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Entry version 186 (08 May 2019)
Sequence version 2 (13 Dec 2002)
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Protein

Solute carrier family 12 member 6

Gene

SLC12A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=10.7 mM for extracellular Rb+ (isoform 1)1 Publication
  2. KM=7.3 mM for extracellular Cl- (isoform 1)1 Publication
  3. KM=17.2 mM for extracellular Rb+ (isoform 2)1 Publication
  4. KM=8.2 mM for extracellular Cl- (isoform 2)1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processIon transport, Potassium transport, Symport, Transport
    LigandChloride, Potassium

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-426117 Cation-coupled Chloride cotransporters
    R-HSA-5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q9UHW9

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.30.1.15 the cation-chloride cotransporter (ccc) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Solute carrier family 12 member 6
    Alternative name(s):
    Electroneutral potassium-chloride cotransporter 3
    K-Cl cotransporter 3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC12A6
    Synonyms:KCC3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:10914 SLC12A6

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    604878 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9UHW9

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 185CytoplasmicSequence analysisAdd BLAST185
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei186 – 208HelicalSequence analysisAdd BLAST23
    Topological domaini209 – 223ExtracellularSequence analysisAdd BLAST15
    Transmembranei224 – 245HelicalSequence analysisAdd BLAST22
    Topological domaini246 – 271CytoplasmicSequence analysisAdd BLAST26
    Transmembranei272 – 295HelicalSequence analysisAdd BLAST24
    Topological domaini296 – 318ExtracellularSequence analysisAdd BLAST23
    Transmembranei319 – 343HelicalSequence analysisAdd BLAST25
    Topological domaini344 – 346CytoplasmicSequence analysis3
    Transmembranei347 – 371HelicalSequence analysisAdd BLAST25
    Topological domaini372 – 479ExtracellularSequence analysisAdd BLAST108
    Transmembranei480 – 501HelicalSequence analysisAdd BLAST22
    Topological domaini502 – 515CytoplasmicSequence analysisAdd BLAST14
    Transmembranei516 – 543HelicalSequence analysisAdd BLAST28
    Topological domaini544 – 557ExtracellularSequence analysisAdd BLAST14
    Transmembranei558 – 581HelicalSequence analysisAdd BLAST24
    Topological domaini582 – 620CytoplasmicSequence analysisAdd BLAST39
    Transmembranei621 – 644HelicalSequence analysisAdd BLAST24
    Topological domaini645 – 647ExtracellularSequence analysis3
    Transmembranei648 – 670HelicalSequence analysisAdd BLAST23
    Topological domaini671 – 676CytoplasmicSequence analysis6
    Transmembranei677 – 695HelicalSequence analysisAdd BLAST19
    Topological domaini696ExtracellularSequence analysis1
    Transmembranei697 – 719HelicalSequence analysisAdd BLAST23
    Topological domaini720 – 1150CytoplasmicSequence analysisAdd BLAST431

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA disease that is characterized by severe progressive sensorimotor neuropathy, mental retardation, dysmorphic features and complete or partial agenesis of the corpus callosum.
    See also OMIM:218000

    Keywords - Diseasei

    Neuropathy

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    9990

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    SLC12A6

    MalaCards human disease database

    More...
    MalaCardsi
    SLC12A6
    MIMi218000 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000140199

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    1496 Corpus callosum agenesis-neuronopathy syndrome

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA35808

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB00761 Potassium Chloride

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC12A6

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    27151690

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001780371 – 1150Solute carrier family 12 member 6Add BLAST1150

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32PhosphoserineCombined sources1
    Modified residuei120PhosphoserineCombined sources1
    Modified residuei148PhosphoserineCombined sources1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
    Modified residuei1032PhosphoserineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated.2 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9UHW9

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9UHW9

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9UHW9

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9UHW9

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9UHW9

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    84422
    84423 [Q9UHW9-2]
    84424 [Q9UHW9-3]
    84425 [Q9UHW9-4]
    84426 [Q9UHW9-5]
    84427 [Q9UHW9-6]

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    1762

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9UHW9

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9UHW9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level).1 Publication

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated by VEGF. Down-regulated by TNF.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000140199 Expressed in 213 organ(s), highest expression level in blood

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9UHW9 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9UHW9 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA034563

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homomultimer and heteromultimer with other K-Cl cotransporters.By similarity

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    115311, 22 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9UHW9, 7 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9UHW9

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000346112

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9UHW9

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi227 – 230Poly-Cys4

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the SLC12A transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2082 Eukaryota
    COG0531 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160238

