UniProtKB - Q9UHP7 (CLC2D_HUMAN)
C-type lectin domain family 2 member D
CLEC2D
Functioni
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513).
Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656).
Inhibits bone resorption (PubMed:14753741).
Modulates the release of interferon-gamma (PubMed:15104121).
Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).
5 PublicationsGO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- natural killer cell lectin-like receptor binding Source: GO_Central
- transmembrane signaling receptor activity Source: ProtInc
GO - Biological processi
- cell surface receptor signaling pathway Source: ProtInc
Keywordsi
Molecular function | Receptor |
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | Q9UHP7 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | Q9UHP7 |
Names & Taxonomyi
Protein namesi | Recommended name: C-type lectin domain family 2 member DAlternative name(s): Lectin-like NK cell receptor Lectin-like transcript 1 Short name: LLT-1 Osteoclast inhibitory lectin |
Gene namesi | Name:CLEC2D Synonyms:CLAX, LLT1, OCIL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14351, CLEC2D |
MIMi | 605659, gene |
neXtProti | NX_Q9UHP7 |
VEuPathDBi | HostDB:ENSG00000069493 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication2 Publications; Single-pass type II membrane protein Sequence analysis
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- cell surface Source: UniProtKB
- membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | CytoplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 59 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 191 | ExtracellularSequence analysisAdd BLAST | 132 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 29121 |
OpenTargetsi | ENSG00000069493 |
PharmGKBi | PA142672100 |
Miscellaneous databases
Pharosi | Q9UHP7, Tbio |
Genetic variation databases
BioMutai | CLEC2D |
DMDMi | 74753331 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315285 | 1 – 191 | C-type lectin domain family 2 member DAdd BLAST | 191 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 75 ↔ 86 | PROSITE-ProRule annotationCombined sources | ||
Glycosylationi | 95 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 103 ↔ 184 | PROSITE-ProRule annotationCombined sources | ||
Glycosylationi | 147 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q9UHP7 |
PeptideAtlasi | Q9UHP7 |
PRIDEi | Q9UHP7 |
ProteomicsDBi | 84389 [Q9UHP7-1] 84390 [Q9UHP7-2] 84391 [Q9UHP7-3] 84393 [Q9UHP7-6] |
PTM databases
GlyGeni | Q9UHP7, 2 sites |
iPTMneti | Q9UHP7 |
PhosphoSitePlusi | Q9UHP7 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000069493, Expressed in small intestine Peyer's patch and 158 other tissues |
ExpressionAtlasi | Q9UHP7, baseline and differential |
Genevisiblei | Q9UHP7, HS |
Organism-specific databases
HPAi | ENSG00000069493, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
4 PublicationsBinary interactionsi
Isoform 1 [Q9UHP7-1]
With | #Exp. | IntAct |
---|---|---|
KLRB1 [Q12918] | 2 | EBI-13640978,EBI-2805465 |
Isoform 2 [Q9UHP7-3]
GO - Molecular functioni
- natural killer cell lectin-like receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 118886, 223 interactors |
IntActi | Q9UHP7, 106 interactors |
STRINGi | 9606.ENSP00000261340 |
Miscellaneous databases
RNActi | Q9UHP7, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9UHP7 |
SMRi | Q9UHP7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 82 – 185 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 104 |
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000155319 |
HOGENOMi | CLU_049894_8_4_1 |
InParanoidi | Q9UHP7 |
OMAi | PAINANC |
OrthoDBi | 1289964at2759 |
PhylomeDBi | Q9UHP7 |
TreeFami | TF351467 |
Family and domain databases
CDDi | cd03593, CLECT_NK_receptors_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR033992, NKR-like_CTLD |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHDSNNVEKD ITPSELPANP GCLHSKEHSI KATLIWRLFF LIMFLTIIVC
60 70 80 90 100
GMVAALSAIR ANCHQEPSVC LQAACPESWI GFQRKCFYFS DDTKNWTSSQ
110 120 130 140 150
RFCDSQDADL AQVESFQELN FLLRYKGPSD HWIGLSREQG QPWKWINGTE
160 170 180 190
WTRQFPILGA GECAYLNDKG ASSARHYTER KWICSKSDIH V
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DG81 | A0A0C4DG81_HUMAN | C-type lectin domain family 2 membe... | CLEC2D | 173 | Annotation score: | ||
A0A0C4DGG4 | A0A0C4DGG4_HUMAN | C-type lectin domain family 2 membe... | CLEC2D | 106 | Annotation score: | ||
F8WF99 | F8WF99_HUMAN | C-type lectin domain family 2 membe... | CLEC2D | 122 | Annotation score: | ||
F5H0P0 | F5H0P0_HUMAN | C-type lectin domain family 2 membe... | CLEC2D | 80 | Annotation score: | ||
F5H5U4 | F5H5U4_HUMAN | C-type lectin domain family 2 membe... | CLEC2D | 54 | Annotation score: | ||
H0YGG6 | H0YGG6_HUMAN | C-type lectin domain family 2 membe... | CLEC2D | 133 | Annotation score: | ||
H0YH49 | H0YH49_HUMAN | C-type lectin domain family 2 membe... | CLEC2D | 140 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038172 | 19 | N → K1 PublicationCorresponds to variant dbSNP:rs16914640Ensembl. | 1 | |
Natural variantiVAR_038173 | 23 | L → V2 PublicationsCorresponds to variant dbSNP:rs3764022Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039676 | 21 – 57 | Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_039678 | 120 – 191 | NFLLR…SDIHV → VSYPGSRRVCLFE in isoform 4. 2 PublicationsAdd BLAST | 72 | |
Alternative sequenceiVSP_039680 | 120 – 132 | NFLLR…PSDHW → VSYPGSRRVCLFE in isoform 6. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_039681 | 133 – 191 | Missing in isoform 6. 1 PublicationAdd BLAST | 59 | |
Alternative sequenceiVSP_039683 | 155 – 191 | FPILG…SDIHV → LVMKEDGANLYVAKVSQVPR MNPRPVMVSYPGSRRVCLFE in isoform 2. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_039682 | 155 – 191 | Missing in isoform 3. 1 PublicationAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133299 mRNA Translation: AAF22159.1 AY144606 Genomic DNA Translation: AAN59996.1 FN813349 mRNA Translation: CBL81070.1 FN813350 mRNA Translation: CBL81071.1 FN813351 mRNA Translation: CBL81072.1 AF285087 mRNA Translation: AAG00514.1 AF285088 mRNA Translation: AAG00515.1 AF285089 mRNA Translation: AAG00516.1 AC007068 Genomic DNA No translation available. AC010186 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96114.1 BC019883 mRNA Translation: AAH19883.1 |
CCDSi | CCDS31741.1 [Q9UHP7-3] CCDS55800.1 [Q9UHP7-5] CCDS55801.1 [Q9UHP7-6] CCDS55802.1 [Q9UHP7-7] CCDS8602.1 [Q9UHP7-1] |
RefSeqi | NP_001004419.1, NM_001004419.4 [Q9UHP7-3] NP_001184246.1, NM_001197317.2 [Q9UHP7-6] NP_001184247.1, NM_001197318.2 [Q9UHP7-5] NP_001184248.1, NM_001197319.2 [Q9UHP7-7] NP_037401.1, NM_013269.5 [Q9UHP7-1] |
Genome annotation databases
Ensembli | ENST00000261339.10; ENSP00000261339.6; ENSG00000069493.15 [Q9UHP7-6] ENST00000261340.11; ENSP00000261340.7; ENSG00000069493.15 [Q9UHP7-3] ENST00000290855.11; ENSP00000290855.6; ENSG00000069493.15 ENST00000479877.5; ENSP00000441653.1; ENSG00000069493.15 [Q9UHP7-2] ENST00000543300.5; ENSP00000443065.1; ENSG00000069493.15 [Q9UHP7-5] ENST00000545918.5; ENSP00000444818.1; ENSG00000069493.15 [Q9UHP7-7] |
