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Protein

Galactoside-binding soluble lectin 13

Gene

LGALS13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis (PubMed:10527825, PubMed:19497882). Has hemagglutinating activity towards chicken erythrocytes (PubMed:29343868).3 Publications

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • lysophospholipase activity Source: ProtInc

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • phospholipid metabolic process Source: ProtInc
  • positive regulation of T cell apoptotic process Source: InterPro

Keywordsi

Molecular functionHemagglutinin
Biological processApoptosis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside-binding soluble lectin 13
Alternative name(s):
Galectin-13
Short name:
Gal-13
Placental tissue protein 13
Short name:
PP13
Short name:
Placental protein 13
Gene namesi
Name:LGALS13
Synonyms:PLAC8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105198.10
HGNCiHGNC:15449 LGALS13
MIMi608717 gene
neXtProtiNX_Q9UHV8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi53R → H: No effect on its haemagglutinating activity. 1 Publication1
Mutagenesisi136C → S: Loss of homodimerization; when associated with S-138. 1 Publication1
Mutagenesisi138C → S: Loss of homodimerization; when associated with S-136. 1 Publication1

Organism-specific databases

DisGeNETi29124
OpenTargetsiENSG00000105198
PharmGKBiPA134923011

Polymorphism and mutation databases

BioMutaiLGALS13
DMDMi41017510

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769631 – 139Galactoside-binding soluble lectin 13Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi136Interchain (with C-138)1 Publication
Disulfide bondi138Interchain (with C-136)1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UHV8
PeptideAtlasiQ9UHV8
PRIDEiQ9UHV8
ProteomicsDBi84418

Expressioni

Tissue specificityi

Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Placental expression originates predominantly from the syncytiotrophoblast.2 Publications

Gene expression databases

BgeeiENSG00000105198
CleanExiHS_LGALS13
HS_PLAC8
ExpressionAtlasiQ9UHV8 baseline and differential
GenevisibleiQ9UHV8 HS

Interactioni

Subunit structurei

Homodimer; disulfide-linked.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118889, 11 interactors
IntActiQ9UHV8, 8 interactors
MINTiQ9UHV8
STRINGi9606.ENSP00000221797

Structurei

Secondary structure

1139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Beta strandi19 – 28Combined sources10
Helixi30 – 32Combined sources3
Beta strandi35 – 45Combined sources11
Beta strandi50 – 57Combined sources8
Turni58 – 60Combined sources3
Beta strandi61 – 68Combined sources8
Beta strandi76 – 79Combined sources4
Beta strandi89 – 95Combined sources7
Beta strandi97 – 104Combined sources8
Beta strandi107 – 113Combined sources7
Helixi118 – 120Combined sources3
Beta strandi123 – 138Combined sources16

3D structure databases

ProteinModelPortaliQ9UHV8
SMRiQ9UHV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 138GalectinPROSITE-ProRule annotationAdd BLAST133

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00530000064497
HOGENOMiHOG000015090
HOVERGENiHBG006255
InParanoidiQ9UHV8
KOiK10096
PhylomeDBiQ9UHV8
TreeFamiTF315551

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030653 Galectin_13
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF120 PTHR11346:SF120, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UHV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI
60 70 80 90 100
AFRFRVHFGN HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY
110 120 130
EIKVNGIRIY GFVHRIPPSF VKMVQVSRDI SLTSVCVCN
Length:139
Mass (Da):16,119
Last modified:May 1, 2000 - v1
Checksum:iD1FE26D66C1F5FD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117383 mRNA Translation: AAF22001.1
AY055826 mRNA Translation: AAL09162.1
FJ613336 mRNA Translation: ACR09638.1
FJ613337 mRNA Translation: ACR09639.1
FJ613338 mRNA Translation: ACR09640.1
CH471126 Genomic DNA Translation: EAW56910.1
BC066304 mRNA Translation: AAH66304.1
BC069312 mRNA Translation: AAH69312.1
CCDSiCCDS33024.1
RefSeqiNP_037400.1, NM_013268.2
UniGeneiHs.23671

Genome annotation databases

EnsembliENST00000221797; ENSP00000221797; ENSG00000105198
GeneIDi29124
KEGGihsa:29124
UCSCiuc002omb.4 human

Similar proteinsi

Entry informationi

Entry nameiPP13_HUMAN
AccessioniPrimary (citable) accession number: Q9UHV8
Secondary accession number(s): C5HZ15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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