TRPS1

Functionⁱ

Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	222 – 247	C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	333 – 358	C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	614 – 637	C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	666 – 689	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	692 – 715	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	896 – 920	GATA-typePROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	1215 – 1237	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1243 – 1267	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 10615131
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
protein domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 15491138
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 14680804
zinc ion binding
Source: ProtInc
Traceable author statementⁱ
- 10615131

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 12885770
NLS-bearing protein import into nucleus
Source: ProtInc
Traceable author statementⁱ
- 10615131
protein heterooligomerization
Source: CAFA
Inferred from mutant phenotypeⁱ
- 15491138
regulation of chondrocyte differentiation Source: UniProtKB
skeletal system development
Source: ProtInc
Traceable author statementⁱ
- 10615131
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 10615131

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	Q9UHF7

SIGNORⁱ

Q9UHF7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger transcription factor Trps1 Alternative name(s): Tricho-rhino-phalangeal syndrome type I protein Zinc finger protein GC79
Gene namesⁱ	Name:TRPS1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104447.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12340 TRPS1
MIMⁱ	604386 gene
neXtProtⁱ	NX_Q9UHF7

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Tricho-rhino-phalangeal syndrome 1 (TRPS1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAutosomal dominant disorder characterized by craniofacial and skeletal abnormalities. It is allelic with tricho-rhino-phalangeal type 3. Typical features include sparse scalp hair, a bulbous tip of the nose, protruding ears, a long flat philtrum and a thin upper vermilion border. Skeletal defects include cone-shaped epiphyses at the phalanges, hip malformations and short stature.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_038198	952	R → C in TRPS1; prevents the transport into the nucleus and thus reduces the nuclear TRPS1 concentration consistent with haploinsufficiency. 1 PublicationCorresponds to variant dbSNP:rs28939069Ensembl.		1
Natural variantⁱVAR_038199	952	R → H in TRPS1; prevents the transport into the nucleus and thus reduces the nuclear TRPS1 concentration consistent with haploinsufficiency. 1 PublicationCorresponds to variant dbSNP:rs28939070Ensembl.		1

Tricho-rhino-phalangeal syndrome 2 (TRPS2)

The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration resulting in the loss of functional copies of TRPS1 and EXT1 has been found in TRPS2 patients.

Disease descriptionA syndrome that combines the clinical features of tricho-rhino-phalangeal syndrome type 1 and multiple exostoses type 1. Affected individuals manifest multiple dysmorphic facial features including large, laterally protruding ears, a bulbous nose, an elongated upper lip, as well as sparse scalp hair, winged scapulae, multiple cartilaginous exostoses, redundant skin, and mental retardation.

Tricho-rhino-phalangeal syndrome 3 (TRPS3)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAutosomal dominant disorder characterized by craniofacial and skeletal abnormalities. It is allelic with tricho-rhino-phalangeal type 1. In TRPS3 a more severe brachydactyly and growth retardation are observed.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_012807	894	V → D in TRPS3; in heterozygous status has a milder effect causing TRPS1. 1 Publication	1
Natural variantⁱVAR_012808	901	T → P in TRPS3; severe. 1 PublicationCorresponds to variant dbSNP:rs121908433Ensembl.	1
Natural variantⁱVAR_012809	908	R → P in TRPS3; severe. 1 Publication	1
Natural variantⁱVAR_012810	908	R → Q in TRPS3. 2 PublicationsCorresponds to variant dbSNP:rs121908435Ensembl.	1
Natural variantⁱVAR_012811	919	A → T in TRPS3. 1 PublicationCorresponds to variant dbSNP:rs1057518972Ensembl.	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	1192	K → R: Very little change in sumoylation and 30% reduction in repression activity. Almost complete loss of sumoylation and 70% reduction in repression activity; when associated with R-1201. 1 Publication		1
Mutagenesisⁱ	1201	K → R: Great loss of sumoylation and 30% reduction in repression activity. Almost complete loss of sumoylation and 70% reduction in repression activity; when associated with R-1192. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7227
MalaCards human disease database More...MalaCardsⁱ	TRPS1
MIMⁱ	150230 phenotype 190350 phenotype 190351 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000104447
Orphanetⁱ	77258 Trichorhinophalangeal syndrome type 1 and 3 502 Trichorhinophalangeal syndrome type 2
PharmGKBⁱ	PA37013

