UniProtKB - Q9UI12 (VATH_HUMAN)
V-type proton ATPase subunit H
ATP6V1H
Functioni
GO - Molecular functioni
- enzyme regulator activity Source: UniProtKB
- proton-transporting ATPase activity, rotational mechanism Source: InterPro
GO - Biological processi
- cellular response to amino acid starvation Source: Reactome
- endocytosis Source: UniProtKB
- insulin receptor signaling pathway Source: Reactome
- ion transmembrane transport Source: Reactome
- phagosome acidification Source: Reactome
- proton transmembrane transport Source: UniProtKB
- regulation of defense response to virus by virus Source: Reactome
- regulation of macroautophagy Source: ParkinsonsUK-UCL
- transferrin transport Source: Reactome
- vacuolar acidification Source: UniProtKB
Keywordsi
Biological process | Host-virus interaction, Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00586-MONOMER |
PathwayCommonsi | Q9UI12 |
Reactomei | R-HSA-1222556, ROS and RNS production in phagocytes R-HSA-167590, Nef Mediated CD4 Down-regulation R-HSA-182218, Nef Mediated CD8 Down-regulation R-HSA-77387, Insulin receptor recycling R-HSA-917977, Transferrin endocytosis and recycling R-HSA-9636467, Blockage of phagosome acidification R-HSA-9639288, Amino acids regulate mTORC1 R-HSA-983712, Ion channel transport |
Protein family/group databases
TCDBi | 3.A.2.2.4, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase subunit HShort name: V-ATPase subunit H Alternative name(s): Nef-binding protein 1 Short name: NBP1 Protein VMA13 homolog V-ATPase 50/57 kDa subunits Vacuolar proton pump subunit H Vacuolar proton pump subunit SFD |
Gene namesi | Name:ATP6V1H ORF Names:CGI-11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18303, ATP6V1H |
MIMi | 608861, gene |
neXtProti | NX_Q9UI12 |
VEuPathDBi | HostDB:ENSG00000047249.16 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- vacuolar proton-transporting V-type ATPase, V1 domain Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 51606 |
OpenTargetsi | ENSG00000047249 |
PharmGKBi | PA38521 |
Miscellaneous databases
Pharosi | Q9UI12, Tbio |
Chemistry databases
DrugBanki | DB01133, Tiludronic acid |
Genetic variation databases
BioMutai | ATP6V1H |
DMDMi | 12643371 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124193 | 1 – 483 | V-type proton ATPase subunit HAdd BLAST | 483 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 483 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UI12 |
jPOSTi | Q9UI12 |
MassIVEi | Q9UI12 |
PaxDbi | Q9UI12 |
PeptideAtlasi | Q9UI12 |
PRIDEi | Q9UI12 |
ProteomicsDBi | 84451 [Q9UI12-1] 84452 [Q9UI12-2] |
PTM databases
iPTMneti | Q9UI12 |
MetOSitei | Q9UI12 |
PhosphoSitePlusi | Q9UI12 |
SwissPalmi | Q9UI12 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000047249, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | Q9UI12, baseline and differential |
Genevisiblei | Q9UI12, HS |
Organism-specific databases
HPAi | ENSG00000047249, Low tissue specificity |
Interactioni
Subunit structurei
V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Interacts with AP2M1 (PubMed:12032142).
Interacts with TM9SF4 in colon cancer cells (PubMed:25659576).
2 Publications(Microbial infection) Interacts with HIV-1 Nef protein.
2 Publications(Microbial infection) Interacts with M.tuberculosis PtpA, which blocks V-ATPase trafficking and phagosome acidification.
