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UniProtKB - Q9UI36 (DACH1_HUMAN)

Entry version 182 (02 Dec 2020)
Sequence version 4 (12 Sep 2018)
Previous versions | rss
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Protein

Dachshund homolog 1

Gene

DACH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UI36

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UI36

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dachshund homolog 1
Short name:
Dach1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DACH1
Synonyms:DACH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000276644.4

Human Gene Nomenclature Database

More...HGNCi		HGNC:2663, DACH1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603803, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UI36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1602

MalaCards human disease database

More...MalaCardsi		DACH1

Open Targets

More...OpenTargetsi		ENSG00000276644

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27134

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UI36, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DACH1

Domain mapping of disease mutations (DMDM)

More...DMDMi		519668677

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000955971 – 758Dachshund homolog 1Add BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei491PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UI36

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UI36

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UI36

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UI36

PeptideAtlas

More...PeptideAtlasi		Q9UI36

PRoteomics IDEntifications database

More...PRIDEi		Q9UI36

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		12719
12720
84464 [Q9UI36-1]
84465 [Q9UI36-2]
84466 [Q9UI36-3]
84467 [Q9UI36-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UI36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UI36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000276644, Expressed in metanephros and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UI36, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UI36, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000276644, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIX1, SIX6 and EYA3.

Interacts with NCOR1 and HDAC3 through its N-terminus.

Interacts with SIN3A through its C-terminus (By similarity).

Interacts with SMAD3 and SMAD4.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107972, 50 interactors

Protein interaction database and analysis system

More...IntActi		Q9UI36, 24 interactors

Molecular INTeraction database

More...MINTi		Q9UI36

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000482245

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UI36, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1758
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UI36

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UI36

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni189 – 384Interaction with SIX6 and HDAC3By similarityAdd BLAST196
Regioni189 – 275DACHbox-NAdd BLAST87
Regioni616 – 696DACHbox-CAdd BLAST81
Regioni627 – 706Interaction with SIN3ABy similarityAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili630 – 718Sequence analysisAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi61 – 68Poly-Ala8
Compositional biasi74 – 87Poly-GlyAdd BLAST14
Compositional biasi90 – 101Poly-GlyAdd BLAST12
Compositional biasi114 – 121Poly-Gly8
Compositional biasi140 – 163Poly-SerAdd BLAST24
Compositional biasi325 – 333Poly-Ala9
Compositional biasi467 – 470Poly-Ala4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DACH/dachshund family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3915, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001134

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027923_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UI36

Identification of Orthologs from Complete Genome Data

More...OMAi		VSHPLNH

Database of Orthologous Groups

More...OrthoDBi		429758at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UI36

TreeFam database of animal gene trees

More...TreeFami		TF316697

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.260.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009061, DNA-bd_dom_put_sf
IPR003380, SKI/SNO/DAC
IPR037000, Ski_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02437, Ski_Sno, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46955, SSF46955, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9UI36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVPAALIPP TQLVPPQPPI STSASSSGTT TSTSSATSSP APSIGPPASS 
        60         70         80         90        100
GPTLFRPEPI ASAAAAAATV TSTGGGGGGG GSGGGGGSSG NGGGGGGGGG 
       110        120        130        140        150
GSNCNPNLAA ASNGSGGGGG GISAGGGVAS STPINASTGS SSSSSSSSSS 
       160        170        180        190        200
SSSSSSSSSS SSSCGPLPGK PVYSTPSPVE NTPQNNECKM VDLRGAKVAS 
       210        220        230        240        250
FTVEGCELIC LPQAFDLFLK HLVGGLHTVY TKLKRLEITP VVCNVEQVRI 
       260        270        280        290        300
LRGLGAIQPG VNRCKLISRK DFETLYNDCT NASSRPGRPP KRTQSVTSPE 
       310        320        330        340        350
NSHIMPHSVP GLMSPGIIPP TGLTAAAAAA AAATNAAIAE AMKVKKIKLE 
       360        370        380        390        400
AMSNYHASNN QHGADSENGD MNSSVGSSDG SWDKETLPSS PSQGPQASIT 
       410        420        430        440        450
HPRMPGARSL PLSHPLNHLQ QSHLLPNGLE LPFMMMPHPL IPVSLPPASV 
       460        470        480        490        500
TMAMSQMNHL STIANMAAAA QVQSPPSRVE TSVIKERVPD SPSPAPSLEE 
       510        520        530        540        550
GRRPGSHPSS HRSSSVSSSP ARTESSSDRI PVHQNGLSMN QMLMGLSPNV 
       560        570        580        590        600
LPGPKEGDLA GHDMGHESKR MHIEKDETPL STPTARDSLD KLSLTGHGQP 
       610        620        630        640        650
LPPGFPSPFL FPDGLSSIET LLTNIQGLLK VAIDNARAQE KQVQLEKTEL 
       660        670        680        690        700
KMDFLREREL RETLEKQLAM EQKNRAIVQK RLKKEKKAKR KLQEALEFET 
       710        720        730        740        750
KRREQAEQTL KQAASTDSLR VLNDSLTPEI EADRSGGRTD AERTIQDGRL 

