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Entry version 179 (13 Feb 2019)
Sequence version 2 (13 Jun 2006)
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Protein

Adhesion G protein-coupled receptor E2

Gene

ADGRE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242).5 Publications

Miscellaneous

Has no murine ortholog.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • chondroitin sulfate binding Source: UniProtKB
  • G protein-coupled receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processCell adhesion, Inflammatory response
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373080 Class B/2 (Secretin family receptors)

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor E21 Publication
Alternative name(s):
EGF-like module receptor 2
EGF-like module-containing mucin-like hormone receptor-like 2
CD_antigen: CD312
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRE2Imported
Synonyms:EMR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127507.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3337 ADGRE2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606100 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UHX3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 540ExtracellularCuratedAdd BLAST517
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei541 – 561Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini562 – 569CytoplasmicCurated8
Transmembranei570 – 590Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini591 – 605ExtracellularCuratedAdd BLAST15
Transmembranei606 – 626Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini627 – 644CytoplasmicCuratedAdd BLAST18
Transmembranei645 – 665Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini666 – 683ExtracellularCuratedAdd BLAST18
Transmembranei684 – 704Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini705 – 735CytoplasmicCuratedAdd BLAST31
Transmembranei736 – 756Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini757 – 760ExtracellularCurated4
Transmembranei761 – 781Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini782 – 823CytoplasmicCuratedAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Vibratory urticaria (VBU)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum.
See also OMIM:125630
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078578492C → Y in VBU; affects the regulation of mast cells degranulation; results in increased vibration-induced mast cells degranulation; no effect on localization to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs199718602EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi518S → A: Abolishes cleavage. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
30817

MalaCards human disease database

More...
MalaCardsi
ADGRE2
MIMi125630 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000127507

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
493342 Vibratory urticaria

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27774

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADGRE2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
108935835

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001287524 – 823Adhesion G protein-coupled receptor E2Add BLAST800

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 39PROSITE-ProRule annotation1 Publication
Disulfide bondi33 ↔ 45PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi47 ↔ 65PROSITE-ProRule annotation1 Publication
Disulfide bondi71 ↔ 85PROSITE-ProRule annotation1 Publication
Disulfide bondi79 ↔ 94PROSITE-ProRule annotation1 Publication
Disulfide bondi96 ↔ 117PROSITE-ProRule annotation1 Publication
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi123 ↔ 136PROSITE-ProRule annotation1 Publication
Disulfide bondi130 ↔ 145PROSITE-ProRule annotation1 Publication
Disulfide bondi147 ↔ 161PROSITE-ProRule annotation
Disulfide bondi167 ↔ 180PROSITE-ProRule annotation
Disulfide bondi174 ↔ 189PROSITE-ProRule annotation
Disulfide bondi191 ↔ 210PROSITE-ProRule annotation
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 229PROSITE-ProRule annotation
Disulfide bondi223 ↔ 238PROSITE-ProRule annotation
Disulfide bondi240 ↔ 259PROSITE-ProRule annotation
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei517 – 518Cleavage; by autolysis1 Publication2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UHX3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UHX3

PeptideAtlas

More...
PeptideAtlasi
Q9UHX3

PRoteomics IDEntifications database

More...
PRIDEi
Q9UHX3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84434
84435 [Q9UHX3-2]
84436 [Q9UHX3-3]
84437 [Q9UHX3-4]
84438 [Q9UHX3-5]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
993

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UHX3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UHX3

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9UHX3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. High expression in mast cells (PubMed:26841242).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127507 Expressed in 120 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UHX3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UHX3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055200

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55.3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119041, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UHX3, 12 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000472280

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1823
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BO2X-ray2.60A/B25-260[»]
2BOUX-ray1.90A25-118[»]
A212-260[»]
2BOXX-ray2.50A25-260[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UHX3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UHX3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UHX3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 66EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini67 – 118EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST52
Domaini119 – 162EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini163 – 211EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST49
Domaini212 – 260EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST49
Domaini479 – 529GPSPROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.1 Publication
Binding to chondroitin sulfate is mediated by the fourth EGF domain.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4193 Eukaryota
ENOG410XSD2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162597

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294115

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG048917

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UHX3

KEGG Orthology (KO)

More...
KOi
K08443

Database of Orthologous Groups

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OrthoDBi
210309at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UHX3

TreeFam database of animal gene trees

More...
TreeFami
TF316380

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR017981 GPCR_2-like
IPR003056 GPCR_2_CD97
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR009030 Growth_fac_rcpt_cys_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF07645 EGF_CA, 4 hits
PF01825 GPS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01278 CD97PROTEIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 4 hits
SM00303 GPS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 4 hits
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are probably produced. A soluble form due to a frameshift which introduced a stop codon immediately before the first TM domain is also detected.

