UniProtKB - Q9UHV9 (PFD2_HUMAN)
Protein
Prefoldin subunit 2
Gene
PFDN2
Organism
Homo sapiens (Human)
Status
Functioni
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication
GO - Molecular functioni
- amyloid-beta binding Source: FlyBase
- protein folding chaperone Source: AgBase
- unfolded protein binding Source: FlyBase
GO - Biological processi
- negative regulation of amyloid fibril formation Source: FlyBase
- positive regulation of cytoskeleton organization Source: AgBase
- protein folding Source: FlyBase
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | Q9UHV9 |
Reactomei | R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC |
Names & Taxonomyi
Protein namesi | Recommended name: Prefoldin subunit 2 |
Gene namesi | Name:PFDN2 Synonyms:PFD2 ORF Names:HSPC231 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8867, PFDN2 |
MIMi | 613466, gene |
neXtProti | NX_Q9UHV9 |
VEuPathDBi | HostDB:ENSG00000143256.4 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 1 Publication
Mitochondrion
- Mitochondrion 1 Publication
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- prefoldin complex Source: FlyBase
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5202 |
OpenTargetsi | ENSG00000143256 |
PharmGKBi | PA33208 |
Miscellaneous databases
Pharosi | Q9UHV9, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295976 |
Genetic variation databases
BioMutai | PFDN2 |
DMDMi | 12643887 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124835 | 1 – 154 | Prefoldin subunit 2Add BLAST | 154 |
Proteomic databases
EPDi | Q9UHV9 |
jPOSTi | Q9UHV9 |
MassIVEi | Q9UHV9 |
MaxQBi | Q9UHV9 |
PaxDbi | Q9UHV9 |
PeptideAtlasi | Q9UHV9 |
PRIDEi | Q9UHV9 |
ProteomicsDBi | 84419 |
TopDownProteomicsi | Q9UHV9 |
PTM databases
iPTMneti | Q9UHV9 |
MetOSitei | Q9UHV9 |
PhosphoSitePlusi | Q9UHV9 |
SwissPalmi | Q9UHV9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000143256, Expressed in adenohypophysis and 239 other tissues |
ExpressionAtlasi | Q9UHV9, baseline and differential |
Genevisiblei | Q9UHV9, HS |
Organism-specific databases
HPAi | ENSG00000143256, Low tissue specificity |
Interactioni
Subunit structurei
Binds to c-Myc; interacts with its N-terminal domain (By similarity). Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.
By similarity1 PublicationBinary interactionsi
Hide detailsQ9UHV9
GO - Molecular functioni
- unfolded protein binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 111224, 126 interactors |
ComplexPortali | CPX-6144, URI1 prefoldin co-chaperone complex CPX-6149, Prefoldin co-chaperone complex |
CORUMi | Q9UHV9 |
DIPi | DIP-27557N |
IntActi | Q9UHV9, 88 interactors |
MINTi | Q9UHV9 |
STRINGi | 9606.ENSP00000356989 |
Miscellaneous databases
RNActi | Q9UHV9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the prefoldin subunit beta family.Curated
Phylogenomic databases
eggNOGi | KOG4098, Eukaryota |
GeneTreei | ENSGT00390000009272 |
HOGENOMi | CLU_113004_0_0_1 |
InParanoidi | Q9UHV9 |
OMAi | DPERKCF |
OrthoDBi | 1564069at2759 |
PhylomeDBi | Q9UHV9 |
TreeFami | TF313252 |
Family and domain databases
Gene3Di | 1.10.287.370, 1 hit |
InterProi | View protein in InterPro IPR027235, PFD2 IPR002777, PFD_beta-like IPR009053, Prefoldin |
PANTHERi | PTHR13303, PTHR13303, 1 hit |
Pfami | View protein in Pfam PF01920, Prefoldin_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UHV9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAENSGRAGK SSGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME
60 70 80 90 100
LNEHSLVIDT LKEVDETRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI
110 120 130 140 150
IETLTQQLQA KGKELNEFRE KHNIRLMGED EKPAAKENSE GAGAKASSAG
VLVS
Sequence cautioni
The sequence AAF36151 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 – 22 | SGAGKGAVS → TPRRGRGRCP in AAD47084 (Ref. 2) Curated | 9 | |
