Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transgelin-3

Gene

TAGLN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: ProtInc
  • negative regulation of transcription by RNA polymerase II Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin-3
Alternative name(s):
Neuronal protein 22
Short name:
NP22
Neuronal protein NP25
Gene namesi
Name:TAGLN3
Synonyms:NP25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144834.12
HGNCiHGNC:29868 TAGLN3
MIMi607953 gene
neXtProtiNX_Q9UI15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi29114
OpenTargetsiENSG00000144834
PharmGKBiPA134896732

Polymorphism and mutation databases

BioMutaiTAGLN3
DMDMi33860182

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047881 – 199Transgelin-3Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UI15
MaxQBiQ9UI15
PaxDbiQ9UI15
PeptideAtlasiQ9UI15
PRIDEiQ9UI15
ProteomicsDBi84454

2D gel databases

UCD-2DPAGEiQ9UI15

PTM databases

iPTMnetiQ9UI15
PhosphoSitePlusiQ9UI15

Expressioni

Tissue specificityi

Widely expressed in the brain. Expression is increased in the superior frontal cortex of alcoholics, but not in the motor cortex or cerebellum.

Gene expression databases

BgeeiENSG00000144834
CleanExiHS_TAGLN3
ExpressionAtlasiQ9UI15 baseline and differential
GenevisibleiQ9UI15 HS

Organism-specific databases

HPAiHPA062620

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118880, 35 interactors
STRINGi9606.ENSP00000273368

Structurei

3D structure databases

ProteinModelPortaliQ9UI15
SMRiQ9UI15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 136Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST113
Repeati174 – 199Calponin-likeAdd BLAST26

Sequence similaritiesi

Belongs to the calponin family.Curated

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOVERGENiHBG005186
InParanoidiQ9UI15
KOiK20526
OMAiETQMAFK
PhylomeDBiQ9UI15
TreeFamiTF313921

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
IPR029973 TAGLN3
PANTHERiPTHR18959:SF57 PTHR18959:SF57, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 1 hit
PF00307 CH, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 1 hit
PS50021 CH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UI15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRA
60 70 80 90 100
HFQKWLMDGT VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA
110 120 130 140 150
ETYGVRTTDI FQTVDLWEGK DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW
160 170 180 190
FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS NKGASQAGMT GYGMPRQIM
Length:199
Mass (Da):22,473
Last modified:August 15, 2003 - v2
Checksum:i09837A0CC2A0E157
GO

Sequence cautioni

The sequence AAF17189 differs from that shown. Reason: Frameshift at position 199.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303058 mRNA Translation: AAL09330.1
AF112201 mRNA Translation: AAF17189.1 Frameshift.
BT007408 mRNA Translation: AAP36076.1
CH471052 Genomic DNA Translation: EAW79685.1
CH471052 Genomic DNA Translation: EAW79686.1
BC015329 mRNA Translation: AAH15329.1
CCDSiCCDS33816.1
RefSeqiNP_001008273.1, NM_001008272.1
NP_001008274.1, NM_001008273.1
NP_037391.2, NM_013259.2
UniGeneiHs.169330

Genome annotation databases

EnsembliENST00000273368; ENSP00000273368; ENSG00000144834
ENST00000393917; ENSP00000377494; ENSG00000144834
ENST00000455401; ENSP00000391160; ENSG00000144834
ENST00000478951; ENSP00000419105; ENSG00000144834
GeneIDi29114
KEGGihsa:29114
UCSCiuc003dyl.4 human

Similar proteinsi

Entry informationi

Entry nameiTAGL3_HUMAN
AccessioniPrimary (citable) accession number: Q9UI15
Secondary accession number(s): D3DN64, Q96A74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 15, 2003
Last modified: June 20, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health