Polymorphism and mutation databases

DMDMⁱ	20140909

DMDMⁱ

20140909

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083508	1 – 1281	Zinc finger transcription factor Trps1Add BLAST		1281

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	29	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	76	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	90	PhosphoserineCombined sources	1
Modified residueⁱ	127	PhosphoserineCombined sources	1
Modified residueⁱ	178	PhosphoserineCombined sources	1
Modified residueⁱ	216	PhosphoserineBy similarity	1
Cross-linkⁱ	263	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	418	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	457	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	474	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	488	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	645	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	737	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	751	PhosphothreonineCombined sources	1
Cross-linkⁱ	755	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	766	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	766	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	825	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	850	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	877	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	879	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	925	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	937	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	965	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	978	PhosphoserineCombined sources	1
Cross-linkⁱ	1003	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1012	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1030	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1040	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	1041	PhosphoserineCombined sources	1
Modified residueⁱ	1066	PhosphoserineCombined sources	1
Cross-linkⁱ	1070	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	1085	PhosphoserineCombined sources	1
Cross-linkⁱ	1192	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate1 Publication
Cross-linkⁱ	1192	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	1201	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linkⁱ	1201	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	1201	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Post-translational modificationⁱ

Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9UHF7
PaxDbⁱ	Q9UHF7
PeptideAtlas More...PeptideAtlasⁱ	Q9UHF7
PRIDEⁱ	Q9UHF7
ProteomicsDBⁱ	84344 84345 [Q9UHF7-2] 84346 [Q9UHF7-3]

PTM databases

iPTMnetⁱ	Q9UHF7
PhosphoSitePlusⁱ	Q9UHF7

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.

Gene expression databases

Bgeeⁱ	ENSG00000104447 Expressed in 226 organ(s), highest expression level in thoracic mammary gland
CleanExⁱ	HS_TRPS1
ExpressionAtlasⁱ	Q9UHF7 baseline and differential
Genevisibleⁱ	Q9UHF7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060380 HPA071767

HPAⁱ

HPA060380
HPA071767

Interactionⁱ

Subunit structureⁱ

Interacts with RNF4; regulates TRPS1 repressor activity. Interacts specifically with the activator form of GLI3 (GLI3A) but not with the repressor form (GLI3R).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ORF	Q9Q2G4	3	EBI-2556151,EBI-6248094	From Human immunodeficiency virus 1.
RNF4	P78317	2	EBI-2556151,EBI-2340927

GO - Molecular functionⁱ

protein domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 15491138

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113078, 31 interactors
ELMⁱ	Q9UHF7
IntActⁱ	Q9UHF7, 23 interactors
Molecular INTeraction database More...MINTⁱ	Q9UHF7
STRINGⁱ	9606.ENSP00000379065

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UHF7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	635 – 819	Mediates interaction with GLI31 PublicationAdd BLAST	185
Regionⁱ	985 – 1184	Mediates interaction with RNF4By similarityAdd BLAST	200
Regionⁱ	1163 – 1281	Transcriptional repressor domainBy similarityAdd BLAST	119

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	222 – 247	C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	333 – 358	C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	614 – 637	C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	666 – 689	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	692 – 715	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	896 – 920	GATA-typePROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	1215 – 1237	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1243 – 1267	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1601 Eukaryota COG5641 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119221
HOGENOMⁱ	HOG000146438
HOVERGENⁱ	HBG067120
InParanoidⁱ	Q9UHF7
KEGG Orthology (KO) More...KOⁱ	K22040
OMAⁱ	NAGYDFT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00VI
PhylomeDBⁱ	Q9UHF7
TreeFamⁱ	TF350812

