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UniProtKB - Q9UHX1 (PUF60_HUMAN)

Entry version 186 (10 Feb 2021)
Sequence version 1 (01 May 2000)
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Protein

Poly(U)-binding-splicing factor PUF60

Gene

PUF60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.6 Publications

Miscellaneous

Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor, Ribonucleoprotein, RNA-binding
Biological processApoptosis, mRNA processing, mRNA splicing, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UHX1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72163, mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly(U)-binding-splicing factor PUF60
Alternative name(s):
60 kDa poly(U)-binding-splicing factor
FUSE-binding protein-interacting repressor
Short name:
FBP-interacting repressor
Ro-binding protein 1
Short name:
RoBP1
Siah-binding protein 1
Short name:
Siah-BP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PUF60
Synonyms:FIR, ROBPI, SIAHBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17042, PUF60

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604819, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UHX1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000179950.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Verheij syndrome (VRJS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by growth retardation, delayed psychomotor development, dysmorphic facial features, and skeletal, mainly vertebral, abnormalities. Additional variable features may include coloboma, renal defects, and cardiac defects.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070939169H → Y in VRJS; loss of function mutation; results in altered dosage of different PUF60 protein forms and abnormal splicing profile of several target genes. 1 PublicationCorresponds to variant dbSNP:rs398123001EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		22827

MalaCards human disease database

More...MalaCardsi		PUF60
MIMi615583, phenotype

Open Targets

More...OpenTargetsi		ENSG00000179950

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		508488, 8q24.3 microdeletion syndrome
508498, Intellectual disability-cardiac anomalies-short stature-joint laxity syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162400364

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UHX1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PUF60

Domain mapping of disease mutations (DMDM)

More...DMDMi		74761960

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995191 – 559Poly(U)-binding-splicing factor PUF60Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki43Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60PhosphothreonineCombined sources1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei112PhosphoserineCombined sources1
Modified residuei244PhosphoserineBy similarity1
Modified residuei251N6-acetyllysineCombined sources1
Modified residuei314PhosphothreonineCombined sources1
Cross-linki419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei454N6-acetyllysineCombined sources1
Cross-linki458Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 5 (identifier: Q9UHX1-5)
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 6 (identifier: Q9UHX1-6)
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UHX1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UHX1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UHX1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UHX1

PeptideAtlas

More...PeptideAtlasi		Q9UHX1

PRoteomics IDEntifications database

More...PRIDEi		Q9UHX1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84428 [Q9UHX1-1]
84429 [Q9UHX1-2]
84430 [Q9UHX1-3]
84431 [Q9UHX1-4]
84432 [Q9UHX1-5]
84433 [Q9UHX1-6]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9UHX1-3 [Q9UHX1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UHX1

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9UHX1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UHX1

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9UHX1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is expressed in colonic epithelium and colorectal epithelium cancer (at protein level). Isoform 6 is expressed in colorectal epithelial cancer but below detection level in colonic epithelium. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000179950, Expressed in stomach and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UHX1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UHX1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000179950, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Associates with the spliceosome.

Found in a complex with TROVE2 and Y5 RNA.

Found in a complex with FUBP1 and far upstream element (FUSE) DNA segment.

Interacts directly with ERCC3.

