PFDN2

Functionⁱ

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

GO - Molecular functionⁱ

protein binding involved in protein folding
Source: AgBase
Inferred from physical interactionⁱ
- 16876117
unfolded protein binding
Source: UniProtKB
Non-traceable author statementⁱ
- 9630229

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of cytoskeleton organization
Source: AgBase
Inferred from direct assayⁱ
- 16876117
protein folding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone

Molecular function

Chaperone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC

Reactomeⁱ

R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prefoldin subunit 2
Gene namesⁱ	Name:PFDN2 Synonyms:PFD2 ORF Names:HSPC231
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143256.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8867 PFDN2
MIMⁱ	613466 gene
neXtProtⁱ	NX_Q9UHV9

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000143256
PharmGKBⁱ	PA33208

Polymorphism and mutation databases

BioMutaⁱ	PFDN2
DMDMⁱ	12643887

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000124835	1 – 154	Prefoldin subunit 2Add BLAST		154

Proteomic databases

EPDⁱ	Q9UHV9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UHV9
PaxDbⁱ	Q9UHV9
PeptideAtlas More...PeptideAtlasⁱ	Q9UHV9
PRIDEⁱ	Q9UHV9
ProteomicsDBⁱ	84419
TopDownProteomicsⁱ	Q9UHV9

PTM databases

iPTMnetⁱ	Q9UHV9
PhosphoSitePlusⁱ	Q9UHV9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000143256 Expressed in 226 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_PFDN2
ExpressionAtlasⁱ	Q9UHV9 baseline and differential
Genevisibleⁱ	Q9UHV9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028700 HPA058304

HPAⁱ

HPA028700
HPA058304

Interactionⁱ

Subunit structureⁱ

Binds to c-Myc; interacts with its N-terminal domain (By similarity). Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	P0C045	4	EBI-359873,EBI-9351969	From Hepatitis C virus genotype 1a (isolate H).
PFDN5	Q99471	3	EBI-359873,EBI-357275
RPAP3	Q9H6T3	2	EBI-359873,EBI-356928
URI1	O94763	2	EBI-359873,EBI-357067
ZNF726	A6NNF4-2	4	EBI-359873,EBI-18338284

GO - Molecular functionⁱ

protein binding involved in protein folding
Source: AgBase
Inferred from physical interactionⁱ
- 16876117
unfolded protein binding
Source: UniProtKB
Non-traceable author statementⁱ
- 9630229

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111224, 95 interactors
CORUMⁱ	Q9UHV9
Database of interacting proteins More...DIPⁱ	DIP-27557N
IntActⁱ	Q9UHV9, 65 interactors
Molecular INTeraction database More...MINTⁱ	Q9UHV9
STRINGⁱ	9606.ENSP00000356989

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UHV9
SMRⁱ	Q9UHV9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4098 Eukaryota ENOG4111S6I LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009272
HOGENOMⁱ	HOG000211843
HOVERGENⁱ	HBG008172
InParanoidⁱ	Q9UHV9
KEGG Orthology (KO) More...KOⁱ	K09549
OMAⁱ	DPERKCF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11OU
PhylomeDBⁱ	Q9UHV9
TreeFamⁱ	TF313252

Family and domain databases

Gene3Dⁱ	1.10.287.370, 1 hit
InterProⁱ	View protein in InterPro IPR027235 PFD2 IPR002777 PFD_beta-like IPR009053 Prefoldin
PANTHERⁱ	PTHR13303 PTHR13303, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01920 Prefoldin_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9UHV9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAENSGRAGK SSGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME 
        60         70         80         90        100
LNEHSLVIDT LKEVDETRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI 
       110        120        130        140        150
IETLTQQLQA KGKELNEFRE KHNIRLMGED EKPAAKENSE GAGAKASSAG 

VLVS

Length:154

Mass (Da):16,648

Last modified:May 1, 2000 - v1

Checksum:ⁱ2FC68A7425412198

GO

Sequence cautionⁱ

The sequence AAF36151 differs from that shown. Reason: Frameshift at positions 8, 23, 28 and 34.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	14 – 22	SGAGKGAVS → TPRRGRGRCP in AAD47084 (Ref. 2) Curated	9
Sequence conflictⁱ	15	Missing in AAF36151 (PubMed:11042152).Curated	1
Sequence conflictⁱ	29 – 34	GFNRLR → SFNAF in AAF36151 (PubMed:11042152).Curated	6

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF117237 mRNA Translation: AAF17218.1 AF165883 mRNA Translation: AAD47084.1 AF151065 mRNA Translation: AAF36151.1 Frameshift. BC012464 mRNA Translation: AAH12464.1 BC047042 mRNA Translation: AAH47042.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1217.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036526.2, NM_012394.3 XP_011507926.1, XM_011509624.2
UniGeneⁱ	Hs.492516

