UniProtKB - Q9UHW5 (GPN3_HUMAN)
Protein
GPN-loop GTPase 3
Gene
GPN3
Organism
Homo sapiens (Human)
Status
Functioni
Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 74 | Stabilizes the phosphate intermediate; shared with dimeric partnerBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 13 – 18 | GTPBy similarity | 6 | |
Nucleotide bindingi | 174 – 177 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UHW5 |
Names & Taxonomyi
Protein namesi | Recommended name: GPN-loop GTPase 31 PublicationAlternative name(s): ATP-binding domain 1 family member C |
Gene namesi | ORF Names:AD-009, UNQ1876/PRO4319 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000111231.8 |
HGNCi | HGNC:30186, GPN3 |
neXtProti | NX_Q9UHW5 |
Subcellular locationi
Other locations
- protein-containing complex Source: LIFEdb
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 51184 |
OpenTargetsi | ENSG00000111231 |
PharmGKBi | PA162390164 |
Miscellaneous databases
Pharosi | Q9UHW5, Tdark |
Polymorphism and mutation databases
BioMutai | GPN3 |
DMDMi | 158564000 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304790 | 1 – 284 | GPN-loop GTPase 3Add BLAST | 284 |
Proteomic databases
EPDi | Q9UHW5 |
jPOSTi | Q9UHW5 |
MassIVEi | Q9UHW5 |
PaxDbi | Q9UHW5 |
PeptideAtlasi | Q9UHW5 |
PRIDEi | Q9UHW5 |
ProteomicsDBi | 27390 84420 [Q9UHW5-1] 84421 [Q9UHW5-2] |
PTM databases
iPTMneti | Q9UHW5 |
PhosphoSitePlusi | Q9UHW5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111231, Expressed in biceps brachii and 235 other tissues |
ExpressionAtlasi | Q9UHW5, baseline and differential |
Genevisiblei | Q9UHW5, HS |
Organism-specific databases
HPAi | ENSG00000111231, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 119359, 77 interactors |
IntActi | Q9UHW5, 62 interactors |
MINTi | Q9UHW5 |
STRINGi | 9606.ENSP00000442770 |
Miscellaneous databases
RNActi | Q9UHW5, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 72 – 74 | Gly-Pro-Asn (GPN)-loop; involved in dimer interfaceBy similarity | 3 |
Sequence similaritiesi
Belongs to the GPN-loop GTPase family.Curated
Phylogenomic databases
eggNOGi | KOG1534, Eukaryota |
GeneTreei | ENSGT00950000183172 |
HOGENOMi | CLU_037460_0_0_1 |
InParanoidi | Q9UHW5 |
OMAi | MEDKYKF |
OrthoDBi | 964931at2759 |
PhylomeDBi | Q9UHW5 |
TreeFami | TF105810 |
Family and domain databases
InterProi | View protein in InterPro IPR004130, Gpn IPR030228, Gpn3 IPR027417, P-loop_NTPase |
PANTHERi | PTHR21231, PTHR21231, 1 hit PTHR21231:SF7, PTHR21231:SF7, 1 hit |
Pfami | View protein in Pfam PF03029, ATP_bind_1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UHW5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPRYAQLVMG PAGSGKSTYC ATMVQHCEAL NRSVQVVNLD PAAEHFNYSV
60 70 80 90 100
MADIRELIEV DDVMEDDSLR FGPNGGLVFC MEYFANNFDW LENCLGHVED
110 120 130 140 150
DYILFDCPGQ IELYTHLPVM KQLVQQLEQW EFRVCGVFLV DSQFMVESFK
160 170 180 190 200
FISGILAALS AMISLEIPQV NIMTKMDLLS KKAKKEIEKF LDPDMYSLLE
210 220 230 240 250
DSTSDLRSKK FKKLTKAICG LIDDYSMVRF LPYDQSDEES MNIVLQHIDF
260 270 280
AIQYGEDLEF KEPKEREDES SSMFDEYFQE CQDE
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W1F4 | F8W1F4_HUMAN | GPN-loop GTPase 3 | GPN3 | 159 | Annotation score: | ||
H0YI19 | H0YI19_HUMAN | GPN-loop GTPase 3 | GPN3 | 118 | Annotation score: | ||
H0YHZ5 | H0YHZ5_HUMAN | GPN-loop GTPase 3 | GPN3 | 120 | Annotation score: | ||
S4R3M7 | S4R3M7_HUMAN | GPN-loop GTPase 3 | GPN3 | 25 | Annotation score: |
Sequence cautioni
The sequence CAD97937 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 – 7 | QL → HC in AAQ76821 (PubMed:16533400).Curated | 2 | |
Sequence conflicti | 6 – 7 | QL → HC in AAF17210 (PubMed:10931946).Curated | 2 | |
Sequence conflicti | 13 – 16 | GSGK → HAKR in AAQ76821 (PubMed:16533400).Curated | 4 | |
Sequence conflicti | 13 – 16 | GSGK → HAKR in AAF17210 (PubMed:10931946).Curated | 4 | |
Sequence conflicti | 122 | Q → H in AAQ89437 (PubMed:12975309).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035107 | 52 | A → V1 PublicationCorresponds to variant dbSNP:rs17856906Ensembl. | 1 | |
Natural variantiVAR_035108 | 244 | V → A1 PublicationCorresponds to variant dbSNP:rs17850320Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047327 | 1 – 16 | MPRYA…AGSGK → MLPKTRGAFHFSIPDPQHIC KSRGSPYRSNVCTQTTDRST WRKDAELYLLSVITQ in isoform 3. CuratedAdd BLAST | 16 | |