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000092644

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9UHW9

    KEGG Orthology (KO)

    More...
    KOi
    K14427

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    KNWRPHI

    Database of Orthologous Groups

    More...
    OrthoDBi
    349744at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9UHW9

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313657

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR004841 AA-permease/SLC12A_dom
    IPR030364 KCC3
    IPR000076 KCL_cotranspt
    IPR018491 SLC12_C
    IPR004842 SLC12A_fam

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11827:SF66 PTHR11827:SF66, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00324 AA_permease, 2 hits
    PF03522 SLC12, 2 hits

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR01081 KCLTRNSPORT

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00930 2a30, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

    This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9UHW9-1) [UniParc]FASTAAdd to basket
    Also known as: KCC3a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MHPPETTTKM ASVRFMVTPT KIDDIPGLSD TSPDLSSRSS SRVRFSSRES
    60 70 80 90 100
    VPETSRSEPM SEMSGATTSL ATVALDPPSD RTSHPQDVIE DLSQNSITGE
    110 120 130 140 150
    HSQLLDDGHK KARNAYLNNS NYEEGDEYFD KNLALFEEEM DTRPKVSSLL
    160 170 180 190 200
    NRMANYTNLT QGAKEHEEAE NITEGKKKPT KTPQMGTFMG VYLPCLQNIF
    210 220 230 240 250
    GVILFLRLTW VVGTAGVLQA FAIVLICCCC TMLTAISMSA IATNGVVPAG
    260 270 280 290 300
    GSYFMISRAL GPEFGGAVGL CFYLGTTFAA AMYILGAIEI FLVYIVPRAA
    310 320 330 340 350
    IFHSDDALKE SAAMLNNMRV YGTAFLVLMV LVVFIGVRYV NKFASLFLAC
    360 370 380 390 400
    VIVSILAIYA GAIKSSFAPP HFPVCMLGNR TLSSRHIDVC SKTKEINNMT
    410 420 430 440 450
    VPSKLWGFFC NSSQFFNATC DEYFVHNNVT SIQGIPGLAS GIITENLWSN
    460 470 480 490 500
    YLPKGEIIEK PSAKSSDVLG SLNHEYVLVD ITTSFTLLVG IFFPSVTGIM
    510 520 530 540 550
    AGSNRSGDLK DAQKSIPIGT ILAILTTSFV YLSNVVLFGA CIEGVVLRDK
    560 570 580 590 600
    FGDAVKGNLV VGTLSWPSPW VIVIGSFFST CGAGLQSLTG APRLLQAIAK
    610 620 630 640 650
    DNIIPFLRVF GHSKANGEPT WALLLTAAIA ELGILIASLD LVAPILSMFF
    660 670 680 690 700
    LMCYLFVNLA CALQTLLRTP NWRPRFRYYH WALSFMGMSI CLALMFISSW
    710 720 730 740 750
    YYAIVAMVIA GMIYKYIEYQ GAEKEWGDGI RGLSLSAARF ALLRLEEGPP
    760 770 780 790 800
    HTKNWRPQLL VLLKLDEDLH VKHPRLLTFA SQLKAGKGLT IVGSVIVGNF
    810 820 830 840 850
    LENYGEALAA EQTIKHLMEA EKVKGFCQLV VAAKLREGIS HLIQSCGLGG
    860 870 880 890 900
    MKHNTVVMGW PNGWRQSEDA RAWKTFIGTV RVTTAAHLAL LVAKNISFFP
    910 920 930 940 950
    SNVEQFSEGN IDVWWIVHDG GMLMLLPFLL KQHKVWRKCS IRIFTVAQLE
    960 970 980 990 1000
    DNSIQMKKDL ATFLYHLRIE AEVEVVEMHD SDISAYTYER TLMMEQRSQM
    1010 1020 1030 1040 1050
    LRHMRLSKTE RDREAQLVKD RNSMLRLTSI GSDEDEETET YQEKVHMTWT
    1060 1070 1080 1090 1100
    KDKYMASRGQ KAKSMEGFQD LLNMRPDQSN VRRMHTAVKL NEVIVNKSHE
    1110 1120 1130 1140 1150
    AKLVLLNMPG PPRNPEGDEN YMEFLEVLTE GLERVLLVRG GGSEVITIYS
    Length:1,150
    Mass (Da):127,617
    Last modified:December 13, 2002 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8BDD39181294EDD
    GO
    Isoform 2 (identifier: Q9UHW9-2) [UniParc]FASTAAdd to basket
    Also known as: KCC3b

    The sequence of this isoform differs from the canonical sequence as follows:
         1-51: Missing.
         52-90: PETSRSEPMS...RTSHPQDVIE → MPHFTVTKVE...KARIQDSDEP

    Note: Produced by alternative promoter usage.
    Show »
    Length:1,099
    Mass (Da):122,091
    Checksum:i1C9D8FE2A060E0DC
    GO
    Isoform 3 (identifier: Q9UHW9-3) [UniParc]FASTAAdd to basket
    Also known as: KCC3a-X2M

    The sequence of this isoform differs from the canonical sequence as follows:
         91-105: Missing.

