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Protein

Prenylcysteine oxidase 1

Gene

PCYOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine.

Caution

Was originally thought to be a lyase and was therefore termed prenylcysteine lyase.1 Publication

Catalytic activityi

An S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.

Cofactori

GO - Molecular functioni

  • chloride-transporting ATPase activity Source: Ensembl
  • prenylcysteine oxidase activity Source: BHF-UCL

GO - Biological processi

  • prenylated protein catabolic process Source: BHF-UCL
  • prenylcysteine catabolic process Source: GO_Central
  • prenylcysteine metabolic process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.8.3.5 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Prenylcysteine oxidase 1 (EC:1.8.3.5)
Alternative name(s):
Prenylcysteine lyase
Gene namesi
Name:PCYOX1
Synonyms:KIAA0908, PCL1
ORF Names:UNQ597/PRO1183
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000116005.11
HGNCiHGNC:20588 PCYOX1
MIMi610995 gene
neXtProtiNX_Q9UHG3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi51449
OpenTargetsiENSG00000116005
PharmGKBiPA134959852

Polymorphism and mutation databases

BioMutaiPCYOX1
DMDMi115311617

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000002329828 – 505Prenylcysteine oxidase 1Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi196N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi323N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi353N-linked (GlcNAc...) asparagine2 Publications1

Post-translational modificationi

The protein is glycosylated at one or more potential N-glycosylation sites.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UHG3
PaxDbiQ9UHG3
PeptideAtlasiQ9UHG3
PRIDEiQ9UHG3
ProteomicsDBi84350
TopDownProteomicsiQ9UHG3-1 [Q9UHG3-1]

PTM databases

iPTMnetiQ9UHG3
PhosphoSitePlusiQ9UHG3
SwissPalmiQ9UHG3

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000116005
CleanExiHS_PCYOX1
ExpressionAtlasiQ9UHG3 baseline and differential
GenevisibleiQ9UHG3 HS

Organism-specific databases

HPAiHPA035193

Interactioni

Protein-protein interaction databases

BioGridi119547, 26 interactors
IntActiQ9UHG3, 5 interactors
MINTiQ9UHG3
STRINGi9606.ENSP00000387654

Structurei

3D structure databases

ProteinModelPortaliQ9UHG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prenylcysteine oxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE2Q Eukaryota
ENOG410Y3UN LUCA
GeneTreeiENSGT00390000011206
HOGENOMiHOG000241149
HOVERGENiHBG053532
InParanoidiQ9UHG3
KOiK05906
OMAiRYQSHDY
OrthoDBiEOG091G0A3Q
PhylomeDBiQ9UHG3
TreeFamiTF329001

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR010795 Prenylcys_lyase
IPR017046 Prenylcysteine_Oxase
PANTHERiPTHR15944 PTHR15944, 1 hit
PfamiView protein in Pfam
PF07156 Prenylcys_lyase, 1 hit
PIRSFiPIRSF036292 Prenylcysteine_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UHG3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRVVAELVS SLLGLWLLLC SCGCPEGAEL RAPPDKIAII GAGIGGTSAA
60 70 80 90 100
YYLRQKFGKD VKIDLFEREE VGGRLATMMV QGQEYEAGGS VIHPLNLHMK
110 120 130 140 150
RFVKDLGLSA VQASGGLLGI YNGETLVFEE SNWFIINVIK LVWRYGFQSL
160 170 180 190 200
RMHMWVEDVL DKFMRIYRYQ SHDYAFSSVE KLLHALGGDD FLGMLNRTLL
210 220 230 240 250
ETLQKAGFSE KFLNEMIAPV MRVNYGQSTD INAFVGAVSL SCSDSGLWAV
260 270 280 290 300
EGGNKLVCSG LLQASKSNLI SGSVMYIEEK TKTKYTGNPT KMYEVVYQIG
310 320 330 340 350
TETRSDFYDI VLVATPLNRK MSNITFLNFD PPIEEFHQYY QHIVTTLVKG
360 370 380 390 400
ELNTSIFSSR PIDKFGLNTV LTTDNSDLFI NSIGIVPSVR EKEDPEPSTD
410 420 430 440 450
GTYVWKIFSQ ETLTKAQILK LFLSYDYAVK KPWLAYPHYK PPEKCPSIIL
460 470 480 490 500
HDRLYYLNGI ECAASAMEMS AIAAHNAALL AYHRWNGHTD MIDQDGLYEK

LKTEL
Length:505
Mass (Da):56,640
Last modified:September 19, 2006 - v3
Checksum:iFB388AF70AF229F5
GO
Isoform 2 (identifier: Q9UHG3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Note: No experimental confirmation available.
Show »
Length:428
Mass (Da):48,507
Checksum:i353962C00F7703DC
GO

Sequence cautioni

The sequence BAA74931 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti341Q → H in AAF16937 (PubMed:10585463).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050469149S → F1 PublicationCorresponds to variant dbSNP:rs2706762Ensembl.1
Natural variantiVAR_050470414T → S. Corresponds to variant dbSNP:rs17005441Ensembl.1
Natural variantiVAR_050471465S → G. Corresponds to variant dbSNP:rs34041544Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0567011 – 77Missing in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181490 mRNA Translation: AAF16937.1
AB020715 mRNA Translation: BAA74931.1 Different initiation.
AY359063 mRNA Translation: AAQ89422.1
AK314453 mRNA Translation: BAG37061.1
AK316013 mRNA Translation: BAH14384.1
AC016700 Genomic DNA No translation available.
AC079338 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99819.1
BC007029 mRNA Translation: AAH07029.1
BC033815 mRNA Translation: AAH33815.1
BC051891 mRNA Translation: AAH51891.1
CCDSiCCDS1902.1 [Q9UHG3-1]
RefSeqiNP_057381.3, NM_016297.3 [Q9UHG3-1]
UniGeneiHs.567502

Genome annotation databases

EnsembliENST00000433351; ENSP00000387654; ENSG00000116005 [Q9UHG3-1]
GeneIDi51449
KEGGihsa:51449
UCSCiuc002sgn.5 human [Q9UHG3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPCYOX_HUMAN
AccessioniPrimary (citable) accession number: Q9UHG3
Secondary accession number(s): B2RB14
, B7Z9P8, O94982, Q8N4N5, Q96QM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 19, 2006
Last modified: June 20, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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