Interacts with CDK7, GTF2H1 and SFRS11. Does not interact with ERCC3 in xeroderma pigmentosum complementation group B (XPB) cells.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9UHX1
With#Exp.IntAct
ARL8A [Q96BM9]3EBI-1053259,EBI-4401082
BORCS5 [Q969J3]4EBI-1053259,EBI-747707
CACNA1A [O00555]2EBI-1053259,EBI-766279
CCNC [P24863]3EBI-1053259,EBI-395261
IQCN [Q9H0B3]3EBI-1053259,EBI-745878
KHDC4 [Q7Z7F0]3EBI-1053259,EBI-751942
MED28 [Q9H204]6EBI-1053259,EBI-514199
PCBP1 [Q15365]2EBI-1053259,EBI-946095
PPP1R16A [Q96I34]2EBI-1053259,EBI-710402
itself4EBI-1053259,EBI-1053259
QRICH1 [Q2TAL8]3EBI-1053259,EBI-2798044
RAD23B [P54727]3EBI-1053259,EBI-954531
SAP30BP [Q9UHR5]10EBI-1053259,EBI-751683
SDCBP [O00560]3EBI-1053259,EBI-727004
SIAH1 [Q8IUQ4]7EBI-1053259,EBI-747107
SRSF11 [Q05519]6EBI-1053259,EBI-1051785
U2AF2 [P26368]5EBI-1053259,EBI-742339
UBE2I [Q7KZS0]3EBI-1053259,EBI-10180829
UPF2 [Q9HAU5]3EBI-1053259,EBI-372073
ZG16 [O60844]3EBI-1053259,EBI-746479
PUF60 - isoform 2 [Q9UHX1-2]
With#Exp.IntAct
DDIT4L [Q96D03]3EBI-11529177,EBI-742054
FTHL17 [Q9BXU8]3EBI-11529177,EBI-12156897
FUBP1 - isoform 1 [Q96AE4-1]2EBI-11529177,EBI-5455665
FUBP1 - isoform 2 [Q96AE4-2]3EBI-11529177,EBI-12121668
GAPDH [P04406]3EBI-11529177,EBI-354056
HTT [P42858]6EBI-11529177,EBI-466029
KHDC4 - isoform 4 [Q7Z7F0-4]10EBI-11529177,EBI-9089060
PCBP3 - isoform 2 [P57721-2]3EBI-11529177,EBI-11983983
itself3EBI-11529177,EBI-11529177
RAD23B [P54727]3EBI-11529177,EBI-954531
SF1 - isoform 4 [Q15637-4]3EBI-11529177,EBI-12223157
SRSF11 - isoform 2 [Q05519-2]6EBI-11529177,EBI-11975029
TAF2 [Q6P1X5]3EBI-11529177,EBI-1560063
TH - isoform 2 [P07101-3]3EBI-11529177,EBI-12001016
U2AF2 - isoform 2 [P26368-2]3EBI-11529177,EBI-11097439
UBTFL1 [P0CB47]3EBI-11529177,EBI-17208936
ZG16 [O60844]3EBI-11529177,EBI-746479
Isoform 5 [Q9UHX1-5]
With#Exp.IntAct
KHDC4 - isoform 4 [Q7Z7F0-4]3EBI-11526420,EBI-9089060
Isoform 6 [Q9UHX1-6]
With#Exp.IntAct
HTT [P42858]9EBI-11085298,EBI-466029
KHDC4 - isoform 4 [Q7Z7F0-4]3EBI-11085298,EBI-9089060

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116502, 252 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9UHX1

Database of interacting proteins

More...DIPi		DIP-34636N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9UHX1

Protein interaction database and analysis system

More...IntActi		Q9UHX1, 73 interactors

Molecular INTeraction database

More...MINTi		Q9UHX1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000434359

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UHX1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1559
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9UHX1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UHX1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UHX1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 207RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini226 – 304RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini462 – 549RRM 3; atypicalPROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 516Inhibits homodimerizationAdd BLAST516
Regioni77 – 559Inhibits transcriptional repression, interaction with ERCC3 and apoptosis inductionAdd BLAST483

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi321 – 343Ala-richAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The third RNA recognition motif, called PUMP domain, is atypical and may rather mediate homodimerization and/or protein-protein interactions.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM half pint family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0124, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155594

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020551_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UHX1

Identification of Orthologs from Complete Genome Data

More...OMAi		QMNGVML

Database of Orthologous Groups

More...OrthoDBi		861359at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UHX1

TreeFam database of animal gene trees

More...TreeFami		TF313987

Family and domain databases

Conserved Domains Database

More...CDDi		cd12370, RRM1_PUF60, 1 hit
cd12371, RRM2_PUF60, 1 hit
cd12648, RRM3_UHM_PUF60, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR006532, PolyU-bd
IPR034209, PUF60_RRM1
IPR034211, PUF60_RRM2
IPR034212, PUF60_RRM3
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR003954, RRM_dom_euk

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 3 hits
SM00361, RRM_1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01645, half-pint, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UHX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATATIALQV NGQQGGGSEP AAAAAVVAAG DKWKPPQGTD SIKMENGQST 
        60         70         80         90        100
AAKLGLPPLT PEQQEALQKA KKYAMEQSIK SVLVKQTIAH QQQQLTNLQM 
       110        120        130        140        150
AAVTMGFGDP LSPLQSMAAQ RQRALAIMCR VYVGSIYYEL GEDTIRQAFA 
       160        170        180        190        200
PFGPIKSIDM SWDSVTMKHK GFAFVEYEVP EAAQLALEQM NSVMLGGRNI 
       210        220        230        240        250
KVGRPSNIGQ AQPIIDQLAE EARAFNRIYV ASVHQDLSDD DIKSVFEAFG 
       260        270        280        290        300
KIKSCTLARD PTTGKHKGYG FIEYEKAQSS QDAVSSMNLF DLGGQYLRVG 
       310        320        330        340        350
KAVTPPMPLL TPATPGGLPP AAAVAAAAAT AKITAQEAVA GAAVLGTLGT 
       360        370        380        390        400
PGLVSPALTL AQPLGTLPQA VMAAQAPGVI TGVTPARPPI PVTIPSVGVV 
       410        420        430        440        450
NPILASPPTL GLLEPKKEKE EEELFPESER PEMLSEQEHM SISGSSARHM 
       460        470        480        490        500
VMQKLLRKQE STVMVLRNMV DPKDIDDDLE GEVTEECGKF GAVNRVIIYQ 
       510        520        530        540        550
EKQGEEEDAE IIVKIFVEFS IASETHKAIQ ALNGRWFAGR KVVAEVYDQE 

RFDNSDLSA
Length:559
Mass (Da):59,875
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i619F3C30D1C5951C
GO
Isoform 2 (identifier: Q9UHX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-117: Missing.

Show »
Length:542
Mass (Da):58,171
Checksum:i2C67EBE529A0922E
GO
Isoform 3 (identifier: Q9UHX1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Show »
Length:516
Mass (Da):55,729
Checksum:iF52D8C619E874B55
GO
Isoform 4 (identifier: Q9UHX1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.
     101-117: Missing.

Show »
Length:499
Mass (Da):54,025
Checksum:i77881512A09C3EFD
GO
Isoform 5 (identifier: Q9UHX1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-37: Missing.

Show »
Length:530
Mass (Da):57,103
Checksum:i850251A390ECD30C
GO
Isoform 6 (identifier: Q9UHX1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-37: Missing.
     101-117: Missing.

Show »
Length:513
Mass (Da):55,399
Checksum:i2A5BA6848E391E3A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YVP6A0A0J9YVP6_HUMAN
60 kDa poly(U)-binding-splicing fac...
PUF60
534Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YYL3A0A0J9YYL3_HUMAN
60 kDa poly(U)-binding-splicing fac...
PUF60
505Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXJ8A0A0J9YXJ8_HUMAN
60 kDa poly(U)-binding-splicing fac...
PUF60
522Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXX5A0A0J9YXX5_HUMAN
60 kDa poly(U)-binding-splicing fac...
PUF60
551Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ56E9PQ56_HUMAN
60 kDa poly(U)-binding-splicing fac...
PUF60
322Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEM1H0YEM1_HUMAN
60 kDa poly(U)-binding-splicing fac...
PUF60
336Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVR6A0A0J9YVR6_HUMAN
60 kDa poly(U)-binding-splicing fac...
PUF60
314Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWM1A0A0J9YWM1_HUMAN
60 kDa poly(U)-binding-splicing fac...
PUF60
329Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMU7E9PMU7_HUMAN
Poly(U)-binding-splicing factor PUF...
PUF60
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN18E9PN18_HUMAN
Poly(U)-binding-splicing factor PUF...
PUF60
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3T → R in AAB41656 (Ref. 7) Curated1
Sequence conflicti123R → G in AAB41656 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070939169H → Y in VRJS; loss of function mutation; results in altered dosage of different PUF60 protein forms and abnormal splicing profile of several target genes. 1 PublicationCorresponds to variant dbSNP:rs398123001EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0277171 – 43Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_0277189 – 37Missing in isoform 5 and isoform 6. CuratedAdd BLAST29
Alternative sequenceiVSP_027719101 – 117Missing in isoform 2, isoform 4 and isoform 6. 3 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF217197 mRNA Translation: AAF27522.2
AF114818 mRNA Translation: AAF23589.1
AK292373 mRNA Translation: BAF85062.1
CR457143 mRNA Translation: CAG33424.1
CH471162 Genomic DNA Translation: EAW82187.1
CH471162 Genomic DNA Translation: EAW82189.1
BC008875 mRNA Translation: AAH08875.1
BC009734 mRNA Translation: AAH09734.1
BC011265 mRNA Translation: AAH11265.1
BC011979 mRNA Translation: AAH11979.1
U51586 mRNA Translation: AAB41656.1
AF190744 mRNA Translation: AAF05605.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47933.1 [Q9UHX1-2]
CCDS47934.1 [Q9UHX1-1]
CCDS47935.1 [Q9UHX1-3]
CCDS59514.1 [Q9UHX1-4]
CCDS59515.1 [Q9UHX1-6]
CCDS59516.1 [Q9UHX1-5]