YLKTTVMY
Length:758
Mass (Da):78,562
Last modified:September 12, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFB5054D7EC5FF11
GO
Isoform 2 (identifier: Q9UI36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-427: Missing.

Note: Major.Curated
Show »
Length:706
Mass (Da):73,030
Checksum:iB9D6BA5058CC23DF
GO
Isoform 3 (identifier: Q9UI36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-427: Missing.
     428-575: Missing.

Show »
Length:558
Mass (Da):57,262
Checksum:i2671E7C3B8906122
GO
Isoform 4 (identifier: Q9UI36-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-575: Missing.

Show »
Length:504
Mass (Da):51,891
Checksum:iD5B52F8AB9A9F05D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA06666 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08066273T → TGG1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009486322 – 575Missing in isoform 4. CuratedAdd BLAST254
Alternative sequenceiVSP_009872376 – 427Missing in isoform 2 and isoform 3. 5 PublicationsAdd BLAST52
Alternative sequenceiVSP_009873428 – 575Missing in isoform 3. CuratedAdd BLAST148

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF102546 mRNA Translation: AAF01351.1
AF069509 mRNA Translation: AAC33466.1
AF356492 mRNA Translation: AAL08487.1
AL138698 Genomic DNA No translation available.
AL139186 Genomic DNA No translation available.
AL163542 Genomic DNA No translation available.
AL354995 Genomic DNA No translation available.
AMYH02028239 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80509.1
CH471093 Genomic DNA Translation: EAW80510.1
AL079278 mRNA Translation: CAB45153.1
AJ005670 mRNA Translation: CAA06666.1 Different initiation.
BC021219 mRNA Translation: AAH21219.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41899.1 [Q9UI36-2]

NCBI Reference Sequences

More...RefSeqi		NP_004383.4, NM_004392.6 [Q9UI36-4]
NP_542937.3, NM_080759.5 [Q9UI36-2]
NP_542938.3, NM_080760.5 [Q9UI36-3]
XP_011533241.1, XM_011534939.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000611519; ENSP00000482493; ENSG00000276644 [Q9UI36-3]
ENST00000613252; ENSP00000482245; ENSG00000276644 [Q9UI36-2]
ENST00000619232; ENSP00000482797; ENSG00000276644 [Q9UI36-1]
ENST00000620444; ENSP00000481551; ENSG00000276644 [Q9UI36-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1602

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1602

UCSC genome browser

More...UCSCi		uc058xki.1, human [Q9UI36-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102546 mRNA Translation: AAF01351.1
AF069509 mRNA Translation: AAC33466.1
AF356492 mRNA Translation: AAL08487.1
AL138698 Genomic DNA No translation available.
AL139186 Genomic DNA No translation available.
AL163542 Genomic DNA No translation available.
AL354995 Genomic DNA No translation available.
AMYH02028239 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80509.1
CH471093 Genomic DNA Translation: EAW80510.1
AL079278 mRNA Translation: CAB45153.1
AJ005670 mRNA Translation: CAA06666.1 Different initiation.
BC021219 mRNA Translation: AAH21219.2
CCDSiCCDS41899.1 [Q9UI36-2]
RefSeqiNP_004383.4, NM_004392.6 [Q9UI36-4]
NP_542937.3, NM_080759.5 [Q9UI36-2]
NP_542938.3, NM_080760.5 [Q9UI36-3]
XP_011533241.1, XM_011534939.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L8RX-ray1.65A/B184-282[»]
SMRiQ9UI36
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107972, 50 interactors
IntActiQ9UI36, 24 interactors
MINTiQ9UI36
STRINGi9606.ENSP00000482245

PTM databases

iPTMnetiQ9UI36
PhosphoSitePlusiQ9UI36

Polymorphism and mutation databases

BioMutaiDACH1
DMDMi519668677

Proteomic databases

EPDiQ9UI36
jPOSTiQ9UI36
MassIVEiQ9UI36
MaxQBiQ9UI36
PeptideAtlasiQ9UI36
PRIDEiQ9UI36
ProteomicsDBi12719
12720
84464 [Q9UI36-1]
84465 [Q9UI36-2]
84466 [Q9UI36-3]
84467 [Q9UI36-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		72801, 283 antibodies

The DNASU plasmid repository

More...DNASUi		1602

Genome annotation databases

EnsembliENST00000611519; ENSP00000482493; ENSG00000276644 [Q9UI36-3]
ENST00000613252; ENSP00000482245; ENSG00000276644 [Q9UI36-2]
ENST00000619232; ENSP00000482797; ENSG00000276644 [Q9UI36-1]
ENST00000620444; ENSP00000481551; ENSG00000276644 [Q9UI36-4]
GeneIDi1602
KEGGihsa:1602
UCSCiuc058xki.1, human [Q9UI36-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1602
DisGeNETi1602
EuPathDBiHostDB:ENSG00000276644.4

GeneCards: human genes, protein and diseases

More...GeneCardsi		DACH1
HGNCiHGNC:2663, DACH1
HPAiENSG00000276644, Low tissue specificity
MalaCardsiDACH1
MIMi603803, gene
neXtProtiNX_Q9UI36
OpenTargetsiENSG00000276644
PharmGKBiPA27134

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3915, Eukaryota
GeneTreeiENSGT00390000001134
HOGENOMiCLU_027923_0_0_1
InParanoidiQ9UI36
OMAiVSHPLNH
OrthoDBi429758at2759
PhylomeDBiQ9UI36
TreeFamiTF316697

Enzyme and pathway databases

PathwayCommonsiQ9UI36
SIGNORiQ9UI36

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1602, 10 hits in 849 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DACH1, human
EvolutionaryTraceiQ9UI36

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DACH1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1602
PharosiQ9UI36, Tbio

Protein Ontology

More...PROi		PR:Q9UI36
RNActiQ9UI36, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000276644, Expressed in metanephros and 198 other tissues
ExpressionAtlasiQ9UI36, baseline and differential
GenevisibleiQ9UI36, HS

Family and domain databases

Gene3Di3.10.260.20, 1 hit
InterProiView protein in InterPro
IPR009061, DNA-bd_dom_put_sf
IPR003380, SKI/SNO/DAC
IPR037000, Ski_DNA-bd_sf
PfamiView protein in Pfam
PF02437, Ski_Sno, 1 hit
SUPFAMiSSF46955, SSF46955, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDACH1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UI36
Secondary accession number(s): A0A087WZP2
, D0FY35, D0FY36, O75523, O75687, Q5VYY3, Q5VYY4, Q96SG3, Q96SG4, Q9H524, Q9UMH4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: September 12, 2018
Last modified: December 2, 2020
This is version 182 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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