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Entry version 130 (08 May 2019)
Sequence version 1 (01 May 2000)
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Protein

Cell surface hyaluronidase

Gene

CEMIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.1 Publication EC:3.2.1.35

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 6-7.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Glycosidase, Hydrolase
Biological processAngiogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell surface hyaluronidase1 Publication (EC:3.2.1.351 Publication)
Alternative name(s):
Cell migration-inducing hyaluronidase 2Imported
Transmembrane protein 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEMIP2Imported
Synonyms:KIAA14121 Publication, TMEM21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11869 CEMIP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605835 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UHN6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 82CytoplasmicCuratedAdd BLAST82
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei83 – 103Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini104 – 1383ExtracellularCuratedAdd BLAST1280

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi260 – 262EKD → NKQ: Does not affect hyaluronidase activity. 1 Publication3
Mutagenesisi265R → A or C: Strongly decreased hyaluronidase activity. 1 Publication1
Mutagenesisi273D → N: Strongly decreased hyaluronidase activity. 1 Publication1
Mutagenesisi275D → N: Does not affect hyaluronidase activity. 1 Publication1
Mutagenesisi281 – 283ESE → QSQ: Does not affect hyaluronidase activity. 1 Publication3
Mutagenesisi286D → N: Strongly decreased hyaluronidase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23670

Open Targets

More...
OpenTargetsi
ENSG00000135048

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36570

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74753330

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002899721 – 1383Cell surface hyaluronidaseAdd BLAST1383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi914N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1234N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UHN6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UHN6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UHN6

PeptideAtlas

More...
PeptideAtlasi
Q9UHN6

PRoteomics IDEntifications database

More...
PRIDEi
Q9UHN6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84383
84384 [Q9UHN6-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1851

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UHN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UHN6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UHN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135048 Expressed in 207 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UHN6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UHN6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044889

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117188, 24 interactors

Protein interaction database and analysis system

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IntActi
Q9UHN6, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366243

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UHN6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini121 – 245G8PROSITE-ProRule annotationAdd BLAST125
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati669 – 691PbH1 1Add BLAST23
Repeati711 – 733PbH1 2Add BLAST23
Repeati791 – 812PbH1 3Add BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEMIP family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFCM Eukaryota
ENOG410XQ01 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153636

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UHN6

KEGG Orthology (KO)

More...
KOi
K22144

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIQMIQD

Database of Orthologous Groups

More...
OrthoDBi
294134at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UHN6

