Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Epidermal growth factor-like protein 7

Gene

EGFL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.2 Publications

Miscellaneous

Endothelial cells depleted in EGFL7 by siRNAs display dramatic alterations in adhesion, morphology, and sprouting. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • signaling receptor binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Cell adhesion, Differentiation
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epidermal growth factor-like protein 7
Short name:
EGF-like protein 7
Alternative name(s):
Multiple epidermal growth factor-like domains protein 7
Short name:
Multiple EGF-like domains protein 7
NOTCH4-like protein
Vascular endothelial statin
Short name:
VE-statin
Zneu1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EGFL7
Synonyms:MEGF7
ORF Names:UNQ187/PRO1449
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000172889.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20594 EGFL7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608582 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UHF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi131G → A: Disrupts RGD motif and results in a 79% loss of cell adhesion. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51162

Open Targets

More...
OpenTargetsi
ENSG00000172889

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134928613

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712972

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EGFL7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
92090985

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000752824 – 273Epidermal growth factor-like protein 7Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 89By similarity
Disulfide bondi56 ↔ 62By similarity
Disulfide bondi88 ↔ 102By similarity
Disulfide bondi107 ↔ 117By similarity
Disulfide bondi111 ↔ 123By similarity
Disulfide bondi125 ↔ 134By similarity
Disulfide bondi141 ↔ 152By similarity
Disulfide bondi148 ↔ 161By similarity
Disulfide bondi163 ↔ 176By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UHF1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UHF1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UHF1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UHF1

PeptideAtlas

More...
PeptideAtlasi
Q9UHF1

PRoteomics IDEntifications database

More...
PRIDEi
Q9UHF1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84339

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UHF1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UHF1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172889 Expressed in 203 organ(s), highest expression level in right lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_EGFL7

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UHF1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UHF1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050716

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ITGAV/ITGB3 in an RGD-dependent manner, increasing endothelial cell's motility.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119343, 46 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UHF1, 22 interactors

Molecular INTeraction database

More...
MINTi
Q9UHF1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307843

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UHF1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UHF1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 104EMIPROSITE-ProRule annotationAdd BLAST78
Domaini103 – 135EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini137 – 177EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili192 – 219Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi130 – 132Cell attachment site3

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
ENOG410XP6K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160015

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231494

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051453

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UHF1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQHCVNT

Database of Orthologous Groups

More...
OrthoDBi
749722at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UHF1

TreeFam database of animal gene trees

More...
TreeFami
TF331360

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR018097 EGF_Ca-bd_CS
IPR013111 EGF_extracell
IPR011489 EMI_domain
IPR009030 Growth_fac_rcpt_cys_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974 EGF_2, 1 hit
PF07645 EGF_CA, 1 hit
PF07546 EMI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit
PS51041 EMI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UHF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGSQEVLLM WLLVLAVGGT EHAYRPGRRV CAVRAHGDPV SESFVQRVYQ
60 70 80 90 100
PFLTTCDGHR ACSTYRTIYR TAYRRSPGLA PARPRYACCP GWKRTSGLPG
110 120 130 140 150
ACGAAICQPP CRNGGSCVQP GRCRCPAGWR GDTCQSDVDE CSARRGGCPQ
160 170 180 190 200
RCVNTAGSYW CQCWEGHSLS ADGTLCVPKG GPPRVAPNPT GVDSAMKEEV
210 220 230 240 250
QRLQSRVDLL EEKLQLVLAP LHSLASQALE HGLPDPGSLL VHSFQQLGRI
260 270
DSLSEQISFL EEQLGSCSCK KDS
Length:273
Mass (Da):29,618
Last modified:March 7, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5740BB845ED5A988
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMT3R4GMT3_HUMAN
Epidermal growth factor-like protei...
EGFL7
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070951114G → R1 PublicationCorresponds to variant dbSNP:rs61736886Ensembl.1
Natural variantiVAR_019791153V → I3 PublicationsCorresponds to variant dbSNP:rs2297538Ensembl.1
Natural variantiVAR_048981183P → S. Corresponds to variant dbSNP:rs35863900Ensembl.1
Natural variantiVAR_048982186A → G. Corresponds to variant dbSNP:rs34142075Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF186111 mRNA Translation: AAF01429.1
AB125649 mRNA Translation: BAD01469.1
KC485578 mRNA Translation: AGJ83826.1
AL512735 mRNA Translation: CAC21666.1
AY358901 mRNA Translation: AAQ89260.1
AY358902 mRNA Translation: AAQ89261.1
AY358903 mRNA Translation: AAQ89262.1
AK091964 mRNA Translation: BAG52452.1
AL590226 Genomic DNA No translation available.
BC012377 mRNA Translation: AAH12377.1
BC088371 mRNA Translation: AAH88371.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7002.1

