UniProtKB - Q9UHN1 (DPOG2_HUMAN)

BLAST

>sp|Q9UHN1|DPOG2_HUMAN DNA polymerase subunit gamma-2, mitochondrial OS=Homo sapiens OX=9606 GN=POLG2 PE=1 SV=1
MRSRVAVRACHKVCRCLLSGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAP
GSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVV
FREQVFPVDALHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGK
LRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLV
WFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELI
ETLWNLGDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENS
FTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLET
MQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKEMMHISKLKDFLIKYIS
SAKNV

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History
Entry version 165 (07 Nov 2018)
Sequence version 1 (01 May 2000)
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Protein

DNA polymerase subunit gamma-2, mitochondrial

Gene

POLG2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.

Catalytic activityⁱ

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-directed DNA polymerase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
identical protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA-dependent DNA replication
Source: ProtInc
Traceable author statementⁱ
- 9153213
DNA repair
Source: UniProtKB
Non-traceable author statementⁱ
- 10608893
DNA replication
Source: UniProtKB
Non-traceable author statementⁱ
- 10608893
in utero embryonic development Source: Ensembl
mitochondrial DNA replication
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitochondrion morphogenesis Source: Ensembl
mitochondrion organization Source: Reactome
respiratory electron transport chain Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological process	DNA replication

Enzyme and pathway databases

BRENDAⁱ	2.7.7.7 2681
Reactomeⁱ	R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA polymerase subunit gamma-2, mitochondrial (EC:2.7.7.7) Alternative name(s): DNA polymerase gamma accessory 55 kDa subunit Short name: p55 Mitochondrial DNA polymerase accessory subunit MtPolB PolG-beta
Gene namesⁱ	Name:POLG2 Synonyms:MTPOLB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000256525.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9180 POLG2
MIMⁱ	604983 gene
neXtProtⁱ	NX_Q9UHN1

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 4 (PEOA4)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029364	451	G → E in PEOA4; affects stimulation of the catalytic subunit. 1 PublicationCorresponds to variant dbSNP:rs104894632EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation, Primary mitochondrial disease, Progressive external ophthalmoplegia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11232
MalaCards human disease database More...MalaCardsⁱ	POLG2
MIMⁱ	610131 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000256525
Orphanetⁱ	254892 Autosomal dominant progressive external ophthalmoplegia
PharmGKBⁱ	PA33501

Chemistry databases

ChEMBLⁱ	CHEMBL3430903

ChEMBLⁱ

CHEMBL3430903

Polymorphism and mutation databases

BioMutaⁱ	POLG2
DMDMⁱ	17367139

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000007314	? – 485	DNA polymerase subunit gamma-2, mitochondrial
Transit peptideⁱ	1 – ?	MitochondrionSequence analysis

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	38	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UHN1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UHN1
PaxDbⁱ	Q9UHN1
PeptideAtlas More...PeptideAtlasⁱ	Q9UHN1
PRIDEⁱ	Q9UHN1
ProteomicsDBⁱ	84382

PTM databases

iPTMnetⁱ	Q9UHN1
PhosphoSitePlusⁱ	Q9UHN1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000256525 Expressed in 205 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_POLG2
ExpressionAtlasⁱ	Q9UHN1 baseline and differential
Genevisibleⁱ	Q9UHN1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB017030 HPA023202

HPAⁱ

CAB017030
HPA023202

Interactionⁱ

Subunit structureⁱ

Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
POLG	P54098	10	EBI-852642,EBI-852624

With

Entry

#Exp.

IntAct

Notes

POLG

P54098

EBI-852642,EBI-852624

GO - Molecular functionⁱ

identical protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116398, 14 interactors
ComplexPortalⁱ	CPX-2093 DNA polymerase gamma complex
IntActⁱ	Q9UHN1, 8 interactors
Molecular INTeraction database More...MINTⁱ	Q9UHN1
STRINGⁱ	9606.ENSP00000442563

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	60 – 66	Combined sources	7
Helixⁱ	69 – 75	Combined sources	7
Beta strandⁱ	78 – 80	Combined sources	3
Turnⁱ	83 – 86	Combined sources	4
Helixⁱ	88 – 92	Combined sources	5
Helixⁱ	101 – 118	Combined sources	18
Turnⁱ	119 – 122	Combined sources	4
Beta strandⁱ	125 – 127	Combined sources	3
Beta strandⁱ	132 – 134	Combined sources	3
Turnⁱ	135 – 137	Combined sources	3
Beta strandⁱ	138 – 141	Combined sources	4
Beta strandⁱ	146 – 149	Combined sources	4
Helixⁱ	150 – 153	Combined sources	4
Helixⁱ	154 – 156	Combined sources	3
Beta strandⁱ	157 – 159	Combined sources	3
Turnⁱ	161 – 165	Combined sources	5
Helixⁱ	166 – 168	Combined sources	3
Helixⁱ	171 – 177	Combined sources	7
Beta strandⁱ	179 – 181	Combined sources	3
Helixⁱ	186 – 192	Combined sources	7
Turnⁱ	193 – 197	Combined sources	5
Helixⁱ	198 – 200	Combined sources	3
Beta strandⁱ	203 – 215	Combined sources	13
Beta strandⁱ	224 – 226	Combined sources	3
Beta strandⁱ	233 – 243	Combined sources	11
Helixⁱ	245 – 247	Combined sources	3
Helixⁱ	248 – 266	Combined sources	19
Helixⁱ	270 – 272	Combined sources	3
Beta strandⁱ	273 – 278	Combined sources	6
Beta strandⁱ	281 – 284	Combined sources	4
Beta strandⁱ	286 – 292	Combined sources	7
Beta strandⁱ	297 – 305	Combined sources	9
Helixⁱ	309 – 314	Combined sources	6
Beta strandⁱ	319 – 322	Combined sources	4
Beta strandⁱ	325 – 328	Combined sources	4
Beta strandⁱ	334 – 341	Combined sources	8
Helixⁱ	342 – 351	Combined sources	10
Turnⁱ	359 – 361	Combined sources	3
Beta strandⁱ	362 – 364	Combined sources	3
Turnⁱ	376 – 378	Combined sources	3
Beta strandⁱ	379 – 381	Combined sources	3
Beta strandⁱ	383 – 389	Combined sources	7
Helixⁱ	395 – 408	Combined sources	14
Beta strandⁱ	413 – 415	Combined sources	3
Helixⁱ	416 – 418	Combined sources	3
Beta strandⁱ	419 – 421	Combined sources	3
Helixⁱ	426 – 432	Combined sources	7
Helixⁱ	433 – 435	Combined sources	3
Beta strandⁱ	438 – 443	Combined sources	6
Helixⁱ	445 – 448	Combined sources	4
Beta strandⁱ	450 – 457	Combined sources	8
Turnⁱ	458 – 460	Combined sources	3
Beta strandⁱ	464 – 467	Combined sources	4
Helixⁱ	470 – 484	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UHN1
SMRⁱ	Q9UHN1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UHN1

EvolutionaryTraceⁱ

Q9UHN1

Family & Domainsⁱ

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG2298 Eukaryota COG0423 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000244
HOGENOMⁱ	HOG000049133
HOVERGENⁱ	HBG051401
InParanoidⁱ	Q9UHN1
KEGG Orthology (KO) More...KOⁱ	K02333
OMAⁱ	NFPWGKE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B28
PhylomeDBⁱ	Q9UHN1
TreeFamⁱ	TF103005

Family and domain databases

Gene3Dⁱ	3.40.50.800, 1 hit
InterProⁱ	View protein in InterPro IPR004154 Anticodon-bd IPR036621 Anticodon-bd_dom_sf IPR027031 Gly-tRNA_synthase/POLG2 IPR027030 POLG2
PANTHERⁱ	PTHR10745 PTHR10745, 1 hit PTHR10745:SF8 PTHR10745:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03129 HGTP_anticodon, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9UHN1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRSRVAVRAC HKVCRCLLSG FGGRVDAGQP ELLTERSSPK GGHVKSHAEL 
        60         70         80         90        100
EGNGEHPEAP GSGEGSEALL EICQRRHFLS GSKQQLSRDS LLSGCHPGFG 
       110        120        130        140        150
PLGVELRKNL AAEWWTSVVV FREQVFPVDA LHHKPGPLLP GDSAFRLVSA 
       160        170        180        190        200
ETLREILQDK ELSKEQLVAF LENVLKTSGK LRENLLHGAL EHYVNCLDLV 
       210        220        230        240        250
NKRLPYGLAQ IGVCFHPVFD TKQIRNGVKS IGEKTEASLV WFTPPRTSNQ 
       260        270        280        290        300
WLDFWLRHRL QWWRKFAMSP SNFSSSDCQD EEGRKGNKLY YNFPWGKELI 
       310        320        330        340        350
ETLWNLGDHE LLHMYPGNVS KLHGRDGRKN VVPCVLSVNG DLDRGMLAYL 
       360        370        380        390        400
YDSFQLTENS FTRKKNLHRK VLKLHPCLAP IKVALDVGRG PTLELRQVCQ 
       410        420        430        440        450
GLFNELLENG ISVWPGYLET MQSSLEQLYS KYDEMSILFT VLVTETTLEN 
       460        470        480 
GLIHLRSRDT TMKEMMHISK LKDFLIKYIS SAKNV

Length:485

Mass (Da):54,911

Last modified:May 1, 2000 - v1

Checksum:ⁱB99734BFEA249192

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3QRU9	J3QRU9_HUMAN	DNA polymerase subunit gamma-2, mit... DNA polymerase subunit gamma-2, mitochondrial	POLG2	81	Annotation score:
J3KRM2	J3KRM2_HUMAN	DNA polymerase subunit gamma-2, mit... DNA polymerase subunit gamma-2, mitochondrial	POLG2	151	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	114 – 124	WWTSVVVFREQ → MVDLGGGVHGA in AAC51321 (PubMed:9153213).CuratedAdd BLAST	11
Sequence conflictⁱ	122	R → T in AAD56542 (PubMed:10677218).Curated	1
Sequence conflictⁱ	136	G → S in AAD56542 (PubMed:10677218).Curated	1
Sequence conflictⁱ	136	G → S in AAC51321 (PubMed:9153213).Curated	1
Sequence conflictⁱ	287 – 292	NKLYYN → TNFTTI in AAC51321 (PubMed:9153213).Curated	6

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_032028	169	A → T2 PublicationsCorresponds to variant dbSNP:rs1427463EnsemblClinVar.	1
Natural variantⁱVAR_078773	182	R → W Probable disease-associated mutation found in a patient with fulminant hepatic failure and mitochondrial DNA depletion. 1 PublicationCorresponds to variant dbSNP:rs886037843EnsemblClinVar.	1
Natural variantⁱVAR_032029	416	G → A Polymorphism; no functional deficit. 2 PublicationsCorresponds to variant dbSNP:rs17850455EnsemblClinVar.	1
Natural variantⁱVAR_029364	451	G → E in PEOA4; affects stimulation of the catalytic subunit. 1 PublicationCorresponds to variant dbSNP:rs104894632EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF142992 mRNA Translation: AAD50382.1 AF177201 mRNA Translation: AAD56640.1 AF184344 mRNA Translation: AAD56542.1 BC000913 mRNA Translation: AAH00913.2 BC009194 mRNA Translation: AAH09194.1 U94703 mRNA Translation: AAC51321.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32706.1
NCBI Reference Sequences More...RefSeqⁱ	NP_009146.2, NM_007215.3
UniGeneⁱ	Hs.437009

Genome annotation databases

Ensemblⁱ	ENST00000539111; ENSP00000442563; ENSG00000256525
GeneIDⁱ	11232
KEGGⁱ	hsa:11232
UCSC genome browser More...UCSCⁱ	uc002jei.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UHN1	Mitochondrial DNA polymerase subunit gamma-2		HUMAN		485	UniRef100_Q9UHN1
UPI0001BE6592		HUMAN		427

Protein	Similar proteins		Species	Score	Length	Source
Q9UHN1	Mitochondrial DNA polymerase subunit gamma-2		HUMAN		485	UniRef90_Q9UHN1
DNA polymerase gamma 2, accessory subunit		MACMU		485
Uncharacterized protein		MACFA		485
DNA polymerase gamma 2, accessory subunit		PANTR		485
DNA polymerase gamma 2, accessory subunit		CALJA		485
+33

Protein	Similar proteins		Species	Score	Length	Source
Q9UHN1	DNA polymerase subunit gamma-2, mitochondrial		BOVIN		485	UniRef50_Q9UHN1
Mitochondrial DNA polymerase subunit gamma-2		HUMAN		485
POLG2 isoform 1		PONAB		485
Uncharacterized protein		PANPA		485
Uncharacterized protein		MANLE		485
+199

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF142992 mRNA Translation: AAD50382.1 AF177201 mRNA Translation: AAD56640.1 AF184344 mRNA Translation: AAD56542.1 BC000913 mRNA Translation: AAH00913.2 BC009194 mRNA Translation: AAH09194.1 U94703 mRNA Translation: AAC51321.1
CCDSⁱ	CCDS32706.1
RefSeqⁱ	NP_009146.2, NM_007215.3
UniGeneⁱ	Hs.437009

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2G4C	X-ray	3.15	A/B/C/D	26-485	[»]
	3IKL	X-ray	3.10	A/B	1-146	[»]
				A/B	181-485	[»]
	3IKM	X-ray	3.24	B/C/E/F	59-485	[»]
	4ZTU	X-ray	3.30	B/C	26-485	[»]
	4ZTZ	X-ray	3.44	B/C	26-485	[»]
	5C51	X-ray	3.43	B/C	1-485	[»]
	5C52	X-ray	3.64	B/C	1-485	[»]
	5C53	X-ray	3.57	B/C	1-485	[»]
ProteinModelPortalⁱ	Q9UHN1
SMRⁱ	Q9UHN1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116398, 14 interactors
ComplexPortalⁱ	CPX-2093 DNA polymerase gamma complex
IntActⁱ	Q9UHN1, 8 interactors
MINTⁱ	Q9UHN1
STRINGⁱ	9606.ENSP00000442563

Chemistry databases

ChEMBLⁱ	CHEMBL3430903

ChEMBLⁱ

CHEMBL3430903

PTM databases

iPTMnetⁱ	Q9UHN1
PhosphoSitePlusⁱ	Q9UHN1

Polymorphism and mutation databases

BioMutaⁱ	POLG2
DMDMⁱ	17367139

Proteomic databases

EPDⁱ	Q9UHN1
MaxQBⁱ	Q9UHN1
PaxDbⁱ	Q9UHN1
PeptideAtlasⁱ	Q9UHN1
PRIDEⁱ	Q9UHN1
ProteomicsDBⁱ	84382

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000539111; ENSP00000442563; ENSG00000256525
GeneIDⁱ	11232
KEGGⁱ	hsa:11232
UCSCⁱ	uc002jei.4 human

Organism-specific databases

CTDⁱ	11232
DisGeNETⁱ	11232
EuPathDBⁱ	HostDB:ENSG00000256525.6
GeneCardsⁱ	POLG2
HGNCⁱ	HGNC:9180 POLG2
HPAⁱ	CAB017030 HPA023202
MalaCardsⁱ	POLG2
MIMⁱ	604983 gene 610131 phenotype
neXtProtⁱ	NX_Q9UHN1
OpenTargetsⁱ	ENSG00000256525
Orphanetⁱ	254892 Autosomal dominant progressive external ophthalmoplegia
PharmGKBⁱ	PA33501
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2298 Eukaryota COG0423 LUCA
GeneTreeⁱ	ENSGT00390000000244
HOGENOMⁱ	HOG000049133
HOVERGENⁱ	HBG051401
InParanoidⁱ	Q9UHN1
KOⁱ	K02333
OMAⁱ	NFPWGKE
OrthoDBⁱ	EOG091G0B28
PhylomeDBⁱ	Q9UHN1
TreeFamⁱ	TF103005

Enzyme and pathway databases

BRENDAⁱ	2.7.7.7 2681
Reactomeⁱ	R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis

Miscellaneous databases

ChiTaRSⁱ	POLG2 human
EvolutionaryTraceⁱ	Q9UHN1
GeneWikiⁱ	POLG2
GenomeRNAiⁱ	11232
Protein Ontology More...PROⁱ	PR:Q9UHN1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000256525 Expressed in 205 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_POLG2
ExpressionAtlasⁱ	Q9UHN1 baseline and differential
Genevisibleⁱ	Q9UHN1 HS

Family and domain databases

Gene3Dⁱ	3.40.50.800, 1 hit
InterProⁱ	View protein in InterPro IPR004154 Anticodon-bd IPR036621 Anticodon-bd_dom_sf IPR027031 Gly-tRNA_synthase/POLG2 IPR027030 POLG2
PANTHERⁱ	PTHR10745 PTHR10745, 1 hit PTHR10745:SF8 PTHR10745:SF8, 1 hit
Pfamⁱ	View protein in Pfam PF03129 HGTP_anticodon, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DPOG2_HUMAN
Accessionⁱ	Q9UHN1Primary (citable) accession number: Q9UHN1 Secondary accession number(s): O00419 , Q0IJ81, Q96GW2, Q9UK35, Q9UK94
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UHN1 (DPOG2_HUMAN)

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DNA polymerase subunit gamma-2, mitochondrial

POLG2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