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Protein

Exportin-7

Gene

XPO7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.2 Publications

GO - Molecular functioni

  • nuclear export signal receptor activity Source: UniProtKB
  • Ran GTPase binding Source: GO_Central

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • protein export from nucleus Source: UniProtKB

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-7
Short name:
Exp7
Alternative name(s):
Ran-binding protein 16
Gene namesi
Name:XPO7
Synonyms:KIAA0745, RANBP16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000130227.16
HGNCiHGNC:14108 XPO7
MIMi606140 gene
neXtProtiNX_Q9UIA9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130227
PharmGKBiPA34207

Polymorphism and mutation databases

BioMutaiXPO7
DMDMi17369686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002047132 – 1087Exportin-7Add BLAST1086

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei570PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UIA9
MaxQBiQ9UIA9
PaxDbiQ9UIA9
PeptideAtlasiQ9UIA9
PRIDEiQ9UIA9
ProteomicsDBi84483

PTM databases

iPTMnetiQ9UIA9
PhosphoSitePlusiQ9UIA9
SwissPalmiQ9UIA9

Expressioni

Tissue specificityi

Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.2 Publications

Gene expression databases

BgeeiENSG00000130227
CleanExiHS_XPO7
ExpressionAtlasiQ9UIA9 baseline and differential
GenevisibleiQ9UIA9 HS

Organism-specific databases

HPAiHPA043727
HPA048153

Interactioni

Subunit structurei

Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP-dependent manner.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
USO1O607633EBI-286668,EBI-356164

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116678, 98 interactors
IntActiQ9UIA9, 43 interactors
MINTiQ9UIA9
STRINGi9606.ENSP00000252512

Structurei

3D structure databases

ProteinModelPortaliQ9UIA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 96Importin N-terminalPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

eggNOGiKOG1410 Eukaryota
ENOG410XRPR LUCA
GeneTreeiENSGT00730000110927
HOGENOMiHOG000018865
HOVERGENiHBG018869
InParanoidiQ9UIA9
KOiK18460
PhylomeDBiQ9UIA9
TreeFamiTF314248

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UIA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADHVQSLAQ LENLCKQLYE TTDTTTRLQA EKALVEFTNS PDCLSKCQLL
60 70 80 90 100
LERGSSSYSQ LLAATCLTKL VSRTNNPLPL EQRIDIRNYV LNYLATRPKL
110 120 130 140 150
ATFVTQALIQ LYARITKLGW FDCQKDDYVF RNAITDVTRF LQDSVEYCII
160 170 180 190 200
GVTILSQLTN EINQADTTHP LTKHRKIASS FRDSSLFDIF TLSCNLLKQA
210 220 230 240 250
SGKNLNLNDE SQHGLLMQLL KLTHNCLNFD FIGTSTDESS DDLCTVQIPT
260 270 280 290 300
SWRSAFLDSS TLQLFFDLYH SIPPSFSPLV LSCLVQIASV RRSLFNNAER
310 320 330 340 350
AKFLSHLVDG VKRILENPQS LSDPNNYHEF CRLLARLKSN YQLGELVKVE
360 370 380 390 400
NYPEVIRLIA NFTVTSLQHW EFAPNSVHYL LSLWQRLAAS VPYVKATEPH
410 420 430 440 450
MLETYTPEVT KAYITSRLES VHIILRDGLE DPLEDTGLVQ QQLDQLSTIG
460 470 480 490 500
RCEYEKTCAL LVQLFDQSAQ SYQELLQSAS ASPMDIAVQE GRLTWLVYII
510 520 530 540 550
GAVIGGRVSF ASTDEQDAMD GELVCRVLQL MNLTDSRLAQ AGNEKLELAM
560 570 580 590 600
LSFFEQFRKI YIGDQVQKSS KLYRRLSEVL GLNDETMVLS VFIGKIITNL
610 620 630 640 650
KYWGRCEPIT SKTLQLLNDL SIGYSSVRKL VKLSAVQFML NNHTSEHFSF
660 670 680 690 700
LGINNQSNLT DMRCRTTFYT ALGRLLMVDL GEDEDQYEQF MLPLTAAFEA
710 720 730 740 750
VAQMFSTNSF NEQEAKRTLV GLVRDLRGIA FAFNAKTSFM MLFEWIYPSY
760 770 780 790 800
MPILQRAIEL WYHDPACTTP VLKLMAELVH NRSQRLQFDV SSPNGILLFR
810 820 830 840 850
ETSKMITMYG NRILTLGEVP KDQVYALKLK GISICFSMLK AALSGSYVNF
860 870 880 890 900
GVFRLYGDDA LDNALQTFIK LLLSIPHSDL LDYPKLSQSY YSLLEVLTQD
910 920 930 940 950
HMNFIASLEP HVIMYILSSI SEGLTALDTM VCTGCCSCLD HIVTYLFKQL
960 970 980 990 1000
SRSTKKRTTP LNQESDRFLH IMQQHPEMIQ QMLSTVLNII IFEDCRNQWS
1010 1020 1030 1040 1050
MSRPLLGLIL LNEKYFSDLR NSIVNSQPPE KQQAMHLCFE NLMEGIERNL
1060 1070 1080
LTKNRDRFTQ NLSAFRREVN DSMKNSTYGV NSNDMMS
Length:1,087
Mass (Da):123,907
Last modified:January 23, 2007 - v3
Checksum:iEB412139046486E2
GO

Sequence cautioni

The sequence BAA34465 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263 – 444Missing in BAA34465 (PubMed:9872452).CuratedAdd BLAST182

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026526398E → D1 PublicationCorresponds to variant dbSNP:rs17856894Ensembl.1
Natural variantiVAR_026527835C → Y1 PublicationCorresponds to variant dbSNP:rs17856895Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064729 mRNA Translation: AAF21771.1
AB018288 mRNA Translation: BAA34465.1 Different initiation.
BC014219 mRNA Translation: AAH14219.1
BC030785 mRNA Translation: AAH30785.1
CCDSiCCDS47818.1
RefSeqiNP_055839.3, NM_015024.4
UniGeneiHs.172685

Genome annotation databases

EnsembliENST00000252512; ENSP00000252512; ENSG00000130227
GeneIDi23039
KEGGihsa:23039
UCSCiuc003xaa.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiXPO7_HUMAN
AccessioniPrimary (citable) accession number: Q9UIA9
Secondary accession number(s): O94846, Q6PJK9, Q8NEK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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