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Protein

Cytohesin-4

Gene

CYTH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei279Phosphatidylinositol 3,4,5-trisphosphateBy similarity1
Binding sitei290Phosphatidylinositol 3,4,5-trisphosphateBy similarity1
Binding sitei300Phosphatidylinositol 3,4,5-trisphosphateBy similarity1

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: UniProtKB
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Cytohesin-4
Alternative name(s):
PH, SEC7 and coiled-coil domain-containing protein 4
Gene namesi
Name:CYTH4
Synonyms:CYT4, PSCD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100055.20
HGNCiHGNC:9505 CYTH4
MIMi606514 gene
neXtProtiNX_Q9UIA0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27128
OpenTargetsiENSG00000100055
PharmGKBiPA164718621

Polymorphism and mutation databases

BioMutaiCYTH4
DMDMi13124094

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202031 – 394Cytohesin-4Add BLAST394

Proteomic databases

MaxQBiQ9UIA0
PaxDbiQ9UIA0
PeptideAtlasiQ9UIA0
PRIDEiQ9UIA0
ProteomicsDBi84482

PTM databases

iPTMnetiQ9UIA0
PhosphoSitePlusiQ9UIA0

Expressioni

Tissue specificityi

Expressed predominantly in peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000100055 Expressed in 155 organ(s), highest expression level in blood
CleanExiHS_CYTH4
ExpressionAtlasiQ9UIA0 baseline and differential
GenevisibleiQ9UIA0 HS

Organism-specific databases

HPAiHPA071573

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IPCEF1Q8WWN94EBI-11521003,EBI-4401965

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118019, 23 interactors
IntActiQ9UIA0, 19 interactors
MINTiQ9UIA0
STRINGi9606.ENSP00000248901

Structurei

3D structure databases

ProteinModelPortaliQ9UIA0
SMRiQ9UIA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 241SEC7PROSITE-ProRule annotationAdd BLAST188
Domaini259 – 375PHPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 275Phosphatidylinositol 3,4,5-trisphosphate bindingBy similarity8
Regioni386 – 394C-terminal autoinhibitory regionBy similarity9

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 65Sequence analysisAdd BLAST54

Domaini

Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.By similarity
Autoinhibited by its C-terminal basic region.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0930 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00760000119036
HOGENOMiHOG000253023
HOVERGENiHBG002647
InParanoidiQ9UIA0
KOiK18441
OMAiQIDCFET
OrthoDBiEOG091G0RZS
PhylomeDBiQ9UIA0
TreeFamiTF352091

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF01369 Sec7, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9UIA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLCHPEPAE LSSGETEELQ RIKWHRKQLL EDIQKLKDEI ADVFAQIDCF
60 70 80 90 100
ESAEESRMAQ KEKELCIGRK KFNMDPAKGI QYFIEHKLLT PDVQDIARFL
110 120 130 140 150
YKGEGLNKTA IGTYLGERDP INLQVLQAFV DCHEFANLNL VQALRQFLWS
160 170 180 190 200
FRLPGEAQKI DRMMEAFATR YCLCNPGVFQ STDTCYVLSF SIIMLNTSLH
210 220 230 240 250
NPNVRDRPPF ERFVSMNRGI NNGSDLPEDQ LRNLFDSIKS EPFSIPEDDG
260 270 280 290 300
NDLTHTFFNP DREGWLLKLG GRVKTWKRRW FILTDNCLYY FEFTTDKEPR
310 320 330 340 350
GIIPLENLSV QKVDDPKKPF CLELYNPSCR GQKIKACKTD GDGRVVEGKH
360 370 380 390
ESYRISATSA EERDQWIESI RASITRVPFY DLVSTRKKKI ASKQ
Length:394
Mass (Da):45,672
Last modified:May 1, 2000 - v1
Checksum:i0C9C8E8AD6890F34
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AHH6B1AHH6_HUMAN
Cytohesin-4
CYTH4
157Annotation score:
B1AHH5B1AHH5_HUMAN
Cytohesin-4
CYTH4
154Annotation score:
B1AHH4B1AHH4_HUMAN
Cytohesin-4
CYTH4
117Annotation score:
H0Y724H0Y724_HUMAN
Cytohesin-4
CYTH4
147Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05192074M → V. Corresponds to variant dbSNP:rs16998061Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125349 mRNA Translation: AAF28896.1
AF075458 mRNA Translation: AAF15389.1
CR456551 mRNA Translation: CAG30437.1
Z94160 Genomic DNA No translation available.
BC041161 mRNA Translation: AAH41161.1
CCDSiCCDS13946.1
RefSeqiNP_001304953.1, NM_001318024.1
NP_037517.1, NM_013385.4
UniGeneiHs.170944

Genome annotation databases

EnsembliENST00000248901; ENSP00000248901; ENSG00000100055
GeneIDi27128
KEGGihsa:27128
UCSCiuc003arf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125349 mRNA Translation: AAF28896.1
AF075458 mRNA Translation: AAF15389.1
CR456551 mRNA Translation: CAG30437.1
Z94160 Genomic DNA No translation available.
BC041161 mRNA Translation: AAH41161.1
CCDSiCCDS13946.1
RefSeqiNP_001304953.1, NM_001318024.1
NP_037517.1, NM_013385.4
UniGeneiHs.170944

3D structure databases

ProteinModelPortaliQ9UIA0
SMRiQ9UIA0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118019, 23 interactors
IntActiQ9UIA0, 19 interactors
MINTiQ9UIA0
STRINGi9606.ENSP00000248901

PTM databases

iPTMnetiQ9UIA0
PhosphoSitePlusiQ9UIA0

Polymorphism and mutation databases

BioMutaiCYTH4
DMDMi13124094

Proteomic databases

MaxQBiQ9UIA0
PaxDbiQ9UIA0
PeptideAtlasiQ9UIA0
PRIDEiQ9UIA0
ProteomicsDBi84482

Protocols and materials databases

DNASUi27128
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248901; ENSP00000248901; ENSG00000100055
GeneIDi27128
KEGGihsa:27128
UCSCiuc003arf.4 human

Organism-specific databases

CTDi27128
DisGeNETi27128
EuPathDBiHostDB:ENSG00000100055.20
GeneCardsiCYTH4
HGNCiHGNC:9505 CYTH4
HPAiHPA071573
MIMi606514 gene
neXtProtiNX_Q9UIA0
OpenTargetsiENSG00000100055
PharmGKBiPA164718621
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0930 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00760000119036
HOGENOMiHOG000253023
HOVERGENiHBG002647
InParanoidiQ9UIA0
KOiK18441
OMAiQIDCFET
OrthoDBiEOG091G0RZS
PhylomeDBiQ9UIA0
TreeFamiTF352091

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic

Miscellaneous databases

ChiTaRSiCYTH4 human
GeneWikiiCYTH4
GenomeRNAii27128
PROiPR:Q9UIA0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100055 Expressed in 155 organ(s), highest expression level in blood
CleanExiHS_CYTH4
ExpressionAtlasiQ9UIA0 baseline and differential
GenevisibleiQ9UIA0 HS

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF01369 Sec7, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYH4_HUMAN
AccessioniPrimary (citable) accession number: Q9UIA0
Secondary accession number(s): Q5R3F9, Q9UGT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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