UniProtKB - Q9UHL4 (DPP2_HUMAN)
Protein
Dipeptidyl peptidase 2
Gene
DPP7
Organism
Homo sapiens (Human)
Status
Functioni
Plays an important role in the degradation of some oligopeptides.1 Publication
Catalytic activityi
- Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.1 Publication EC:3.4.14.2
pH dependencei
Optimum pH is 5.5. Has low activity at pH 7 and is inactive at pH 8.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 162 | Charge relay systemSequence analysis | 1 | |
Active sitei | 418 | Charge relay systemSequence analysis | 1 | |
Active sitei | 443 | Charge relay systemSequence analysis | 1 |
GO - Molecular functioni
- dipeptidyl-peptidase activity Source: GO_Central
- serine-type peptidase activity Source: ProtInc
GO - Biological processi
- neutrophil degranulation Source: Reactome
- proteolysis Source: GO_Central
Keywordsi
Molecular function | Aminopeptidase, Hydrolase, Protease, Serine protease |
Enzyme and pathway databases
BRENDAi | 3.4.14.2, 2681 |
PathwayCommonsi | Q9UHL4 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Protein family/group databases
ESTHERi | human-DPP7, Prolylcarboxypeptidase |
MEROPSi | S28.002 |
Names & Taxonomyi
Protein namesi | Recommended name: Dipeptidyl peptidase 2 (EC:3.4.14.2)Alternative name(s): Dipeptidyl aminopeptidase II Dipeptidyl peptidase 7 Dipeptidyl peptidase II Short name: DPP II Quiescent cell proline dipeptidase |
Gene namesi | Name:DPP7 Synonyms:DPP2, QPP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14892, DPP7 |
MIMi | 610537, gene |
neXtProti | NX_Q9UHL4 |
VEuPathDBi | HostDB:ENSG00000176978.13 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Lysosome
- Lysosome 1 Publication
Other locations
- Cytoplasmic vesicle 1 Publication
Cytosol
- cytosol Source: Ensembl
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Golgi apparatus
- Golgi apparatus Source: HPA
Lysosome
- azurophil granule lumen Source: Reactome
Other locations
- intracellular membrane-bounded organelle Source: HPA
- vesicle Source: CACAO
Keywords - Cellular componenti
Cytoplasmic vesicle, Lysosome, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 29952 |
OpenTargetsi | ENSG00000176978 |
PharmGKBi | PA27469 |
Miscellaneous databases
Pharosi | Q9UHL4, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3976 |
DrugCentrali | Q9UHL4 |
GuidetoPHARMACOLOGYi | 1605 |
Genetic variation databases
BioMutai | DPP7 |
DMDMi | 212276510 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000027314 | 22 – 25 | Sequence analysis | 4 | |
ChainiPRO_0000027315 | 26 – 492 | Dipeptidyl peptidase 2Add BLAST | 467 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 50 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 86 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 315 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 356 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 363 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 428 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.2 Publications
Keywords - PTMi
Cleavage on pair of basic residues, Glycoprotein, ZymogenProteomic databases
CPTACi | CPTAC-1304 |
EPDi | Q9UHL4 |
jPOSTi | Q9UHL4 |
MassIVEi | Q9UHL4 |
MaxQBi | Q9UHL4 |
PaxDbi | Q9UHL4 |
PeptideAtlasi | Q9UHL4 |
PRIDEi | Q9UHL4 |
ProteomicsDBi | 84375 |
PTM databases
GlyConnecti | 1176, 6 N-Linked glycans (2 sites) |
GlyGeni | Q9UHL4, 6 sites |
iPTMneti | Q9UHL4 |
PhosphoSitePlusi | Q9UHL4 |
Expressioni
Tissue specificityi
Detected in seminal plasma (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000176978, Expressed in left lobe of thyroid gland and 203 other tissues |
ExpressionAtlasi | Q9UHL4, baseline and differential |
Genevisiblei | Q9UHL4, HS |
Organism-specific databases
HPAi | ENSG00000176978, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 118989, 23 interactors |
IntActi | Q9UHL4, 29 interactors |
MINTi | Q9UHL4 |
STRINGi | 9606.ENSP00000360635 |
Chemistry databases
BindingDBi | Q9UHL4 |
Miscellaneous databases
RNActi | Q9UHL4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UHL4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UHL4 |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase S28 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2183, Eukaryota |
GeneTreei | ENSGT00940000159838 |
HOGENOMi | CLU_020959_0_0_1 |
InParanoidi | Q9UHL4 |
OMAi | AFQQIKD |
OrthoDBi | 555765at2759 |
PhylomeDBi | Q9UHL4 |
TreeFami | TF314414 |
Family and domain databases
Gene3Di | 1.20.120.980, 1 hit 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR008758, Peptidase_S28 IPR042269, Ser_carbopepase_S28_SKS |
Pfami | View protein in Pfam PF05577, Peptidase_S28, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9UHL4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSAPWAPVL LLALGLRGLQ AGARRAPDPG FQERFFQQRL DHFNFERFGN
60 70 80 90 100
KTFPQRFLVS DRFWVRGEGP IFFYTGNEGD VWAFANNSAF VAELAAERGA
110 120 130 140 150
LLVFAEHRYY GKSLPFGAQS TQRGHTELLT VEQALADFAE LLRALRRDLG
160 170 180 190 200
AQDAPAIAFG GSYGGMLSAY LRMKYPHLVA GALAASAPVL AVAGLGDSNQ
210 220 230 240 250
FFRDVTADFE GQSPKCTQGV REAFRQIKDL FLQGAYDTVR WEFGTCQPLS
260 270 280 290 300
DEKDLTQLFM FARNAFTVLA MMDYPYPTDF LGPLPANPVK VGCDRLLSEA
310 320 330 340 350
QRITGLRALA GLVYNASGSE HCYDIYRLYH SCADPTGCGT GPDARAWDYQ
360 370 380 390 400
ACTEINLTFA SNNVTDMFPD LPFTDELRQR YCLDTWGVWP RPDWLLTSFW
410 420 430 440 450
GGDLRAASNI IFSNGNLDPW AGGGIRRNLS ASVIAVTIQG GAHHLDLRAS
460 470 480 490
HPEDPASVVE ARKLEATIIG EWVKAARREQ QPALRGGPRL SL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketR4GMR2 | R4GMR2_HUMAN | Dipeptidyl peptidase 2 | DPP7 | 244 | Annotation score: | ||
R4GNE8 | R4GNE8_HUMAN | Dipeptidyl peptidase 2 | DPP7 | 272 | Annotation score: | ||
R4GMV4 | R4GMV4_HUMAN | Dipeptidyl peptidase 2 | DPP7 | 120 | Annotation score: | ||
R4GMU5 | R4GMU5_HUMAN | Dipeptidyl peptidase 2 | DPP7 | 61 | Annotation score: | ||
R4GN05 | R4GN05_HUMAN | Dipeptidyl peptidase 2 | DPP7 | 155 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 71 | I → T in AAF12747 (PubMed:10567372).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047087 | 89 | A → G2 PublicationsCorresponds to variant dbSNP:rs10747049Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF154502 mRNA Translation: AAF12747.1 AK292112 mRNA Translation: BAF84801.1 AL929554 Genomic DNA No translation available. BC011907 mRNA Translation: AAH11907.1 BC016961 mRNA Translation: AAH16961.1 |
CCDSi | CCDS7030.1 |
PIRi | S77568 |
RefSeqi | NP_037511.2, NM_013379.2 |
Genome annotation databases
Ensembli | ENST00000371579; ENSP00000360635; ENSG00000176978 |
GeneIDi | 29952 |
KEGGi | hsa:29952 |
