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UniProtKB - Q9UHP7 (CLC2D_HUMAN)

Entry version 145 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein

C-type lectin domain family 2 member D

Gene

CLEC2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
LigandLectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UHP7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-type lectin domain family 2 member D
Alternative name(s):
Lectin-like NK cell receptor
Lectin-like transcript 1
Short name:
LLT-1
Osteoclast inhibitory lectin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLEC2D
Synonyms:CLAX, LLT1, OCIL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000069493.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:14351, CLEC2D

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605659, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UHP7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini60 – 191ExtracellularSequence analysisAdd BLAST132

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		29121

Open Targets

More...OpenTargetsi		ENSG00000069493

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672100

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UHP7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CLEC2D

Domain mapping of disease mutations (DMDM)

More...DMDMi		74753331

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003152851 – 191C-type lectin domain family 2 member DAdd BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi75 ↔ 86PROSITE-ProRule annotationCombined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi95N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi103 ↔ 184PROSITE-ProRule annotationCombined sources
Glycosylationi147N-linked (GlcNAc...) asparagineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UHP7

PeptideAtlas

More...PeptideAtlasi		Q9UHP7

PRoteomics IDEntifications database

More...PRIDEi		Q9UHP7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84389 [Q9UHP7-1]
84390 [Q9UHP7-2]
84391 [Q9UHP7-3]
84392 [Q9UHP7-5]
84393 [Q9UHP7-6]
84394 [Q9UHP7-7]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UHP7, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UHP7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UHP7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by IL1A/interleukin-1 alpha and prostaglandin E2 in cultured osteogenic sarcoma cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000069493, Expressed in small intestine Peyer's patch and 158 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UHP7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UHP7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000069493, Group enriched (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118886, 90 interactors

Protein interaction database and analysis system

More...IntActi		Q9UHP7, 105 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261340

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UHP7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UHP7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini82 – 185C-type lectinPROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4297, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155319

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049894_8_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UHP7

KEGG Orthology (KO)

More...KOi		K10072

Identification of Orthologs from Complete Genome Data

More...OMAi		PAINANC

Database of Orthologous Groups

More...OrthoDBi		1289964at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UHP7

TreeFam database of animal gene trees

More...TreeFami		TF351467

Family and domain databases

Conserved Domains Database

More...CDDi		cd03593, CLECT_NK_receptors_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR033992, NKR-like_CTLD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00059, Lectin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00034, CLECT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UHP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHDSNNVEKD ITPSELPANP GCLHSKEHSI KATLIWRLFF LIMFLTIIVC 
        60         70         80         90        100
GMVAALSAIR ANCHQEPSVC LQAACPESWI GFQRKCFYFS DDTKNWTSSQ 
       110        120        130        140        150
RFCDSQDADL AQVESFQELN FLLRYKGPSD HWIGLSREQG QPWKWINGTE 
       160        170        180        190 
WTRQFPILGA GECAYLNDKG ASSARHYTER KWICSKSDIH V
Length:191
Mass (Da):21,849
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE71F3E21DC361F10
GO
Isoform 3 (identifier: Q9UHP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-191: Missing.

Show »
Length:154
Mass (Da):17,742
Checksum:i776D60662399E38D
GO
Isoform 2 (identifier: Q9UHP7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-191: FPILGAGECA...WICSKSDIHV → LVMKEDGANL...PGSRRVCLFE

Show »
Length:194
Mass (Da):22,263
Checksum:i96982E9EEA0C3410
GO
Isoform 4 (identifier: Q9UHP7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-191: NFLLRYKGPS...WICSKSDIHV → VSYPGSRRVCLFE

Show »
Length:132
Mass (Da):14,969
Checksum:i28BEC8140C9D7B96
GO
Isoform 5 (identifier: Q9UHP7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-57: Missing.

Show »
Length:154
Mass (Da):17,703
Checksum:iBF7D57B198B8A7F9
GO
Isoform 6 (identifier: Q9UHP7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-57: Missing.
     120-132: NFLLRYKGPSDHW → VSYPGSRRVCLFE
     133-191: Missing.

