UniProtKB - Q9UHI6 (DDX20_HUMAN)

BLAST

>sp|Q9UHI6|DDX20_HUMAN Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2
MAAAFEASGALAAVATAMPAEHVAVQVPAPEPTPGPVRILRTAQDLSSPRTRTGDVLLAE
PADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIA
LDSLVLENLSTQILILAPTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKK
CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASKQML
AVSATYPEFLANALTKYMRDPTFVRLNSSDPSLIGLKQYYKVVNSYPLAHKVFEEKTQHL
QELFSRIPFNQALVFSNLHSRAQHLADILSSKGFPAECISGNMNQNQRLDAMAKLKHFHC
RVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGEEEN
MMMRIAQKCNINLLPLPDPIPSGLMEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIE
RTLQIQKAHGDHMASSRNNSVSGLSVKSKNNTKQKLPVKSHSECGIIEKATSPKELGCDR
QSEEQMKNSVQTPVENSTNSQHQVKEALPVSLPQIPCLSSFKIHQPYTLTFAELVEDYEH
YIKEGLEKPVEIIRHYTGPGDQTVNPQNGFVRNKVIEQRVPVLASSSQSGDSESDSDSYS
SRTSSQSKGNKSYLEGSSDNQLKDSESTPVDDRISLEQPPNGSDTPNPEKYQESPGIQMK
TRLKEGASQRAKQSRRNLPRRSSFRLQTEAQEDDWYDCHREIRLSFSDTYQDYEEYWRAY
YRAWQEYYAAASHSYYWNAQRHPSWMAAYHMNTIYLQEMMHSNQ

Align

Format
Add to basket Added to basket
History
Entry version 201 (07 Nov 2018)
Sequence version 2 (01 Dec 2000)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Probable ATP-dependent RNA helicase DDX20

Gene

DDX20

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).1 Publication

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	84	ATP; via carbonyl oxygen		1
Binding siteⁱ	89	ATP		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	109 – 114	ATP		6

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
ATP-dependent RNA helicase activity
Source: ProtInc
Traceable author statementⁱ
- 10383418
DNA binding Source: UniProtKB-KW
histone deacetylase binding Source: Ensembl
protein binding, bridging Source: Ensembl
protein domain specific binding Source: Ensembl
repressing transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12007404

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

import into nucleus Source: Reactome
negative regulation of cell proliferation Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 12007404
oogenesis Source: Ensembl
positive regulation of apoptotic process
Source: MGI
Inferred from genetic interactionⁱ
- 16153597
regulation of steroid biosynthetic process Source: Ensembl
RNA processing
Source: ProtInc
Traceable author statementⁱ
- 10601333
spliceosomal snRNP assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 18984161
spliceosomal tri-snRNP complex assembly
Source: ProtInc
Traceable author statementⁱ
- 10601333

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Helicase, Hydrolase
Biological process	mRNA processing, mRNA splicing
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-191859 snRNP Assembly
SIGNORⁱ	Q9UHI6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable ATP-dependent RNA helicase DDX20 (EC:3.6.4.13) Alternative name(s): Component of gems 3 DEAD box protein 20 DEAD box protein DP 103 Gemin-3
Gene namesⁱ	Name:DDX20 Synonyms:DP103, GEMIN3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000064703.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2743 DDX20
MIMⁱ	606168 gene
neXtProtⁱ	NX_Q9UHI6

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11218
Open Targets More...OpenTargetsⁱ	ENSG00000064703
PharmGKBⁱ	PA27209

Polymorphism and mutation databases

BioMutaⁱ	DDX20
DMDMⁱ	12643886

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000055025	1 – 824	Probable ATP-dependent RNA helicase DDX20Add BLAST		824

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	48	PhosphoserineCombined sources	1
Modified residueⁱ	187	PhosphoserineCombined sources	1
Modified residueⁱ	268	PhosphoserineCombined sources	1
Modified residueⁱ	269	PhosphoserineCombined sources	1
Modified residueⁱ	500	PhosphoserineCombined sources	1
Modified residueⁱ	505	PhosphoserineCombined sources	1
Modified residueⁱ	532	PhosphoserineCombined sources	1
Modified residueⁱ	552	PhosphothreonineCombined sources	1
Modified residueⁱ	560	PhosphoserineCombined sources	1
Modified residueⁱ	652	PhosphoserineCombined sources	1
Modified residueⁱ	654	PhosphoserineCombined sources	1
Modified residueⁱ	656	PhosphoserineCombined sources	1
Modified residueⁱ	672	PhosphoserineCombined sources	1
Modified residueⁱ	677	PhosphoserineCombined sources	1
Modified residueⁱ	678	PhosphoserineCombined sources	1
Modified residueⁱ	688	PhosphothreonineCombined sources	1
Modified residueⁱ	703	PhosphoserineCombined sources	1
Modified residueⁱ	705	PhosphothreonineCombined sources	1
Modified residueⁱ	714	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UHI6
PaxDbⁱ	Q9UHI6
PeptideAtlas More...PeptideAtlasⁱ	Q9UHI6
PRIDEⁱ	Q9UHI6
ProteomicsDBⁱ	84357

PTM databases

iPTMnetⁱ	Q9UHI6
PhosphoSitePlusⁱ	Q9UHI6

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000064703 Expressed in 189 organ(s), highest expression level in testis
CleanExⁱ	HS_DDX20
ExpressionAtlasⁱ	Q9UHI6 baseline and differential
Genevisibleⁱ	Q9UHI6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB015427 HPA005516

HPAⁱ

CAB015427
HPA005516

Interactionⁱ

Subunit structureⁱ

Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN5. Interacts directly with SNUPN. Interacts with PPP4R2. Interacts with FOXL2. Interacts with EBV EBNA2 and EBNA3C. Interacts with NANOS1 and PUM2.8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GEMIN4	P57678	5	EBI-347658,EBI-356700

With

Entry

#Exp.

IntAct

Notes

GEMIN4

P57678

EBI-347658,EBI-356700

GO - Molecular functionⁱ

histone deacetylase binding Source: Ensembl
protein binding, bridging Source: Ensembl
protein domain specific binding Source: Ensembl
repressing transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12007404

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116387, 90 interactors
CORUMⁱ	Q9UHI6
Database of interacting proteins More...DIPⁱ	DIP-32606N
IntActⁱ	Q9UHI6, 33 interactors
Molecular INTeraction database More...MINTⁱ	Q9UHI6
STRINGⁱ	9606.ENSP00000358716

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	64 – 67	Combined sources	4
Helixⁱ	71 – 79	Combined sources	9
Helixⁱ	87 – 97	Combined sources	11
Beta strandⁱ	102 – 105	Combined sources	4
Helixⁱ	112 – 123	Combined sources	12
Beta strandⁱ	133 – 136	Combined sources	4
Helixⁱ	140 – 153	Combined sources	14
Turnⁱ	154 – 156	Combined sources	3
Beta strandⁱ	162 – 165	Combined sources	4
Helixⁱ	171 – 177	Combined sources	7
Beta strandⁱ	182 – 186	Combined sources	5
Helixⁱ	188 – 196	Combined sources	9
Helixⁱ	202 – 204	Combined sources	3
Beta strandⁱ	207 – 212	Combined sources	6
Helixⁱ	213 – 217	Combined sources	5
Helixⁱ	223 – 232	Combined sources	10
Beta strandⁱ	238 – 244	Combined sources	7
Helixⁱ	248 – 254	Combined sources	7
Turnⁱ	255 – 257	Combined sources	3
Beta strandⁱ	262 – 264	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UHI6
SMRⁱ	Q9UHI6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9UHI6

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	93 – 264	Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST		172
Domainⁱ	299 – 448	Helicase C-terminalPROSITE-ProRule annotationAdd BLAST		150

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	456 – 548	SMN interactingAdd BLAST		93

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	62 – 90	Q motifAdd BLAST		29
Motifⁱ	211 – 214	DEAD box		4

Sequence similaritiesⁱ

Belongs to the DEAD box helicase family. DDX20 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG4284 Eukaryota COG0513 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00830000128348
HOGENOMⁱ	HOG000112184
HOVERGENⁱ	HBG051330
InParanoidⁱ	Q9UHI6
KEGG Orthology (KO) More...KOⁱ	K13131
OMAⁱ	PGLMEEC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0461
PhylomeDBⁱ	Q9UHI6
TreeFamⁱ	TF352222

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR000629 RNA-helicase_DEAD-box_CS IPR014014 RNA_helicase_DEAD_Q_motif
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00039 DEAD_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UHI6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAFEASGA LAAVATAMPA EHVAVQVPAP EPTPGPVRIL RTAQDLSSPR 
        60         70         80         90        100
TRTGDVLLAE PADFESLLLS RPVLEGLRAA GFERPSPVQL KAIPLGRCGL 
       110        120        130        140        150
DLIVQAKSGT GKTCVFSTIA LDSLVLENLS TQILILAPTR EIAVQIHSVI 
       160        170        180        190        200
TAIGIKMEGL ECHVFIGGTP LSQDKTRLKK CHIAVGSPGR IKQLIELDYL 
       210        220        230        240        250
NPGSIRLFIL DEADKLLEEG SFQEQINWIY SSLPASKQML AVSATYPEFL 
       260        270        280        290        300
ANALTKYMRD PTFVRLNSSD PSLIGLKQYY KVVNSYPLAH KVFEEKTQHL 
       310        320        330        340        350
QELFSRIPFN QALVFSNLHS RAQHLADILS SKGFPAECIS GNMNQNQRLD 
       360        370        380        390        400
AMAKLKHFHC RVLISTDLTS RGIDAEKVNL VVNLDVPLDW ETYMHRIGRA 
       410        420        430        440        450
GRFGTLGLTV TYCCRGEEEN MMMRIAQKCN INLLPLPDPI PSGLMEECVD 
       460        470        480        490        500
WDVEVKAAVH TYGIASVPNQ PLKKQIQKIE RTLQIQKAHG DHMASSRNNS 
       510        520        530        540        550
VSGLSVKSKN NTKQKLPVKS HSECGIIEKA TSPKELGCDR QSEEQMKNSV 
       560        570        580        590        600
QTPVENSTNS QHQVKEALPV SLPQIPCLSS FKIHQPYTLT FAELVEDYEH 
       610        620        630        640        650
YIKEGLEKPV EIIRHYTGPG DQTVNPQNGF VRNKVIEQRV PVLASSSQSG 
       660        670        680        690        700
DSESDSDSYS SRTSSQSKGN KSYLEGSSDN QLKDSESTPV DDRISLEQPP 
       710        720        730        740        750
NGSDTPNPEK YQESPGIQMK TRLKEGASQR AKQSRRNLPR RSSFRLQTEA 
       760        770        780        790        800
QEDDWYDCHR EIRLSFSDTY QDYEEYWRAY YRAWQEYYAA ASHSYYWNAQ 
       810        820 
RHPSWMAAYH MNTIYLQEMM HSNQ

Length:824

Mass (Da):92,241

Last modified:December 1, 2000 - v2

Checksum:ⁱ76712F014B2A0CF2

Isoform 2 (identifier: Q9UHI6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
133-138: ILILAP → AELSNS
139-824: Missing.

« Hide

        10         20         30         40         50
MAAAFEASGA LAAVATAMPA EHVAVQVPAP EPTPGPVRIL RTAQDLSSPR 
        60         70         80         90        100
TRTGDVLLAE PADFESLLLS RPVLEGLRAA GFERPSPVQL KAIPLGRCGL 
       110        120        130 
DLIVQAKSGT GKTCVFSTIA LDSLVLENLS TQAELSNS

Note: No experimental confirmation available.

Show »

Length:138

Mass (Da):14,272

Checksum:ⁱA3075B1CEE1AF15C

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PJ60	E9PJ60_HUMAN		Probable ATP-dependent RNA helicase... Probable ATP-dependent RNA helicase DDX20	DDX20	432	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	5	F → V in AAD42744 (PubMed:10383418).Curated	1
Sequence conflictⁱ	279	Y → C in BAA91727 (PubMed:14702039).Curated	1
Sequence conflictⁱ	639	R → K in AAF14544 (PubMed:10601333).Curated	1
Sequence conflictⁱ	659	Y → H in AAD42744 (PubMed:10383418).Curated	1
Sequence conflictⁱ	676	G → S in AAF14544 (PubMed:10601333).Curated	1
Sequence conflictⁱ	703	S → T in AAF14544 (PubMed:10601333).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_057231	636	I → T1 PublicationCorresponds to variant dbSNP:rs197412Ensembl.	1
Natural variantⁱVAR_057232	693	R → S. Corresponds to variant dbSNP:rs197414Ensembl.	1
Natural variantⁱVAR_057233	762	I → T. Corresponds to variant dbSNP:rs85276Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056505	133 – 138	ILILAP → AELSNS in isoform 2. 1 Publication		6
Alternative sequenceⁱVSP_056506	139 – 824	Missing in isoform 2. 1 PublicationAdd BLAST		686

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF171063 mRNA Translation: AAF14544.1 AF106019 mRNA Translation: AAD42744.1 AK001506 mRNA Translation: BAA91727.1 AK301697 mRNA Translation: BAG63169.1 AL049557 Genomic DNA No translation available. BC011556 mRNA Translation: AAH11556.1 AL133598 mRNA Translation: CAB63734.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS842.1 [Q9UHI6-1]
PIRⁱ	T43476
NCBI Reference Sequences More...RefSeqⁱ	NP_009135.4, NM_007204.4 [Q9UHI6-1]
UniGeneⁱ	Hs.591405

Genome annotation databases

Ensemblⁱ	ENST00000369702; ENSP00000358716; ENSG00000064703 [Q9UHI6-1] ENST00000533164; ENSP00000434085; ENSG00000064703 [Q9UHI6-2]
GeneIDⁱ	11218
KEGGⁱ	hsa:11218
UCSC genome browser More...UCSCⁱ	uc001ebs.4 human [Q9UHI6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UHI6	DEAD-box helicase 20		PANTR		861	UniRef90_Q9UHI6
Uncharacterized protein		PANPA		861
Uncharacterized protein		CERAT		856
Uncharacterized protein		MACFA		856
Putative ATP-dependent RNA helicase DDX20		MACMU		825
+47
Q9UHI6-2	DDX20 isoform 4		PONAB		138	UniRef90_Q9UHI6-2
DDX20 isoform 4		PANTR		138

Protein	Similar proteins		Species	Score	Length	Source
Q9UHI6	Probable ATP-dependent RNA helicase DDX20		MOUSE		825	UniRef50_Q9UHI6
DEAD-box helicase 20		PANTR		861
Uncharacterized protein		PANPA		861
Uncharacterized protein		CERAT		856
Uncharacterized protein		MACFA		856
+244
Q9UHI6-2	DDX20 isoform 4		PONAB		138	UniRef50_Q9UHI6-2
DDX20 isoform 4		PANTR		138
Probable ATP-dependent RNA helicase DDX20		MOUSE		139
UPI0003F13283		CHRAS		138
UPI0003F0BB9A		ELEED		134
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF171063 mRNA Translation: AAF14544.1 AF106019 mRNA Translation: AAD42744.1 AK001506 mRNA Translation: BAA91727.1 AK301697 mRNA Translation: BAG63169.1 AL049557 Genomic DNA No translation available. BC011556 mRNA Translation: AAH11556.1 AL133598 mRNA Translation: CAB63734.2
CCDSⁱ	CCDS842.1 [Q9UHI6-1]
PIRⁱ	T43476
RefSeqⁱ	NP_009135.4, NM_007204.4 [Q9UHI6-1]
UniGeneⁱ	Hs.591405

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2OXC	X-ray	1.30	A/B	41-268	[»]
	3B7G	X-ray	1.90	A/B	41-268	[»]
ProteinModelPortalⁱ	Q9UHI6
SMRⁱ	Q9UHI6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116387, 90 interactors
CORUMⁱ	Q9UHI6
DIPⁱ	DIP-32606N
IntActⁱ	Q9UHI6, 33 interactors
MINTⁱ	Q9UHI6
STRINGⁱ	9606.ENSP00000358716

PTM databases

iPTMnetⁱ	Q9UHI6
PhosphoSitePlusⁱ	Q9UHI6

Polymorphism and mutation databases

BioMutaⁱ	DDX20
DMDMⁱ	12643886

Proteomic databases

EPDⁱ	Q9UHI6
PaxDbⁱ	Q9UHI6
PeptideAtlasⁱ	Q9UHI6
PRIDEⁱ	Q9UHI6
ProteomicsDBⁱ	84357

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11218
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369702; ENSP00000358716; ENSG00000064703 [Q9UHI6-1] ENST00000533164; ENSP00000434085; ENSG00000064703 [Q9UHI6-2]
GeneIDⁱ	11218
KEGGⁱ	hsa:11218
UCSCⁱ	uc001ebs.4 human [Q9UHI6-1]

Organism-specific databases

CTDⁱ	11218
DisGeNETⁱ	11218
EuPathDBⁱ	HostDB:ENSG00000064703.11
GeneCardsⁱ	DDX20
HGNCⁱ	HGNC:2743 DDX20
HPAⁱ	CAB015427 HPA005516
MIMⁱ	606168 gene
neXtProtⁱ	NX_Q9UHI6
OpenTargetsⁱ	ENSG00000064703
PharmGKBⁱ	PA27209
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4284 Eukaryota COG0513 LUCA
GeneTreeⁱ	ENSGT00830000128348
HOGENOMⁱ	HOG000112184
HOVERGENⁱ	HBG051330
InParanoidⁱ	Q9UHI6
KOⁱ	K13131
OMAⁱ	PGLMEEC
OrthoDBⁱ	EOG091G0461
PhylomeDBⁱ	Q9UHI6
TreeFamⁱ	TF352222

Enzyme and pathway databases

Reactomeⁱ	R-HSA-191859 snRNP Assembly
SIGNORⁱ	Q9UHI6

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UHI6
GeneWikiⁱ	DDX20
GenomeRNAiⁱ	11218
Protein Ontology More...PROⁱ	PR:Q9UHI6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000064703 Expressed in 189 organ(s), highest expression level in testis
CleanExⁱ	HS_DDX20
ExpressionAtlasⁱ	Q9UHI6 baseline and differential
Genevisibleⁱ	Q9UHI6 HS

Family and domain databases

CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR000629 RNA-helicase_DEAD-box_CS IPR014014 RNA_helicase_DEAD_Q_motif
Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00039 DEAD_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DDX20_HUMAN
Accessionⁱ	Q9UHI6Primary (citable) accession number: Q9UHI6 Secondary accession number(s): B4DWV7 , Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	December 1, 2000
	Last modified:	November 7, 2018
	This is version 201 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UHI6 (DDX20_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Probable ATP-dependent RNA helicase DDX20

DDX20

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