UniProtKB - Q9UI08 (EVL_HUMAN)
Ena/VASP-like protein
EVL
Functioni
Miscellaneous
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- profilin binding Source: UniProtKB
- SH3 domain binding Source: UniProtKB
GO - Biological processi
- actin filament organization Source: ProtInc
- actin nucleation Source: InterPro
- actin polymerization or depolymerization Source: UniProtKB
- animal organ morphogenesis Source: UniProtKB
- axon guidance Source: Reactome
- cell surface receptor signaling pathway Source: UniProtKB
- cellular response to interferon-gamma Source: Ensembl
- negative regulation of epithelial cell migration Source: UniProtKB
- negative regulation of ruffle assembly Source: UniProtKB
- nervous system development Source: UniProtKB
- positive regulation of actin filament polymerization Source: GO_Central
- positive regulation of stress fiber assembly Source: UniProtKB
- protein homotetramerization Source: InterPro
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UI08 |
Reactomei | R-HSA-202433, Generation of second messenger molecules R-HSA-376176, Signaling by ROBO receptors R-HSA-5663220, RHO GTPases Activate Formins |
SignaLinki | Q9UI08 |
Names & Taxonomyi
Protein namesi | Recommended name: Ena/VASP-like proteinAlternative name(s): Ena/vasodilator-stimulated phosphoprotein-like |
Gene namesi | Name:EVL Synonyms:RNB6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20234, EVL |
neXtProti | NX_Q9UI08 |
VEuPathDBi | HostDB:ENSG00000196405.12 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
- stress fiber By similarity
Other locations
- lamellipodium By similarity
Note: Targeted to the leading edge of lamellipodia and the distal tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Other locations
- cytoplasm Source: UniProtKB
- focal adhesion Source: UniProtKB
- lamellipodium Source: UniProtKB
- membrane Source: UniProtKB
- phagocytic vesicle Source: Ensembl
Keywords - Cellular componenti
Cell projection, Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 51466 |
OpenTargetsi | ENSG00000196405 |
PharmGKBi | PA134890866 |
Miscellaneous databases
Pharosi | Q9UI08, Tbio |
Genetic variation databases
BioMutai | EVL |
DMDMi | 25090276 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087104 | 1 – 416 | Ena/VASP-like proteinAdd BLAST | 416 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 130 | PhosphoserineBy similarity | 1 | |
Modified residuei | 246 | PhosphoserineCombined sources | 1 | |
Modified residuei | 259 | PhosphoserineBy similarity | 1 | |
Modified residuei | 304 | PhosphoserineCombined sources | 1 | |
Modified residuei | 306 | PhosphoserineCombined sources | 1 | |
Modified residuei | 329 | PhosphoserineCombined sources | 1 | |
Modified residuei | 331 | PhosphoserineCombined sources | 1 | |
Modified residuei | 341 | PhosphoserineCombined sources | 1 | |
Modified residuei | 349 | PhosphoserineCombined sources | 1 | |
Modified residuei | 354 | PhosphoserineCombined sources | 1 | |
Modified residuei | 369 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UI08 |
jPOSTi | Q9UI08 |
MassIVEi | Q9UI08 |
PaxDbi | Q9UI08 |
PeptideAtlasi | Q9UI08 |
PRIDEi | Q9UI08 |
ProteomicsDBi | 6523 84445 [Q9UI08-1] 84446 [Q9UI08-2] |
PTM databases
iPTMneti | Q9UI08 |
MetOSitei | Q9UI08 |
PhosphoSitePlusi | Q9UI08 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196405, Expressed in right hemisphere of cerebellum and 233 other tissues |
ExpressionAtlasi | Q9UI08, baseline and differential |
Genevisiblei | Q9UI08, HS |
Organism-specific databases
HPAi | ENSG00000196405, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Homotetramer (By similarity). Binds to the SH3 domains of ABL1, LYN and SRC. Also binds to profilin, with preference for isoform IIa of PFN2, and the WW domain of APBB1/FE65. Binds to SEMA6A.
Interacts, via the Pro-rich region, with the C-terminal SH3 domain of DNMBP.
