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Protein

Prefoldin subunit 2

Gene

PFDN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

GO - Molecular functioni

  • protein binding involved in protein folding Source: AgBase
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • positive regulation of cytoskeleton organization Source: AgBase
  • protein folding Source: GO_Central

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 2
Gene namesi
Name:PFDN2
Synonyms:PFD2
ORF Names:HSPC231
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143256.4
HGNCiHGNC:8867 PFDN2
MIMi613466 gene
neXtProtiNX_Q9UHV9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143256
PharmGKBiPA33208

Polymorphism and mutation databases

BioMutaiPFDN2
DMDMi12643887

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001248351 – 154Prefoldin subunit 2Add BLAST154

Proteomic databases

EPDiQ9UHV9
MaxQBiQ9UHV9
PaxDbiQ9UHV9
PeptideAtlasiQ9UHV9
PRIDEiQ9UHV9
ProteomicsDBi84419
TopDownProteomicsiQ9UHV9

PTM databases

iPTMnetiQ9UHV9
PhosphoSitePlusiQ9UHV9

Expressioni

Gene expression databases

BgeeiENSG00000143256 Expressed in 226 organ(s), highest expression level in adenohypophysis
CleanExiHS_PFDN2
ExpressionAtlasiQ9UHV9 baseline and differential
GenevisibleiQ9UHV9 HS

Organism-specific databases

HPAiHPA028700
HPA058304

Interactioni

Subunit structurei

Binds to c-Myc; interacts with its N-terminal domain (By similarity). Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111224, 95 interactors
CORUMiQ9UHV9
DIPiDIP-27557N
IntActiQ9UHV9, 65 interactors
MINTiQ9UHV9
STRINGi9606.ENSP00000356989

Structurei

3D structure databases

ProteinModelPortaliQ9UHV9
SMRiQ9UHV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG4098 Eukaryota
ENOG4111S6I LUCA
GeneTreeiENSGT00390000009272
HOGENOMiHOG000211843
HOVERGENiHBG008172
InParanoidiQ9UHV9
KOiK09549
OMAiDPERKCF
OrthoDBiEOG091G11OU
PhylomeDBiQ9UHV9
TreeFamiTF313252

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR027235 PFD2
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PANTHERiPTHR13303 PTHR13303, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UHV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENSGRAGK SSGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME
60 70 80 90 100
LNEHSLVIDT LKEVDETRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI
110 120 130 140 150
IETLTQQLQA KGKELNEFRE KHNIRLMGED EKPAAKENSE GAGAKASSAG

VLVS
Length:154
Mass (Da):16,648
Last modified:May 1, 2000 - v1
Checksum:i2FC68A7425412198
GO

Sequence cautioni

The sequence AAF36151 differs from that shown. Reason: Frameshift at positions 8, 23, 28 and 34.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14 – 22SGAGKGAVS → TPRRGRGRCP in AAD47084 (Ref. 2) Curated9
Sequence conflicti15Missing in AAF36151 (PubMed:11042152).Curated1
Sequence conflicti29 – 34GFNRLR → SFNAF in AAF36151 (PubMed:11042152).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117237 mRNA Translation: AAF17218.1
AF165883 mRNA Translation: AAD47084.1
AF151065 mRNA Translation: AAF36151.1 Frameshift.
BC012464 mRNA Translation: AAH12464.1
BC047042 mRNA Translation: AAH47042.1
CCDSiCCDS1217.1
RefSeqiNP_036526.2, NM_012394.3
XP_011507926.1, XM_011509624.2
UniGeneiHs.492516

Genome annotation databases

EnsembliENST00000368010; ENSP00000356989; ENSG00000143256
GeneIDi5202
KEGGihsa:5202
UCSCiuc001fxu.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117237 mRNA Translation: AAF17218.1
AF165883 mRNA Translation: AAD47084.1
AF151065 mRNA Translation: AAF36151.1 Frameshift.
BC012464 mRNA Translation: AAH12464.1
BC047042 mRNA Translation: AAH47042.1
CCDSiCCDS1217.1
RefSeqiNP_036526.2, NM_012394.3
XP_011507926.1, XM_011509624.2
UniGeneiHs.492516

3D structure databases

ProteinModelPortaliQ9UHV9
SMRiQ9UHV9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111224, 95 interactors
CORUMiQ9UHV9
DIPiDIP-27557N
IntActiQ9UHV9, 65 interactors
MINTiQ9UHV9
STRINGi9606.ENSP00000356989

PTM databases

iPTMnetiQ9UHV9
PhosphoSitePlusiQ9UHV9

Polymorphism and mutation databases

BioMutaiPFDN2
DMDMi12643887

Proteomic databases

EPDiQ9UHV9
MaxQBiQ9UHV9
PaxDbiQ9UHV9
PeptideAtlasiQ9UHV9
PRIDEiQ9UHV9
ProteomicsDBi84419
TopDownProteomicsiQ9UHV9

Protocols and materials databases

DNASUi5202
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368010; ENSP00000356989; ENSG00000143256
GeneIDi5202
KEGGihsa:5202
UCSCiuc001fxu.4 human

Organism-specific databases

CTDi5202
EuPathDBiHostDB:ENSG00000143256.4
GeneCardsiPFDN2
HGNCiHGNC:8867 PFDN2
HPAiHPA028700
HPA058304
MIMi613466 gene
neXtProtiNX_Q9UHV9
OpenTargetsiENSG00000143256
PharmGKBiPA33208
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4098 Eukaryota
ENOG4111S6I LUCA
GeneTreeiENSGT00390000009272
HOGENOMiHOG000211843
HOVERGENiHBG008172
InParanoidiQ9UHV9
KOiK09549
OMAiDPERKCF
OrthoDBiEOG091G11OU
PhylomeDBiQ9UHV9
TreeFamiTF313252

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC

Miscellaneous databases

ChiTaRSiPFDN2 human
GeneWikiiPFDN2
GenomeRNAii5202
PROiPR:Q9UHV9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143256 Expressed in 226 organ(s), highest expression level in adenohypophysis
CleanExiHS_PFDN2
ExpressionAtlasiQ9UHV9 baseline and differential
GenevisibleiQ9UHV9 HS

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR027235 PFD2
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PANTHERiPTHR13303 PTHR13303, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPFD2_HUMAN
AccessioniPrimary (citable) accession number: Q9UHV9
Secondary accession number(s): Q9P0P7, Q9UN05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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