    Note: Does not differ in the osmotic set point of swelling activation but, activation is more rapid.
    Show »
    Length:1,135
    Mass (Da):125,993
    Checksum:iED4C3E7101CB0378
    GO
    Isoform 4 (identifier: Q9UHW9-4) [UniParc]FASTAAdd to basket
    Also known as: KCC3a-S3

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: Missing.

    Show »
    Length:1,141
    Mass (Da):126,594
    Checksum:i1B71C660733649AF
    GO
    Isoform 5 (identifier: Q9UHW9-5) [UniParc]FASTAAdd to basket
    Also known as: KCC3a-S, KCC3a-S1, KCC3a-S2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-59: Missing.

    Note: Does not differ in the osmotic set point of swelling activation but, activation is more rapid.
    Show »
    Length:1,091
    Mass (Da):121,125
    Checksum:iCFF92252688CAC1A
    GO
    Isoform 6 (identifier: Q9UHW9-6) [UniParc]FASTAAdd to basket
    Also known as: KCC3b-X2M

    The sequence of this isoform differs from the canonical sequence as follows:
         1-51: Missing.
         52-90: PETSRSEPMS...RTSHPQDVIE → MPHFTVTKVE...KARIQDSDEP
         91-105: Missing.

    Show »
    Length:1,084
    Mass (Da):120,467
    Checksum:i1A8328CEC2EC3E54
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H0YKQ8H0YKQ8_HUMAN
    Solute carrier family 12 member 6
    SLC12A6
    942Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YNJ5H0YNJ5_HUMAN
    Solute carrier family 12 member 6
    SLC12A6
    107Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YMQ9H0YMQ9_HUMAN
    Solute carrier family 12 (Potassium...
    SLC12A6 hCG_1998565
    906Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B3KXX3B3KXX3_HUMAN
    Solute carrier family 12 member 6
    SLC12A6
    962Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YKE6H0YKE6_HUMAN
    Solute carrier family 12 member 6
    SLC12A6
    152Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YKJ2H0YKJ2_HUMAN
    Solute carrier family 12 member 6
    SLC12A6
    135Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YKL8H0YKL8_HUMAN
    Solute carrier family 12 member 6
    SLC12A6
    60Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti802E → H in AAF24986 (PubMed:10600773).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014960415F → S. Corresponds to variant dbSNP:rs2705339Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0413871 – 59Missing in isoform 5. 1 PublicationAdd BLAST59
    Alternative sequenceiVSP_0061151 – 51Missing in isoform 2 and isoform 6. 3 PublicationsAdd BLAST51
    Alternative sequenceiVSP_0413881 – 9Missing in isoform 4. 1 Publication9
    Alternative sequenceiVSP_00611652 – 90PETSR…QDVIE → MPHFTVTKVEDPEEGAAASI SQEPSLADIKARIQDSDEP in isoform 2 and isoform 6. 3 PublicationsAdd BLAST39
    Alternative sequenceiVSP_04138991 – 105Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST15