NCBI Reference Sequences

More...RefSeqi		NP_001129505.1, NM_001136033.2 [Q9UHX1-3]
NP_001258025.1, NM_001271096.1
NP_001258026.1, NM_001271097.1 [Q9UHX1-6]
NP_001258027.1, NM_001271098.1
NP_001258028.1, NM_001271099.1 [Q9UHX1-5]
NP_001258029.1, NM_001271100.1 [Q9UHX1-4]
NP_055096.2, NM_014281.4 [Q9UHX1-2]
NP_510965.1, NM_078480.2 [Q9UHX1-1]
XP_016868728.1, XM_017013239.1 [Q9UHX1-3]
XP_016868729.1, XM_017013240.1 [Q9UHX1-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313352; ENSP00000322016; ENSG00000179950 [Q9UHX1-4]
ENST00000349157; ENSP00000322036; ENSG00000179950 [Q9UHX1-2]
ENST00000453551; ENSP00000402953; ENSG00000179950 [Q9UHX1-3]
ENST00000456095; ENSP00000395417; ENSG00000179950 [Q9UHX1-5]
ENST00000526683; ENSP00000434359; ENSG00000179950 [Q9UHX1-1]
ENST00000527197; ENSP00000431960; ENSG00000179950 [Q9UHX1-6]
ENST00000612237; ENSP00000478495; ENSG00000274081 [Q9UHX1-2]
ENST00000620341; ENSP00000484860; ENSG00000274081 [Q9UHX1-1]
ENST00000620953; ENSP00000478209; ENSG00000274081 [Q9UHX1-5]
ENST00000632444; ENSP00000487945; ENSG00000274081 [Q9UHX1-3]
ENST00000633206; ENSP00000487930; ENSG00000274081 [Q9UHX1-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22827

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22827

UCSC genome browser

More...UCSCi		uc003yzq.5, human [Q9UHX1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217197 mRNA Translation: AAF27522.2
AF114818 mRNA Translation: AAF23589.1
AK292373 mRNA Translation: BAF85062.1
CR457143 mRNA Translation: CAG33424.1
CH471162 Genomic DNA Translation: EAW82187.1
CH471162 Genomic DNA Translation: EAW82189.1
BC008875 mRNA Translation: AAH08875.1
BC009734 mRNA Translation: AAH09734.1
BC011265 mRNA Translation: AAH11265.1
BC011979 mRNA Translation: AAH11979.1
U51586 mRNA Translation: AAB41656.1
AF190744 mRNA Translation: AAF05605.1
CCDSiCCDS47933.1 [Q9UHX1-2]
CCDS47934.1 [Q9UHX1-1]
CCDS47935.1 [Q9UHX1-3]
CCDS59514.1 [Q9UHX1-4]
CCDS59515.1 [Q9UHX1-6]
CCDS59516.1 [Q9UHX1-5]
RefSeqiNP_001129505.1, NM_001136033.2 [Q9UHX1-3]
NP_001258025.1, NM_001271096.1
NP_001258026.1, NM_001271097.1 [Q9UHX1-6]
NP_001258027.1, NM_001271098.1
NP_001258028.1, NM_001271099.1 [Q9UHX1-5]
NP_001258029.1, NM_001271100.1 [Q9UHX1-4]
NP_055096.2, NM_014281.4 [Q9UHX1-2]
NP_510965.1, NM_078480.2 [Q9UHX1-1]
XP_016868728.1, XM_017013239.1 [Q9UHX1-3]
XP_016868729.1, XM_017013240.1 [Q9UHX1-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DNYNMR-A454-559[»]
2KXFNMR-A119-314[»]
2KXHNMR-A119-314[»]
2QFJX-ray2.10A/B118-316[»]
3DXBX-ray2.20A/B/C/D/E/F/G/H460-559[»]
3UE2X-ray1.23A443-559[»]
3US5X-ray1.38A443-559[»]
3UWTX-ray2.50A118-316[»]
5KVYX-ray1.95A/B118-316[»]
5KW1X-ray2.10A/B118-316[»]
5KW6X-ray1.91A/B118-316[»]
5KWQX-ray2.80A/B118-316[»]
6LURX-ray2.00A/B/C/D/E/F/G/H460-559[»]
6SLOX-ray1.94A/B/C/D460-559[»]
BMRBiQ9UHX1
SMRiQ9UHX1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116502, 252 interactors
CORUMiQ9UHX1
DIPiDIP-34636N
ELMiQ9UHX1
IntActiQ9UHX1, 73 interactors
MINTiQ9UHX1
STRINGi9606.ENSP00000434359