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00202 ZnF_GATA, 1 hit
Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR039355 Transcription_factor_GATA IPR028440 TRPS1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type IPR000679 Znf_GATA IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR10071 PTHR10071, 1 hit PTHR10071:SF176 PTHR10071:SF176, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00320 GATA, 1 hit
PRINTSⁱ	PR00619 GATAZNFINGER
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 9 hits SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS00344 GATA_ZN_FINGER_1, 1 hit PS50114 GATA_ZN_FINGER_2, 1 hit PS00028 ZINC_FINGER_C2H2_1, 2 hits PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UHF7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRKKNPPLR NVASEGEGQI LEPIGTESKV SGKNKEFSAD QMSENTDQSD 
        60         70         80         90        100
AAELNHKEEH SLHVQDPSSS SKKDLKSAVL SEKAGFNYES PSKGGNFPSF 
       110        120        130        140        150
PHDEVTDRNM LAFSSPAAGG VCEPLKSPQR AEADDPQDMA CTPSGDSLET 
       160        170        180        190        200
KEDQKMSPKA TEETGQAQSG QANCQGLSPV SVASKNPQVP SDGGVRLNKS 
       210        220        230        240        250
KTDLLVNDNP DPAPLSPELQ DFKCNICGYG YYGNDPTDLI KHFRKYHLGL 
       260        270        280        290        300
HNRTRQDAEL DSKILALHNM VQFSHSKDFQ KVNRSVFSGV LQDINSSRPV 
       310        320        330        340        350
LLNGTYDVQV TSGGTFIGIG RKTPDCQGNT KYFRCKFCNF TYMGNSSTEL 
       360        370        380        390        400
EQHFLQTHPN KIKASLPSSE VAKPSEKNSN KSIPALQSSD SGDLGKWQDK 
       410        420        430        440        450
ITVKAGDDTP VGYSVPIKPL DSSRQNGTEA TSYYWCKFCS FSCESSSSLK 
       460        470        480        490        500
LLEHYGKQHG AVQSGGLNPE LNDKLSRGSV INQNDLAKSS EGETMTKTDK 
       510        520        530        540        550
SSSGAKKKDF SSKGAEDNMV TSYNCQFCDF RYSKSHGPDV IVVGPLLRHY 
       560        570        580        590        600
QQLHNIHKCT IKHCPFCPRG LCSPEKHLGE ITYPFACRKS NCSHCALLLL 
       610        620        630        640        650
HLSPGAAGSS RVKHQCHQCS FTTPDVDVLL FHYESVHESQ ASDVKQEANH 
       660        670        680        690        700
LQGSDGQQSV KESKEHSCTK CDFITQVEEE ISRHYRRAHS CYKCRQCSFT 
       710        720        730        740        750
AADTQSLLEH FNTVHCQEQD ITTANGEEDG HAISTIKEEP KIDFRVYNLL 
       760        770        780        790        800
TPDSKMGEPV SESVVKREKL EEKDGLKEKV WTESSSDDLR NVTWRGADIL 
       810        820        830        840        850
RGSPSYTQAS LGLLTPVSGT QEQTKTLRDS PNVEAAHLAR PIYGLAVETK 
       860        870        880        890        900
GFLQGAPAGG EKSGALPQQY PASGENKSKD ESQSLLRRRR GSGVFCANCL 
       910        920        930        940        950
TTKTSLWRKN ANGGYVCNAC GLYQKLHSTP RPLNIIKQNN GEQIIRRRTR 
       960        970        980        990       1000
KRLNPEALQA EQLNKQQRGS NEEQVNGSPL ERRSEDHLTE SHQREIPLPS 
      1010       1020       1030       1040       1050
LSKYEAQGSL TKSHSAQQPV LVSQTLDIHK RMQPLHIQIK SPQESTGDPG 
      1060       1070       1080       1090       1100
NSSSVSEGKG SSERGSPIEK YMRPAKHPNY SPPGSPIEKY QYPLFGLPFV 
      1110       1120       1130       1140       1150
HNDFQSEADW LRFWSKYKLS VPGNPHYLSH VPGLPNPCQN YVPYPTFNLP 
      1160       1170       1180       1190       1200
PHFSAVGSDN DIPLDLAIKH SRPGPTANGA SKEKTKAPPN VKNEGPLNVV 
      1210       1220       1230       1240       1250
KTEKVDRSTQ DELSTKCVHC GIVFLDEVMY ALHMSCHGDS GPFQCSICQH 
      1260       1270       1280 
LCTDKYDFTT HIQRGLHRNN AQVEKNGKPK E