Interacts with RAPH1. Binds, via the EVH1 domain, the Pro-rich domain of Listeria monocytogenes actA (By similarity). Binds, via the EVH1 domain, the Pro-rich domain of ZYX.
Interacts with FYB1 (PubMed:10747096).
Interacts with ZDHHC17 (PubMed:28882895).
By similarity5 PublicationsBinary interactionsi
Hide detailsQ9UI08
With | #Exp. | IntAct |
---|---|---|
ABI3 [Q9P2A4] | 4 | EBI-346653,EBI-742038 |
SPTAN1 [Q13813] | 4 | EBI-346653,EBI-351450 |
TRIM9 [Q9C026] | 3 | EBI-346653,EBI-720828 |
Isoform 1 [Q9UI08-2]
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- profilin binding Source: UniProtKB
- SH3 domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119556, 50 interactors |
ELMi | Q9UI08 |
IntActi | Q9UI08, 42 interactors |
MINTi | Q9UI08 |
STRINGi | 9606.ENSP00000376652 |
Miscellaneous databases
RNActi | Q9UI08, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 112 | WH1PROSITE-ProRule annotationAdd BLAST | 112 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 222 – 413 | EVH2Add BLAST | 192 | |
Regioni | 222 – 242 | EVH2 block AAdd BLAST | 21 | |
Regioni | 265 – 282 | EVH2 block BAdd BLAST | 18 | |
Regioni | 342 – 362 | Required for interaction with ZDHHC171 PublicationAdd BLAST | 21 | |
Regioni | 379 – 413 | EVH2 block CAdd BLAST | 35 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 231 – 234 | KLKR | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 162 – 206 | Pro-richAdd BLAST | 45 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SH3-bindingPhylogenomic databases
eggNOGi | KOG4590, Eukaryota |
GeneTreei | ENSGT00940000157826 |
InParanoidi | Q9UI08 |
OMAi | RTHYGIN |
PhylomeDBi | Q9UI08 |
TreeFami | TF321411 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR034319, ENA/VASP-like_protein IPR042180, IF_rod_dom_coil1B IPR011993, PH-like_dom_sf IPR017354, VASP/EVL IPR038023, VASP_sf IPR014885, VASP_tetra IPR000697, WH1/EVH1_dom |
PANTHERi | PTHR11202:SF4, PTHR11202:SF4, 1 hit |
Pfami | View protein in Pfam PF08776, VASP_tetra, 1 hit PF00568, WH1, 1 hit |
PIRSFi | PIRSF038010, Vasodilator_Phospo, 1 hit |
SMARTi | View protein in SMART SM00461, WH1, 1 hit |
SUPFAMi | SSF118370, SSF118370, 1 hit |
PROSITEi | View protein in PROSITE PS50229, WH1, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSEQSICQAR ASVMVYDDTS KKWVPIKPGQ QGFSRINIYH NTASNTFRVV
60 70 80 90 100
GVKLQDQQVV INYSIVKGLK YNQATPTFHQ WRDARQVYGL NFASKEEATT
110 120 130 140 150
FSNAMLFALN IMNSQEGGPS SQRQVQNGPS PDEMDIQRRQ VMEQHQQQRQ
160 170 180 190 200
ESLERRTSAT GPILPPGHPS SAASAPVSCS GPPPPPPPPV PPPPTGATPP
210 220 230 240 250
PPPPLPAGGA QGSSHDESSM SGLAAAIAGA KLRRVQRPED ASGGSSPSGT
260 270 280 290 300
SKSDANRASS GGGGGGLMEE MNKLLAKRRK AASQSDKPAE KKEDESQMED
310 320 330 340 350
PSTSPSPGTR AASQPPNSSE AGRKPWERSN SVEKPVSSIL SRTPSVAKSP
360 370 380 390 400
EAKSPLQSQP HSRMKPAGSV NDMALDAFDL DRMKQEILEE VVRELHKVKE
410
EIIDAIRQEL SGISTT
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V5F7 | G3V5F7_HUMAN | Ena/VASP-like protein | EVL | 168 | Annotation score: | ||
G3V3G2 | G3V3G2_HUMAN | Ena/VASP-like protein | EVL | 121 | Annotation score: | ||
G3V2K5 | G3V2K5_HUMAN | Ena/VASP-like protein | EVL | 115 | Annotation score: | ||