Show »
Length:95
Mass (Da):10,823
Checksum:iAA71B3302B66BD3A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DG81A0A0C4DG81_HUMAN
C-type lectin domain family 2 membe...
CLEC2D
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGG4A0A0C4DGG4_HUMAN
C-type lectin domain family 2 membe...
CLEC2D
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF99F8WF99_HUMAN
C-type lectin domain family 2 membe...
CLEC2D
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGG6H0YGG6_HUMAN
C-type lectin domain family 2 membe...
CLEC2D
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH49H0YH49_HUMAN
C-type lectin domain family 2 membe...
CLEC2D
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0P0F5H0P0_HUMAN
C-type lectin domain family 2 membe...
CLEC2D
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5U4F5H5U4_HUMAN
C-type lectin domain family 2 membe...
CLEC2D
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03817219N → K1 PublicationCorresponds to variant dbSNP:rs16914640Ensembl.1
Natural variantiVAR_03817323L → V2 PublicationsCorresponds to variant dbSNP:rs3764022Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03967621 – 57Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_039678120 – 191NFLLR…SDIHV → VSYPGSRRVCLFE in isoform 4. 2 PublicationsAdd BLAST72
Alternative sequenceiVSP_039680120 – 132NFLLR…PSDHW → VSYPGSRRVCLFE in isoform 6. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_039681133 – 191Missing in isoform 6. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_039683155 – 191FPILG…SDIHV → LVMKEDGANLYVAKVSQVPR MNPRPVMVSYPGSRRVCLFE in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_039682155 – 191Missing in isoform 3. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF133299 mRNA Translation: AAF22159.1
AY144606 Genomic DNA Translation: AAN59996.1
FN813349 mRNA Translation: CBL81070.1
FN813350 mRNA Translation: CBL81071.1
FN813351 mRNA Translation: CBL81072.1
AF285087 mRNA Translation: AAG00514.1
AF285088 mRNA Translation: AAG00515.1
AF285089 mRNA Translation: AAG00516.1
AC007068 Genomic DNA No translation available.
AC010186 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96114.1
BC019883 mRNA Translation: AAH19883.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31741.1 [Q9UHP7-3]
CCDS55800.1 [Q9UHP7-5]
CCDS55801.1 [Q9UHP7-6]
CCDS55802.1 [Q9UHP7-7]
CCDS8602.1 [Q9UHP7-1]

NCBI Reference Sequences

More...RefSeqi		NP_001004419.1, NM_001004419.4 [Q9UHP7-3]
NP_001184246.1, NM_001197317.2 [Q9UHP7-6]
NP_001184247.1, NM_001197318.2 [Q9UHP7-5]
NP_001184248.1, NM_001197319.2 [Q9UHP7-7]
NP_037401.1, NM_013269.5 [Q9UHP7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261339; ENSP00000261339; ENSG00000069493 [Q9UHP7-6]
ENST00000261340; ENSP00000261340; ENSG00000069493 [Q9UHP7-3]
ENST00000290855; ENSP00000290855; ENSG00000069493 [Q9UHP7-1]
ENST00000479877; ENSP00000441653; ENSG00000069493 [Q9UHP7-2]
ENST00000543300; ENSP00000443065; ENSG00000069493 [Q9UHP7-5]
ENST00000545918; ENSP00000444818; ENSG00000069493 [Q9UHP7-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		29121

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:29121

UCSC genome browser

More...UCSCi		uc001qwf.4, human [Q9UHP7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