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UHX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGRVFLVFL AFCVWLTLPG AETQDSRGCA RWCPQDSSCV NATACRCNPG
60 70 80 90 100
FSSFSEIITT PMETCDDINE CATLSKVSCG KFSDCWNTEG SYDCVCSPGY
110 120 130 140 150
EPVSGAKTFK NESENTCQDV DECQQNPRLC KSYGTCVNTL GSYTCQCLPG
160 170 180 190 200
FKLKPEDPKL CTDVNECTSG QNPCHSSTHC LNNVGSYQCR CRPGWQPIPG
210 220 230 240 250
SPNGPNNTVC EDVDECSSGQ HQCDSSTVCF NTVGSYSCRC RPGWKPRHGI
260 270 280 290 300
PNNQKDTVCE DMTFSTWTPP PGVHSQTLSR FFDKVQDLGR DYKPGLANNT
310 320 330 340 350
IQSILQALDE LLEAPGDLET LPRLQQHCVA SHLLDGLEDV LRGLSKNLSN
360 370 380 390 400
GLLNFSYPAG TELSLEVQKQ VDRSVTLRQN QAVMQLDWNQ AQKSGDPGPS
410 420 430 440 450
VVGLVSIPGM GKLLAEAPLV LEPEKQMLLH ETHQGLLQDG SPILLSDVIS
460 470 480 490 500
AFLSNNDTQN LSSPVTFTFS HRSVIPRQKV LCVFWEHGQN GCGHWATTGC
510 520 530 540 550
STIGTRDTST ICRCTHLSSF AVLMAHYDVQ EEDPVLTVIT YMGLSVSLLC
560 570 580 590 600
LLLAALTFLL CKAIQNTSTS LHLQLSLCLF LAHLLFLVAI DQTGHKVLCS
610 620 630 640 650
IIAGTLHYLY LATLTWMLLE ALYLFLTARN LTVVNYSSIN RFMKKLMFPV
660 670 680 690 700
GYGVPAVTVA ISAASRPHLY GTPSRCWLQP EKGFIWGFLG PVCAIFSVNL
710 720 730 740 750
VLFLVTLWIL KNRLSSLNSE VSTLRNTRML AFKATAQLFI LGCTWCLGIL
760 770 780 790 800
QVGPAARVMA YLFTIINSLQ GVFIFLVYCL LSQQVREQYG KWSKGIRKLK
810 820
TESEMHTLSS SAKADTSKPS TVN
Length:823
Mass (Da):90,472
Last modified:June 13, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D38C30A07B46FF4
GO
Isoform 2 (identifier: Q9UHX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-407: Missing.

Show »
Length:812
Mass (Da):89,466
Checksum:i9A98853A77E71FFD
GO
Isoform 3 (identifier: Q9UHX3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-211: Missing.

Show »
Length:774
Mass (Da):85,230
Checksum:i9687785185F52A7F
GO
Isoform 4 (identifier: Q9UHX3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-211: Missing.

Show »
Length:730
Mass (Da):80,351
Checksum:iA7509F01725F3A18
GO
Isoform 5 (identifier: Q9UHX3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-260: Missing.

Show »
Length:681
Mass (Da):74,936
Checksum:iADE8AC326340F0CB
GO
Isoform 6 (identifier: Q9UHX3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     473-530: Missing.

Note: No experimental confirmation available.
Show »
Length:765
Mass (Da):84,079
Checksum:iD427C949296B61F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R0K5M0R0K5_HUMAN
Adhesion G protein-coupled receptor...
ADGRE2
831Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DWB8B4DWB8_HUMAN
Adhesion G protein-coupled receptor...
ADGRE2
379Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY55M0QY55_HUMAN
Adhesion G protein-coupled receptor...
ADGRE2
330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC06146 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti531Missing in AAC05172 (PubMed:15057824).Curated1
Sequence conflicti823N → R in BAC06146 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061229314A → V. Corresponds to variant dbSNP:rs35612307Ensembl.1
Natural variantiVAR_078578492C → Y in VBU; affects the regulation of mast cells degranulation; results in increased vibration-induced mast cells degranulation; no effect on localization to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs199718602EnsemblClinVar.1
Natural variantiVAR_026719605T → I. Corresponds to variant dbSNP:rs4410209Ensembl.1
Natural variantiVAR_026720614L → F3 PublicationsCorresponds to variant dbSNP:rs2524383Ensembl.1
Natural variantiVAR_026721665S → F. Corresponds to variant dbSNP:rs3752187Ensembl.1
Natural variantiVAR_061230720E → D. Corresponds to variant dbSNP:rs57865820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041364119 – 260Missing in isoform 5. CuratedAdd BLAST142
Alternative sequenceiVSP_041365119 – 211Missing in isoform 4. CuratedAdd BLAST93
Alternative sequenceiVSP_041366163 – 211Missing in isoform 3. CuratedAdd BLAST49
Alternative sequenceiVSP_041367397 – 407Missing in isoform 2. CuratedAdd BLAST11
Alternative sequenceiVSP_047535473 – 530Missing in isoform 6. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF114491 mRNA Translation: AAF21974.1
AB065931 Genomic DNA Translation: BAC06146.1 Sequence problems.
AK298700 mRNA Translation: BAG60858.1
AC004262 Genomic DNA Translation: AAC05172.1
AC005327 Genomic DNA No translation available.
AC090427 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32935.1 [Q9UHX3-1]
CCDS59361.1 [Q9UHX3-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001257981.1, NM_001271052.1 [Q9UHX3-6]
NP_038475.2, NM_013447.3 [Q9UHX3-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.531619