Genome annotation databases

Ensemblⁱ	ENST00000368010; ENSP00000356989; ENSG00000143256
GeneIDⁱ	5202
KEGGⁱ	hsa:5202
UCSC genome browser More...UCSCⁱ	uc001fxu.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UHV9	Prefoldin subunit 2		HUMAN		154	UniRef100_Q9UHV9
PFDN2 isoform 2		PANTR		154
Prefoldin subunit 2		MACMU		154
PFDN2 isoform 2		PONAB		154
Uncharacterized protein		PROCO		154
+14

Protein	Similar proteins		Species	Score	Length	Source
Q9UHV9	Prefoldin subunit 2		MOUSE		154	UniRef90_Q9UHV9
Prefoldin subunit 2		HUMAN		154
PFDN2 isoform 2		PANTR		154
Prefoldin subunit 2		MACMU		154
PFDN2 isoform 2		PONAB		154
+60

Protein	Similar proteins		Species	Score	Length	Source
Q9UHV9	Prefoldin subunit 2		MOUSE		154	UniRef50_Q9UHV9
Prefoldin subunit 2		BOVIN		154
Prefoldin subunit 2		RAT		154
Prefoldin subunit 2		HUMAN		154
PFDN2 isoform 2		PANTR		154
+240

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF117237 mRNA Translation: AAF17218.1 AF165883 mRNA Translation: AAD47084.1 AF151065 mRNA Translation: AAF36151.1 Frameshift. BC012464 mRNA Translation: AAH12464.1 BC047042 mRNA Translation: AAH47042.1
CCDSⁱ	CCDS1217.1
RefSeqⁱ	NP_036526.2, NM_012394.3 XP_011507926.1, XM_011509624.2
UniGeneⁱ	Hs.492516

3D structure databases

ProteinModelPortalⁱ	Q9UHV9
SMRⁱ	Q9UHV9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111224, 95 interactors
CORUMⁱ	Q9UHV9
DIPⁱ	DIP-27557N
IntActⁱ	Q9UHV9, 65 interactors
MINTⁱ	Q9UHV9
STRINGⁱ	9606.ENSP00000356989

PTM databases

iPTMnetⁱ	Q9UHV9
PhosphoSitePlusⁱ	Q9UHV9

Polymorphism and mutation databases

BioMutaⁱ	PFDN2
DMDMⁱ	12643887

Proteomic databases

EPDⁱ	Q9UHV9
MaxQBⁱ	Q9UHV9
PaxDbⁱ	Q9UHV9
PeptideAtlasⁱ	Q9UHV9
PRIDEⁱ	Q9UHV9
ProteomicsDBⁱ	84419
TopDownProteomicsⁱ	Q9UHV9

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5202
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368010; ENSP00000356989; ENSG00000143256
GeneIDⁱ	5202
KEGGⁱ	hsa:5202
UCSCⁱ	uc001fxu.4 human

Organism-specific databases

CTDⁱ	5202
EuPathDBⁱ	HostDB:ENSG00000143256.4
GeneCardsⁱ	PFDN2
HGNCⁱ	HGNC:8867 PFDN2
HPAⁱ	HPA028700 HPA058304
MIMⁱ	613466 gene
neXtProtⁱ	NX_Q9UHV9
OpenTargetsⁱ	ENSG00000143256
PharmGKBⁱ	PA33208
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4098 Eukaryota ENOG4111S6I LUCA
GeneTreeⁱ	ENSGT00390000009272
HOGENOMⁱ	HOG000211843
HOVERGENⁱ	HBG008172
InParanoidⁱ	Q9UHV9
KOⁱ	K09549
OMAⁱ	DPERKCF
OrthoDBⁱ	EOG091G11OU
PhylomeDBⁱ	Q9UHV9
TreeFamⁱ	TF313252

Enzyme and pathway databases

Reactomeⁱ	R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC

Reactomeⁱ

R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC

Miscellaneous databases

ChiTaRSⁱ	PFDN2 human
GeneWikiⁱ	PFDN2
GenomeRNAiⁱ	5202
Protein Ontology More...PROⁱ	PR:Q9UHV9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143256 Expressed in 226 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_PFDN2
ExpressionAtlasⁱ	Q9UHV9 baseline and differential
Genevisibleⁱ	Q9UHV9 HS

Family and domain databases

Gene3Dⁱ	1.10.287.370, 1 hit
InterProⁱ	View protein in InterPro IPR027235 PFD2 IPR002777 PFD_beta-like IPR009053 Prefoldin
PANTHERⁱ	PTHR13303 PTHR13303, 1 hit
Pfamⁱ	View protein in Pfam PF01920 Prefoldin_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PFD2_HUMAN
Accessionⁱ	Q9UHV9Primary (citable) accession number: Q9UHV9 Secondary accession number(s): Q9P0P7, Q9UN05
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UHV9 (PFD2_HUMAN)

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Prefoldin subunit 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Nucleus

Other locations

Cytosol

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