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Entry version 152 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

Multifunctional methyltransferase subunit TRM112-like protein

Gene

TRMT112

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604, PubMed:18539146, PubMed:20308323, PubMed:25851604, PubMed:31328227, PubMed:31636962, PubMed:31061526).

Together with methyltransferase BUD23, methylates the N7 position of a guanine in 18S rRNA (PubMed:25851604).

The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146, PubMed:31636962, PubMed:31061526).

The heterodimer with HEMK2/N6AMT1 also monomethylates 'Lys-12' of histone H4 (H4K12me1) (PubMed:31061526).

The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323).

Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604).

Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:31328227).

6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processrRNA processing

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000173113-MONOMER

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UI30

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156581, Methylation
R-HSA-6782315, tRNA modification in the nucleus and cytosol
R-HSA-6790901, rRNA modification in the nucleus and cytosol
R-HSA-72764, Eukaryotic Translation Termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multifunctional methyltransferase subunit TRM112-like protein
Alternative name(s):
tRNA methyltransferase 112 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRMT1121 PublicationImported
ORF Names:AD-001, HSPC152, HSPC170
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26940, TRMT112

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618630, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UI30

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000173113.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi8L → D: Strongly reduced ability to promote N5-methylation of ETF1 together with HEMK2/N6AMT1. 1 Publication1
Mutagenesisi9L → D: Strongly reduced ability to promote N5-methylation of ETF1 together with HEMK2/N6AMT1. 1 Publication1
Mutagenesisi113I → D: Strongly reduced ability to promote N5-methylation of ETF1 together with HEMK2/N6AMT1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51504

Open Targets

More...
OpenTargetsi
ENSG00000173113

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165543757

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UI30, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4295977

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRMT112

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47606219

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002157971 – 125Multifunctional methyltransferase subunit TRM112-like proteinAdd BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei119PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UI30

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UI30

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UI30

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UI30

PeptideAtlas

More...
PeptideAtlasi
Q9UI30

PRoteomics IDEntifications database

More...
PRIDEi
Q9UI30

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84459 [Q9UI30-1]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9UI30-1 [Q9UI30-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UI30

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UI30

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UI30

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000173113, Expressed in oocyte and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UI30, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UI30, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000173113, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with BUD23; this heterodimerization is necessary for the metabolic stability and activity of the catalytic subunit BUD23 (PubMed:25851604). Heterodimer with N6AMT1/HEMK2; this heterodimerization is necessary for S-adenosyl-L-methionine-binding to N6AMT1/HEMK2 (PubMed:20308323, PubMed:25851604, PubMed:31632689, PubMed:31636962, PubMed:31061526). Heterodimer with ALKBH8 (PubMed:20308323). Heterodimer with METTL5; this heterodimerization is necessary for the stability of the catalytic subunit METTL5 (PubMed:31328227, PubMed:32217665).

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119576, 60 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UI30, 29 interactors

Molecular INTeraction database

More...
MINTi
Q9UI30

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000438349

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UI30, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UI30

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 119TRM112Add BLAST118

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRM112 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1088, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009268

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_086140_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UI30

Identification of Orthologs from Complete Genome Data

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OMAi
KVNEVEF

Database of Orthologous Groups

More...
OrthoDBi
1465773at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UI30

TreeFam database of animal gene trees

More...
TreeFami
TF313256

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039127, Trm112
IPR005651, Trm112-like

The PANTHER Classification System

More...
PANTHERi
PTHR12773, PTHR12773, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03966, Trm112p, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UI30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLLTHNLLS SHVRGVGSRG FPLRLQATEV RICPVEFNPN FVARMIPKVE
60 70 80 90 100
WSAFLEAADN LRLIQVPKGP VEGYEENEEF LRTMHHLLLE VEVIEGTLQC
110 120
PESGRMFPIS RGIPNMLLSE EETES
Length:125
Mass (Da):14,199
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA943569364D4FFEA
GO
Isoform 2 (identifier: Q9UI30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-65: Missing.

Show »
Length:120
Mass (Da):13,576
Checksum:i6CC084E35370CF66
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GX77F5GX77_HUMAN
Multifunctional methyltransferase s...
TRMT112
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYQ2F5GYQ2_HUMAN
Multifunctional methyltransferase s...
TRMT112
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZZ7F5GZZ7_HUMAN
Multifunctional methyltransferase s...
TRMT112
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti120E → G in AAH29482 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05474861 – 65Missing in isoform 2. Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF110774 mRNA Translation: AAF14857.1
AF229068 mRNA Translation: AAF82266.1
AF161501 mRNA Translation: AAF29116.1
AK312050 mRNA Translation: BAG34986.1
AP001453 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74251.1
BC017172 mRNA Translation: AAH17172.1
BC029482 mRNA Translation: AAH29482.1
BC105294 mRNA Translation: AAI05295.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS66113.1 [Q9UI30-2]
CCDS8068.1 [Q9UI30-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001273011.1, NM_001286082.1 [Q9UI30-2]
NP_057488.1, NM_016404.2 [Q9UI30-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308774; ENSP00000309433; ENSG00000173113 [Q9UI30-2]
ENST00000544844; ENSP00000438349; ENSG00000173113 [Q9UI30-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51504

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51504

UCSC genome browser

More...
UCSCi
uc001nzt.5, human [Q9UI30-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110774 mRNA Translation: AAF14857.1
AF229068 mRNA Translation: AAF82266.1
AF161501 mRNA Translation: AAF29116.1
AK312050 mRNA Translation: BAG34986.1
AP001453 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74251.1
BC017172 mRNA Translation: AAH17172.1
BC029482 mRNA Translation: AAH29482.1
BC105294 mRNA Translation: AAI05295.1
CCDSiCCDS66113.1 [Q9UI30-2]
CCDS8068.1 [Q9UI30-1]
RefSeqiNP_001273011.1, NM_001286082.1 [Q9UI30-2]
NP_057488.1, NM_016404.2 [Q9UI30-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G4Welectron microscopy4.50r1-125[»]
6H1DX-ray1.94B2-125[»]
6H1EX-ray1.90B2-125[»]
6H2UX-ray1.60B1-118[»]
6H2VX-ray2.49B/D1-125[»]
6K0XX-ray2.20B1-125[»]
6KHSX-ray1.90B1-125[»]
6KMRX-ray2.00A1-125[»]
6KMSX-ray3.20A/B1-125[»]
6PEDX-ray2.30B1-125[»]
SMRiQ9UI30
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119576, 60 interactors
IntActiQ9UI30, 29 interactors
MINTiQ9UI30
STRINGi9606.ENSP00000438349

Chemistry databases

ChEMBLiCHEMBL4295977

PTM databases

iPTMnetiQ9UI30
PhosphoSitePlusiQ9UI30
SwissPalmiQ9UI30

Genetic variation databases

BioMutaiTRMT112
DMDMi47606219

Proteomic databases

EPDiQ9UI30
jPOSTiQ9UI30
MassIVEiQ9UI30
PaxDbiQ9UI30
PeptideAtlasiQ9UI30
PRIDEiQ9UI30
ProteomicsDBi84459 [Q9UI30-1]
TopDownProteomicsiQ9UI30-1 [Q9UI30-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29268, 82 antibodies

The DNASU plasmid repository

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DNASUi
51504

Genome annotation databases

EnsembliENST00000308774; ENSP00000309433; ENSG00000173113 [Q9UI30-2]
ENST00000544844; ENSP00000438349; ENSG00000173113 [Q9UI30-1]
GeneIDi51504
KEGGihsa:51504
UCSCiuc001nzt.5, human [Q9UI30-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51504
DisGeNETi51504

GeneCards: human genes, protein and diseases

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GeneCardsi
TRMT112
HGNCiHGNC:26940, TRMT112
HPAiENSG00000173113, Low tissue specificity
MIMi618630, gene
neXtProtiNX_Q9UI30
OpenTargetsiENSG00000173113
PharmGKBiPA165543757
VEuPathDBiHostDB:ENSG00000173113.6

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1088, Eukaryota
GeneTreeiENSGT00390000009268
HOGENOMiCLU_086140_2_0_1
InParanoidiQ9UI30
OMAiKVNEVEF
OrthoDBi1465773at2759
PhylomeDBiQ9UI30
TreeFamiTF313256

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000173113-MONOMER
PathwayCommonsiQ9UI30
ReactomeiR-HSA-156581, Methylation
R-HSA-6782315, tRNA modification in the nucleus and cytosol
R-HSA-6790901, rRNA modification in the nucleus and cytosol
R-HSA-72764, Eukaryotic Translation Termination

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51504, 786 hits in 966 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRMT112, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51504
PharosiQ9UI30, Tbio

Protein Ontology

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PROi
PR:Q9UI30
RNActiQ9UI30, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000173113, Expressed in oocyte and 240 other tissues
ExpressionAtlasiQ9UI30, baseline and differential
GenevisibleiQ9UI30, HS

Family and domain databases

InterProiView protein in InterPro
IPR039127, Trm112
IPR005651, Trm112-like
PANTHERiPTHR12773, PTHR12773, 1 hit
PfamiView protein in Pfam
PF03966, Trm112p, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTR112_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UI30
Secondary accession number(s): B2R539
, J3KNG5, Q3MHC7, Q8N2Z4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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