UCSCi | uc004clh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF154502 mRNA Translation: AAF12747.1 AK292112 mRNA Translation: BAF84801.1 AL929554 Genomic DNA No translation available. BC011907 mRNA Translation: AAH11907.1 BC016961 mRNA Translation: AAH16961.1 |
CCDSi | CCDS7030.1 |
PIRi | S77568 |
RefSeqi | NP_037511.2, NM_013379.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3JYH | X-ray | 2.19 | A/B/C/D | 28-492 | [»] | |
3N0T | X-ray | 2.45 | A/B/C/D | 28-492 | [»] | |
4EBB | X-ray | 2.00 | A/B | 27-492 | [»] | |
SMRi | Q9UHL4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118989, 23 interactors |
IntActi | Q9UHL4, 29 interactors |
MINTi | Q9UHL4 |
STRINGi | 9606.ENSP00000360635 |
Chemistry databases
BindingDBi | Q9UHL4 |
ChEMBLi | CHEMBL3976 |
DrugCentrali | Q9UHL4 |
GuidetoPHARMACOLOGYi | 1605 |
Protein family/group databases
ESTHERi | human-DPP7, Prolylcarboxypeptidase |
MEROPSi | S28.002 |
PTM databases
GlyConnecti | 1176, 6 N-Linked glycans (2 sites) |
GlyGeni | Q9UHL4, 6 sites |
iPTMneti | Q9UHL4 |
PhosphoSitePlusi | Q9UHL4 |
Genetic variation databases
BioMutai | DPP7 |
DMDMi | 212276510 |
Proteomic databases
CPTACi | CPTAC-1304 |
EPDi | Q9UHL4 |
jPOSTi | Q9UHL4 |
MassIVEi | Q9UHL4 |
MaxQBi | Q9UHL4 |
PaxDbi | Q9UHL4 |
PeptideAtlasi | Q9UHL4 |
PRIDEi | Q9UHL4 |
ProteomicsDBi | 84375 |
Protocols and materials databases
Antibodypediai | 18905, 289 antibodies |
DNASUi | 29952 |
Genome annotation databases
Ensembli | ENST00000371579; ENSP00000360635; ENSG00000176978 |
GeneIDi | 29952 |
KEGGi | hsa:29952 |
UCSCi | uc004clh.4, human |
Organism-specific databases
CTDi | 29952 |
DisGeNETi | 29952 |
GeneCardsi | DPP7 |
HGNCi | HGNC:14892, DPP7 |
HPAi | ENSG00000176978, Low tissue specificity |
MIMi | 610537, gene |
neXtProti | NX_Q9UHL4 |
OpenTargetsi | ENSG00000176978 |
PharmGKBi | PA27469 |
VEuPathDBi | HostDB:ENSG00000176978.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2183, Eukaryota |
GeneTreei | ENSGT00940000159838 |
HOGENOMi | CLU_020959_0_0_1 |
InParanoidi | Q9UHL4 |
OMAi | AFQQIKD |
OrthoDBi | 555765at2759 |
PhylomeDBi | Q9UHL4 |
TreeFami | TF314414 |
Enzyme and pathway databases
BRENDAi | 3.4.14.2, 2681 |
PathwayCommonsi | Q9UHL4 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 29952, 8 hits in 873 CRISPR screens |
ChiTaRSi | DPP7, human |
EvolutionaryTracei | Q9UHL4 |
GeneWikii | DPP7 |
GenomeRNAii | 29952 |
Pharosi | Q9UHL4, Tchem |
PROi | PR:Q9UHL4 |
RNActi | Q9UHL4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176978, Expressed in left lobe of thyroid gland and 203 other tissues |
ExpressionAtlasi | Q9UHL4, baseline and differential |
Genevisiblei | Q9UHL4, HS |
Family and domain databases
Gene3Di | 1.20.120.980, 1 hit 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR008758, Peptidase_S28 IPR042269, Ser_carbopepase_S28_SKS |
Pfami | View protein in Pfam PF05577, Peptidase_S28, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DPP2_HUMAN | |
Accessioni | Q9UHL4Primary (citable) accession number: Q9UHL4 Secondary accession number(s): A8K7U7, Q5VSF1, Q969X4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | November 4, 2008 | |
Last modified: | February 10, 2021 | |
This is version 179 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Peptidase families
Classification of peptidase families and list of entries