1 PublicationBinary interactionsi
Hide detailsQ9UI12
Protein-protein interaction databases
BioGRIDi | 119635, 70 interactors |
IntActi | Q9UI12, 34 interactors |
STRINGi | 9606.ENSP00000352522 |
Miscellaneous databases
RNActi | Q9UI12, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2759, Eukaryota |
GeneTreei | ENSGT00390000003289 |
InParanoidi | Q9UI12 |
OMAi | FHETAGK |
PhylomeDBi | Q9UI12 |
TreeFami | TF313488 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 1.25.40.150, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR004908, ATPase_V1-cplx_hsu IPR011987, ATPase_V1-cplx_hsu_C IPR038497, ATPase_V1-cplx_hsu_C_sf |
PANTHERi | PTHR10698, PTHR10698, 1 hit |
Pfami | View protein in Pfam PF11698, V-ATPase_H_C, 1 hit PF03224, V-ATPase_H_N, 1 hit |
PIRSFi | PIRSF032184, ATPase_V1_H, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTKMDIRGAV DAAVPTNIIA AKAAEVRANK VNWQSYLQGQ MISAEDCEFI
60 70 80 90 100
QRFEMKRSPE EKQEMLQTEG SQCAKTFINL MTHICKEQTV QYILTMVDDM
110 120 130 140 150
LQENHQRVSI FFDYARCSKN TAWPYFLPML NRQDPFTVHM AARIIAKLAA
160 170 180 190 200
WGKELMEGSD LNYYFNWIKT QLSSQKLRGS GVAVETGTVS SSDSSQYVQC
210 220 230 240 250
VAGCLQLMLR VNEYRFAWVE ADGVNCIMGV LSNKCGFQLQ YQMIFSIWLL
260 270 280 290 300
AFSPQMCEHL RRYNIIPVLS DILQESVKEK VTRIILAAFR NFLEKSTERE
310 320 330 340 350
TRQEYALAMI QCKVLKQLEN LEQQKYDDED ISEDIKFLLE KLGESVQDLS
360 370 380 390 400
SFDEYSSELK SGRLEWSPVH KSEKFWRENA VRLNEKNYEL LKILTKLLEV
410 420 430 440 450
SDDPQVLAVA AHDVGEYVRH YPRGKRVIEQ LGGKQLVMNH MHHEDQQVRY
460 470 480
NALLAVQKLM VHNWEYLGKQ LQSEQPQTAA ARS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V126 | G3V126_HUMAN | V-type proton ATPase subunit H | ATP6V1H hCG_27354 | 443 | Annotation score: | ||
E5RHH0 | E5RHH0_HUMAN | V-type proton ATPase subunit H | ATP6V1H | 102 | Annotation score: | ||
E5RG49 | E5RG49_HUMAN | V-type proton ATPase subunit H | ATP6V1H | 101 | Annotation score: | ||
H0YB41 | H0YB41_HUMAN | V-type proton ATPase subunit H | ATP6V1H | 86 | Annotation score: | ||
E5RJG1 | E5RJG1_HUMAN | V-type proton ATPase subunit H | ATP6V1H | 48 | Annotation score: | ||
E5RK31 | E5RK31_HUMAN | V-type proton ATPase subunit H | ATP6V1H | 36 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 129 | M → I in AAD27720 (PubMed:10810093).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012274 | 176 – 193 | Missing in isoform 2. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF113222 mRNA Translation: AAG39293.1 AF298777 mRNA Translation: AAG22809.1 AF112204 mRNA Translation: AAF17192.1 AF132945 mRNA Translation: AAD27720.1 AK022345 mRNA Translation: BAG51072.1 CH471068 Genomic DNA Translation: EAW86727.1 BC025275 mRNA Translation: AAH25275.1 |
CCDSi | CCDS6153.1 [Q9UI12-1] CCDS6154.1 [Q9UI12-2] |
RefSeqi | NP_057025.2, NM_015941.3 [Q9UI12-1] NP_998784.1, NM_213619.2 [Q9UI12-2] NP_998785.1, NM_213620.2 [Q9UI12-1] XP_006716518.1, XM_006716455.2 [Q9UI12-2] |
Genome annotation databases
Ensembli | ENST00000355221; ENSP00000347359; ENSG00000047249 [Q9UI12-2] ENST00000359530; ENSP00000352522; ENSG00000047249 [Q9UI12-1] ENST00000396774; ENSP00000379995; ENSG00000047249 [Q9UI12-1] |
GeneIDi | 51606 |
KEGGi | hsa:51606 |
UCSCi | uc003xrl.5, human [Q9UI12-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF113222 mRNA Translation: AAG39293.1 AF298777 mRNA Translation: AAG22809.1 AF112204 mRNA Translation: AAF17192.1 AF132945 mRNA Translation: AAD27720.1 AK022345 mRNA Translation: BAG51072.1 CH471068 Genomic DNA Translation: EAW86727.1 BC025275 mRNA Translation: AAH25275.1 |
