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Protein

Fasciculation and elongation protein zeta-2

Gene

FEZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in axonal outgrowth and fasciculation.By similarity

GO - Biological processi

  • axon guidance Source: ProtInc
  • negative regulation of autophagosome assembly Source: GO_Central
  • nervous system development Source: ProtInc
  • signal transduction Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Fasciculation and elongation protein zeta-2
Alternative name(s):
Zygin II
Zygin-2
Gene namesi
Name:FEZ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000171055.14
HGNCiHGNC:3660 FEZ2
MIMi604826 gene
neXtProtiNX_Q9UHY8

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi9637
OpenTargetsiENSG00000171055
PharmGKBiPA28101

Polymorphism and mutation databases

BioMutaiFEZ2
DMDMi76803658

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895281 – 353Fasciculation and elongation protein zeta-2Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineCombined sources1
Disulfide bondi153InterchainSequence analysis
Modified residuei176PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ9UHY8
PeptideAtlasiQ9UHY8
PRIDEiQ9UHY8
ProteomicsDBi84442
84443 [Q9UHY8-2]

PTM databases

iPTMnetiQ9UHY8
PhosphoSitePlusiQ9UHY8

Expressioni

Tissue specificityi

Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and melanocytes.

Gene expression databases

BgeeiENSG00000171055 Expressed in 241 organ(s), highest expression level in endothelial cell
CleanExiHS_FEZ2
ExpressionAtlasiQ9UHY8 baseline and differential
GenevisibleiQ9UHY8 HS

Organism-specific databases

HPAiHPA035978

Interactioni

Subunit structurei

Homodimer; disulfide-linked. May form heterodimers with FEZ1. Interacts with synaptotagmin.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114996, 26 interactors
IntActiQ9UHY8, 6 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9UHY8
SMRiQ9UHY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili214 – 286Sequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi278 – 284Poly-Lys7

Sequence similaritiesi

Belongs to the zygin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000017627
HOGENOMiHOG000019494
HOVERGENiHBG005657
InParanoidiQ9UHY8
OMAiWTITGTF
OrthoDBiEOG091G0AC6
PhylomeDBiQ9UHY8
TreeFamiTF313128

Family and domain databases

InterProiView protein in InterPro
IPR011680 FEZ
IPR015641 FEZ_2
PANTHERiPTHR12394 PTHR12394, 2 hits
PTHR12394:SF11 PTHR12394:SF11, 2 hits
PfamiView protein in Pfam
PF07763 FEZ, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UHY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAADGDWQDF YEFQEPARSL LDQENCNASP EPGAEAGAEA GGGADGFPAP
60 70 80 90 100
ACSLEEKLSL CFRPSDPGAE PPRTAVRPIT ERSLLQGDEI WNALTDNYGN
110 120 130 140 150
VMPVDWKSSH TRTLHLLTLN LSEKGVSDSL LFDTSDDEEL REQLDMHSII
160 170 180 190 200
VSCVNDEPLF TADQVIEEIE EMMQESPDPE DDETPTQSDR LSMLSQEIQT
210 220 230 240 250
LKRSSTGSYE ERVKRLSVSE LNEILEEIET AIKEYSEELV QQLALRDELE
260 270 280 290 300
FEKEVKNSFI SVLIEVQNKQ KEHKETAKKK KKLKNGSSQN GKNERSHMPG
310 320 330 340 350
TYLTTVIPYE KKNGPPSVED LQILTKILRA MKEDSEKVPS LLTDYILKVL

CPT
Length:353
Mass (Da):39,666
Last modified:September 27, 2005 - v2
Checksum:i4F55D0FC1A6B3421
GO
Isoform 2 (identifier: Q9UHY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-301: T → TRFSMEGISNVIQNGLRHTFGNSGGEKQ

Show »
Length:380
Mass (Da):42,613
Checksum:i25203DE1EA50A35C
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z674Q7Z674_HUMAN
Fasciculation and elongation protei...
FEZ2 DKFZp779C2259, hCG_1641050
182Annotation score:
H7C434H7C434_HUMAN
Fasciculation and elongation protei...
FEZ2
183Annotation score:
H7C0L4H7C0L4_HUMAN
Fasciculation and elongation protei...
FEZ2
138Annotation score:
G3V0F5G3V0F5_HUMAN
Fasciculation and elongation protei...
FEZ2 hCG_1641050
305Annotation score:
F8W6C0F8W6C0_HUMAN
Fasciculation and elongation protei...
FEZ2
245Annotation score:
F8WB37F8WB37_HUMAN
Fasciculation and elongation protei...
FEZ2
63Annotation score:
H7C0W1H7C0W1_HUMAN
Fasciculation and elongation protei...
FEZ2
70Annotation score:

Sequence cautioni

The sequence AAF14865 differs from that shown. Reason: Frameshift at positions 41, 51, 71, 78 and 84.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 36GAEA → WAKG in AAF14865 (PubMed:10931946).Curated4
Sequence conflicti40A → T in AAF14865 (PubMed:10931946).Curated1
Sequence conflicti82R → L in AAF14865 (PubMed:10931946).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05377150P → L1 PublicationCorresponds to variant dbSNP:rs1544655Ensembl.1
Natural variantiVAR_053772329R → C. Corresponds to variant dbSNP:rs848642Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041368301T → TRFSMEGISNVIQNGLRHTF GNSGGEKQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076184 mRNA Translation: BAD06207.1
AC007401 Genomic DNA Translation: AAY14650.1
BC089390 mRNA Translation: AAH89390.1
AF113124 mRNA Translation: AAF14865.1 Frameshift.
U69140 mRNA Translation: AAB40661.1
U60061 mRNA Translation: AAC51283.1
CCDSiCCDS46257.1 [Q9UHY8-1]
CCDS46258.1 [Q9UHY8-2]
RefSeqiNP_001036013.1, NM_001042548.1 [Q9UHY8-2]
NP_005093.2, NM_005102.2 [Q9UHY8-1]
UniGeneiHs.258563

Genome annotation databases

EnsembliENST00000379245; ENSP00000368547; ENSG00000171055 [Q9UHY8-2]
ENST00000405912; ENSP00000385112; ENSG00000171055 [Q9UHY8-1]
GeneIDi9637
KEGGihsa:9637
UCSCiuc002rpg.3 human [Q9UHY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076184 mRNA Translation: BAD06207.1
AC007401 Genomic DNA Translation: AAY14650.1
BC089390 mRNA Translation: AAH89390.1
AF113124 mRNA Translation: AAF14865.1 Frameshift.
U69140 mRNA Translation: AAB40661.1
U60061 mRNA Translation: AAC51283.1
CCDSiCCDS46257.1 [Q9UHY8-1]
CCDS46258.1 [Q9UHY8-2]
RefSeqiNP_001036013.1, NM_001042548.1 [Q9UHY8-2]
NP_005093.2, NM_005102.2 [Q9UHY8-1]
UniGeneiHs.258563

3D structure databases

ProteinModelPortaliQ9UHY8
SMRiQ9UHY8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114996, 26 interactors
IntActiQ9UHY8, 6 interactors

PTM databases

iPTMnetiQ9UHY8
PhosphoSitePlusiQ9UHY8

Polymorphism and mutation databases

BioMutaiFEZ2
DMDMi76803658

Proteomic databases

EPDiQ9UHY8
PeptideAtlasiQ9UHY8
PRIDEiQ9UHY8
ProteomicsDBi84442
84443 [Q9UHY8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379245; ENSP00000368547; ENSG00000171055 [Q9UHY8-2]
ENST00000405912; ENSP00000385112; ENSG00000171055 [Q9UHY8-1]
GeneIDi9637
KEGGihsa:9637
UCSCiuc002rpg.3 human [Q9UHY8-1]

Organism-specific databases

CTDi9637
DisGeNETi9637
EuPathDBiHostDB:ENSG00000171055.14
GeneCardsiFEZ2
HGNCiHGNC:3660 FEZ2
HPAiHPA035978
MIMi604826 gene
neXtProtiNX_Q9UHY8
OpenTargetsiENSG00000171055
PharmGKBiPA28101
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000017627
HOGENOMiHOG000019494
HOVERGENiHBG005657
InParanoidiQ9UHY8
OMAiWTITGTF
OrthoDBiEOG091G0AC6
PhylomeDBiQ9UHY8
TreeFamiTF313128

Miscellaneous databases

ChiTaRSiFEZ2 human
GeneWikiiFEZ2
GenomeRNAii9637
PROiPR:Q9UHY8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171055 Expressed in 241 organ(s), highest expression level in endothelial cell
CleanExiHS_FEZ2
ExpressionAtlasiQ9UHY8 baseline and differential
GenevisibleiQ9UHY8 HS

Family and domain databases

InterProiView protein in InterPro
IPR011680 FEZ
IPR015641 FEZ_2
PANTHERiPTHR12394 PTHR12394, 2 hits
PTHR12394:SF11 PTHR12394:SF11, 2 hits
PfamiView protein in Pfam
PF07763 FEZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFEZ2_HUMAN
AccessioniPrimary (citable) accession number: Q9UHY8
Secondary accession number(s): Q5EBN3, Q76LN0, Q99690
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: September 27, 2005
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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