UniProtKB - Q9UHV8 (PP13_HUMAN)
Protein
Galactoside-binding soluble lectin 13
Gene
LGALS13
Organism
Homo sapiens (Human)
Status
Functioni
Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis (PubMed:10527825, PubMed:19497882). Has hemagglutinating activity towards chicken erythrocytes (PubMed:29343868).3 Publications
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- lysophospholipase activity Source: ProtInc
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- phospholipid metabolic process Source: ProtInc
- positive regulation of T cell apoptotic process Source: InterPro
Keywordsi
Molecular function | Hemagglutinin |
Biological process | Apoptosis |
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | Q9UHV8 |
Protein family/group databases
UniLectini | Q9UHV8 |
Names & Taxonomyi
Protein namesi | Recommended name: Galactoside-binding soluble lectin 13Alternative name(s): Galectin-13 Short name: Gal-13 Placental tissue protein 13 Short name: PP13 Short name: Placental protein 13 |
Gene namesi | Name:LGALS13 Synonyms:PLAC8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000105198.10 |
HGNCi | HGNC:15449, LGALS13 |
MIMi | 608717, gene |
neXtProti | NX_Q9UHV8 |
Subcellular locationi
Nucleus
- Nucleus matrix 1 Publication
Other locations
- Cytoplasm 1 Publication
Nucleus
- nuclear matrix Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 53 | R → H: No effect on its haemagglutinating activity. 1 Publication | 1 | |
Mutagenesisi | 136 | C → S: Loss of homodimerization; when associated with S-138. 1 Publication | 1 | |
Mutagenesisi | 138 | C → S: Loss of homodimerization; when associated with S-136. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 29124 |
OpenTargetsi | ENSG00000105198 |
PharmGKBi | PA134923011 |
Miscellaneous databases
Pharosi | Q9UHV8, Tbio |
Polymorphism and mutation databases
BioMutai | LGALS13 |
DMDMi | 41017510 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076963 | 1 – 139 | Galactoside-binding soluble lectin 13Add BLAST | 139 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 136 | Interchain (with C-138)1 Publication | ||
Disulfide bondi | 138 | Interchain (with C-136)1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | Q9UHV8 |
PaxDbi | Q9UHV8 |
PeptideAtlasi | Q9UHV8 |
PRIDEi | Q9UHV8 |
ProteomicsDBi | 84418 |
Expressioni
Tissue specificityi
Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Placental expression originates predominantly from the syncytiotrophoblast.2 Publications
Gene expression databases
Bgeei | ENSG00000105198, Expressed in chorionic villus and 42 other tissues |
ExpressionAtlasi | Q9UHV8, baseline and differential |
Genevisiblei | Q9UHV8, HS |
Organism-specific databases
HPAi | ENSG00000105198, Tissue enriched (placenta) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
2 PublicationsBinary interactionsi
Hide detailsQ9UHV8
Protein-protein interaction databases
BioGRIDi | 118889, 14 interactors |
IntActi | Q9UHV8, 14 interactors |
MINTi | Q9UHV8 |
STRINGi | 9606.ENSP00000221797 |
Miscellaneous databases
RNActi | Q9UHV8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UHV8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 138 | GalectinPROSITE-ProRule annotationAdd BLAST | 133 |
Phylogenomic databases
eggNOGi | KOG3587, Eukaryota |
GeneTreei | ENSGT00940000162909 |
HOGENOMi | CLU_037794_4_0_1 |
InParanoidi | Q9UHV8 |
OrthoDBi | 829777at2759 |
PhylomeDBi | Q9UHV8 |
TreeFami | TF315551 |
Family and domain databases
CDDi | cd00070, GLECT, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR030653, Galectin_13 IPR001079, Galectin_CRD |
PANTHERi | PTHR11346:SF120, PTHR11346:SF120, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 1 hit |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 1 hit SM00276, GLECT, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9UHV8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI
60 70 80 90 100
AFRFRVHFGN HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY
110 120 130