Sequence conflicti | 15 | Missing in AAF36151 (PubMed:11042152).Curated | 1 | |
Sequence conflicti | 29 – 34 | GFNRLR → SFNAF in AAF36151 (PubMed:11042152).Curated | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117237 mRNA Translation: AAF17218.1 AF165883 mRNA Translation: AAD47084.1 AF151065 mRNA Translation: AAF36151.1 Frameshift. BC012464 mRNA Translation: AAH12464.1 BC047042 mRNA Translation: AAH47042.1 |
CCDSi | CCDS1217.1 |
RefSeqi | NP_036526.2, NM_012394.3 XP_011507926.1, XM_011509624.2 |
Genome annotation databases
Ensembli | ENST00000368010; ENSP00000356989; ENSG00000143256 |
GeneIDi | 5202 |
KEGGi | hsa:5202 |
UCSCi | uc001fxu.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117237 mRNA Translation: AAF17218.1 AF165883 mRNA Translation: AAD47084.1 AF151065 mRNA Translation: AAF36151.1 Frameshift. BC012464 mRNA Translation: AAH12464.1 BC047042 mRNA Translation: AAH47042.1 |
CCDSi | CCDS1217.1 |
RefSeqi | NP_036526.2, NM_012394.3 XP_011507926.1, XM_011509624.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6NR8 | electron microscopy | 7.80 | 2 | 22-124 | [»] | |
6NR9 | electron microscopy | 8.50 | 2 | 22-124 | [»] | |
6NRB | electron microscopy | 8.70 | 2 | 22-124 | [»] | |
6NRC | electron microscopy | 8.30 | 2 | 22-124 | [»] | |
6NRD | electron microscopy | 8.20 | 2 | 22-124 | [»] | |
SMRi | Q9UHV9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111224, 126 interactors |
ComplexPortali | CPX-6144, URI1 prefoldin co-chaperone complex CPX-6149, Prefoldin co-chaperone complex |
CORUMi | Q9UHV9 |
DIPi | DIP-27557N |
IntActi | Q9UHV9, 88 interactors |
MINTi | Q9UHV9 |
STRINGi | 9606.ENSP00000356989 |
Chemistry databases
ChEMBLi | CHEMBL4295976 |
PTM databases
iPTMneti | Q9UHV9 |
MetOSitei | Q9UHV9 |
PhosphoSitePlusi | Q9UHV9 |
SwissPalmi | Q9UHV9 |
Genetic variation databases
BioMutai | PFDN2 |
DMDMi | 12643887 |
Proteomic databases
EPDi | Q9UHV9 |
jPOSTi | Q9UHV9 |
MassIVEi | Q9UHV9 |
MaxQBi | Q9UHV9 |
PaxDbi | Q9UHV9 |
PeptideAtlasi | Q9UHV9 |
PRIDEi | Q9UHV9 |
ProteomicsDBi | 84419 |
TopDownProteomicsi | Q9UHV9 |
Protocols and materials databases
Antibodypediai | 34290, 170 antibodies |
DNASUi | 5202 |
Genome annotation databases
Ensembli | ENST00000368010; ENSP00000356989; ENSG00000143256 |
GeneIDi | 5202 |
KEGGi | hsa:5202 |
UCSCi | uc001fxu.4, human |
Organism-specific databases
CTDi | 5202 |
DisGeNETi | 5202 |
GeneCardsi | PFDN2 |
HGNCi | HGNC:8867, PFDN2 |
HPAi | ENSG00000143256, Low tissue specificity |
MIMi | 613466, gene |
neXtProti | NX_Q9UHV9 |
OpenTargetsi | ENSG00000143256 |
PharmGKBi | PA33208 |
VEuPathDBi | HostDB:ENSG00000143256.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4098, Eukaryota |
GeneTreei | ENSGT00390000009272 |
HOGENOMi | CLU_113004_0_0_1 |
InParanoidi | Q9UHV9 |
OMAi | DPERKCF |
OrthoDBi | 1564069at2759 |
PhylomeDBi | Q9UHV9 |
TreeFami | TF313252 |
Enzyme and pathway databases
PathwayCommonsi | Q9UHV9 |
Reactomei | R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC |
Miscellaneous databases
BioGRID-ORCSi | 5202, 773 hits in 995 CRISPR screens |
ChiTaRSi | PFDN2, human |
GeneWikii | PFDN2 |
GenomeRNAii | 5202 |
Pharosi | Q9UHV9, Tbio |
PROi | PR:Q9UHV9 |
RNActi | Q9UHV9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143256, Expressed in adenohypophysis and 239 other tissues |
ExpressionAtlasi | Q9UHV9, baseline and differential |
Genevisiblei | Q9UHV9, HS |
Family and domain databases
Gene3Di | 1.10.287.370, 1 hit |
InterProi | View protein in InterPro IPR027235, PFD2 IPR002777, PFD_beta-like IPR009053, Prefoldin |
PANTHERi | PTHR13303, PTHR13303, 1 hit |
Pfami | View protein in Pfam PF01920, Prefoldin_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PFD2_HUMAN | |
Accessioni | Q9UHV9Primary (citable) accession number: Q9UHV9 Secondary accession number(s): Q9P0P7, Q9UN05 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families