Length:1,281

Mass (Da):141,521

Last modified:March 27, 2002 - v2

Checksum:ⁱ2157B04F5BEB71CC

GO

Isoform 2 (identifier: Q9UHF7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MPYEVNAGYDFTNM

« Hide

        10         20         30         40         50
MPYEVNAGYD FTNMVRKKNP PLRNVASEGE GQILEPIGTE SKVSGKNKEF 
        60         70         80         90        100
SADQMSENTD QSDAAELNHK EEHSLHVQDP SSSSKKDLKS AVLSEKAGFN 
       110        120        130        140        150
YESPSKGGNF PSFPHDEVTD RNMLAFSSPA AGGVCEPLKS PQRAEADDPQ 
       160        170        180        190        200
DMACTPSGDS LETKEDQKMS PKATEETGQA QSGQANCQGL SPVSVASKNP 
       210        220        230        240        250
QVPSDGGVRL NKSKTDLLVN DNPDPAPLSP ELQDFKCNIC GYGYYGNDPT 
       260        270        280        290        300
DLIKHFRKYH LGLHNRTRQD AELDSKILAL HNMVQFSHSK DFQKVNRSVF 
       310        320        330        340        350
SGVLQDINSS RPVLLNGTYD VQVTSGGTFI GIGRKTPDCQ GNTKYFRCKF 
       360        370        380        390        400
CNFTYMGNSS TELEQHFLQT HPNKIKASLP SSEVAKPSEK NSNKSIPALQ 
       410        420        430        440        450
SSDSGDLGKW QDKITVKAGD DTPVGYSVPI KPLDSSRQNG TEATSYYWCK 
       460        470        480        490        500
FCSFSCESSS SLKLLEHYGK QHGAVQSGGL NPELNDKLSR GSVINQNDLA 
       510        520        530        540        550
KSSEGETMTK TDKSSSGAKK KDFSSKGAED NMVTSYNCQF CDFRYSKSHG 
       560        570        580        590        600
PDVIVVGPLL RHYQQLHNIH KCTIKHCPFC PRGLCSPEKH LGEITYPFAC 
       610        620        630        640        650
RKSNCSHCAL LLLHLSPGAA GSSRVKHQCH QCSFTTPDVD VLLFHYESVH 
       660        670        680        690        700
ESQASDVKQE ANHLQGSDGQ QSVKESKEHS CTKCDFITQV EEEISRHYRR 
       710        720        730        740        750
AHSCYKCRQC SFTAADTQSL LEHFNTVHCQ EQDITTANGE EDGHAISTIK 
       760        770        780        790        800
EEPKIDFRVY NLLTPDSKMG EPVSESVVKR EKLEEKDGLK EKVWTESSSD 
       810        820        830        840        850
DLRNVTWRGA DILRGSPSYT QASLGLLTPV SGTQEQTKTL RDSPNVEAAH 
       860        870        880        890        900
LARPIYGLAV ETKGFLQGAP AGGEKSGALP QQYPASGENK SKDESQSLLR 
       910        920        930        940        950
RRRGSGVFCA NCLTTKTSLW RKNANGGYVC NACGLYQKLH STPRPLNIIK 
       960        970        980        990       1000
QNNGEQIIRR RTRKRLNPEA LQAEQLNKQQ RGSNEEQVNG SPLERRSEDH 
      1010       1020       1030       1040       1050
LTESHQREIP LPSLSKYEAQ GSLTKSHSAQ QPVLVSQTLD IHKRMQPLHI 
      1060       1070       1080       1090       1100
QIKSPQESTG DPGNSSSVSE GKGSSERGSP IEKYMRPAKH PNYSPPGSPI 
      1110       1120       1130       1140       1150
EKYQYPLFGL PFVHNDFQSE ADWLRFWSKY KLSVPGNPHY LSHVPGLPNP 
      1160       1170       1180       1190       1200
CQNYVPYPTF NLPPHFSAVG SDNDIPLDLA IKHSRPGPTA NGASKEKTKA 
      1210       1220       1230       1240       1250
PPNVKNEGPL NVVKTEKVDR STQDELSTKC VHCGIVFLDE VMYALHMSCH 
      1260       1270       1280       1290 
GDSGPFQCSI CQHLCTDKYD FTTHIQRGLH RNNAQVEKNG KPKE

