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Entry version 170 (11 Dec 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Mediator of RNA polymerase II transcription subunit 13

Gene

MED13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 13
Alternative name(s):
Activator-recruited cofactor 250 kDa component
Short name:
ARC250
Mediator complex subunit 13
Thyroid hormone receptor-associated protein 1
Thyroid hormone receptor-associated protein complex 240 kDa component
Short name:
Trap240
Vitamin D3 receptor-interacting protein complex component DRIP250
Short name:
DRIP250
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED13
Synonyms:ARC250, KIAA0593, THRAP1, TRAP240
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000108510.9

Human Gene Nomenclature Database

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HGNCi
HGNC:22474 MED13

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603808 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UHV7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9969

Open Targets

More...
OpenTargetsi
ENSG00000108510

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162395168

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UHV7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MED13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373421

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000655841 – 2174Mediator of RNA polymerase II transcription subunit 13Add BLAST2174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei395PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1
Modified residuei504PhosphoserineCombined sources1
Modified residuei530PhosphoserineBy similarity1
Modified residuei537PhosphoserineCombined sources1
Modified residuei826PhosphoserineCombined sources1
Modified residuei890PhosphoserineCombined sources1
Modified residuei1029PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UHV7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UHV7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UHV7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9UHV7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UHV7

PeptideAtlas

More...
PeptideAtlasi
Q9UHV7

PRoteomics IDEntifications database

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PRIDEi
Q9UHV7

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
84417

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UHV7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UHV7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000108510 Expressed in 245 organ(s), highest expression level in oviduct epithelium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UHV7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UHV7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA067939

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

5 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115294, 58 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3232 CKM complex variant 1
CPX-3263 CKM complex variant 2

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UHV7

Database of interacting proteins

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DIPi
DIP-31468N

Protein interaction database and analysis system

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IntActi
Q9UHV7, 32 interactors

Molecular INTeraction database

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MINTi
Q9UHV7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380888

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UHV7 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1188 – 1192LXXLL motif 15
Motifi1279 – 1283LXXLL motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1508 – 1573Ser-richAdd BLAST66

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 13 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3600 Eukaryota
ENOG410XPV2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013680

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000012893

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UHV7

KEGG Orthology (KO)

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KOi
K15164

Identification of Orthologs from Complete Genome Data

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OMAi
WTVGKLD

Database of Orthologous Groups

More...
OrthoDBi
177884at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UHV7

TreeFam database of animal gene trees

More...
TreeFami
TF316867

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009401 Med13_C
IPR021643 Mediator_Med13_N_met/fun
IPR041285 MID_MedPIWI

