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Protein

Solute carrier family 23 member 1

Gene

SLC23A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

Miscellaneous

Treatment with the protein kinase C stimulator PMA results in a 10-fold decrease in ascorbate accumulation in transfected cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-196836 Vitamin C (ascorbate) metabolism

Protein family/group databases

TCDBi2.A.40.6.5 the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 1
Alternative name(s):
Na(+)/L-ascorbic acid transporter 1
Sodium-dependent vitamin C transporter 1
Short name:
hSVCT1
Yolk sac permease-like molecule 3
Gene namesi
Name:SLC23A1
Synonyms:SVCT1, YSPL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170482.16
HGNCiHGNC:10974 SLC23A1
MIMi603790 gene
neXtProtiNX_Q9UHI7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 81ExtracellularSequence analysis8
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103CytoplasmicSequence analysis1
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 159ExtracellularSequence analysisAdd BLAST35
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 207CytoplasmicSequence analysisAdd BLAST27
Transmembranei208 – 225HelicalSequence analysisAdd BLAST18
Topological domaini226 – 229ExtracellularSequence analysis4
Intramembranei230 – 243HelicalSequence analysisAdd BLAST14
Topological domaini244 – 250ExtracellularSequence analysis7
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 312CytoplasmicSequence analysisAdd BLAST41
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 358ExtracellularSequence analysisAdd BLAST25
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Topological domaini380 – 402CytoplasmicSequence analysisAdd BLAST23
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 426ExtracellularSequence analysis3
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 457CytoplasmicSequence analysis10
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 490ExtracellularSequence analysisAdd BLAST12
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 598CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9963
PharmGKBiPA35850

Chemistry databases

DrugBankiDB00126 Vitamin C
GuidetoPHARMACOLOGYi1041

Polymorphism and mutation databases

BioMutaiSLC23A1
DMDMi296452969

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659751 – 598Solute carrier family 23 member 1Add BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi138N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi144N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei591PhosphothreonineBy similarity1
Modified residuei593PhosphoserineBy similarity1
Modified residuei596PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UHI7
PeptideAtlasiQ9UHI7
PRIDEiQ9UHI7
ProteomicsDBi84358
84359 [Q9UHI7-2]
84360 [Q9UHI7-3]

PTM databases

iPTMnetiQ9UHI7
PhosphoSitePlusiQ9UHI7

Expressioni

Tissue specificityi

Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.

Gene expression databases

BgeeiENSG00000170482 Expressed in 98 organ(s), highest expression level in right uterine tube
CleanExiHS_SLC23A1
ExpressionAtlasiQ9UHI7 baseline and differential
GenevisibleiQ9UHI7 HS

Organism-specific databases

HPAiHPA047612

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi115288, 12 interactors
IntActiQ9UHI7, 24 interactors
STRINGi9606.ENSP00000302851

Structurei

3D structure databases

ProteinModelPortaliQ9UHI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292 Eukaryota
COG2233 LUCA
HOGENOMiHOG000038201
HOVERGENiHBG056256
InParanoidiQ9UHI7
KOiK14611
OrthoDBiEOG091G063Y
PhylomeDBiQ9UHI7
TreeFamiTF313272

Family and domain databases

InterProiView protein in InterPro
IPR029954 SLC23A1
IPR006043 Xant/urac/vitC
PANTHERiPTHR11119:SF21 PTHR11119:SF21, 1 hit
PfamiView protein in Pfam
PF00860 Xan_ur_permease, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UHI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAQEDLEGR TQHETTRDPS TPLPTEPKFD MLYKIEDVPP WYLCILLGFQ
60 70 80 90 100
HYLTCFSGTI AVPFLLAEAL CVGHDQHMVS QLIGTIFTCV GITTLIQTTV
110 120 130 140 150
GIRLPLFQAS AFAFLVPAKA ILALERWKCP PEEEIYGNWS LPLNTSHIWH
160 170 180 190 200
PRIREVQGAI MVSSVVEVVI GLLGLPGALL NYIGPLTVTP TVSLIGLSVF
210 220 230 240 250
QAAGDRAGSH WGISACSILL IILFSQYLRN LTFLLPVYRW GKGLTLLRIQ
260 270 280 290 300
IFKMFPIMLA IMTVWLLCYV LTLTDVLPTD PKAYGFQART DARGDIMAIA
310 320 330 340 350
PWIRIPYPCQ WGLPTVTAAA VLGMFSATLA GIIESIGDYY ACARLAGAPP
360 370 380 390 400
PPVHAINRGI FTEGICCIIA GLLGTGNGST SSSPNIGVLG ITKVGSRRVV
410 420 430 440 450
QYGAAIMLVL GTIGKFTALF SSLPDPILGG MFCTLFGMIT AVGLSNLQFV
460 470 480 490 500
DMNSSRNLFV LGFSMFFGLT LPNYLESNPG AINTGILEVD QILIVLLTTE
510 520 530 540 550
MFVGGCLAFI LDNTVPGSPE ERGLIQWKAG AHANSDMSSS LKSYDFPIGM
560 570 580 590
GIVKRITFLK YIPICPVFKG FSSSSKDQIA IPEDTPENTE TASVCTKV
Length:598
Mass (Da):64,831
Last modified:May 18, 2010 - v3
Checksum:i1191B2B43CE76FD6
GO
Isoform 2 (identifier: Q9UHI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-156: V → VGLHV

Note: Inactive.
Show »
Length:602
Mass (Da):65,238
Checksum:i0D03E3405E2E1EB3
GO
Isoform 3 (identifier: Q9UHI7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-430: Missing.

Show »
Length:259
Mass (Da):28,531
Checksum:i1F422EEA2AE6A2C5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAJ1H0YAJ1_HUMAN
Solute carrier family 23 member 1
SLC23A1
169Annotation score:
H0Y902H0Y902_HUMAN
Solute carrier family 23 member 1
SLC23A1
136Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11T → A in AAF24759 (PubMed:10556483).Curated1
Sequence conflicti52 – 57YLTCFS → IHDCLR in AAC78804 (PubMed:9804989).Curated6
Sequence conflicti75 – 80DQHMVS → SQTLHC in AAC78804 (PubMed:9804989).Curated6
Sequence conflicti139W → S in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti153I → N in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti155E → D in AAF22490 (PubMed:10556483).Curated1
Sequence conflicti182 – 183YI → SL in AAC78804 (PubMed:9804989).Curated2
Sequence conflicti207A → P in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti269Y → I in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti275D → E in AAF22490 (PubMed:10556483).Curated1
Sequence conflicti284Y → I in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti434T → S in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti451 – 452DM → AL in AAC78804 (PubMed:9804989).Curated2
Sequence conflicti476 – 477ES → SP in AAF22490 (PubMed:10556483).Curated2
Sequence conflicti548I → F in AAC78804 (PubMed:9804989).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053451218I → V. Corresponds to variant dbSNP:rs34521685Ensembl.1
Natural variantiVAR_053452258M → V. Corresponds to variant dbSNP:rs35817838Ensembl.1
Natural variantiVAR_053453264V → M. Corresponds to variant dbSNP:rs33972313Ensembl.1
Natural variantiVAR_062111421S → A7 PublicationsCorresponds to variant dbSNP:rs6596474Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00681392 – 430Missing in isoform 3. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_006814156V → VGLHV in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058317 mRNA Translation: AAC78804.1
AF170911 mRNA Translation: AAF24759.1
AJ269477 mRNA Translation: CAB58119.1
AF098277 mRNA Translation: AAF22490.1
AF375875 Genomic DNA Translation: AAK97398.1
AJ250807 mRNA Translation: CAC15384.1
AC135457 Genomic DNA No translation available.
BC019225 mRNA Translation: AAH19225.1
BC050261 mRNA Translation: AAH50261.1
CCDSiCCDS4212.1 [Q9UHI7-1]
CCDS4213.1 [Q9UHI7-2]
PIRiJC7182
RefSeqiNP_005838.3, NM_005847.4
NP_689898.2, NM_152685.3
UniGeneiHs.643467

Genome annotation databases

EnsembliENST00000348729; ENSP00000302701; ENSG00000170482
ENST00000353963; ENSP00000302851; ENSG00000170482
GeneIDi9963
KEGGihsa:9963
UCSCiuc003leg.4 human [Q9UHI7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058317 mRNA Translation: AAC78804.1
AF170911 mRNA Translation: AAF24759.1
AJ269477 mRNA Translation: CAB58119.1
AF098277 mRNA Translation: AAF22490.1
AF375875 Genomic DNA Translation: AAK97398.1
AJ250807 mRNA Translation: CAC15384.1
AC135457 Genomic DNA No translation available.
BC019225 mRNA Translation: AAH19225.1
BC050261 mRNA Translation: AAH50261.1
CCDSiCCDS4212.1 [Q9UHI7-1]
CCDS4213.1 [Q9UHI7-2]
PIRiJC7182
RefSeqiNP_005838.3, NM_005847.4
NP_689898.2, NM_152685.3
UniGeneiHs.643467

3D structure databases

ProteinModelPortaliQ9UHI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115288, 12 interactors
IntActiQ9UHI7, 24 interactors
STRINGi9606.ENSP00000302851

Chemistry databases

DrugBankiDB00126 Vitamin C
GuidetoPHARMACOLOGYi1041

Protein family/group databases

TCDBi2.A.40.6.5 the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

PTM databases

iPTMnetiQ9UHI7
PhosphoSitePlusiQ9UHI7

Polymorphism and mutation databases

BioMutaiSLC23A1
DMDMi296452969

Proteomic databases

PaxDbiQ9UHI7
PeptideAtlasiQ9UHI7
PRIDEiQ9UHI7
ProteomicsDBi84358
84359 [Q9UHI7-2]
84360 [Q9UHI7-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348729; ENSP00000302701; ENSG00000170482
ENST00000353963; ENSP00000302851; ENSG00000170482
GeneIDi9963
KEGGihsa:9963
UCSCiuc003leg.4 human [Q9UHI7-1]

Organism-specific databases

CTDi9963
DisGeNETi9963
EuPathDBiHostDB:ENSG00000170482.16
GeneCardsiSLC23A1
HGNCiHGNC:10974 SLC23A1
HPAiHPA047612
MIMi603790 gene
neXtProtiNX_Q9UHI7
PharmGKBiPA35850
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1292 Eukaryota
COG2233 LUCA
HOGENOMiHOG000038201
HOVERGENiHBG056256
InParanoidiQ9UHI7
KOiK14611
OrthoDBiEOG091G063Y
PhylomeDBiQ9UHI7
TreeFamiTF313272

Enzyme and pathway databases

ReactomeiR-HSA-196836 Vitamin C (ascorbate) metabolism

Miscellaneous databases

GeneWikiiSLC23A1
GenomeRNAii9963
PROiPR:Q9UHI7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170482 Expressed in 98 organ(s), highest expression level in right uterine tube
CleanExiHS_SLC23A1
ExpressionAtlasiQ9UHI7 baseline and differential
GenevisibleiQ9UHI7 HS

Family and domain databases

InterProiView protein in InterPro
IPR029954 SLC23A1
IPR006043 Xant/urac/vitC
PANTHERiPTHR11119:SF21 PTHR11119:SF21, 1 hit
PfamiView protein in Pfam
PF00860 Xan_ur_permease, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS23A1_HUMAN
AccessioniPrimary (citable) accession number: Q9UHI7
Secondary accession number(s): O95191
, Q8WWB6, Q9UGH4, Q9UI39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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