Show »

Length:1,294

Mass (Da):143,023

Checksum:ⁱ0801087C5B0E5196

GO

Isoform 3 (identifier: Q9UHF7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MQSNM

« Hide

        10         20         30         40         50
MQSNMVRKKN PPLRNVASEG EGQILEPIGT ESKVSGKNKE FSADQMSENT 
        60         70         80         90        100
DQSDAAELNH KEEHSLHVQD PSSSSKKDLK SAVLSEKAGF NYESPSKGGN 
       110        120        130        140        150
FPSFPHDEVT DRNMLAFSSP AAGGVCEPLK SPQRAEADDP QDMACTPSGD 
       160        170        180        190        200
SLETKEDQKM SPKATEETGQ AQSGQANCQG LSPVSVASKN PQVPSDGGVR 
       210        220        230        240        250
LNKSKTDLLV NDNPDPAPLS PELQDFKCNI CGYGYYGNDP TDLIKHFRKY 
       260        270        280        290        300
HLGLHNRTRQ DAELDSKILA LHNMVQFSHS KDFQKVNRSV FSGVLQDINS 
       310        320        330        340        350
SRPVLLNGTY DVQVTSGGTF IGIGRKTPDC QGNTKYFRCK FCNFTYMGNS 
       360        370        380        390        400
STELEQHFLQ THPNKIKASL PSSEVAKPSE KNSNKSIPAL QSSDSGDLGK 
       410        420        430        440        450
WQDKITVKAG DDTPVGYSVP IKPLDSSRQN GTEATSYYWC KFCSFSCESS 
       460        470        480        490        500
SSLKLLEHYG KQHGAVQSGG LNPELNDKLS RGSVINQNDL AKSSEGETMT 
       510        520        530        540        550
KTDKSSSGAK KKDFSSKGAE DNMVTSYNCQ FCDFRYSKSH GPDVIVVGPL 
       560        570        580        590        600
LRHYQQLHNI HKCTIKHCPF CPRGLCSPEK HLGEITYPFA CRKSNCSHCA 
       610        620        630        640        650
LLLLHLSPGA AGSSRVKHQC HQCSFTTPDV DVLLFHYESV HESQASDVKQ 
       660        670        680        690        700
EANHLQGSDG QQSVKESKEH SCTKCDFITQ VEEEISRHYR RAHSCYKCRQ 
       710        720        730        740        750
CSFTAADTQS LLEHFNTVHC QEQDITTANG EEDGHAISTI KEEPKIDFRV 
       760        770        780        790        800
YNLLTPDSKM GEPVSESVVK REKLEEKDGL KEKVWTESSS DDLRNVTWRG 
       810        820        830        840        850
ADILRGSPSY TQASLGLLTP VSGTQEQTKT LRDSPNVEAA HLARPIYGLA 
       860        870        880        890        900
VETKGFLQGA PAGGEKSGAL PQQYPASGEN KSKDESQSLL RRRRGSGVFC 
       910        920        930        940        950
ANCLTTKTSL WRKNANGGYV CNACGLYQKL HSTPRPLNII KQNNGEQIIR 
       960        970        980        990       1000
RRTRKRLNPE ALQAEQLNKQ QRGSNEEQVN GSPLERRSED HLTESHQREI 
      1010       1020       1030       1040       1050
PLPSLSKYEA QGSLTKSHSA QQPVLVSQTL DIHKRMQPLH IQIKSPQEST 
      1060       1070       1080       1090       1100
GDPGNSSSVS EGKGSSERGS PIEKYMRPAK HPNYSPPGSP IEKYQYPLFG 
      1110       1120       1130       1140       1150
LPFVHNDFQS EADWLRFWSK YKLSVPGNPH YLSHVPGLPN PCQNYVPYPT 
      1160       1170       1180       1190       1200
FNLPPHFSAV GSDNDIPLDL AIKHSRPGPT ANGASKEKTK APPNVKNEGP 
      1210       1220       1230       1240       1250
LNVVKTEKVD RSTQDELSTK CVHCGIVFLD EVMYALHMSC HGDSGPFQCS 
      1260       1270       1280 
ICQHLCTDKY DFTTHIQRGL HRNNAQVEKN GKPKE