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF116242 mRNA Translation: AAF24986.1
    AF108831 mRNA Translation: AAD25337.1
    AF105366 mRNA Translation: AAD39742.1
    AF314956
    , AF314931, AF314933, AF314934, AF314935, AF314936, AF314937, AF314938, AF314939, AF314940, AF314941, AF314942, AF314943, AF314944, AF314945, AF314946, AF314947, AF314948, AF314949, AF314950, AF314951, AF314952, AF314953, AF314954, AF314955 Genomic DNA Translation: AAM96215.1
    AF314956
    , AF314932, AF314933, AF314934, AF314935, AF314936, AF314937, AF314938, AF314939, AF314940, AF314941, AF314942, AF314943, AF314944, AF314945, AF314946, AF314947, AF314948, AF314949, AF314950, AF314951, AF314952, AF314953, AF314954, AF314955 Genomic DNA Translation: AAM96216.1
    AF531258 mRNA Translation: AAQ10026.1
    AF531259 mRNA Translation: AAQ10027.1
    AF531260 mRNA Translation: AAQ10028.1
    DQ138323 mRNA Translation: ABA02873.1
    AK315283 mRNA Translation: BAG37692.1
    AC021822 Genomic DNA No translation available.
    AC079203 Genomic DNA No translation available.
    CH471125 Genomic DNA Translation: EAW92295.1
    CH471125 Genomic DNA Translation: EAW92297.1
    CH471125 Genomic DNA Translation: EAW92301.1
    BC126241 mRNA Translation: AAI26242.1
    BC126243 mRNA Translation: AAI26244.1
    AF477977 mRNA Translation: AAL85335.1
    AL117500 mRNA Translation: CAB55965.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS10036.1 [Q9UHW9-2]
    CCDS42010.1 [Q9UHW9-3]
    CCDS42011.1 [Q9UHW9-4]
    CCDS42012.1 [Q9UHW9-5]
    CCDS58352.1 [Q9UHW9-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T17275

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001035959.1, NM_001042494.1 [Q9UHW9-5]
    NP_001035960.1, NM_001042495.1 [Q9UHW9-5]
    NP_001035961.1, NM_001042496.1 [Q9UHW9-4]
    NP_001035962.1, NM_001042497.1 [Q9UHW9-3]
    NP_005126.1, NM_005135.2 [Q9UHW9-2]
    NP_598408.1, NM_133647.1 [Q9UHW9-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000290209; ENSP00000290209; ENSG00000140199 [Q9UHW9-2]
    ENST00000354181; ENSP00000346112; ENSG00000140199 [Q9UHW9-1]
    ENST00000397702; ENSP00000380814; ENSG00000140199 [Q9UHW9-5]
    ENST00000397707; ENSP00000380819; ENSG00000140199 [Q9UHW9-3]
    ENST00000458406; ENSP00000387725; ENSG00000140199 [Q9UHW9-5]
    ENST00000558589; ENSP00000452776; ENSG00000140199 [Q9UHW9-4]
    ENST00000558667; ENSP00000453473; ENSG00000140199 [Q9UHW9-1]
    ENST00000560611; ENSP00000454168; ENSG00000140199 [Q9UHW9-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    9990

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:9990

    UCSC genome browser

    More...
    UCSCi
    uc001zhv.4 human [Q9UHW9-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF116242 mRNA Translation: AAF24986.1
    AF108831 mRNA Translation: AAD25337.1
    AF105366 mRNA Translation: AAD39742.1
    AF314956
    , AF314931, AF314933, AF314934, AF314935, AF314936, AF314937, AF314938, AF314939, AF314940, AF314941, AF314942, AF314943, AF314944, AF314945, AF314946, AF314947, AF314948, AF314949, AF314950, AF314951, AF314952, AF314953, AF314954, AF314955 Genomic DNA Translation: AAM96215.1
    AF314956
    , AF314932, AF314933, AF314934, AF314935, AF314936, AF314937, AF314938, AF314939, AF314940, AF314941, AF314942, AF314943, AF314944, AF314945, AF314946, AF314947, AF314948, AF314949, AF314950, AF314951, AF314952, AF314953, AF314954, AF314955 Genomic DNA Translation: AAM96216.1
    AF531258 mRNA Translation: AAQ10026.1
    AF531259 mRNA Translation: AAQ10027.1
    AF531260 mRNA Translation: AAQ10028.1
    DQ138323 mRNA Translation: ABA02873.1
    AK315283 mRNA Translation: BAG37692.1
    AC021822 Genomic DNA No translation available.
    AC079203 Genomic DNA No translation available.
    CH471125 Genomic DNA Translation: EAW92295.1
    CH471125 Genomic DNA Translation: EAW92297.1
    CH471125 Genomic DNA Translation: EAW92301.1
    BC126241 mRNA Translation: AAI26242.1
    BC126243 mRNA Translation: AAI26244.1
    AF477977 mRNA Translation: AAL85335.1
    AL117500 mRNA Translation: CAB55965.1
    CCDSiCCDS10036.1 [Q9UHW9-2]
    CCDS42010.1 [Q9UHW9-3]
    CCDS42011.1 [Q9UHW9-4]
    CCDS42012.1 [Q9UHW9-5]
    CCDS58352.1 [Q9UHW9-1]
    PIRiT17275
    RefSeqiNP_001035959.1, NM_001042494.1 [Q9UHW9-5]
    NP_001035960.1, NM_001042495.1 [Q9UHW9-5]
    NP_001035961.1, NM_001042496.1 [Q9UHW9-4]
    NP_001035962.1, NM_001042497.1 [Q9UHW9-3]
    NP_005126.1, NM_005135.2 [Q9UHW9-2]
    NP_598408.1, NM_133647.1 [Q9UHW9-1]