PTM databases

iPTMnetiQ9UHX1
MetOSiteiQ9UHX1
PhosphoSitePlusiQ9UHX1
SwissPalmiQ9UHX1

Genetic variation databases

BioMutaiPUF60
DMDMi74761960

Proteomic databases

EPDiQ9UHX1
jPOSTiQ9UHX1
MassIVEiQ9UHX1
PaxDbiQ9UHX1
PeptideAtlasiQ9UHX1
PRIDEiQ9UHX1
ProteomicsDBi84428 [Q9UHX1-1]
84429 [Q9UHX1-2]
84430 [Q9UHX1-3]
84431 [Q9UHX1-4]
84432 [Q9UHX1-5]
84433 [Q9UHX1-6]
TopDownProteomicsiQ9UHX1-3 [Q9UHX1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28098, 424 antibodies

Genome annotation databases

EnsembliENST00000313352; ENSP00000322016; ENSG00000179950 [Q9UHX1-4]
ENST00000349157; ENSP00000322036; ENSG00000179950 [Q9UHX1-2]
ENST00000453551; ENSP00000402953; ENSG00000179950 [Q9UHX1-3]
ENST00000456095; ENSP00000395417; ENSG00000179950 [Q9UHX1-5]
ENST00000526683; ENSP00000434359; ENSG00000179950 [Q9UHX1-1]
ENST00000527197; ENSP00000431960; ENSG00000179950 [Q9UHX1-6]
ENST00000612237; ENSP00000478495; ENSG00000274081 [Q9UHX1-2]
ENST00000620341; ENSP00000484860; ENSG00000274081 [Q9UHX1-1]
ENST00000620953; ENSP00000478209; ENSG00000274081 [Q9UHX1-5]
ENST00000632444; ENSP00000487945; ENSG00000274081 [Q9UHX1-3]
ENST00000633206; ENSP00000487930; ENSG00000274081 [Q9UHX1-4]
GeneIDi22827
KEGGihsa:22827
UCSCiuc003yzq.5, human [Q9UHX1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22827
DisGeNETi22827

GeneCards: human genes, protein and diseases

More...GeneCardsi		PUF60
HGNCiHGNC:17042, PUF60
HPAiENSG00000179950, Low tissue specificity
MalaCardsiPUF60
MIMi604819, gene
615583, phenotype
neXtProtiNX_Q9UHX1
OpenTargetsiENSG00000179950
Orphaneti508488, 8q24.3 microdeletion syndrome
508498, Intellectual disability-cardiac anomalies-short stature-joint laxity syndrome
PharmGKBiPA162400364
VEuPathDBiHostDB:ENSG00000179950.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0124, Eukaryota
GeneTreeiENSGT00940000155594
HOGENOMiCLU_020551_3_1_1
InParanoidiQ9UHX1
OMAiQMNGVML
OrthoDBi861359at2759
PhylomeDBiQ9UHX1
TreeFamiTF313987

Enzyme and pathway databases

PathwayCommonsiQ9UHX1
ReactomeiR-HSA-72163, mRNA Splicing - Major Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22827, 771 hits in 885 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PUF60, human
EvolutionaryTraceiQ9UHX1

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PUF60

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22827
PharosiQ9UHX1, Tbio

Protein Ontology

More...PROi		PR:Q9UHX1
RNActiQ9UHX1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000179950, Expressed in stomach and 246 other tissues
ExpressionAtlasiQ9UHX1, baseline and differential
GenevisibleiQ9UHX1, HS

Family and domain databases

CDDicd12370, RRM1_PUF60, 1 hit
cd12371, RRM2_PUF60, 1 hit
cd12648, RRM3_UHM_PUF60, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR006532, PolyU-bd
IPR034209, PUF60_RRM1
IPR034211, PUF60_RRM2
IPR034212, PUF60_RRM3
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR003954, RRM_dom_euk
PfamiView protein in Pfam
PF00076, RRM_1, 2 hits
SMARTiView protein in SMART
SM00360, RRM, 3 hits
SM00361, RRM_1, 2 hits
SUPFAMiSSF54928, SSF54928, 2 hits
TIGRFAMsiTIGR01645, half-pint, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPUF60_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHX1
Secondary accession number(s): A8K8K8
, Q969E7, Q96D94, Q96H63, Q99628, Q9NZA0, Q9UJY7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 186 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with genetic variants
    List of human entries with genetic variants
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