Show »

Length:1,285

Mass (Da):141,981

Checksum:ⁱACA951C56206BA8F

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RFF3	E5RFF3_HUMAN	Zinc finger transcription factor Tr... Zinc finger transcription factor Trps1	TRPS1	1,035	Annotation score:
H0YAV4	H0YAV4_HUMAN	Zinc finger transcription factor Tr... Zinc finger transcription factor Trps1	TRPS1	271	Annotation score:
H0YC29	H0YC29_HUMAN	Zinc finger transcription factor Tr... Zinc finger transcription factor Trps1	TRPS1	691	Annotation score:
E5RJ97	E5RJ97_HUMAN	Zinc finger transcription factor Tr... Zinc finger transcription factor Trps1	TRPS1	902	Annotation score:
C9J6L7	C9J6L7_HUMAN	Zinc finger transcription factor Tr... Zinc finger transcription factor Trps1	TRPS1	61	Annotation score:
F8W8T0	F8W8T0_HUMAN	Zinc finger transcription factor Tr... Zinc finger transcription factor Trps1	TRPS1	117	Annotation score:
E7EVN4	E7EVN4_HUMAN	Zinc finger transcription factor Tr... Zinc finger transcription factor Trps1	TRPS1	108	Annotation score:
A0A1D5RMP4	A0A1D5RMP4_HUMAN	Zinc finger transcription factor Tr... Zinc finger transcription factor Trps1	TRPS1	9	Annotation score:

Sequence cautionⁱ

The sequence AAI25021 differs from that shown. Reason: Erroneous termination at position 854. Translated as Gln.Curated

The sequence BAA91441 differs from that shown. Reason: Frameshift at position 1276.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	115	S → F in AAF23614 (PubMed:10615131).Curated		1
Sequence conflictⁱ	582	T → A in BAG64957 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_038197	654	S → L. Corresponds to variant dbSNP:rs7002384Ensembl.	1
Natural variantⁱVAR_012807	894	V → D in TRPS3; in heterozygous status has a milder effect causing TRPS1. 1 Publication	1
Natural variantⁱVAR_012808	901	T → P in TRPS3; severe. 1 PublicationCorresponds to variant dbSNP:rs121908433Ensembl.	1
Natural variantⁱVAR_012809	908	R → P in TRPS3; severe. 1 Publication	1
Natural variantⁱVAR_012810	908	R → Q in TRPS3. 2 PublicationsCorresponds to variant dbSNP:rs121908435Ensembl.	1
Natural variantⁱVAR_012811	919	A → T in TRPS3. 1 PublicationCorresponds to variant dbSNP:rs1057518972Ensembl.	1
Natural variantⁱVAR_038198	952	R → C in TRPS1; prevents the transport into the nucleus and thus reduces the nuclear TRPS1 concentration consistent with haploinsufficiency. 1 PublicationCorresponds to variant dbSNP:rs28939069Ensembl.	1
Natural variantⁱVAR_038199	952	R → H in TRPS1; prevents the transport into the nucleus and thus reduces the nuclear TRPS1 concentration consistent with haploinsufficiency. 1 PublicationCorresponds to variant dbSNP:rs28939070Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037549	1	M → MPYEVNAGYDFTNM in isoform 2. 1 Publication		1
Alternative sequenceⁱVSP_037550	1	M → MQSNM in isoform 3. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF183810 mRNA Translation: AAF23614.1 AF264784 mRNA Translation: AAG21134.1 AK000948 mRNA Translation: BAA91441.1 Frameshift. AK304046 mRNA Translation: BAG64957.1 AF178030 Genomic DNA No translation available. BC125020 mRNA Translation: AAI25021.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6318.2 [Q9UHF7-2] CCDS64957.1 [Q9UHF7-3] CCDS83316.1 [Q9UHF7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001269831.1, NM_001282902.2 [Q9UHF7-3] NP_001269832.1, NM_001282903.2 NP_001317528.1, NM_001330599.1 [Q9UHF7-1] NP_054831.2, NM_014112.4 [Q9UHF7-2] XP_006716688.1, XM_006716625.1 [Q9UHF7-2] XP_011515566.1, XM_011517264.1 [Q9UHF7-2] XP_011515568.1, XM_011517266.2 [Q9UHF7-2] XP_011515570.1, XM_011517268.1 [Q9UHF7-1]
UniGeneⁱ	Hs.657018