EIKVNGIRIY GFVHRIPPSF VKMVQVSRDI SLTSVCVCN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R015 | M0R015_HUMAN | Galectin | LGALS13 | 83 | Annotation score: | ||
A0A087X0J5 | A0A087X0J5_HUMAN | Galectin | LGALS13 | 141 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117383 mRNA Translation: AAF22001.1 AY055826 mRNA Translation: AAL09162.1 FJ613336 mRNA Translation: ACR09638.1 FJ613337 mRNA Translation: ACR09639.1 FJ613338 mRNA Translation: ACR09640.1 CH471126 Genomic DNA Translation: EAW56910.1 BC066304 mRNA Translation: AAH66304.1 BC069312 mRNA Translation: AAH69312.1 |
CCDSi | CCDS33024.1 |
RefSeqi | NP_037400.1, NM_013268.2 |
Genome annotation databases
Ensembli | ENST00000221797; ENSP00000221797; ENSG00000105198 |
GeneIDi | 29124 |
KEGGi | hsa:29124 |
UCSCi | uc002omb.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117383 mRNA Translation: AAF22001.1 AY055826 mRNA Translation: AAL09162.1 FJ613336 mRNA Translation: ACR09638.1 FJ613337 mRNA Translation: ACR09639.1 FJ613338 mRNA Translation: ACR09640.1 CH471126 Genomic DNA Translation: EAW56910.1 BC066304 mRNA Translation: AAH66304.1 BC069312 mRNA Translation: AAH69312.1 |
CCDSi | CCDS33024.1 |
RefSeqi | NP_037400.1, NM_013268.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1F87 | model | - | A | 1-139 | [»] | |
5XG7 | X-ray | 1.55 | A | 1-139 | [»] | |
5XG8 | X-ray | 1.55 | A | 2-139 | [»] | |
5Y03 | X-ray | 2.12 | A | 1-139 | [»] | |
6A62 | X-ray | 2.03 | A | 2-139 | [»] | |
6A63 | X-ray | 1.63 | A | 2-139 | [»] | |
6A64 | X-ray | 1.63 | A | 2-139 | [»] | |
6A65 | X-ray | 1.77 | A | 2-139 | [»] | |
6A66 | X-ray | 1.40 | A | 2-139 | [»] | |
6KJW | X-ray | 1.36 | A | 1-139 | [»] | |
6KJX | X-ray | 1.53 | A | 1-139 | [»] | |
6KJY | X-ray | 1.50 | A | 1-139 | [»] | |
SMRi | Q9UHV8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118889, 14 interactors |
IntActi | Q9UHV8, 14 interactors |
MINTi | Q9UHV8 |
STRINGi | 9606.ENSP00000221797 |
Protein family/group databases
UniLectini | Q9UHV8 |
Polymorphism and mutation databases
BioMutai | LGALS13 |
DMDMi | 41017510 |
Proteomic databases
MassIVEi | Q9UHV8 |
PaxDbi | Q9UHV8 |
PeptideAtlasi | Q9UHV8 |
PRIDEi | Q9UHV8 |
ProteomicsDBi | 84418 |
Protocols and materials databases
Antibodypediai | 16851, 442 antibodies |
DNASUi | 29124 |
Genome annotation databases
Ensembli | ENST00000221797; ENSP00000221797; ENSG00000105198 |
GeneIDi | 29124 |
KEGGi | hsa:29124 |
UCSCi | uc002omb.4, human |
Organism-specific databases
CTDi | 29124 |
DisGeNETi | 29124 |
EuPathDBi | HostDB:ENSG00000105198.10 |
GeneCardsi | LGALS13 |
HGNCi | HGNC:15449, LGALS13 |
HPAi | ENSG00000105198, Tissue enriched (placenta) |
MIMi | 608717, gene |
neXtProti | NX_Q9UHV8 |
OpenTargetsi | ENSG00000105198 |
PharmGKBi | PA134923011 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3587, Eukaryota |
GeneTreei | ENSGT00940000162909 |
HOGENOMi | CLU_037794_4_0_1 |
InParanoidi | Q9UHV8 |
OrthoDBi | 829777at2759 |
PhylomeDBi | Q9UHV8 |
TreeFami | TF315551 |
Enzyme and pathway databases
PathwayCommonsi | Q9UHV8 |
Miscellaneous databases
BioGRID-ORCSi | 29124, 3 hits in 840 CRISPR screens |
GeneWikii | LGALS13 |
GenomeRNAii | 29124 |
Pharosi | Q9UHV8, Tbio |
PROi | PR:Q9UHV8 |
RNActi | Q9UHV8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105198, Expressed in chorionic villus and 42 other tissues |
ExpressionAtlasi | Q9UHV8, baseline and differential |
Genevisiblei | Q9UHV8, HS |
Family and domain databases
CDDi | cd00070, GLECT, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR030653, Galectin_13 IPR001079, Galectin_CRD |
PANTHERi | PTHR11346:SF120, PTHR11346:SF120, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 1 hit |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 1 hit SM00276, GLECT, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PP13_HUMAN | |
Accessioni | Q9UHV8Primary (citable) accession number: Q9UHV8 Secondary accession number(s): C5HZ15 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM