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Entry version 161 (13 Feb 2019)
Sequence version 3 (18 May 2010)
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Protein

Solute carrier family 23 member 1

Gene

SLC23A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

Miscellaneous

Treatment with the protein kinase C stimulator PMA results in a 10-fold decrease in ascorbate accumulation in transfected cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dehydroascorbic acid transmembrane transporter activity Source: UniProtKB
  • L-ascorbate:sodium symporter activity Source: UniProtKB
  • L-ascorbic acid transmembrane transporter activity Source: UniProtKB
  • nucleobase transmembrane transporter activity Source: ProtInc
  • sodium-dependent L-ascorbate transmembrane transporter activity Source: UniProtKB
  • sodium ion transmembrane transporter activity Source: UniProtKB
  • transporter activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196836 Vitamin C (ascorbate) metabolism

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.40.6.5 the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 23 member 1
Alternative name(s):
Na(+)/L-ascorbic acid transporter 1
Sodium-dependent vitamin C transporter 1
Short name:
hSVCT1
Yolk sac permease-like molecule 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC23A1
Synonyms:SVCT1, YSPL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170482.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10974 SLC23A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603790 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UHI7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 81ExtracellularSequence analysis8
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103CytoplasmicSequence analysis1
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 159ExtracellularSequence analysisAdd BLAST35
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 207CytoplasmicSequence analysisAdd BLAST27
Transmembranei208 – 225HelicalSequence analysisAdd BLAST18
Topological domaini226 – 229ExtracellularSequence analysis4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei230 – 243HelicalSequence analysisAdd BLAST14
Topological domaini244 – 250ExtracellularSequence analysis7
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 312CytoplasmicSequence analysisAdd BLAST41
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 358ExtracellularSequence analysisAdd BLAST25
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Topological domaini380 – 402CytoplasmicSequence analysisAdd BLAST23
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 426ExtracellularSequence analysis3
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 457CytoplasmicSequence analysis10
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 490ExtracellularSequence analysisAdd BLAST12
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 598CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9963

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35850

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00126 Vitamin C

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1041

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC23A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452969

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001659751 – 598Solute carrier family 23 member 1Add BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi138N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi144N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei591PhosphothreonineBy similarity1
Modified residuei593PhosphoserineBy similarity1
Modified residuei596PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UHI7

PeptideAtlas

More...
PeptideAtlasi
Q9UHI7

PRoteomics IDEntifications database

More...
PRIDEi
Q9UHI7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84358
84359 [Q9UHI7-2]
84360 [Q9UHI7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UHI7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UHI7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170482 Expressed in 98 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UHI7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UHI7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047612

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115288, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UHI7, 24 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302851

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UHI7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1292 Eukaryota
COG2233 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000038201

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056256

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UHI7

KEGG Orthology (KO)

More...
KOi
K14611

Database of Orthologous Groups

More...
OrthoDBi
1337671at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UHI7

TreeFam database of animal gene trees

More...
TreeFami
TF313272

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029954 SLC23A1
IPR006043 Xant/urac/vitC

The PANTHER Classification System

More...
PANTHERi
PTHR11119:SF21 PTHR11119:SF21, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00860 Xan_ur_permease, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UHI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAQEDLEGR TQHETTRDPS TPLPTEPKFD MLYKIEDVPP WYLCILLGFQ
60 70 80 90 100
HYLTCFSGTI AVPFLLAEAL CVGHDQHMVS QLIGTIFTCV GITTLIQTTV
110 120 130 140 150
GIRLPLFQAS AFAFLVPAKA ILALERWKCP PEEEIYGNWS LPLNTSHIWH
160 170 180 190 200
PRIREVQGAI MVSSVVEVVI GLLGLPGALL NYIGPLTVTP TVSLIGLSVF
210 220 230 240 250
QAAGDRAGSH WGISACSILL IILFSQYLRN LTFLLPVYRW GKGLTLLRIQ
260 270 280 290 300
IFKMFPIMLA IMTVWLLCYV LTLTDVLPTD PKAYGFQART DARGDIMAIA
310 320 330 340 350
PWIRIPYPCQ WGLPTVTAAA VLGMFSATLA GIIESIGDYY ACARLAGAPP
360 370 380 390 400
PPVHAINRGI FTEGICCIIA GLLGTGNGST SSSPNIGVLG ITKVGSRRVV
410 420 430 440 450
QYGAAIMLVL GTIGKFTALF SSLPDPILGG MFCTLFGMIT AVGLSNLQFV
460 470 480 490 500
DMNSSRNLFV LGFSMFFGLT LPNYLESNPG AINTGILEVD QILIVLLTTE
510 520 530 540 550
MFVGGCLAFI LDNTVPGSPE ERGLIQWKAG AHANSDMSSS LKSYDFPIGM
560 570 580 590
GIVKRITFLK YIPICPVFKG FSSSSKDQIA IPEDTPENTE TASVCTKV
Length:598
Mass (Da):64,831
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1191B2B43CE76FD6
GO
Isoform 2 (identifier: Q9UHI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-156: V → VGLHV

Note: Inactive.
Show »
Length:602
Mass (Da):65,238
Checksum:i0D03E3405E2E1EB3
GO
Isoform 3 (identifier: Q9UHI7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-430: Missing.