Genome annotation databases

Ensemblⁱ	ENST00000220888; ENSP00000220888; ENSG00000104447 [Q9UHF7-1] ENST00000395715; ENSP00000379065; ENSG00000104447 [Q9UHF7-2] ENST00000520276; ENSP00000428680; ENSG00000104447 [Q9UHF7-3] ENST00000640765; ENSP00000492037; ENSG00000104447 [Q9UHF7-1]
GeneIDⁱ	7227
KEGGⁱ	hsa:7227
UCSC genome browser More...UCSCⁱ	uc003yny.5 human [Q9UHF7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UHF7	Zinc finger transcription factor Trps1		MOUSE		1281	UniRef90_Q9UHF7
Isoform 2 of Zinc finger transcription factor Trps1		HUMAN		1294
Uncharacterized protein		Cebus capucinus imitator		1301
Uncharacterized protein		PROCO		1297
zinc finger transcription factor Trps1 isoform X1		ERIEU		1295
+331

Protein	Similar proteins		Species	Score	Length	Source
Q9UHF7	Zinc finger transcription factor Trps1		MOUSE		1281	UniRef50_Q9UHF7
Zinc finger transcription factor Trps1		XENLA		1271
Isoform 2 of Zinc finger transcription factor Trps1		HUMAN		1294
Uncharacterized protein		Cebus capucinus imitator		1301
Uncharacterized protein		PROCO		1297
+637

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF183810 mRNA Translation: AAF23614.1 AF264784 mRNA Translation: AAG21134.1 AK000948 mRNA Translation: BAA91441.1 Frameshift. AK304046 mRNA Translation: BAG64957.1 AF178030 Genomic DNA No translation available. BC125020 mRNA Translation: AAI25021.1 Sequence problems.
CCDSⁱ	CCDS6318.2 [Q9UHF7-2] CCDS64957.1 [Q9UHF7-3] CCDS83316.1 [Q9UHF7-1]
RefSeqⁱ	NP_001269831.1, NM_001282902.2 [Q9UHF7-3] NP_001269832.1, NM_001282903.2 NP_001317528.1, NM_001330599.1 [Q9UHF7-1] NP_054831.2, NM_014112.4 [Q9UHF7-2] XP_006716688.1, XM_006716625.1 [Q9UHF7-2] XP_011515566.1, XM_011517264.1 [Q9UHF7-2] XP_011515568.1, XM_011517266.2 [Q9UHF7-2] XP_011515570.1, XM_011517268.1 [Q9UHF7-1]
UniGeneⁱ	Hs.657018

3D structure databases

ProteinModelPortalⁱ	Q9UHF7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113078, 31 interactors
ELMⁱ	Q9UHF7
IntActⁱ	Q9UHF7, 23 interactors
MINTⁱ	Q9UHF7
STRINGⁱ	9606.ENSP00000379065