TreeFam database of animal gene trees

More...
TreeFami
TF316575

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13938 PANDER_like_TMEM2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019316 G8_domain
IPR039477 ILEI/PANDER_dom
IPR011050 Pectin_lyase_fold/virulence
IPR039473 TMEM2_PANDER-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10162 G8, 1 hit
PF15711 ILEI, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01225 G8, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51126 SSF51126, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51484 G8, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UHN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYATDSRGHS PAFLQPQNGN SRHPSGYVPG KVVPLRPPPP PKSQASAKFT
60 70 80 90 100
SIRREDRATF AFSPEEQQAQ RESQKQKRHK NTFICFAITS FSFFIALAII
110 120 130 140 150
LGISSKYAPD ENCPDQNPRL RNWDPGQDSA KQVVIKEGDM LRLTSDATVH
160 170 180 190 200
SIVIQDGGLL VFGDNKDGSR NITLRTHYIL IQDGGALHIG AEKCRYKSKA
210 220 230 240 250
TITLYGKSDE GESMPTFGKK FIGVEAGGTL ELHGARKASW TLLARTLNSS
260 270 280 290 300
GLPFGSYTFE KDFSRGLNVR VIDQDTAKIL ESERFDTHEY RNESRRLQEF
310 320 330 340 350
LRFQDPGRIV AIAVGDSAAK SLLQGTIQMI QERLGSELIQ GLGYRQAWAL
360 370 380 390 400
VGVIDGGSTS CNESVRNYEN HSSGGKALAQ REFYTVDGQK FSVTAYSEWI
410 420 430 440 450
EGVSLSGFRV EVVDGVKLNL LDDVSSWKPG DQIVVASTDY SMYQAEEFTL
460 470 480 490 500
LPCSECSHFQ VKVKETPQFL HMGEIIDGVD MRAEVGILTR NIVIQGEVED
510 520 530 540 550
SCYAENQCQF FDYDTFGGHI MIMKNFTSVH LSYVELKHMG QQQMGRYPVH
560 570 580 590 600
FHLCGDVDYK GGYRHATFVD GLSIHHSFSR CITVHGTNGL LIKDTIGFDT
610 620 630 640 650
LGHCFFLEDG IEQRNTLFHN LGLLTKPGTL LPTDRNNSMC TTMRDKVFGN
660 670 680 690 700
YIPVPATDCM AVSTFWIAHP NNNLINNAAA GSQDAGIWYL FHKEPTGESS
710 720 730 740 750
GLQLLAKPEL TPLGIFYNNR VHSNFKAGLF IDKGVKTTNS SAADPREYLC
760 770 780 790 800
LDNSARFRPH QDANPEKPRV AALIDRLIAF KNNDNGAWVR GGDIIVQNSA
810 820 830 840 850
FADNGIGLTF ASDGSFPSDE GSSQEVSESL FVGESRNYGF QGGQNKYVGT
860 870 880 890 900
GGIDQKPRTL PRNRTFPIRG FQIYDGPIHL TRSTFKKYVP TPDRYSSAIG
910 920 930 940 950
FLMKNSWQIT PRNNISLVKF GPHVSLNVFF GKPGPWFEDC EMDGDKNSIF
960 970 980 990 1000
HDIDGSVTGY KDAYVGRMDN YLIRHPSCVN VSKWNAVICS GTYAQVYVQT
1010 1020 1030 1040 1050
WSTQNLSMTI TRDEYPSNPM VLRGINQKAA FPQYQPVVML EKGYTIHWNG
1060 1070 1080 1090 1100
PAPRTTFLYL VNFNKNDWIR VGLCYPSNTS FQVTFGYLQR QNGSLSKIEE
1110 1120 1130 1140 1150
YEPVHSLEEL QRKQSERKFY FDSSTGLLFL YLKAKSHRHG HSYCSSQGCE
1160 1170 1180 1190 1200
RVKIQAATDS KDISNCMAKA YPQYYRKPSV VKRMPAMLTG LCQGCGTRQV
1210 1220 1230 1240 1250
VFTSDPHKSY LPVQFQSPDK AETQRGDPSV ISVNGTDFTF RSAGVLLLVV
1260 1270 1280 1290 1300
DPCSVPFRLT EKTVFPLADV SRIEEYLKTG IPPRSIVLLS TRGEIKQLNI
1310 1320 1330 1340 1350
SHLLVPLGLA KPAHLYDKGS TIFLGFSGNF KPSWTKLFTS PAGQGLGVLE
1360 1370 1380
QFIPLQLDEY GCPRATTVRR RDLELLKQAS KAH
Length:1,383
Mass (Da):154,374
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18954F8ADF94C317
GO
Isoform 2 (identifier: Q9UHN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-464: Missing.

Show »
Length:1,320
Mass (Da):147,439
Checksum:i7F4A1223B8BFBFF3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6B2F5H6B2_HUMAN
Cell surface hyaluronidase
CEMIP2
580Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4E1B9B4E1B9_HUMAN
Cell surface hyaluronidase
CEMIP2
376Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLY0H3BLY0_HUMAN
Cell surface hyaluronidase
CEMIP2
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLX9H3BLX9_HUMAN
Cell surface hyaluronidase
CEMIP2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZC1F5GZC1_HUMAN
Cell surface hyaluronidase
CEMIP2
18Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92650 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11574 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1223T → A in BAC11574 (PubMed:14702039).Curated1
Sequence conflicti1322I → V in BAC11574 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032669245R → K. Corresponds to variant dbSNP:rs25688Ensembl.1
Natural variantiVAR_032670291R → H. Corresponds to variant dbSNP:rs25689Ensembl.1
Natural variantiVAR_062197291R → L. Corresponds to variant dbSNP:rs25689Ensembl.1
Natural variantiVAR_062198291R → P. Corresponds to variant dbSNP:rs25689Ensembl.1
Natural variantiVAR_032671423D → E. Corresponds to variant dbSNP:rs25695Ensembl.1
Natural variantiVAR_032672765P → S. Corresponds to variant dbSNP:rs25692Ensembl.1
Natural variantiVAR_0326731010I → V. Corresponds to variant dbSNP:rs17057133Ensembl.1
Natural variantiVAR_0326741254S → N. Corresponds to variant dbSNP:rs2297089Ensembl.1
Natural variantiVAR_0326751280G → D. Corresponds to variant dbSNP:rs17475375Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041401402 – 464Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF137030 mRNA Translation: AAF21348.1
AB037833 mRNA Translation: BAA92650.2 Different initiation.
AL161732 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62518.1
BC140773 mRNA Translation: AAI40774.1
BC146780 mRNA Translation: AAI46781.1
AK075370 mRNA Translation: BAC11574.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS47979.1 [Q9UHN6-2]
CCDS6638.1 [Q9UHN6-1]

NCBI Reference Sequences

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RefSeqi
NP_001129292.1, NM_001135820.1 [Q9UHN6-2]
NP_037522.1, NM_013390.2 [Q9UHN6-1]
XP_005251926.1, XM_005251869.4 [Q9UHN6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000377044; ENSP00000366243; ENSG00000135048 [Q9UHN6-1]
ENST00000377066; ENSP00000366266; ENSG00000135048 [Q9UHN6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23670

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23670

UCSC genome browser

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UCSCi
uc010mos.3 human [Q9UHN6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137030 mRNA Translation: AAF21348.1
AB037833 mRNA Translation: BAA92650.2 Different initiation.
AL161732 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62518.1
BC140773 mRNA Translation: AAI40774.1
BC146780 mRNA Translation: AAI46781.1
AK075370 mRNA Translation: BAC11574.1 Different initiation.
CCDSiCCDS47979.1 [Q9UHN6-2]
CCDS6638.1 [Q9UHN6-1]
RefSeqiNP_001129292.1, NM_001135820.1 [Q9UHN6-2]
NP_037522.1, NM_013390.2 [Q9UHN6-1]
XP_005251926.1, XM_005251869.4 [Q9UHN6-1]

3D structure databases

SMRiQ9UHN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117188, 24 interactors
IntActiQ9UHN6, 4 interactors
STRINGi9606.ENSP00000366243

PTM databases

GlyConnecti1851
iPTMnetiQ9UHN6
PhosphoSitePlusiQ9UHN6
SwissPalmiQ9UHN6

Polymorphism and mutation databases

BioMutaiTMEM2
DMDMi74753330

Proteomic databases

EPDiQ9UHN6
jPOSTiQ9UHN6
PaxDbiQ9UHN6
PeptideAtlasiQ9UHN6
PRIDEiQ9UHN6
ProteomicsDBi84383
84384 [Q9UHN6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377044; ENSP00000366243; ENSG00000135048 [Q9UHN6-1]
ENST00000377066; ENSP00000366266; ENSG00000135048 [Q9UHN6-2]
GeneIDi23670
KEGGihsa:23670
UCSCiuc010mos.3 human [Q9UHN6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23670
DisGeNETi23670

GeneCards: human genes, protein and diseases

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GeneCardsi
CEMIP2
HGNCiHGNC:11869 CEMIP2
HPAiHPA044889
MIMi605835 gene
neXtProtiNX_Q9UHN6
OpenTargetsiENSG00000135048
PharmGKBiPA36570

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFCM Eukaryota
ENOG410XQ01 LUCA
GeneTreeiENSGT00940000153636
InParanoidiQ9UHN6
KOiK22144
OMAiTIQMIQD
OrthoDBi294134at2759
PhylomeDBiQ9UHN6
TreeFamiTF316575

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEM2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23670

Protein Ontology

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PROi
PR:Q9UHN6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135048 Expressed in 207 organ(s), highest expression level in right lung
ExpressionAtlasiQ9UHN6 baseline and differential
GenevisibleiQ9UHN6 HS

Family and domain databases

CDDicd13938 PANDER_like_TMEM2, 1 hit
InterProiView protein in InterPro
IPR019316 G8_domain
IPR039477 ILEI/PANDER_dom
IPR011050 Pectin_lyase_fold/virulence
IPR039473 TMEM2_PANDER-like
PfamiView protein in Pfam
PF10162 G8, 1 hit
PF15711 ILEI, 2 hits
SMARTiView protein in SMART
SM01225 G8, 1 hit
SUPFAMiSSF51126 SSF51126, 1 hit
PROSITEiView protein in PROSITE
PS51484 G8, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEIP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHN6
Secondary accession number(s): A6H8W9
, B2RTQ6, Q5T838, Q5T839, Q5T840, Q5T841, Q8NBP6, Q9P2D5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: May 1, 2000
Last modified: May 8, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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