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06333 Med13_C, 1 hit
PF11597 Med13_N, 1 hit
PF18296 MID_MedPIWI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UHV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSASFVPNGA SLEDCHCNLF CLADLTGIKW KKYVWQGPTS APILFPVTEE
60 70 80 90 100
DPILSSFSRC LKADVLGVWR RDQRPGRREL WIFWWGEDPS FADLIHHDLS
110 120 130 140 150
EEEDGVWENG LSYECRTLLF KAVHNLLERC LMNRNFVRIG KWFVKPYEKD
160 170 180 190 200
EKPINKSEHL SCSFTFFLHG DSNVCTSVEI NQHQPVYLLS EEHITLAQQS
210 220 230 240 250
NSPFQVILCP FGLNGTLTGQ AFKMSDSATK KLIGEWKQFY PISCCLKEMS
260 270 280 290 300
EEKQEDMDWE DDSLAAVEVL VAGVRMIYPA CFVLVPQSDI PTPSPVGSTH
310 320 330 340 350
CSSSCLGVHQ VPASTRDPAM SSVTLTPPTS PEEVQTVDPQ SVQKWVKFSS
360 370 380 390 400
VSDGFNSDST SHHGGKIPRK LANHVVDRVW QECNMNRAQN KRKYSASSGG
410 420 430 440 450
LCEEATAAKV ASWDFVEATQ RTNCSCLRHK NLKSRNAGQQ GQAPSLGQQQ
460 470 480 490 500
QILPKHKTNE KQEKSEKPQK RPLTPFHHRV SVSDDVGMDA DSASQRLVIS
510 520 530 540 550
APDSQVRFSN IRTNDVAKTP QMHGTEMANS PQPPPLSPHP CDVVDEGVTK
560 570 580 590 600
TPSTPQSQHF YQMPTPDPLV PSKPMEDRID SLSQSFPPQY QEAVEPTVYV
610 620 630 640 650
GTAVNLEEDE ANIAWKYYKF PKKKDVEFLP PQLPSDKFKD DPVGPFGQES
660 670 680 690 700
VTSVTELMVQ CKKPLKVSDE LVQQYQIKNQ CLSAIASDAE QEPKIDPYAF
710 720 730 740 750
VEGDEEFLFP DKKDRQNSER EAGKKHKVED GTSSVTVLSH EEDAMSLFSP
760 770 780 790 800
SIKQDAPRPT SHARPPSTSL IYDSDLAVSY TDLDNLFNSD EDELTPGSKK
810 820 830 840 850
SANGSDDKAS CKESKTGNLD PLSCISTADL HKMYPTPPSL EQHIMGFSPM
860 870 880 890 900
NMNNKEYGSM DTTPGGTVLE GNSSSIGAQF KIEVDEGFCS PKPSEIKDFS
910 920 930 940 950
YVYKPENCQI LVGCSMFAPL KTLPSQYLPP IKLPEECIYR QSWTVGKLEL
960 970 980 990 1000
LSSGPSMPFI KEGDGSNMDQ EYGTAYTPQT HTSFGMPPSS APPSNSGAGI
1010 1020 1030 1040 1050
LPSPSTPRFP TPRTPRTPRT PRGAGGPASA QGSVKYENSD LYSPASTPST
1060 1070 1080 1090 1100
CRPLNSVEPA TVPSIPEAHS LYVNLILSES VMNLFKDCNF DSCCICVCNM
1110 1120 1130 1140 1150
NIKGADVGVY IPDPTQEAQY RCTCGFSAVM NRKFGNNSGL FLEDELDIIG
1160 1170 1180 1190 1200
RNTDCGKEAE KRFEALRATS AEHVNGGLKE SEKLSDDLIL LLQDQCTNLF
1210 1220 1230 1240 1250
SPFGAADQDP FPKSGVISNW VRVEERDCCN DCYLALEHGR QFMDNMSGGK
1260 1270 1280 1290 1300
VDEALVKSSC LHPWSKRNDV SMQCSQDILR MLLSLQPVLQ DAIQKKRTVR
1310 1320 1330 1340 1350
PWGVQGPLTW QQFHKMAGRG SYGTDESPEP LPIPTFLLGY DYDYLVLSPF
1360 1370 1380 1390 1400
ALPYWERLML EPYGSQRDIA YVVLCPENEA LLNGAKSFFR DLTAIYESCR
1410 1420 1430 1440 1450
LGQHRPVSRL LTDGIMRVGS TASKKLSEKL VAEWFSQAAD GNNEAFSKLK
1460 1470 1480 1490 1500
LYAQVCRYDL GPYLASLPLD SSLLSQPNLV APTSQSLITP PQMTNTGNAN
1510 1520 1530 1540 1550
TPSATLASAA SSTMTVTSGV AISTSVATAN STLTTASTSS SSSSNLNSGV
1560 1570 1580 1590 1600
SSNKLPSFPP FGSMNSNAAG SMSTQANTVQ SGQLGGQQTS ALQTAGISGE
1610 1620 1630 1640 1650
SSSLPTQPHP DVSESTMDRD KVGIPTDGDS HAVTYPPAIV VYIIDPFTYE
1660 1670 1680 1690 1700
NTDESTNSSS VWTLGLLRCF LEMVQTLPPH IKSTVSVQII PCQYLLQPVK
1710 1720 1730 1740 1750
HEDREIYPQH LKSLAFSAFT QCRRPLPTST NVKTLTGFGP GLAMETALRS
1760 1770 1780 1790 1800
PDRPECIRLY APPFILAPVK DKQTELGETF GEAGQKYNVL FVGYCLSHDQ
1810 1820 1830 1840 1850
RWILASCTDL YGELLETCII NIDVPNRARR KKSSARKFGL QKLWEWCLGL
1860 1870 1880 1890 1900
VQMSSLPWRV VIGRLGRIGH GELKDWSCLL SRRNLQSLSK RLKDMCRMCG
1910 1920 1930 1940 1950
ISAADSPSIL SACLVAMEPQ GSFVIMPDSV STGSVFGRST TLNMQTSQLN
1960 1970 1980 1990 2000
TPQDTSCTHI LVFPTSASVQ VASATYTTEN LDLAFNPNND GADGMGIFDL
2010 2020 2030 2040 2050
LDTGDDLDPD IINILPASPT GSPVHSPGSH YPHGGDAGKG QSTDRLLSTE
2060 2070 2080 2090 2100
PHEEVPNILQ QPLALGYFVS TAKAGPLPDW FWSACPQAQY QCPLFLKASL
2110 2120 2130 2140 2150
HLHVPSVQSD ELLHSKHSHP LDSNQTSDVL RFVLEQYNAL SWLTCDPATQ
2160 2170
DRRSCLPIHF VVLNQLYNFI MNML
Length:2,174
Mass (Da):239,297
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FA54C84FE2C91E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRB7J3QRB7_HUMAN
Mediator of RNA polymerase II trans...
MED13
327Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD22032 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106V → M in AAD22032 (PubMed:10198638).Curated1
Sequence conflicti392R → K in AAD22032 (PubMed:10198638).Curated1
Sequence conflicti467K → E in AAD22032 (PubMed:10198638).Curated1
Sequence conflicti712K → A AA sequence (PubMed:10198638).Curated1
Sequence conflicti800K → R in AAD22032 (PubMed:10198638).Curated1
Sequence conflicti930P → L in AAD22032 (PubMed:10198638).Curated1
Sequence conflicti984F → C in AAD22032 (PubMed:10198638).Curated1
Sequence conflicti1090F → S in AAD22032 (PubMed:10198638).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0577921370A → P. Corresponds to variant dbSNP:rs34805963Ensembl.1
Natural variantiVAR_0577931385A → P. Corresponds to variant dbSNP:rs35996128Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF117754 mRNA Translation: AAD22032.1 Frameshift.
AC008158 Genomic DNA No translation available.
AC018628 Genomic DNA No translation available.
AC060798 Genomic DNA No translation available.
CH471179 Genomic DNA Translation: EAW51438.1
BC140891 mRNA Translation: AAI40892.1
AB011165 mRNA Translation: BAA25519.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS42366.1