NCBI Reference Sequences

More...
RefSeqi
NP_057299.1, NM_016215.4
NP_958854.1, NM_201446.2
XP_011517066.1, XM_011518764.1
XP_011517067.1, XM_011518765.1
XP_011517068.1, XM_011518766.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.91481

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308874; ENSP00000307843; ENSG00000172889
ENST00000371698; ENSP00000360763; ENSG00000172889
ENST00000371699; ENSP00000360764; ENSG00000172889
ENST00000406555; ENSP00000385639; ENSG00000172889

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51162

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51162

UCSC genome browser

More...
UCSCi
uc004cid.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186111 mRNA Translation: AAF01429.1
AB125649 mRNA Translation: BAD01469.1
KC485578 mRNA Translation: AGJ83826.1
AL512735 mRNA Translation: CAC21666.1
AY358901 mRNA Translation: AAQ89260.1
AY358902 mRNA Translation: AAQ89261.1
AY358903 mRNA Translation: AAQ89262.1
AK091964 mRNA Translation: BAG52452.1
AL590226 Genomic DNA No translation available.
BC012377 mRNA Translation: AAH12377.1
BC088371 mRNA Translation: AAH88371.1
CCDSiCCDS7002.1
RefSeqiNP_057299.1, NM_016215.4
NP_958854.1, NM_201446.2
XP_011517066.1, XM_011518764.1
XP_011517067.1, XM_011518765.1
XP_011517068.1, XM_011518766.1
UniGeneiHs.91481

3D structure databases

ProteinModelPortaliQ9UHF1
SMRiQ9UHF1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119343, 46 interactors
IntActiQ9UHF1, 22 interactors
MINTiQ9UHF1
STRINGi9606.ENSP00000307843

Chemistry databases

ChEMBLiCHEMBL3712972

PTM databases

iPTMnetiQ9UHF1
PhosphoSitePlusiQ9UHF1

Polymorphism and mutation databases

BioMutaiEGFL7
DMDMi92090985

Proteomic databases

EPDiQ9UHF1
jPOSTiQ9UHF1
MaxQBiQ9UHF1
PaxDbiQ9UHF1
PeptideAtlasiQ9UHF1
PRIDEiQ9UHF1
ProteomicsDBi84339

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51162
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308874; ENSP00000307843; ENSG00000172889
ENST00000371698; ENSP00000360763; ENSG00000172889
ENST00000371699; ENSP00000360764; ENSG00000172889
ENST00000406555; ENSP00000385639; ENSG00000172889
GeneIDi51162
KEGGihsa:51162
UCSCiuc004cid.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51162
DisGeNETi51162
EuPathDBiHostDB:ENSG00000172889.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EGFL7

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0058702
HGNCiHGNC:20594 EGFL7
HPAiHPA050716
MIMi608582 gene
neXtProtiNX_Q9UHF1
OpenTargetsiENSG00000172889
PharmGKBiPA134928613

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00940000160015
HOGENOMiHOG000231494
HOVERGENiHBG051453
InParanoidiQ9UHF1
OMAiPQHCVNT
OrthoDBi749722at2759
PhylomeDBiQ9UHF1
TreeFamiTF331360

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EGFL7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51162

Protein Ontology

More...
PROi
PR:Q9UHF1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172889 Expressed in 203 organ(s), highest expression level in right lung
CleanExiHS_EGFL7
ExpressionAtlasiQ9UHF1 baseline and differential
GenevisibleiQ9UHF1 HS

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR018097 EGF_Ca-bd_CS
IPR013111 EGF_extracell
IPR011489 EMI_domain
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF07974 EGF_2, 1 hit
PF07645 EGF_CA, 1 hit
PF07546 EMI, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit
PS51041 EMI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEGFL7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHF1
Secondary accession number(s): B3KRP0
, M9VTX9, Q5M7Y5, Q5VUD5, Q96EG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: March 7, 2006
Last modified: January 16, 2019
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again