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000315576; ENSP00000319883; ENSG00000127507 [Q9UHX3-1]
ENST00000392965; ENSP00000376692; ENSG00000127507 [Q9UHX3-6]
ENST00000594076; ENSP00000472735; ENSG00000127507 [Q9UHX3-4]
ENST00000594294; ENSP00000470725; ENSG00000127507 [Q9UHX3-3]
ENST00000595839; ENSP00000469277; ENSG00000127507 [Q9UHX3-5]
ENST00000596991; ENSP00000472280; ENSG00000127507 [Q9UHX3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
30817

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:30817

UCSC genome browser

More...
UCSCi
uc002mzp.3 human [Q9UHX3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114491 mRNA Translation: AAF21974.1
AB065931 Genomic DNA Translation: BAC06146.1 Sequence problems.
AK298700 mRNA Translation: BAG60858.1
AC004262 Genomic DNA Translation: AAC05172.1
AC005327 Genomic DNA No translation available.
AC090427 Genomic DNA No translation available.
CCDSiCCDS32935.1 [Q9UHX3-1]
CCDS59361.1 [Q9UHX3-6]
RefSeqiNP_001257981.1, NM_001271052.1 [Q9UHX3-6]
NP_038475.2, NM_013447.3 [Q9UHX3-1]
UniGeneiHs.531619

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BO2X-ray2.60A/B25-260[»]
2BOUX-ray1.90A25-118[»]
A212-260[»]
2BOXX-ray2.50A25-260[»]
ProteinModelPortaliQ9UHX3
SMRiQ9UHX3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119041, 3 interactors
IntActiQ9UHX3, 12 interactors
STRINGi9606.ENSP00000472280

Protein family/group databases

MEROPSiP02.001

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyConnecti993
iPTMnetiQ9UHX3
PhosphoSitePlusiQ9UHX3

Polymorphism and mutation databases

BioMutaiADGRE2
DMDMi108935835

Proteomic databases

jPOSTiQ9UHX3
PaxDbiQ9UHX3
PeptideAtlasiQ9UHX3
PRIDEiQ9UHX3
ProteomicsDBi84434
84435 [Q9UHX3-2]
84436 [Q9UHX3-3]
84437 [Q9UHX3-4]
84438 [Q9UHX3-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315576; ENSP00000319883; ENSG00000127507 [Q9UHX3-1]
ENST00000392965; ENSP00000376692; ENSG00000127507 [Q9UHX3-6]
ENST00000594076; ENSP00000472735; ENSG00000127507 [Q9UHX3-4]
ENST00000594294; ENSP00000470725; ENSG00000127507 [Q9UHX3-3]
ENST00000595839; ENSP00000469277; ENSG00000127507 [Q9UHX3-5]
ENST00000596991; ENSP00000472280; ENSG00000127507 [Q9UHX3-2]
GeneIDi30817
KEGGihsa:30817
UCSCiuc002mzp.3 human [Q9UHX3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30817
DisGeNETi30817
EuPathDBiHostDB:ENSG00000127507.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADGRE2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0174383
HGNCiHGNC:3337 ADGRE2
HPAiHPA055200
MalaCardsiADGRE2
MIMi125630 phenotype
606100 gene
neXtProtiNX_Q9UHX3
OpenTargetsiENSG00000127507
Orphaneti493342 Vibratory urticaria
PharmGKBiPA27774

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00940000162597
HOGENOMiHOG000294115
HOVERGENiHBG048917
InParanoidiQ9UHX3
KOiK08443
OrthoDBi210309at2759
PhylomeDBiQ9UHX3
TreeFamiTF316380

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADGRE2 human
EvolutionaryTraceiQ9UHX3

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EMR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
30817
PMAP-CutDBiQ9UHX3

Protein Ontology

More...
PROi
PR:Q9UHX3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127507 Expressed in 120 organ(s), highest expression level in blood
ExpressionAtlasiQ9UHX3 baseline and differential
GenevisibleiQ9UHX3 HS

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR017981 GPCR_2-like
IPR003056 GPCR_2_CD97
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF07645 EGF_CA, 4 hits
PF01825 GPS, 1 hit
PRINTSiPR01278 CD97PROTEIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 4 hits
SM00303 GPS, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 4 hits
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRE2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHX3
Secondary accession number(s): B4DQ96
, E7ESD7, E9PBR1, E9PEL6, E9PFQ5, E9PG91, Q8NG96, Q9Y4B1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 13, 2006
Last modified: February 13, 2019
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  8. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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