Alternative sequenceiVSP_028125 | 15 | G → GKVRICGDKER in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY364262 mRNA Translation: AAQ76821.1 AM992619 mRNA Translation: CAQ52399.1 AM992620 mRNA Translation: CAQ52400.1 AF117229 mRNA Translation: AAF17210.1 AY359078 mRNA Translation: AAQ89437.1 BX537973 mRNA Translation: CAD97937.1 Different initiation. AK314946 mRNA Translation: BAG37451.1 AK223209 mRNA Translation: BAD96929.1 AC002350 Genomic DNA No translation available. AC144548 Genomic DNA No translation available. BC008416 mRNA Translation: AAH08416.1 BC031024 mRNA Translation: AAH31024.1 |
CCDSi | CCDS53830.1 [Q9UHW5-2] CCDS53831.1 [Q9UHW5-3] CCDS9147.1 [Q9UHW5-1] |
RefSeqi | NP_001157844.1, NM_001164372.1 [Q9UHW5-3] NP_001157845.1, NM_001164373.1 [Q9UHW5-2] NP_057385.3, NM_016301.3 [Q9UHW5-1] |
Genome annotation databases
Ensembli | ENST00000228827; ENSP00000228827; ENSG00000111231 [Q9UHW5-1] ENST00000537466; ENSP00000443068; ENSG00000111231 [Q9UHW5-2] ENST00000543199; ENSP00000442770; ENSG00000111231 [Q9UHW5-3] |
GeneIDi | 51184 |
KEGGi | hsa:51184 |
UCSCi | uc001tqr.4, human [Q9UHW5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY364262 mRNA Translation: AAQ76821.1 AM992619 mRNA Translation: CAQ52399.1 AM992620 mRNA Translation: CAQ52400.1 AF117229 mRNA Translation: AAF17210.1 AY359078 mRNA Translation: AAQ89437.1 BX537973 mRNA Translation: CAD97937.1 Different initiation. AK314946 mRNA Translation: BAG37451.1 AK223209 mRNA Translation: BAD96929.1 AC002350 Genomic DNA No translation available. AC144548 Genomic DNA No translation available. BC008416 mRNA Translation: AAH08416.1 BC031024 mRNA Translation: AAH31024.1 |
CCDSi | CCDS53830.1 [Q9UHW5-2] CCDS53831.1 [Q9UHW5-3] CCDS9147.1 [Q9UHW5-1] |
RefSeqi | NP_001157844.1, NM_001164372.1 [Q9UHW5-3] NP_001157845.1, NM_001164373.1 [Q9UHW5-2] NP_057385.3, NM_016301.3 [Q9UHW5-1] |
3D structure databases
SMRi | Q9UHW5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119359, 77 interactors |
IntActi | Q9UHW5, 62 interactors |
MINTi | Q9UHW5 |
STRINGi | 9606.ENSP00000442770 |
PTM databases
iPTMneti | Q9UHW5 |
PhosphoSitePlusi | Q9UHW5 |
Polymorphism and mutation databases
BioMutai | GPN3 |
DMDMi | 158564000 |
Proteomic databases
EPDi | Q9UHW5 |
jPOSTi | Q9UHW5 |
MassIVEi | Q9UHW5 |
PaxDbi | Q9UHW5 |
PeptideAtlasi | Q9UHW5 |
PRIDEi | Q9UHW5 |
ProteomicsDBi | 27390 84420 [Q9UHW5-1] 84421 [Q9UHW5-2] |
Protocols and materials databases
Antibodypediai | 31008, 55 antibodies |
DNASUi | 51184 |
Genome annotation databases
Ensembli | ENST00000228827; ENSP00000228827; ENSG00000111231 [Q9UHW5-1] ENST00000537466; ENSP00000443068; ENSG00000111231 [Q9UHW5-2] ENST00000543199; ENSP00000442770; ENSG00000111231 [Q9UHW5-3] |
GeneIDi | 51184 |
KEGGi | hsa:51184 |
UCSCi | uc001tqr.4, human [Q9UHW5-1] |
Organism-specific databases
CTDi | 51184 |
DisGeNETi | 51184 |
EuPathDBi | HostDB:ENSG00000111231.8 |
GeneCardsi | GPN3 |
HGNCi | HGNC:30186, GPN3 |
HPAi | ENSG00000111231, Low tissue specificity |
neXtProti | NX_Q9UHW5 |
OpenTargetsi | ENSG00000111231 |
PharmGKBi | PA162390164 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1534, Eukaryota |
GeneTreei | ENSGT00950000183172 |
HOGENOMi | CLU_037460_0_0_1 |
InParanoidi | Q9UHW5 |
OMAi | MEDKYKF |
OrthoDBi | 964931at2759 |
PhylomeDBi | Q9UHW5 |
TreeFami | TF105810 |
Enzyme and pathway databases
PathwayCommonsi | Q9UHW5 |
Miscellaneous databases
BioGRID-ORCSi | 51184, 674 hits in 855 CRISPR screens |
ChiTaRSi | GPN3, human |
GenomeRNAii | 51184 |
Pharosi | Q9UHW5, Tdark |
PROi | PR:Q9UHW5 |
RNActi | Q9UHW5, protein |
Gene expression databases
Bgeei | ENSG00000111231, Expressed in biceps brachii and 235 other tissues |
ExpressionAtlasi | Q9UHW5, baseline and differential |
Genevisiblei | Q9UHW5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004130, Gpn IPR030228, Gpn3 IPR027417, P-loop_NTPase |
PANTHERi | PTHR21231, PTHR21231, 1 hit PTHR21231:SF7, PTHR21231:SF7, 1 hit |
Pfami | View protein in Pfam PF03029, ATP_bind_1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPN3_HUMAN | |
Accessioni | Q9UHW5Primary (citable) accession number: Q9UHW5 Secondary accession number(s): B2RC54 Q96HK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | September 11, 2007 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations