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Entry version 170 (08 May 2019)
Sequence version 1 (01 May 2000)
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Protein

Large neutral amino acids transporter small subunit 2

Gene

SLC7A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.8 Publications

Miscellaneous

L-leucine transport activity inhibited by small zwitterionic amino acids (i.e. glycine, alanine, serine, threonine asparagine, glutamine, methionine, leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, histidine and cysteine) and by glutamine and asparagine. Methionine uptake was inhibited by the L-system substrates L-leucine, 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylate (BCH), L-cysteine and by the MeHg-L-cysteine complex and structurally related S-ethyl-L-cysteine. MeHg-L-cysteine uptake is inhibited by L-methionine, L-leucine, BCH and S-ethyl-L-cysteine. L-leucine uptake was inhibited by L-CNSO.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=221 µM for L-leucine4 Publications
  2. KM=64 µM for MeHg-L-cysteine4 Publications
  3. KM=161 µM for methionine4 Publications
  4. KM=978 µM for L-alanine4 Publications
  5. KM=89.35 µM for L-phenylalanine4 Publications
  6. KM=57.3 µM for L-tryptophan4 Publications
  7. KM=48.8 µM for L-tyrosine4 Publications

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Transport

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:ENSG00000092068-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-210991 Basigin interactions
    R-HSA-352230 Amino acid transport across the plasma membrane

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9UHI5

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.3.8.20 the amino acid-polyamine-organocation (apc) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Large neutral amino acids transporter small subunit 2
    Alternative name(s):
    L-type amino acid transporter 2
    Short name:
    hLAT2
    Solute carrier family 7 member 8
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC7A8
    Synonyms:LAT2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:11066 SLC7A8

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    604235 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9UHI5

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
    Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
    Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
    Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
    Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
    Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
    Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
    Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
    Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
    Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
    Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
    Transmembranei447 – 467HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    23428

    Open Targets

    More...
    OpenTargetsi
    ENSG00000092068

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA35926

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB00160 L-Alanine
    DB00130 L-Glutamine
    DB00120 L-Phenylalanine
    DB01235 Levodopa
    DB02750 S-(Methylmercury)-L-Cysteine

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC7A8

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    12643348

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000542731 – 535Large neutral amino acids transporter small subunit 2Add BLAST535

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29PhosphoserineBy similarity1

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9UHI5

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9UHI5

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9UHI5

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9UHI5

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9UHI5

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    84356

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9UHI5

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9UHI5

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q9UHI5

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Strongest expression is observed in kidney and moderate expression in placenta and brain, followed by liver, prostate, testis, ovary, lymph node, thymus, spleen, skeletal muscle and heart. Also expressed in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell line Caco-2.4 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Activity in polarized intestinal cells is regulated by the association between SLC3A2/4F2 (in the SLC3A2/4F2-LAT2 heterodimer) and ICAM1.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000092068 Expressed in 228 organ(s), highest expression level in cortex of kidney

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9UHI5 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9UHI5 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB046015
    HPA051950
    HPA060672

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.6 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    116996, 1 interactor

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q9UHI5

    Protein interaction database and analysis system

    More...
    IntActi
    Q9UHI5, 22 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000320378

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1287 Eukaryota
    COG0531 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000158278

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000098892

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9UHI5

    KEGG Orthology (KO)

    More...
    KOi
    K13781

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    YWLEPAN

    Database of Orthologous Groups

    More...
    OrthoDBi
    621852at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9UHI5

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313355

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002293 AA/rel_permease1
    IPR004760 L_AA_transporter

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13520 AA_permease_2, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF006060 AA_transporter, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00911 2A0308, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9UHI5-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MEEGARHRNN TEKKHPGGGE SDASPEAGSG GGGVALKKEI GLVSACGIIV
    60 70 80 90 100
    GNIIGSGIFV SPKGVLENAG SVGLALIVWI VTGFITVVGA LCYAELGVTI
    110 120 130 140 150
    PKSGGDYSYV KDIFGGLAGF LRLWIAVLVI YPTNQAVIAL TFSNYVLQPL
    160 170 180 190 200
    FPTCFPPESG LRLLAAICLL LLTWVNCSSV RWATRVQDIF TAGKLLALAL
    210 220 230 240 250
    IIIMGIVQIC KGEYFWLEPK NAFENFQEPD IGLVALAFLQ GSFAYGGWNF
    260 270 280 290 300
    LNYVTEELVD PYKNLPRAIF ISIPLVTFVY VFANVAYVTA MSPQELLASN
    310 320 330 340 350
    AVAVTFGEKL LGVMAWIMPI SVALSTFGGV NGSLFTSSRL FFAGAREGHL
    360 370 380 390 400
    PSVLAMIHVK RCTPIPALLF TCISTLLMLV TSDMYTLINY VGFINYLFYG
    410 420 430 440 450
    VTVAGQIVLR WKKPDIPRPI KINLLFPIIY LLFWAFLLVF SLWSEPVVCG
    460 470 480 490 500
    IGLAIMLTGV PVYFLGVYWQ HKPKCFSDFI ELLTLVSQKM CVVVYPEVER
    510 520 530
    GSGTEEANED MEEQQQPMYQ PTPTKDKDVA GQPQP
    Length:535
    Mass (Da):58,382
    Last modified:May 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC129146353F1E47
    GO
    Isoform 2 (identifier: Q9UHI5-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-203: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:332
    Mass (Da):37,184
    Checksum:iE6DD8F71252E064D
    GO
    Isoform 3 (identifier: Q9UHI5-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-263: MEEGARHRNN...VTEELVDPYK → MGQLFQCAVG...HHGDCTDMQR

    Note: No experimental confirmation available.
    Show »
    Length:311
    Mass (Da):34,602
    Checksum:i4CF5A20AD230155C
    GO
    Isoform 4 (identifier: Q9UHI5-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-169: MEEGARHRNN...GLRLLAAICL → MGQYGQELSW...LEGVPRFLKR

    Note: No experimental confirmation available.
    Show »
    Length:430
    Mass (Da):48,283
    Checksum:i4F7293A07EBFE696
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H0Y2X7H0Y2X7_HUMAN
    Large neutral amino acids transport...
    SLC7A8
    230Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PLV9E9PLV9_HUMAN
    Large neutral amino acids transport...
    SLC7A8
    289Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087WWF3A0A087WWF3_HUMAN
    Large neutral amino acids transport...
    SLC7A8
    210Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PQT4E9PQT4_HUMAN
    Large neutral amino acids transport...
    SLC7A8
    94Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PIC3E9PIC3_HUMAN
    Large neutral amino acids transport...
    SLC7A8
    78Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PS92E9PS92_HUMAN
    Large neutral amino acids transport...
    SLC7A8
    49Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence CAD62616 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti225N → D in CAB40137 (PubMed:10080183).Curated1
    Sequence conflicti401V → G in CAB40137 (PubMed:10080183).Curated1
    Sequence conflicti503G → R in AAF05696 (PubMed:10391915).Curated1
    Sequence conflicti503G → R in AAF05697 (PubMed:10391915).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469451 – 263MEEGA…VDPYK → MGQLFQCAVGHPGSRHLHSW EAPGLGPDYHHGDCTDMQR in isoform 3. 1 PublicationAdd BLAST263
    Alternative sequenceiVSP_0469461 – 203Missing in isoform 2. 1 PublicationAdd BLAST203
    Alternative sequenceiVSP_0469471 – 169MEEGA…AAICL → MGQYGQELSWKCLVKAVCLQ EHSQPSQLLCTLLLCWCVLG RERPFRKAQSTSSPLEGVPR FLKR in isoform 4. 1 PublicationAdd BLAST169

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF135828 mRNA Translation: AAF05695.1
    AF135829 mRNA Translation: AAF05696.1
    AF135830 mRNA Translation: AAF05697.1
    AF171669 mRNA Translation: AAF20381.1
    Y18483 mRNA Translation: CAB40137.1
    AB037669 mRNA Translation: BAB21519.1
    BX248288 mRNA Translation: CAD62616.1 Different initiation.
    AK296702 mRNA Translation: BAG59296.1
    AK300384 mRNA Translation: BAG62118.1
    AK313465 mRNA Translation: BAG36251.1
    AL117258 Genomic DNA No translation available.
    CH471078 Genomic DNA Translation: EAW66181.1
    CH471078 Genomic DNA Translation: EAW66182.1
    BC052250 mRNA Translation: AAH52250.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS41924.1 [Q9UHI5-2]
    CCDS58304.1 [Q9UHI5-3]
    CCDS58305.1 [Q9UHI5-4]
    CCDS9590.1 [Q9UHI5-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001253965.1, NM_001267036.1 [Q9UHI5-4]
    NP_001253966.1, NM_001267037.1 [Q9UHI5-3]
    NP_036376.2, NM_012244.3 [Q9UHI5-1]
    NP_877392.1, NM_182728.2 [Q9UHI5-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000316902; ENSP00000320378; ENSG00000092068 [Q9UHI5-1]
    ENST00000422941; ENSP00000416398; ENSG00000092068 [Q9UHI5-3]
    ENST00000453702; ENSP00000391577; ENSG00000092068 [Q9UHI5-2]
    ENST00000529705; ENSP00000434345; ENSG00000092068 [Q9UHI5-4]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    23428

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:23428

    UCSC genome browser

    More...
    UCSCi
    uc001wix.5 human [Q9UHI5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF135828 mRNA Translation: AAF05695.1
    AF135829 mRNA Translation: AAF05696.1
    AF135830 mRNA Translation: AAF05697.1
    AF171669 mRNA Translation: AAF20381.1
    Y18483 mRNA Translation: CAB40137.1
    AB037669 mRNA Translation: BAB21519.1
    BX248288 mRNA Translation: CAD62616.1 Different initiation.
    AK296702 mRNA Translation: BAG59296.1
    AK300384 mRNA Translation: BAG62118.1
    AK313465 mRNA Translation: BAG36251.1
    AL117258 Genomic DNA No translation available.
    CH471078 Genomic DNA Translation: EAW66181.1
    CH471078 Genomic DNA Translation: EAW66182.1
    BC052250 mRNA Translation: AAH52250.1
    CCDSiCCDS41924.1 [Q9UHI5-2]
    CCDS58304.1 [Q9UHI5-3]
    CCDS58305.1 [Q9UHI5-4]
    CCDS9590.1 [Q9UHI5-1]
    RefSeqiNP_001253965.1, NM_001267036.1 [Q9UHI5-4]
    NP_001253966.1, NM_001267037.1 [Q9UHI5-3]
    NP_036376.2, NM_012244.3 [Q9UHI5-1]
    NP_877392.1, NM_182728.2 [Q9UHI5-2]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi116996, 1 interactor
    CORUMiQ9UHI5
    IntActiQ9UHI5, 22 interactors
    STRINGi9606.ENSP00000320378

    Chemistry databases

    DrugBankiDB00160 L-Alanine
    DB00130 L-Glutamine
    DB00120 L-Phenylalanine
    DB01235 Levodopa
    DB02750 S-(Methylmercury)-L-Cysteine

    Protein family/group databases

    TCDBi2.A.3.8.20 the amino acid-polyamine-organocation (apc) family

    PTM databases

    iPTMnetiQ9UHI5
    PhosphoSitePlusiQ9UHI5
    SwissPalmiQ9UHI5

    Polymorphism and mutation databases

    BioMutaiSLC7A8
    DMDMi12643348

    Proteomic databases

    EPDiQ9UHI5
    jPOSTiQ9UHI5
    PaxDbiQ9UHI5
    PeptideAtlasiQ9UHI5
    PRIDEiQ9UHI5
    ProteomicsDBi84356

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000316902; ENSP00000320378; ENSG00000092068 [Q9UHI5-1]
    ENST00000422941; ENSP00000416398; ENSG00000092068 [Q9UHI5-3]
    ENST00000453702; ENSP00000391577; ENSG00000092068 [Q9UHI5-2]
    ENST00000529705; ENSP00000434345; ENSG00000092068 [Q9UHI5-4]
    GeneIDi23428
    KEGGihsa:23428
    UCSCiuc001wix.5 human [Q9UHI5-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    23428
    DisGeNETi23428

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC7A8
    HGNCiHGNC:11066 SLC7A8
    HPAiCAB046015
    HPA051950
    HPA060672
    MIMi604235 gene
    neXtProtiNX_Q9UHI5
    OpenTargetsiENSG00000092068
    PharmGKBiPA35926

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1287 Eukaryota
    COG0531 LUCA
    GeneTreeiENSGT00940000158278
    HOGENOMiHOG000098892
    InParanoidiQ9UHI5
    KOiK13781
    OMAiYWLEPAN
    OrthoDBi621852at2759
    PhylomeDBiQ9UHI5
    TreeFamiTF313355

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000092068-MONOMER
    ReactomeiR-HSA-210991 Basigin interactions
    R-HSA-352230 Amino acid transport across the plasma membrane
    SABIO-RKiQ9UHI5

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC7A8 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SLC7A8

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    23428

    Protein Ontology

    More...
    PROi
    PR:Q9UHI5

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000092068 Expressed in 228 organ(s), highest expression level in cortex of kidney
    ExpressionAtlasiQ9UHI5 baseline and differential
    GenevisibleiQ9UHI5 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR002293 AA/rel_permease1
    IPR004760 L_AA_transporter
    PfamiView protein in Pfam
    PF13520 AA_permease_2, 1 hit
    PIRSFiPIRSF006060 AA_transporter, 1 hit
    TIGRFAMsiTIGR00911 2A0308, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAT2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHI5
    Secondary accession number(s): B2R8Q4
    , B4DKT4, B4DTV6, D3DS46, F2Z2J4, Q86U05, Q9UKQ6, Q9UKQ7, Q9UKQ8, Q9Y445
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 2000
    Last modified: May 8, 2019
    This is version 170 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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