Show »
Length:259
Mass (Da):28,531
Checksum:i1F422EEA2AE6A2C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAJ1H0YAJ1_HUMAN
Solute carrier family 23 member 1
SLC23A1
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y902H0Y902_HUMAN
Solute carrier family 23 member 1
SLC23A1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11T → A in AAF24759 (PubMed:10556483).Curated1
Sequence conflicti52 – 57YLTCFS → IHDCLR in AAC78804 (PubMed:9804989).Curated6
Sequence conflicti75 – 80DQHMVS → SQTLHC in AAC78804 (PubMed:9804989).Curated6
Sequence conflicti139W → S in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti153I → N in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti155E → D in AAF22490 (PubMed:10556483).Curated1
Sequence conflicti182 – 183YI → SL in AAC78804 (PubMed:9804989).Curated2
Sequence conflicti207A → P in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti269Y → I in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti275D → E in AAF22490 (PubMed:10556483).Curated1
Sequence conflicti284Y → I in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti434T → S in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti451 – 452DM → AL in AAC78804 (PubMed:9804989).Curated2
Sequence conflicti476 – 477ES → SP in AAF22490 (PubMed:10556483).Curated2
Sequence conflicti548I → F in AAC78804 (PubMed:9804989).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053451218I → V. Corresponds to variant dbSNP:rs34521685Ensembl.1
Natural variantiVAR_053452258M → V. Corresponds to variant dbSNP:rs35817838Ensembl.1
Natural variantiVAR_053453264V → M. Corresponds to variant dbSNP:rs33972313Ensembl.1
Natural variantiVAR_062111421S → A7 PublicationsCorresponds to variant dbSNP:rs6596474Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00681392 – 430Missing in isoform 3. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_006814156V → VGLHV in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF058317 mRNA Translation: AAC78804.1
AF170911 mRNA Translation: AAF24759.1
AJ269477 mRNA Translation: CAB58119.1
AF098277 mRNA Translation: AAF22490.1
AF375875 Genomic DNA Translation: AAK97398.1
AJ250807 mRNA Translation: CAC15384.1
AC135457 Genomic DNA No translation available.
BC019225 mRNA Translation: AAH19225.1
BC050261 mRNA Translation: AAH50261.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4212.1 [Q9UHI7-1]
CCDS4213.1 [Q9UHI7-2]

Protein sequence database of the Protein Information Resource

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PIRi
JC7182

NCBI Reference Sequences

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RefSeqi
NP_005838.3, NM_005847.4
NP_689898.2, NM_152685.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.643467

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000348729; ENSP00000302701; ENSG00000170482
ENST00000353963; ENSP00000302851; ENSG00000170482

Database of genes from NCBI RefSeq genomes

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GeneIDi
9963

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9963

UCSC genome browser

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UCSCi
uc003leg.4 human [Q9UHI7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058317 mRNA Translation: AAC78804.1
AF170911 mRNA Translation: AAF24759.1
AJ269477 mRNA Translation: CAB58119.1
AF098277 mRNA Translation: AAF22490.1
AF375875 Genomic DNA Translation: AAK97398.1
AJ250807 mRNA Translation: CAC15384.1
AC135457 Genomic DNA No translation available.
BC019225 mRNA Translation: AAH19225.1
BC050261 mRNA Translation: AAH50261.1
CCDSiCCDS4212.1 [Q9UHI7-1]
CCDS4213.1 [Q9UHI7-2]
PIRiJC7182
RefSeqiNP_005838.3, NM_005847.4
NP_689898.2, NM_152685.3
UniGeneiHs.643467

3D structure databases

ProteinModelPortaliQ9UHI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115288, 12 interactors
IntActiQ9UHI7, 24 interactors
STRINGi9606.ENSP00000302851

Chemistry databases

DrugBankiDB00126 Vitamin C
GuidetoPHARMACOLOGYi1041

Protein family/group databases

TCDBi2.A.40.6.5 the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

PTM databases

iPTMnetiQ9UHI7
PhosphoSitePlusiQ9UHI7

Polymorphism and mutation databases

BioMutaiSLC23A1
DMDMi296452969

Proteomic databases

PaxDbiQ9UHI7
PeptideAtlasiQ9UHI7
PRIDEiQ9UHI7
ProteomicsDBi84358
84359 [Q9UHI7-2]
84360 [Q9UHI7-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348729; ENSP00000302701; ENSG00000170482
ENST00000353963; ENSP00000302851; ENSG00000170482
GeneIDi9963
KEGGihsa:9963
UCSCiuc003leg.4 human [Q9UHI7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9963
DisGeNETi9963
EuPathDBiHostDB:ENSG00000170482.16

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC23A1
HGNCiHGNC:10974 SLC23A1
HPAiHPA047612
MIMi603790 gene
neXtProtiNX_Q9UHI7
PharmGKBiPA35850

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1292 Eukaryota
COG2233 LUCA
HOGENOMiHOG000038201
HOVERGENiHBG056256
InParanoidiQ9UHI7
KOiK14611
OrthoDBi1337671at2759
PhylomeDBiQ9UHI7
TreeFamiTF313272

Enzyme and pathway databases

ReactomeiR-HSA-196836 Vitamin C (ascorbate) metabolism

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC23A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9963

Protein Ontology

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PROi
PR:Q9UHI7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170482 Expressed in 98 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ9UHI7 baseline and differential
GenevisibleiQ9UHI7 HS

Family and domain databases

InterProiView protein in InterPro
IPR029954 SLC23A1
IPR006043 Xant/urac/vitC
PANTHERiPTHR11119:SF21 PTHR11119:SF21, 1 hit
PfamiView protein in Pfam
PF00860 Xan_ur_permease, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS23A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHI7
Secondary accession number(s): O95191
, Q8WWB6, Q9UGH4, Q9UI39
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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