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Protein

Interleukin-17B

Gene

IL17B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.

GO - Molecular functioni

  • cytokine activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

SIGNORiQ9UHF5

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17B
Short name:
IL-17B
Alternative name(s):
Cytokine Zcyto7
Interleukin-20
Short name:
IL-20
Neuronal interleukin-17-related factor
Gene namesi
Name:IL17B
Synonyms:IL20, NIRF, ZCYTO7
ORF Names:UNQ516/PRO1031
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000127743.5
HGNCiHGNC:5982 IL17B
MIMi604627 gene
neXtProtiNX_Q9UHF5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi27190
OpenTargetsiENSG00000127743
PharmGKBiPA29795

Polymorphism and mutation databases

BioMutaiIL17B
DMDMi20143877

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001542621 – 180Interleukin-17BAdd BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 176By similarity
Disulfide bondi126 ↔ 178By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UHF5
PeptideAtlasiQ9UHF5
PRIDEiQ9UHF5
ProteomicsDBi84343

Expressioni

Tissue specificityi

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Gene expression databases

BgeeiENSG00000127743 Expressed in 98 organ(s), highest expression level in tibia
CleanExiHS_IL17B
HS_IL20
GenevisibleiQ9UHF5 HS

Organism-specific databases

HPAiHPA042441

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118065, 25 interactors
IntActiQ9UHF5, 1 interactor
STRINGi9606.ENSP00000261796

Structurei

3D structure databases

ProteinModelPortaliQ9UHF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXUM Eukaryota
ENOG410ZKTD LUCA
GeneTreeiENSGT00730000110983
HOGENOMiHOG000113030
HOVERGENiHBG052095
InParanoidiQ9UHF5
KOiK05490
OMAiPEAQCLC
OrthoDBiEOG091G17O0
PhylomeDBiQ9UHF5
TreeFamiTF314701

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UHF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDWPHNLLFL LTISIFLGLG QPRSPKSKRK GQGRPGPLAP GPHQVPLDLV
60 70 80 90 100
SRMKPYARME EYERNIEEMV AQLRNSSELA QRKCEVNLQL WMSNKRSLSP
110 120 130 140 150
WGYSINHDPS RIPVDLPEAR CLCLGCVNPF TMQEDRSMVS VPVFSQVPVR
160 170 180
RRLCPPPPRT GPCRQRAVME TIAVGCTCIF
Length:180
Mass (Da):20,437
Last modified:May 1, 2000 - v1
Checksum:iF1B0BC1446D0B14A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184969 mRNA Translation: AAF01318.1
AF212311 mRNA Translation: AAF78775.1
AF152098 mRNA Translation: AAF28104.1
AF218727 mRNA Translation: AAG44136.1
AF110385 mRNA Translation: AAG39637.1
AY358931 mRNA Translation: AAQ89290.1
AF386077 Genomic DNA Translation: AAK60336.1
BC113925 mRNA Translation: AAI13926.1
BC113946 mRNA Translation: AAI13947.1
CCDSiCCDS4297.1
RefSeqiNP_001304916.1, NM_001317987.1
NP_055258.1, NM_014443.2
UniGeneiHs.156979

Genome annotation databases

EnsembliENST00000261796; ENSP00000261796; ENSG00000127743
GeneIDi27190
KEGGihsa:27190
UCSCiuc003lqo.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-17 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184969 mRNA Translation: AAF01318.1
AF212311 mRNA Translation: AAF78775.1
AF152098 mRNA Translation: AAF28104.1
AF218727 mRNA Translation: AAG44136.1
AF110385 mRNA Translation: AAG39637.1
AY358931 mRNA Translation: AAQ89290.1
AF386077 Genomic DNA Translation: AAK60336.1
BC113925 mRNA Translation: AAI13926.1
BC113946 mRNA Translation: AAI13947.1
CCDSiCCDS4297.1
RefSeqiNP_001304916.1, NM_001317987.1
NP_055258.1, NM_014443.2
UniGeneiHs.156979

3D structure databases

ProteinModelPortaliQ9UHF5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118065, 25 interactors
IntActiQ9UHF5, 1 interactor
STRINGi9606.ENSP00000261796

Polymorphism and mutation databases

BioMutaiIL17B
DMDMi20143877

Proteomic databases

PaxDbiQ9UHF5
PeptideAtlasiQ9UHF5
PRIDEiQ9UHF5
ProteomicsDBi84343

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261796; ENSP00000261796; ENSG00000127743
GeneIDi27190
KEGGihsa:27190
UCSCiuc003lqo.4 human

Organism-specific databases

CTDi27190
DisGeNETi27190
EuPathDBiHostDB:ENSG00000127743.5
GeneCardsiIL17B
HGNCiHGNC:5982 IL17B
HPAiHPA042441
MIMi604627 gene
neXtProtiNX_Q9UHF5
OpenTargetsiENSG00000127743
PharmGKBiPA29795
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXUM Eukaryota
ENOG410ZKTD LUCA
GeneTreeiENSGT00730000110983
HOGENOMiHOG000113030
HOVERGENiHBG052095
InParanoidiQ9UHF5
KOiK05490
OMAiPEAQCLC
OrthoDBiEOG091G17O0
PhylomeDBiQ9UHF5
TreeFamiTF314701

Enzyme and pathway databases

SIGNORiQ9UHF5

Miscellaneous databases

GenomeRNAii27190
PROiPR:Q9UHF5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127743 Expressed in 98 organ(s), highest expression level in tibia
CleanExiHS_IL17B
HS_IL20
GenevisibleiQ9UHF5 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL17B_HUMAN
AccessioniPrimary (citable) accession number: Q9UHF5
Secondary accession number(s): Q14CE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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