PTM databases

iPTMnetⁱ	Q9UHF7
PhosphoSitePlusⁱ	Q9UHF7

Polymorphism and mutation databases

DMDMⁱ	20140909

DMDMⁱ

20140909

Proteomic databases

EPDⁱ	Q9UHF7
PaxDbⁱ	Q9UHF7
PeptideAtlasⁱ	Q9UHF7
PRIDEⁱ	Q9UHF7
ProteomicsDBⁱ	84344 84345 [Q9UHF7-2] 84346 [Q9UHF7-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000220888; ENSP00000220888; ENSG00000104447 [Q9UHF7-1] ENST00000395715; ENSP00000379065; ENSG00000104447 [Q9UHF7-2] ENST00000520276; ENSP00000428680; ENSG00000104447 [Q9UHF7-3] ENST00000640765; ENSP00000492037; ENSG00000104447 [Q9UHF7-1]
GeneIDⁱ	7227
KEGGⁱ	hsa:7227
UCSCⁱ	uc003yny.5 human [Q9UHF7-1]

Organism-specific databases

CTDⁱ	7227
DisGeNETⁱ	7227
EuPathDBⁱ	HostDB:ENSG00000104447.11
GeneCardsⁱ	TRPS1
HGNCⁱ	HGNC:12340 TRPS1
HPAⁱ	HPA060380 HPA071767
MalaCardsⁱ	TRPS1
MIMⁱ	150230 phenotype 190350 phenotype 190351 phenotype 604386 gene
neXtProtⁱ	NX_Q9UHF7
OpenTargetsⁱ	ENSG00000104447
Orphanetⁱ	77258 Trichorhinophalangeal syndrome type 1 and 3 502 Trichorhinophalangeal syndrome type 2
PharmGKBⁱ	PA37013
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1601 Eukaryota COG5641 LUCA
GeneTreeⁱ	ENSGT00760000119221
HOGENOMⁱ	HOG000146438
HOVERGENⁱ	HBG067120
InParanoidⁱ	Q9UHF7
KOⁱ	K22040
OMAⁱ	NAGYDFT
OrthoDBⁱ	EOG091G00VI
PhylomeDBⁱ	Q9UHF7
TreeFamⁱ	TF350812

Enzyme and pathway databases

SIGNORⁱ	Q9UHF7

SIGNORⁱ

Q9UHF7

Miscellaneous databases

ChiTaRSⁱ	TRPS1 human
GeneWikiⁱ	Tricho-rhino-phalangeal_syndrome_Type_1
GenomeRNAiⁱ	7227
Protein Ontology More...PROⁱ	PR:Q9UHF7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000104447 Expressed in 226 organ(s), highest expression level in thoracic mammary gland
CleanExⁱ	HS_TRPS1
ExpressionAtlasⁱ	Q9UHF7 baseline and differential
Genevisibleⁱ	Q9UHF7 HS

Family and domain databases

CDDⁱ	cd00202 ZnF_GATA, 1 hit
Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR039355 Transcription_factor_GATA IPR028440 TRPS1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type IPR000679 Znf_GATA IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR10071 PTHR10071, 1 hit PTHR10071:SF176 PTHR10071:SF176, 1 hit
Pfamⁱ	View protein in Pfam PF00320 GATA, 1 hit
PRINTSⁱ	PR00619 GATAZNFINGER
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 9 hits SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS00344 GATA_ZN_FINGER_1, 1 hit PS50114 GATA_ZN_FINGER_2, 1 hit PS00028 ZINC_FINGER_C2H2_1, 2 hits PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRPS1_HUMAN
Accessionⁱ	Q9UHF7Primary (citable) accession number: Q9UHF7 Secondary accession number(s): B4E1Z5 , Q08AU2, Q9NWE1, Q9UHH6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
	Last sequence update:	March 27, 2002
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - Q9UHF7 (TRPS1_HUMAN)

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Zinc finger transcription factor Trps1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Tricho-rhino-phalangeal syndrome 2 (TRPS2)

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