GeneIDi | 29121 |
KEGGi | hsa:29121 |
MANE-Selecti | ENST00000290855.11; ENSP00000290855.6; NM_013269.6; NP_037401.1 |
UCSCi | uc001qwf.4, human [Q9UHP7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding LLT1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133299 mRNA Translation: AAF22159.1 AY144606 Genomic DNA Translation: AAN59996.1 FN813349 mRNA Translation: CBL81070.1 FN813350 mRNA Translation: CBL81071.1 FN813351 mRNA Translation: CBL81072.1 AF285087 mRNA Translation: AAG00514.1 AF285088 mRNA Translation: AAG00515.1 AF285089 mRNA Translation: AAG00516.1 AC007068 Genomic DNA No translation available. AC010186 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96114.1 BC019883 mRNA Translation: AAH19883.1 |
CCDSi | CCDS31741.1 [Q9UHP7-3] CCDS55800.1 [Q9UHP7-5] CCDS55801.1 [Q9UHP7-6] CCDS55802.1 [Q9UHP7-7] CCDS8602.1 [Q9UHP7-1] |
RefSeqi | NP_001004419.1, NM_001004419.4 [Q9UHP7-3] NP_001184246.1, NM_001197317.2 [Q9UHP7-6] NP_001184247.1, NM_001197318.2 [Q9UHP7-5] NP_001184248.1, NM_001197319.2 [Q9UHP7-7] NP_037401.1, NM_013269.5 [Q9UHP7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4QKG | X-ray | 1.95 | A | 72-191 | [»] | |
4QKH | X-ray | 1.80 | A/B | 72-191 | [»] | |
4QKI | X-ray | 1.80 | A/B | 72-191 | [»] | |
4QKJ | X-ray | 2.75 | A | 72-191 | [»] | |
4WCO | X-ray | 2.46 | A/B/C | 71-191 | [»] | |
5MGT | X-ray | 1.90 | A/B | 72-191 | [»] | |
AlphaFoldDBi | Q9UHP7 | |||||
SMRi | Q9UHP7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118886, 223 interactors |
IntActi | Q9UHP7, 106 interactors |
STRINGi | 9606.ENSP00000261340 |
PTM databases
GlyGeni | Q9UHP7, 2 sites |
iPTMneti | Q9UHP7 |
PhosphoSitePlusi | Q9UHP7 |
Genetic variation databases
BioMutai | CLEC2D |
DMDMi | 74753331 |
Proteomic databases
MassIVEi | Q9UHP7 |
PeptideAtlasi | Q9UHP7 |
PRIDEi | Q9UHP7 |
ProteomicsDBi | 84389 [Q9UHP7-1] 84390 [Q9UHP7-2] 84391 [Q9UHP7-3] 84393 [Q9UHP7-6] |
Protocols and materials databases
Antibodypediai | 2229, 291 antibodies from 31 providers |
DNASUi | 29121 |
Genome annotation databases
Organism-specific databases
CTDi | 29121 |
DisGeNETi | 29121 |
GeneCardsi | CLEC2D |
HGNCi | HGNC:14351, CLEC2D |
HPAi | ENSG00000069493, Tissue enhanced (lymphoid) |
MIMi | 605659, gene |
neXtProti | NX_Q9UHP7 |
OpenTargetsi | ENSG00000069493 |
PharmGKBi | PA142672100 |
VEuPathDBi | HostDB:ENSG00000069493 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000155319 |
HOGENOMi | CLU_049894_8_4_1 |
InParanoidi | Q9UHP7 |
OMAi | PAINANC |
OrthoDBi | 1289964at2759 |
PhylomeDBi | Q9UHP7 |
TreeFami | TF351467 |
Enzyme and pathway databases
PathwayCommonsi | Q9UHP7 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | Q9UHP7 |
Miscellaneous databases
BioGRID-ORCSi | 29121, 11 hits in 1072 CRISPR screens |
ChiTaRSi | CLEC2D, human |
GeneWikii | CLEC2D |
GenomeRNAii | 29121 |
Pharosi | Q9UHP7, Tbio |
PROi | PR:Q9UHP7 |
RNActi | Q9UHP7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000069493, Expressed in small intestine Peyer's patch and 158 other tissues |
ExpressionAtlasi | Q9UHP7, baseline and differential |
Genevisiblei | Q9UHP7, HS |
Family and domain databases
CDDi | cd03593, CLECT_NK_receptors_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR033992, NKR-like_CTLD |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CLC2D_HUMAN | |
Accessioni | Q9UHP7Primary (citable) accession number: Q9UHP7 Secondary accession number(s): D6CI39 Q9HD38 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references