LLT1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133299 mRNA Translation: AAF22159.1
AY144606 Genomic DNA Translation: AAN59996.1
FN813349 mRNA Translation: CBL81070.1
FN813350 mRNA Translation: CBL81071.1
FN813351 mRNA Translation: CBL81072.1
AF285087 mRNA Translation: AAG00514.1
AF285088 mRNA Translation: AAG00515.1
AF285089 mRNA Translation: AAG00516.1
AC007068 Genomic DNA No translation available.
AC010186 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96114.1
BC019883 mRNA Translation: AAH19883.1
CCDSiCCDS31741.1 [Q9UHP7-3]
CCDS55800.1 [Q9UHP7-5]
CCDS55801.1 [Q9UHP7-6]
CCDS55802.1 [Q9UHP7-7]
CCDS8602.1 [Q9UHP7-1]
RefSeqiNP_001004419.1, NM_001004419.4 [Q9UHP7-3]
NP_001184246.1, NM_001197317.2 [Q9UHP7-6]
NP_001184247.1, NM_001197318.2 [Q9UHP7-5]
NP_001184248.1, NM_001197319.2 [Q9UHP7-7]
NP_037401.1, NM_013269.5 [Q9UHP7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QKGX-ray1.95A72-191[»]
4QKHX-ray1.80A/B72-191[»]
4QKIX-ray1.80A/B72-191[»]
4QKJX-ray2.75A72-191[»]
4WCOX-ray2.46A/B/C71-191[»]
5MGTX-ray1.90A/B72-191[»]
SMRiQ9UHP7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118886, 90 interactors
IntActiQ9UHP7, 105 interactors
STRINGi9606.ENSP00000261340

PTM databases

GlyGeniQ9UHP7, 2 sites
iPTMnetiQ9UHP7
PhosphoSitePlusiQ9UHP7

Polymorphism and mutation databases

BioMutaiCLEC2D
DMDMi74753331

Proteomic databases

MassIVEiQ9UHP7
PeptideAtlasiQ9UHP7
PRIDEiQ9UHP7
ProteomicsDBi84389 [Q9UHP7-1]
84390 [Q9UHP7-2]
84391 [Q9UHP7-3]
84392 [Q9UHP7-5]
84393 [Q9UHP7-6]
84394 [Q9UHP7-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2229, 274 antibodies

Genome annotation databases

EnsembliENST00000261339; ENSP00000261339; ENSG00000069493 [Q9UHP7-6]
ENST00000261340; ENSP00000261340; ENSG00000069493 [Q9UHP7-3]
ENST00000290855; ENSP00000290855; ENSG00000069493 [Q9UHP7-1]
ENST00000479877; ENSP00000441653; ENSG00000069493 [Q9UHP7-2]
ENST00000543300; ENSP00000443065; ENSG00000069493 [Q9UHP7-5]
ENST00000545918; ENSP00000444818; ENSG00000069493 [Q9UHP7-7]
GeneIDi29121
KEGGihsa:29121
UCSCiuc001qwf.4, human [Q9UHP7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		29121
DisGeNETi29121
EuPathDBiHostDB:ENSG00000069493.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		CLEC2D
HGNCiHGNC:14351, CLEC2D
HPAiENSG00000069493, Group enriched (blood, lymphoid tissue)
MIMi605659, gene
neXtProtiNX_Q9UHP7
OpenTargetsiENSG00000069493
PharmGKBiPA142672100

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT00940000155319
HOGENOMiCLU_049894_8_4_1
InParanoidiQ9UHP7
KOiK10072
OMAiPAINANC
OrthoDBi1289964at2759
PhylomeDBiQ9UHP7
TreeFamiTF351467

Enzyme and pathway databases

PathwayCommonsiQ9UHP7
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		29121, 6 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CLEC2D, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CLEC2D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		29121
PharosiQ9UHP7, Tbio

Protein Ontology

More...PROi		PR:Q9UHP7
RNActiQ9UHP7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000069493, Expressed in small intestine Peyer's patch and 158 other tissues
ExpressionAtlasiQ9UHP7, baseline and differential
GenevisibleiQ9UHP7, HS

Family and domain databases

CDDicd03593, CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR033992, NKR-like_CTLD
PfamiView protein in Pfam
PF00059, Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SUPFAMiSSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLC2D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHP7
Secondary accession number(s): D6CI39
, D6CI40, D6CI41, Q6YID5, Q8WUP7, Q9HD37, Q9HD38
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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