G3V535 | G3V535_HUMAN | Ena/VASP-like protein | EVL | 124 | Annotation score: | ||
A0A087WYI2 | A0A087WYI2_HUMAN | Ena/VASP-like protein | EVL | 283 | Annotation score: | ||
H0YJN0 | H0YJN0_HUMAN | Ena/VASP-like protein | EVL | 212 | Annotation score: | ||
G3V314 | G3V314_HUMAN | Ena/VASP-like protein | EVL | 215 | Annotation score: | ||
H0YJL6 | H0YJL6_HUMAN | Ena/VASP-like protein | EVL | 104 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 201 | P → S in AAF17197 (PubMed:10931946).Curated | 1 | |
Sequence conflicti | 329 | S → N in AAP97156 (Ref. 2) Curated | 1 | |
Sequence conflicti | 364 | M → Y in CAB63763 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036464 | 188 | P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs367737727Ensembl. | 1 | |
Natural variantiVAR_036465 | 247 | P → L in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004044 | 1 | M → MAT in isoform 1 and isoform 5. 4 Publications | 1 | |
Alternative sequenceiVSP_057322 | 1 | M → MFAFEEF in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_058778 | 342 – 362 | Missing in isoform 5. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_057323 | 364 – 416 | MKPAG…GISTT → YRTTLLLTCPPGFGAPLSPV P in isoform 3. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_058779 | 368 – 397 | Missing in isoform 4. Add BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF052504 mRNA Translation: AAF21709.1 AF087843 mRNA Translation: AAP97156.1 AF112209 mRNA Translation: AAF17197.1 AK289720 mRNA Translation: BAF82409.1 AK295919 mRNA Translation: BAH12221.1 AL133368 Genomic DNA No translation available. AL133523 Genomic DNA No translation available. AL157912 Genomic DNA No translation available. KF456005 Genomic DNA No translation available. KF456007 Genomic DNA No translation available. KF456010 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81684.1 BC023997 mRNA Translation: AAH23997.1 BC032358 mRNA Translation: AAH32358.1 AF131766 mRNA Translation: AAD20040.1 AL133642 mRNA Translation: CAB63763.2 |
CCDSi | CCDS81851.1 [Q9UI08-1] CCDS9955.1 [Q9UI08-2] |
RefSeqi | NP_001317150.1, NM_001330221.1 [Q9UI08-1] NP_057421.1, NM_016337.2 [Q9UI08-2] |
Genome annotation databases
Ensembli | ENST00000392920; ENSP00000376652; ENSG00000196405 [Q9UI08-2] ENST00000402714; ENSP00000384720; ENSG00000196405 [Q9UI08-1] ENST00000544450; ENSP00000437904; ENSG00000196405 [Q9UI08-3] |
GeneIDi | 51466 |
KEGGi | hsa:51466 |
UCSCi | uc001ygt.4, human [Q9UI08-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF052504 mRNA Translation: AAF21709.1 AF087843 mRNA Translation: AAP97156.1 AF112209 mRNA Translation: AAF17197.1 AK289720 mRNA Translation: BAF82409.1 AK295919 mRNA Translation: BAH12221.1 AL133368 Genomic DNA No translation available. AL133523 Genomic DNA No translation available. AL157912 Genomic DNA No translation available. KF456005 Genomic DNA No translation available. KF456007 Genomic DNA No translation available. KF456010 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81684.1 BC023997 mRNA Translation: AAH23997.1 BC032358 mRNA Translation: AAH32358.1 AF131766 mRNA Translation: AAD20040.1 AL133642 mRNA Translation: CAB63763.2 |
