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UniProtKB - Q9UHF7 (TRPS1_HUMAN)

Entry version 189 (23 Feb 2022)
Sequence version 2 (27 Mar 2002)
Previous versions | rss
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Protein

Zinc finger transcription factor Trps1

Gene

TRPS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri222 – 247C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri333 – 358C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri614 – 637C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri666 – 689C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri692 – 715C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri896 – 920GATA-typePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1215 – 1237C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1243 – 1267C2H2-type 7PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UHF7

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UHF7

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UHF7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger transcription factor Trps1
Alternative name(s):
Tricho-rhino-phalangeal syndrome type I protein
Zinc finger protein GC79
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRPS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12340, TRPS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604386, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UHF7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000104447

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Tricho-rhino-phalangeal syndrome 1 (TRPS1)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAutosomal dominant disorder characterized by craniofacial and skeletal abnormalities. It is allelic with tricho-rhino-phalangeal type 3. Typical features include sparse scalp hair, a bulbous tip of the nose, protruding ears, a long flat philtrum and a thin upper vermilion border. Skeletal defects include cone-shaped epiphyses at the phalanges, hip malformations and short stature.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038198952R → C in TRPS1; prevents the transport into the nucleus and thus reduces the nuclear TRPS1 concentration consistent with haploinsufficiency. 1 PublicationCorresponds to variant dbSNP:rs28939069Ensembl.1
Natural variantiVAR_038199952R → H in TRPS1; prevents the transport into the nucleus and thus reduces the nuclear TRPS1 concentration consistent with haploinsufficiency. 1 PublicationCorresponds to variant dbSNP:rs28939070Ensembl.1
Tricho-rhino-phalangeal syndrome 2 (TRPS2)
The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration resulting in the loss of functional copies of TRPS1 and EXT1 has been found in TRPS2 patients.
Disease descriptionA syndrome that combines the clinical features of tricho-rhino-phalangeal syndrome type 1 and multiple exostoses type 1. Affected individuals manifest multiple dysmorphic facial features including large, laterally protruding ears, a bulbous nose, an elongated upper lip, as well as sparse scalp hair, winged scapulae, multiple cartilaginous exostoses, redundant skin, and mental retardation.
Related information in OMIM
Tricho-rhino-phalangeal syndrome 3 (TRPS3)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAutosomal dominant disorder characterized by craniofacial and skeletal abnormalities. It is allelic with tricho-rhino-phalangeal type 1. In TRPS3 a more severe brachydactyly and growth retardation are observed.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012807894V → D in TRPS3; in heterozygous status has a milder effect causing TRPS1. 1 Publication1
Natural variantiVAR_012808901T → P in TRPS3; severe. 1 PublicationCorresponds to variant dbSNP:rs121908433Ensembl.1
Natural variantiVAR_012809908R → P in TRPS3; severe. 1 Publication1
Natural variantiVAR_012810908R → Q in TRPS3. 2 PublicationsCorresponds to variant dbSNP:rs121908435Ensembl.1
Natural variantiVAR_012811919A → T in TRPS3. 1 PublicationCorresponds to variant dbSNP:rs1057518972Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1192K → R: Very little change in sumoylation and 30% reduction in repression activity. Almost complete loss of sumoylation and 70% reduction in repression activity; when associated with R-1201. 1 Publication1
Mutagenesisi1201K → R: Great loss of sumoylation and 30% reduction in repression activity. Almost complete loss of sumoylation and 70% reduction in repression activity; when associated with R-1192. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		7227

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		TRPS1

MalaCards human disease database

More...MalaCardsi		TRPS1
MIMi150230, phenotype
190350, phenotype
190351, phenotype

Open Targets

More...OpenTargetsi		ENSG00000104447

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		77258, Trichorhinophalangeal syndrome type 1 and 3
502, Trichorhinophalangeal syndrome type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37013

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UHF7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRPS1

Domain mapping of disease mutations (DMDM)