CCDSi | CCDS6153.1 [Q9UI12-1] CCDS6154.1 [Q9UI12-2] |
RefSeqi | NP_057025.2, NM_015941.3 [Q9UI12-1] NP_998784.1, NM_213619.2 [Q9UI12-2] NP_998785.1, NM_213620.2 [Q9UI12-1] XP_006716518.1, XM_006716455.2 [Q9UI12-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6WM2 | electron microscopy | 3.10 | P | 1-483 | [»] | |
6WM3 | electron microscopy | 3.40 | P | 1-483 | [»] | |
6WM4 | electron microscopy | 3.60 | P | 1-483 | [»] | |
SMRi | Q9UI12 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119635, 70 interactors |
IntActi | Q9UI12, 34 interactors |
STRINGi | 9606.ENSP00000352522 |
Chemistry databases
DrugBanki | DB01133, Tiludronic acid |
Protein family/group databases
TCDBi | 3.A.2.2.4, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
PTM databases
iPTMneti | Q9UI12 |
MetOSitei | Q9UI12 |
PhosphoSitePlusi | Q9UI12 |
SwissPalmi | Q9UI12 |
Genetic variation databases
BioMutai | ATP6V1H |
DMDMi | 12643371 |
Proteomic databases
EPDi | Q9UI12 |
jPOSTi | Q9UI12 |
MassIVEi | Q9UI12 |
PaxDbi | Q9UI12 |
PeptideAtlasi | Q9UI12 |
PRIDEi | Q9UI12 |
ProteomicsDBi | 84451 [Q9UI12-1] 84452 [Q9UI12-2] |
Protocols and materials databases
Antibodypediai | 4026, 146 antibodies |
DNASUi | 51606 |
Genome annotation databases
Ensembli | ENST00000355221; ENSP00000347359; ENSG00000047249 [Q9UI12-2] ENST00000359530; ENSP00000352522; ENSG00000047249 [Q9UI12-1] ENST00000396774; ENSP00000379995; ENSG00000047249 [Q9UI12-1] |
GeneIDi | 51606 |
KEGGi | hsa:51606 |
UCSCi | uc003xrl.5, human [Q9UI12-1] |
Organism-specific databases
CTDi | 51606 |
DisGeNETi | 51606 |
GeneCardsi | ATP6V1H |
HGNCi | HGNC:18303, ATP6V1H |
HPAi | ENSG00000047249, Low tissue specificity |
MIMi | 608861, gene |
neXtProti | NX_Q9UI12 |
OpenTargetsi | ENSG00000047249 |
PharmGKBi | PA38521 |
VEuPathDBi | HostDB:ENSG00000047249.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2759, Eukaryota |
GeneTreei | ENSGT00390000003289 |
InParanoidi | Q9UI12 |
OMAi | FHETAGK |
PhylomeDBi | Q9UI12 |
TreeFami | TF313488 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00586-MONOMER |
PathwayCommonsi | Q9UI12 |
Reactomei | R-HSA-1222556, ROS and RNS production in phagocytes R-HSA-167590, Nef Mediated CD4 Down-regulation R-HSA-182218, Nef Mediated CD8 Down-regulation R-HSA-77387, Insulin receptor recycling R-HSA-917977, Transferrin endocytosis and recycling R-HSA-9636467, Blockage of phagosome acidification R-HSA-9639288, Amino acids regulate mTORC1 R-HSA-983712, Ion channel transport |
Miscellaneous databases
BioGRID-ORCSi | 51606, 638 hits in 1012 CRISPR screens |
ChiTaRSi | ATP6V1H, human |
GeneWikii | ATP6V1H |
GenomeRNAii | 51606 |
Pharosi | Q9UI12, Tbio |
PROi | PR:Q9UI12 |
RNActi | Q9UI12, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000047249, Expressed in corpus callosum and 241 other tissues |
ExpressionAtlasi | Q9UI12, baseline and differential |
Genevisiblei | Q9UI12, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 1.25.40.150, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR004908, ATPase_V1-cplx_hsu IPR011987, ATPase_V1-cplx_hsu_C IPR038497, ATPase_V1-cplx_hsu_C_sf |
PANTHERi | PTHR10698, PTHR10698, 1 hit |
Pfami | View protein in Pfam PF11698, V-ATPase_H_C, 1 hit PF03224, V-ATPase_H_N, 1 hit |
PIRSFi | PIRSF032184, ATPase_V1_H, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VATH_HUMAN | |
Accessioni | Q9UI12Primary (citable) accession number: Q9UI12 Secondary accession number(s): B3KMR0 Q9Y300 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 194 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families