Protein sequence database of the Protein Information Resource

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PIRi
T01238

NCBI Reference Sequences

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RefSeqi
NP_005112.2, NM_005121.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000397786; ENSP00000380888; ENSG00000108510

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9969

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9969

UCSC genome browser

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UCSCi
uc002izo.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117754 mRNA Translation: AAD22032.1 Frameshift.
AC008158 Genomic DNA No translation available.
AC018628 Genomic DNA No translation available.
AC060798 Genomic DNA No translation available.
CH471179 Genomic DNA Translation: EAW51438.1
BC140891 mRNA Translation: AAI40892.1
AB011165 mRNA Translation: BAA25519.2
CCDSiCCDS42366.1
PIRiT01238
RefSeqiNP_005112.2, NM_005121.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115294, 58 interactors
ComplexPortaliCPX-3232 CKM complex variant 1
CPX-3263 CKM complex variant 2
CORUMiQ9UHV7
DIPiDIP-31468N
IntActiQ9UHV7, 32 interactors
MINTiQ9UHV7
STRINGi9606.ENSP00000380888

PTM databases

iPTMnetiQ9UHV7
PhosphoSitePlusiQ9UHV7

Polymorphism and mutation databases

BioMutaiMED13
DMDMi317373421

Proteomic databases

EPDiQ9UHV7
jPOSTiQ9UHV7
MassIVEiQ9UHV7
MaxQBiQ9UHV7
PaxDbiQ9UHV7
PeptideAtlasiQ9UHV7
PRIDEiQ9UHV7
ProteomicsDBi84417

Genome annotation databases

EnsembliENST00000397786; ENSP00000380888; ENSG00000108510
GeneIDi9969
KEGGihsa:9969
UCSCiuc002izo.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9969
DisGeNETi9969
EuPathDBiHostDB:ENSG00000108510.9

GeneCards: human genes, protein and diseases

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GeneCardsi
MED13
HGNCiHGNC:22474 MED13
HPAiHPA067939
MIMi603808 gene
neXtProtiNX_Q9UHV7
OpenTargetsiENSG00000108510
PharmGKBiPA162395168

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3600 Eukaryota
ENOG410XPV2 LUCA
GeneTreeiENSGT00390000013680
HOGENOMiHOG000012893
InParanoidiQ9UHV7
KOiK15164
OMAiWTVGKLD
OrthoDBi177884at2759
PhylomeDBiQ9UHV7
TreeFamiTF316867

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MED13 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MED13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9969
PharosiQ9UHV7 Tbio

Protein Ontology

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PROi
PR:Q9UHV7
RNActiQ9UHV7 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108510 Expressed in 245 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasiQ9UHV7 baseline and differential
GenevisibleiQ9UHV7 HS

Family and domain databases

InterProiView protein in InterPro
IPR009401 Med13_C
IPR021643 Mediator_Med13_N_met/fun
IPR041285 MID_MedPIWI
PfamiView protein in Pfam
PF06333 Med13_C, 1 hit
PF11597 Med13_N, 1 hit
PF18296 MID_MedPIWI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHV7
Secondary accession number(s): B2RU05, O60334
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: January 11, 2011
Last modified: December 11, 2019
This is version 170 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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