PeptideAtlasiQ9UIB8
PRIDEiQ9UIB8
ProteomicsDBi84484
84485 [Q9UIB8-2]
84486 [Q9UIB8-3]
84487 [Q9UIB8-4]
84488 [Q9UIB8-5]
84489 [Q9UIB8-6]
84490 [Q9UIB8-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8832
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311224; ENSP00000312367; ENSG00000066294 [Q9UIB8-1]
ENST00000368048; ENSP00000357027; ENSG00000066294 [Q9UIB8-2]
ENST00000368051; ENSP00000357030; ENSG00000066294 [Q9UIB8-5]
ENST00000368054; ENSP00000357033; ENSG00000066294 [Q9UIB8-3]
ENST00000534968; ENSP00000442845; ENSG00000066294 [Q9UIB8-7]
GeneIDi8832
KEGGihsa:8832
UCSCiuc001fwf.5 human [Q9UIB8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8832
DisGeNETi8832
EuPathDBiHostDB:ENSG00000066294.14

GeneCards: human genes, protein and diseases

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GeneCardsi
CD84
HGNCiHGNC:1704 CD84
HPAiHPA070502
MIMi604513 gene
neXtProtiNX_Q9UIB8
OpenTargetsiENSG00000066294
PharmGKBiPA26242

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVV0 Eukaryota
ENOG410Z5M6 LUCA
GeneTreeiENSGT00940000154401
HOVERGENiHBG093961
InParanoidiQ9UIB8
KOiK06511
OMAiITQSLMT
OrthoDBi990343at2759
PhylomeDBiQ9UIB8
TreeFamiTF334964

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CD84 human
EvolutionaryTraceiQ9UIB8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD84

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8832

Protein Ontology

More...
PROi
PR:Q9UIB8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000066294 Expressed in 187 organ(s), highest expression level in visceral pleura
GenevisibleiQ9UIB8 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLAF5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIB8
Secondary accession number(s): B2R8T1
, B7Z3R8, O15430, O95266, O95660, Q5H9R1, Q6FHA8, Q8WLP1, Q8WWI8, Q9UF04, Q9UIB6, Q9UIB7, Q9UIT7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 1, 2000
Last modified: January 16, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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