More...DMDMi		20140909

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000835081 – 1281Zinc finger transcription factor Trps1Add BLAST1281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei90PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei216PhosphoserineBy similarity1
Cross-linki263Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki418Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki457Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki474Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki488Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki645Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki737Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei751PhosphothreonineCombined sources1
Cross-linki755Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki766Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki766Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki825Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki850Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki877Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki925Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki937Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki965Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei978PhosphoserineCombined sources1
Cross-linki1003Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1012Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1030Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1040Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1041PhosphoserineCombined sources1
Modified residuei1066PhosphoserineCombined sources1
Cross-linki1070Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1085PhosphoserineCombined sources1
Cross-linki1192Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate1 Publication
Cross-linki1192Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki1201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki1201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UHF7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UHF7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UHF7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UHF7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UHF7

PeptideAtlas

More...PeptideAtlasi		Q9UHF7

PRoteomics IDEntifications database

More...PRIDEi		Q9UHF7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84344 [Q9UHF7-1]
84345 [Q9UHF7-2]
84346 [Q9UHF7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UHF7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UHF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000104447, Expressed in thoracic mammary gland and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UHF7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UHF7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000104447, Tissue enhanced (brain, breast)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RNF4; regulates TRPS1 repressor activity.

Interacts specifically with the activator form of GLI3 (GLI3A) but not with the repressor form (GLI3R).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113078, 66 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9UHF7

Protein interaction database and analysis system

More...IntActi		Q9UHF7, 31 interactors

Molecular INTeraction database

More...MINTi		Q9UHF7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379065

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UHF7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 198DisorderedSequence analysisAdd BLAST198
Regioni365 – 394DisorderedSequence analysisAdd BLAST30
Regioni483 – 512DisorderedSequence analysisAdd BLAST30
Regioni635 – 819Mediates interaction with GLI31 PublicationAdd BLAST185
Regioni856 – 887DisorderedSequence analysisAdd BLAST32
Regioni961 – 1000DisorderedSequence analysisAdd BLAST40
Regioni985 – 1184Mediates interaction with RNF4By similarityAdd BLAST200
Regioni1039 – 1080DisorderedSequence analysisAdd BLAST42
Regioni1163 – 1281Transcriptional repressor domainBy similarityAdd BLAST119
Regioni1168 – 1196DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi31 – 49Polar residuesSequence analysisAdd BLAST19
Compositional biasi50 – 70Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi160 – 195Polar residuesSequence analysisAdd BLAST36
Compositional biasi371 – 394Polar residuesSequence analysisAdd BLAST24
Compositional biasi492 – 512Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi961 – 977Polar residuesSequence analysisAdd BLAST17
Compositional biasi978 – 993Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1039 – 1061Polar residuesSequence analysisAdd BLAST23

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 247C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri333 – 358C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri614 – 637C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri666 – 689C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri692 – 715C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri896 – 920GATA-typePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1215 – 1237C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1243 – 1267C2H2-type 7PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1601, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157893

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UHF7

Identification of Orthologs from Complete Genome Data

More...OMAi		SCHTLIN

Database of Orthologous Groups

More...OrthoDBi		120630at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UHF7

TreeFam database of animal gene trees

More...TreeFami		TF350812

Family and domain databases

Conserved Domains Database

More...CDDi		cd00202, ZnF_GATA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028440, TRPS1
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
IPR000679, Znf_GATA
IPR013088, Znf_NHR/GATA

