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Protein

B-cell receptor-associated protein 29

Gene

BCAP29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis, ER-Golgi transport, Protein transport, Transport

Protein family/group databases

TCDBi3.A.5.9.1 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell receptor-associated protein 29
Short name:
BCR-associated protein 29
Short name:
Bap29
Gene namesi
Name:BCAP29
Synonyms:BAP29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000075790.10
HGNCiHGNC:24131 BCAP29
neXtProtiNX_Q9UHQ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6LumenalSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 43CytoplasmicSequence analysisAdd BLAST16
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 103LumenalSequence analysisAdd BLAST39
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 241CytoplasmicSequence analysisAdd BLAST117

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55973
OpenTargetsiENSG00000075790
PharmGKBiPA134939094

Polymorphism and mutation databases

BioMutaiBCAP29
DMDMi25008167

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001428881 – 241B-cell receptor-associated protein 29Add BLAST241

Proteomic databases

EPDiQ9UHQ4
PaxDbiQ9UHQ4
PeptideAtlasiQ9UHQ4
PRIDEiQ9UHQ4
ProteomicsDBi84399

PTM databases

iPTMnetiQ9UHQ4
PhosphoSitePlusiQ9UHQ4
SwissPalmiQ9UHQ4

Expressioni

Gene expression databases

BgeeiENSG00000075790
CleanExiHS_BCAP29
ExpressionAtlasiQ9UHQ4 baseline and differential
GenevisibleiQ9UHQ4 HS

Organism-specific databases

HPAiHPA029215
HPA049694

Interactioni

Subunit structurei

Homodimer (PubMed:25327138). Heterodimer with BCAP31. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi121019, 18 interactors
IntActiQ9UHQ4, 2 interactors
MINTiQ9UHQ4
STRINGi9606.ENSP00000368414

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi168 – 225Combined sources58

3D structure databases

ProteinModelPortaliQ9UHQ4
SMRiQ9UHQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili166 – 2331 PublicationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi238 – 241Di-lysine motif4

Sequence similaritiesi

Belongs to the BCAP29/BCAP31 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1962 Eukaryota
COG5374 LUCA
GeneTreeiENSGT00390000011863
HOGENOMiHOG000204790
HOVERGENiHBG050661
InParanoidiQ9UHQ4
OMAiAQNDVMT
OrthoDBiEOG091G0MHN
PhylomeDBiQ9UHQ4
TreeFamiTF315310

Family and domain databases

InterProiView protein in InterPro
IPR008417 BAP29/BAP31
PANTHERiPTHR12701 PTHR12701, 1 hit
PfamiView protein in Pfam
PF05529 Bap31, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UHQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLQWAAVAT FLYAEIGLIL IFCLPFIPPQ RWQKIFSFNV WGKIATFWNK
60 70 80 90 100
AFLTIIILLI VLFLDAVREV RKYSSVHTIE KSSTSRPDAY EHTQMKLFRS
110 120 130 140 150
QRNLYISGFS LFFWLVLRRL VTLITQLAKE LSNKGVLKTQ AENTNKAAKK
160 170 180 190 200
FMEENEKLKR ILKSHGKDEE CVLEAENKKL VEDQEKLKTE LRKTSDALSK
210 220 230 240
AQNDVMEMKM QSERLSKEYD QLLKEHSELQ DRLERGNKKR L
Length:241
Mass (Da):28,320
Last modified:November 8, 2002 - v2
Checksum:i964C39A53E072274
GO
Isoform 2 (identifier: Q9UHQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-241: DRLERGNKKRL → HSSFGEFLSK...ISMLNTIFTY

Note: Gene prediction based on EST data.
Show »
Length:348
Mass (Da):40,797
Checksum:i81A54C8F30A0A58E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25P → L in AAF17230 (PubMed:10931946).Curated1
Sequence conflicti105 – 106YI → SIL in AAF17230 (PubMed:10931946).Curated2
Sequence conflicti131L → R in AAF17230 (PubMed:10931946).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047096231 – 241DRLERGNKKRL → HSSFGEFLSKRSHKNGSIGK QTGSRKGSFRKRQQEKTVNF IKDTCNILCQNDNFVMLASR KFKFRKMHYDRFVIFLMPHI GCIVMALSKYLMMFQIYCKV CIPALKKNISMLNTIFTY in isoform 2. CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126020 mRNA Translation: AAF17230.1
BT006981 mRNA Translation: AAP35627.1
AC004839 Genomic DNA Translation: AAC83971.1
AC078937 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83408.1
BC008478 mRNA Translation: AAH08478.1
CCDSiCCDS34730.1 [Q9UHQ4-2]
CCDS34731.1 [Q9UHQ4-1]
RefSeqiNP_001008405.1, NM_001008405.2 [Q9UHQ4-2]
NP_061332.2, NM_018844.3 [Q9UHQ4-1]
XP_006716114.1, XM_006716051.2 [Q9UHQ4-2]
XP_011514708.1, XM_011516406.2 [Q9UHQ4-2]
UniGeneiHs.303787

Genome annotation databases

EnsembliENST00000005259; ENSP00000005259; ENSG00000075790 [Q9UHQ4-1]
ENST00000379117; ENSP00000368412; ENSG00000075790 [Q9UHQ4-1]
ENST00000379119; ENSP00000368414; ENSG00000075790 [Q9UHQ4-2]
ENST00000445771; ENSP00000400718; ENSG00000075790 [Q9UHQ4-2]
ENST00000639675; ENSP00000492448; ENSG00000283852 [Q9UHQ4-2]
ENST00000639808; ENSP00000491076; ENSG00000283852 [Q9UHQ4-1]
ENST00000640380; ENSP00000491325; ENSG00000283852 [Q9UHQ4-2]
ENST00000640400; ENSP00000492046; ENSG00000283852 [Q9UHQ4-1]
GeneIDi55973
KEGGihsa:55973
UCSCiuc003vej.3 human [Q9UHQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBAP29_HUMAN
AccessioniPrimary (citable) accession number: Q9UHQ4
Secondary accession number(s): G5E9L4, O95003
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: July 18, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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