CCDSi | CCDS81851.1 [Q9UI08-1] CCDS9955.1 [Q9UI08-2] |
RefSeqi | NP_001317150.1, NM_001330221.1 [Q9UI08-1] NP_057421.1, NM_016337.2 [Q9UI08-2] |
3D structure databases
SMRi | Q9UI08 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119556, 50 interactors |
ELMi | Q9UI08 |
IntActi | Q9UI08, 42 interactors |
MINTi | Q9UI08 |
STRINGi | 9606.ENSP00000376652 |
PTM databases
iPTMneti | Q9UI08 |
MetOSitei | Q9UI08 |
PhosphoSitePlusi | Q9UI08 |
Genetic variation databases
BioMutai | EVL |
DMDMi | 25090276 |
Proteomic databases
EPDi | Q9UI08 |
jPOSTi | Q9UI08 |
MassIVEi | Q9UI08 |
PaxDbi | Q9UI08 |
PeptideAtlasi | Q9UI08 |
PRIDEi | Q9UI08 |
ProteomicsDBi | 6523 84445 [Q9UI08-1] 84446 [Q9UI08-2] |
Protocols and materials databases
Antibodypediai | 14371, 158 antibodies |
DNASUi | 51466 |
Genome annotation databases
Ensembli | ENST00000392920; ENSP00000376652; ENSG00000196405 [Q9UI08-2] ENST00000402714; ENSP00000384720; ENSG00000196405 [Q9UI08-1] ENST00000544450; ENSP00000437904; ENSG00000196405 [Q9UI08-3] |
GeneIDi | 51466 |
KEGGi | hsa:51466 |
UCSCi | uc001ygt.4, human [Q9UI08-1] |
Organism-specific databases
CTDi | 51466 |
DisGeNETi | 51466 |
GeneCardsi | EVL |
HGNCi | HGNC:20234, EVL |
HPAi | ENSG00000196405, Tissue enhanced (lymphoid) |
neXtProti | NX_Q9UI08 |
OpenTargetsi | ENSG00000196405 |
PharmGKBi | PA134890866 |
VEuPathDBi | HostDB:ENSG00000196405.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4590, Eukaryota |
GeneTreei | ENSGT00940000157826 |
InParanoidi | Q9UI08 |
OMAi | RTHYGIN |
PhylomeDBi | Q9UI08 |
TreeFami | TF321411 |
Enzyme and pathway databases
PathwayCommonsi | Q9UI08 |
Reactomei | R-HSA-202433, Generation of second messenger molecules R-HSA-376176, Signaling by ROBO receptors R-HSA-5663220, RHO GTPases Activate Formins |
SignaLinki | Q9UI08 |
Miscellaneous databases
BioGRID-ORCSi | 51466, 4 hits in 870 CRISPR screens |
ChiTaRSi | EVL, human |
GeneWikii | Enah/Vasp-like |
GenomeRNAii | 51466 |
Pharosi | Q9UI08, Tbio |
PROi | PR:Q9UI08 |
RNActi | Q9UI08, protein |
Gene expression databases
Bgeei | ENSG00000196405, Expressed in right hemisphere of cerebellum and 233 other tissues |
ExpressionAtlasi | Q9UI08, baseline and differential |
Genevisiblei | Q9UI08, HS |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR034319, ENA/VASP-like_protein IPR042180, IF_rod_dom_coil1B IPR011993, PH-like_dom_sf IPR017354, VASP/EVL IPR038023, VASP_sf IPR014885, VASP_tetra IPR000697, WH1/EVH1_dom |
PANTHERi | PTHR11202:SF4, PTHR11202:SF4, 1 hit |
Pfami | View protein in Pfam PF08776, VASP_tetra, 1 hit PF00568, WH1, 1 hit |
PIRSFi | PIRSF038010, Vasodilator_Phospo, 1 hit |
SMARTi | View protein in SMART SM00461, WH1, 1 hit |
SUPFAMi | SSF118370, SSF118370, 1 hit |
PROSITEi | View protein in PROSITE PS50229, WH1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EVL_HUMAN | |
Accessioni | Q9UI08Primary (citable) accession number: Q9UI08 Secondary accession number(s): A8K105 Q9UIC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | November 15, 2002 | |
Last modified: | February 10, 2021 | |
This is version 189 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families