The PANTHER Classification System

More...PANTHERi		PTHR47034, PTHR47034, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00320, GATA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00619, GATAZNFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 9 hits
SM00401, ZnF_GATA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00344, GATA_ZN_FINGER_1, 1 hit
PS50114, GATA_ZN_FINGER_2, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UHF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRKKNPPLR NVASEGEGQI LEPIGTESKV SGKNKEFSAD QMSENTDQSD 
        60         70         80         90        100
AAELNHKEEH SLHVQDPSSS SKKDLKSAVL SEKAGFNYES PSKGGNFPSF 
       110        120        130        140        150
PHDEVTDRNM LAFSSPAAGG VCEPLKSPQR AEADDPQDMA CTPSGDSLET 
       160        170        180        190        200
KEDQKMSPKA TEETGQAQSG QANCQGLSPV SVASKNPQVP SDGGVRLNKS 
       210        220        230        240        250
KTDLLVNDNP DPAPLSPELQ DFKCNICGYG YYGNDPTDLI KHFRKYHLGL 
       260        270        280        290        300
HNRTRQDAEL DSKILALHNM VQFSHSKDFQ KVNRSVFSGV LQDINSSRPV 
       310        320        330        340        350
LLNGTYDVQV TSGGTFIGIG RKTPDCQGNT KYFRCKFCNF TYMGNSSTEL 
       360        370        380        390        400
EQHFLQTHPN KIKASLPSSE VAKPSEKNSN KSIPALQSSD SGDLGKWQDK 
       410        420        430        440        450
ITVKAGDDTP VGYSVPIKPL DSSRQNGTEA TSYYWCKFCS FSCESSSSLK 
       460        470        480        490        500
LLEHYGKQHG AVQSGGLNPE LNDKLSRGSV INQNDLAKSS EGETMTKTDK 
       510        520        530        540        550
SSSGAKKKDF SSKGAEDNMV TSYNCQFCDF RYSKSHGPDV IVVGPLLRHY 
       560        570        580        590        600
QQLHNIHKCT IKHCPFCPRG LCSPEKHLGE ITYPFACRKS NCSHCALLLL 
       610        620        630        640        650
HLSPGAAGSS RVKHQCHQCS FTTPDVDVLL FHYESVHESQ ASDVKQEANH 
       660        670        680        690        700
LQGSDGQQSV KESKEHSCTK CDFITQVEEE ISRHYRRAHS CYKCRQCSFT 
       710        720        730        740        750
AADTQSLLEH FNTVHCQEQD ITTANGEEDG HAISTIKEEP KIDFRVYNLL 
       760        770        780        790        800
TPDSKMGEPV SESVVKREKL EEKDGLKEKV WTESSSDDLR NVTWRGADIL 
       810        820        830        840        850
RGSPSYTQAS LGLLTPVSGT QEQTKTLRDS PNVEAAHLAR PIYGLAVETK 
       860        870        880        890        900
GFLQGAPAGG EKSGALPQQY PASGENKSKD ESQSLLRRRR GSGVFCANCL 
       910        920        930        940        950
TTKTSLWRKN ANGGYVCNAC GLYQKLHSTP RPLNIIKQNN GEQIIRRRTR 
       960        970        980        990       1000
KRLNPEALQA EQLNKQQRGS NEEQVNGSPL ERRSEDHLTE SHQREIPLPS 
      1010       1020       1030       1040       1050
LSKYEAQGSL TKSHSAQQPV LVSQTLDIHK RMQPLHIQIK SPQESTGDPG 
      1060       1070       1080       1090       1100
NSSSVSEGKG SSERGSPIEK YMRPAKHPNY SPPGSPIEKY QYPLFGLPFV 
      1110       1120       1130       1140       1150
HNDFQSEADW LRFWSKYKLS VPGNPHYLSH VPGLPNPCQN YVPYPTFNLP 
      1160       1170       1180       1190       1200
PHFSAVGSDN DIPLDLAIKH SRPGPTANGA SKEKTKAPPN VKNEGPLNVV 
      1210       1220       1230       1240       1250
KTEKVDRSTQ DELSTKCVHC GIVFLDEVMY ALHMSCHGDS GPFQCSICQH 
      1260       1270       1280 
LCTDKYDFTT HIQRGLHRNN AQVEKNGKPK E
Length:1,281
Mass (Da):141,521
Last modified:March 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2157B04F5BEB71CC
GO
Isoform 2 (identifier: Q9UHF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPYEVNAGYDFTNM

Show »
Length:1,294
Mass (Da):143,023
Checksum:i0801087C5B0E5196
GO
Isoform 3 (identifier: Q9UHF7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQSNM

Show »
Length:1,285
Mass (Da):141,981
Checksum:iACA951C56206BA8F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFF3E5RFF3_HUMAN
Zinc finger transcription factor Tr...
TRPS1
1,035Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAV4H0YAV4_HUMAN
Zinc finger transcription factor Tr...
TRPS1
271Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC29H0YC29_HUMAN
Zinc finger transcription factor Tr...
TRPS1
691Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6L7C9J6L7_HUMAN
Zinc finger transcription factor Tr...
TRPS1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ97E5RJ97_HUMAN
Zinc finger transcription factor Tr...
TRPS1
902Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W8T0F8W8T0_HUMAN
Zinc finger transcription factor Tr...
TRPS1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVN4E7EVN4_HUMAN
Zinc finger transcription factor Tr...
TRPS1
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMP4A0A1D5RMP4_HUMAN
Zinc finger transcription factor Tr...
TRPS1
9Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI25021 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAA91441 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti115S → F in AAF23614 (PubMed:10615131).Curated1
Sequence conflicti582T → A in BAG64957 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038197654S → L. Corresponds to variant dbSNP:rs7002384Ensembl.1
Natural variantiVAR_012807894V → D in TRPS3; in heterozygous status has a milder effect causing TRPS1. 1 Publication1
Natural variantiVAR_012808901T → P in TRPS3; severe. 1 PublicationCorresponds to variant dbSNP:rs121908433Ensembl.1
Natural variantiVAR_012809908R → P in TRPS3; severe. 1 Publication1
Natural variantiVAR_012810908R → Q in TRPS3. 2 PublicationsCorresponds to variant dbSNP:rs121908435Ensembl.1
Natural variantiVAR_012811919A → T in TRPS3. 1 PublicationCorresponds to variant dbSNP:rs1057518972Ensembl.1
Natural variantiVAR_038198952R → C in TRPS1; prevents the transport into the nucleus and thus reduces the nuclear TRPS1 concentration consistent with haploinsufficiency. 1 PublicationCorresponds to variant dbSNP:rs28939069Ensembl.1
Natural variantiVAR_038199952R → H in TRPS1; prevents the transport into the nucleus and thus reduces the nuclear TRPS1 concentration consistent with haploinsufficiency. 1 PublicationCorresponds to variant dbSNP:rs28939070Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0375491M → MPYEVNAGYDFTNM in isoform 2. 1 Publication1
Alternative sequenceiVSP_0375501M → MQSNM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF183810 mRNA Translation: AAF23614.1
AF264784 mRNA Translation: AAG21134.1
AK000948 mRNA Translation: BAA91441.1 Frameshift.
AK304046 mRNA Translation: BAG64957.1
AF178030 Genomic DNA No translation available.
BC125020 mRNA Translation: AAI25021.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6318.2 [Q9UHF7-2]
CCDS64957.1 [Q9UHF7-3]
CCDS83316.1 [Q9UHF7-1]

NCBI Reference Sequences

More...RefSeqi		NP_001269831.1, NM_001282902.2 [Q9UHF7-3]
NP_001269832.1, NM_001282903.2
NP_001317528.1, NM_001330599.1 [Q9UHF7-1]
NP_054831.2, NM_014112.4 [Q9UHF7-2]
XP_006716688.1, XM_006716625.1
XP_011515566.1, XM_011517264.1
XP_011515568.1, XM_011517266.2
XP_011515570.1, XM_011517268.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000220888; ENSP00000220888; ENSG00000104447
ENST00000395715; ENSP00000379065; ENSG00000104447 [Q9UHF7-2]
ENST00000520276; ENSP00000428680; ENSG00000104447 [Q9UHF7-3]
ENST00000640765; ENSP00000492037; ENSG00000104447

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7227

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7227

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000395715.8; ENSP00000379065.3; NM_014112.5; NP_054831.2 [Q9UHF7-2]