    3D structure databases

    SMRiQ9UHW9
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi115311, 22 interactors
    IntActiQ9UHW9, 7 interactors
    MINTiQ9UHW9
    STRINGi9606.ENSP00000346112

    Chemistry databases

    DrugBankiDB00761 Potassium Chloride

    Protein family/group databases

    TCDBi2.A.30.1.15 the cation-chloride cotransporter (ccc) family

    PTM databases

    GlyConnecti1762
    iPTMnetiQ9UHW9
    PhosphoSitePlusiQ9UHW9

    Polymorphism and mutation databases

    BioMutaiSLC12A6
    DMDMi27151690

    Proteomic databases

    EPDiQ9UHW9
    jPOSTiQ9UHW9
    PaxDbiQ9UHW9
    PeptideAtlasiQ9UHW9
    PRIDEiQ9UHW9
    ProteomicsDBi84422
    84423 [Q9UHW9-2]
    84424 [Q9UHW9-3]
    84425 [Q9UHW9-4]
    84426 [Q9UHW9-5]
    84427 [Q9UHW9-6]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000290209; ENSP00000290209; ENSG00000140199 [Q9UHW9-2]
    ENST00000354181; ENSP00000346112; ENSG00000140199 [Q9UHW9-1]
    ENST00000397702; ENSP00000380814; ENSG00000140199 [Q9UHW9-5]
    ENST00000397707; ENSP00000380819; ENSG00000140199 [Q9UHW9-3]
    ENST00000458406; ENSP00000387725; ENSG00000140199 [Q9UHW9-5]
    ENST00000558589; ENSP00000452776; ENSG00000140199 [Q9UHW9-4]
    ENST00000558667; ENSP00000453473; ENSG00000140199 [Q9UHW9-1]
    ENST00000560611; ENSP00000454168; ENSG00000140199 [Q9UHW9-1]
    GeneIDi9990
    KEGGihsa:9990
    UCSCiuc001zhv.4 human [Q9UHW9-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    9990
    DisGeNETi9990

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC12A6
    GeneReviewsiSLC12A6
    HGNCiHGNC:10914 SLC12A6
    HPAiHPA034563
    MalaCardsiSLC12A6
    MIMi218000 phenotype
    604878 gene
    neXtProtiNX_Q9UHW9
    OpenTargetsiENSG00000140199
    Orphaneti1496 Corpus callosum agenesis-neuronopathy syndrome
    PharmGKBiPA35808

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2082 Eukaryota
    COG0531 LUCA
    GeneTreeiENSGT00940000160238
    HOGENOMiHOG000092644
    InParanoidiQ9UHW9
    KOiK14427
    OMAiKNWRPHI
    OrthoDBi349744at2759
    PhylomeDBiQ9UHW9
    TreeFamiTF313657

    Enzyme and pathway databases

    ReactomeiR-HSA-426117 Cation-coupled Chloride cotransporters
    R-HSA-5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)
    SIGNORiQ9UHW9

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC12A6 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SLC12A6

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    9990

    Protein Ontology

    More...
    PROi
    PR:Q9UHW9

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000140199 Expressed in 213 organ(s), highest expression level in blood
    ExpressionAtlasiQ9UHW9 baseline and differential
    GenevisibleiQ9UHW9 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR004841 AA-permease/SLC12A_dom
    IPR030364 KCC3
    IPR000076 KCL_cotranspt
    IPR018491 SLC12_C
    IPR004842 SLC12A_fam
    PANTHERiPTHR11827:SF66 PTHR11827:SF66, 1 hit
    PfamiView protein in Pfam
    PF00324 AA_permease, 2 hits
    PF03522 SLC12, 2 hits
    PRINTSiPR01081 KCLTRNSPORT
    TIGRFAMsiTIGR00930 2a30, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS12A6_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHW9
    Secondary accession number(s): A0AV76
    , Q2VI00, Q7Z2E7, Q7Z4G5, Q8TDD4, Q9UFR2, Q9Y642, Q9Y665
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
    Last sequence update: December 13, 2002
    Last modified: May 8, 2019
    This is version 186 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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