UCSC genome browser

More...UCSCi		uc003yny.5, human [Q9UHF7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF183810 mRNA Translation: AAF23614.1
AF264784 mRNA Translation: AAG21134.1
AK000948 mRNA Translation: BAA91441.1 Frameshift.
AK304046 mRNA Translation: BAG64957.1
AF178030 Genomic DNA No translation available.
BC125020 mRNA Translation: AAI25021.1 Sequence problems.
CCDSiCCDS6318.2 [Q9UHF7-2]
CCDS64957.1 [Q9UHF7-3]
CCDS83316.1 [Q9UHF7-1]
RefSeqiNP_001269831.1, NM_001282902.2 [Q9UHF7-3]
NP_001269832.1, NM_001282903.2
NP_001317528.1, NM_001330599.1 [Q9UHF7-1]
NP_054831.2, NM_014112.4 [Q9UHF7-2]
XP_006716688.1, XM_006716625.1
XP_011515566.1, XM_011517264.1
XP_011515568.1, XM_011517266.2
XP_011515570.1, XM_011517268.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi113078, 66 interactors
ELMiQ9UHF7
IntActiQ9UHF7, 31 interactors
MINTiQ9UHF7
STRINGi9606.ENSP00000379065

PTM databases

iPTMnetiQ9UHF7
PhosphoSitePlusiQ9UHF7

Genetic variation databases

BioMutaiTRPS1
DMDMi20140909

Proteomic databases

EPDiQ9UHF7
jPOSTiQ9UHF7
MassIVEiQ9UHF7
MaxQBiQ9UHF7
PaxDbiQ9UHF7
PeptideAtlasiQ9UHF7
PRIDEiQ9UHF7
ProteomicsDBi84344 [Q9UHF7-1]
84345 [Q9UHF7-2]
84346 [Q9UHF7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42950, 131 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		7227

Genome annotation databases

EnsembliENST00000220888; ENSP00000220888; ENSG00000104447
ENST00000395715; ENSP00000379065; ENSG00000104447 [Q9UHF7-2]
ENST00000520276; ENSP00000428680; ENSG00000104447 [Q9UHF7-3]
ENST00000640765; ENSP00000492037; ENSG00000104447
GeneIDi7227
KEGGihsa:7227
MANE-SelectiENST00000395715.8; ENSP00000379065.3; NM_014112.5; NP_054831.2 [Q9UHF7-2]
UCSCiuc003yny.5, human [Q9UHF7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7227
DisGeNETi7227

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRPS1
GeneReviewsiTRPS1
HGNCiHGNC:12340, TRPS1
HPAiENSG00000104447, Tissue enhanced (brain, breast)
MalaCardsiTRPS1
MIMi150230, phenotype
190350, phenotype
190351, phenotype
604386, gene
neXtProtiNX_Q9UHF7
OpenTargetsiENSG00000104447
Orphaneti77258, Trichorhinophalangeal syndrome type 1 and 3
502, Trichorhinophalangeal syndrome type 2
PharmGKBiPA37013
VEuPathDBiHostDB:ENSG00000104447

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1601, Eukaryota
GeneTreeiENSGT00940000157893
InParanoidiQ9UHF7
OMAiSCHTLIN
OrthoDBi120630at2759
PhylomeDBiQ9UHF7
TreeFamiTF350812

Enzyme and pathway databases

PathwayCommonsiQ9UHF7
SignaLinkiQ9UHF7
SIGNORiQ9UHF7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7227, 26 hits in 1069 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRPS1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Tricho-rhino-phalangeal_syndrome_Type_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7227
PharosiQ9UHF7, Tbio

Protein Ontology

More...PROi		PR:Q9UHF7
RNActiQ9UHF7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000104447, Expressed in thoracic mammary gland and 238 other tissues
ExpressionAtlasiQ9UHF7, baseline and differential
GenevisibleiQ9UHF7, HS

Family and domain databases

CDDicd00202, ZnF_GATA, 1 hit
Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR028440, TRPS1
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
IPR000679, Znf_GATA
IPR013088, Znf_NHR/GATA
PANTHERiPTHR47034, PTHR47034, 1 hit
PfamiView protein in Pfam
PF00320, GATA, 1 hit
PRINTSiPR00619, GATAZNFINGER
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 9 hits
SM00401, ZnF_GATA, 1 hit
SUPFAMiSSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00344, GATA_ZN_FINGER_1, 1 hit
PS50114, GATA_ZN_FINGER_2, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHF7
Secondary accession number(s): B4E1Z5
, Q08AU2, Q9NWE1, Q9UHH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: February 23, 2022
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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