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Entry version 163 (22 Apr 2020)
Sequence version 1 (01 May 2000)
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Protein

Tachykinin-3

Gene

TAC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-380095 Tachykinin receptors bind tachykinins
R-HSA-416476 G alpha (q) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tachykinin-3
Alternative name(s):
ZNEUROK1
Cleaved into the following chain:
Neurokinin-B
Short name:
NKB
Alternative name(s):
Neuromedin-K
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAC3
Synonyms:NKNB
ORF Names:UNQ585/PRO1155
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11521 TAC3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
162330 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UHF0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypogonadotropic hypogonadism 10 with or without anosmia (HH10)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06996980R → S in HH10; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; the patient also carries a mutation in HS6ST1. 1 PublicationCorresponds to variant dbSNP:rs727505372EnsemblClinVar.1
Natural variantiVAR_06917690M → T in HH10; has markedly reduced activity. 1 PublicationCorresponds to variant dbSNP:rs121918123EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism

Organism-specific databases

DisGeNET

More...
DisGeNETi
6866

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TAC3

MalaCards human disease database

More...
MalaCardsi
TAC3
MIMi614839 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166863

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
432 Normosmic congenital hypogonadotropic hypogonadism

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36298

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UHF0 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3707470

Drug and drug target database

More...
DrugBanki
DB09130 Copper

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAC3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
18203501

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000003356517 – 78By similarityAdd BLAST62
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000003356681 – 90Neurokinin-B10
PropeptideiPRO_000003356794 – 121By similarityAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei90Methionine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UHF0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UHF0

PeptideAtlas

More...
PeptideAtlasi
Q9UHF0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UHF0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84336 [Q9UHF0-1]
84337 [Q9UHF0-2]
84338 [Q9UHF0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UHF0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UHF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In pregnancy, the expression of NKB is confined to the outer syncytiotrophoblast of the placenta, significant concentrations of NKB can be detected in plasma as early as week 9, and plasma concentrations of NKB are grossly elevated in pregnancy-induced hypertension and pre-eclampsia.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166863 Expressed in placenta and 119 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UHF0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UHF0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166863 Tissue enriched (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112729, 10 interactors

Protein interaction database and analysis system

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IntActi
Q9UHF0, 9 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000483110

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UHF0

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UHF0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1121
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UHF0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UHF0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J2QH Eukaryota
ENOG4111D7S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000335

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_138627_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UHF0

KEGG Orthology (KO)

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KOi
K05240

Identification of Orthologs from Complete Genome Data

More...
OMAi
AVCEESQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UHF0

TreeFam database of animal gene trees

More...
TreeFami
TF337038

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003635 Neurokinin-B/TAC3
IPR013055 Tachy_Neuro_lke_CS

The PANTHER Classification System

More...
PANTHERi
PTHR15536 PTHR15536, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03823 Neurokinin_B, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001843 Neurokinin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01828 NEUROKININB

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00267 TACHYKININ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UHF0-1) [UniParc]FASTAAdd to basket
Also known as: Beta tachykinin 3

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRIMLLFTAI LAFSLAQSFG AVCKEPQEEV VPGGGRSKRD PDLYQLLQRL
60 70 80 90 100
FKSHSSLEGL LKALSQASTD PKESTSPEKR DMHDFFVGLM GKRSVQPDSP
110 120
TDVNQENVPS FGILKYPPRA E
Length:121
Mass (Da):13,438
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14C9AFE2EE9EDECA
GO
Isoform 2 (identifier: Q9UHF0-2) [UniParc]FASTAAdd to basket
Also known as: Alpha tachykinin 3

The sequence of this isoform differs from the canonical sequence as follows:
     98-121: DSPTDVNQENVPSFGILKYPPRAE → EGKTGPFLPSVRVPRPLHPNQLGSTGKSSLGTEEQRPL

Show »
Length:135
Mass (Da):14,833
Checksum:i4C6DBBDBE30851F3
GO
Isoform 3 (identifier: Q9UHF0-3) [UniParc]FASTAAdd to basket
Also known as: Gamma tachykinin 3

The sequence of this isoform differs from the canonical sequence as follows:
     80-98: RDMHDFFVGLMGKRSVQPD → H

Show »
Length:103
Mass (Da):11,358
Checksum:i2D0026B586B03FC6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121E → D in CAG33474 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06996980R → S in HH10; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; the patient also carries a mutation in HS6ST1. 1 PublicationCorresponds to variant dbSNP:rs727505372EnsemblClinVar.1
Natural variantiVAR_06917690M → T in HH10; has markedly reduced activity. 1 PublicationCorresponds to variant dbSNP:rs121918123EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01318680 – 98RDMHD…SVQPD → H in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_01318798 – 121DSPTD…PPRAE → EGKTGPFLPSVRVPRPLHPN QLGSTGKSSLGTEEQRPL in isoform 2. 2 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF186112 mRNA Translation: AAF01430.1
AF216586 mRNA Translation: AAF76980.1
AF537113 mRNA Translation: AAQ10783.1
AF537114 mRNA Translation: AAQ10784.1
AF537115 mRNA Translation: AAQ10785.1
AF537116 mRNA Translation: AAQ10786.1
AF537117 mRNA Translation: AAQ10787.1
AF537118 mRNA Translation: AAQ10788.1
AF537119 mRNA Translation: AAQ10789.1
AF537120 mRNA Translation: AAQ10790.1
AF537121 mRNA Translation: AAQ10791.1
AY358679 mRNA Translation: AAQ89042.1
CR457193 mRNA Translation: CAG33474.1
BC032145 mRNA Translation: AAH32145.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53803.1 [Q9UHF0-3]
CCDS8928.1 [Q9UHF0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001171525.1, NM_001178054.1 [Q9UHF0-3]
NP_037383.1, NM_013251.3 [Q9UHF0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300108; ENSP00000300108; ENSG00000166863 [Q9UHF0-1]
ENST00000357616; ENSP00000350236; ENSG00000166863 [Q9UHF0-2]
ENST00000379411; ENSP00000368721; ENSG00000166863 [Q9UHF0-3]
ENST00000393867; ENSP00000377445; ENSG00000166863 [Q9UHF0-2]
ENST00000415231; ENSP00000402995; ENSG00000166863 [Q9UHF0-1]
ENST00000423597; ENSP00000416292; ENSG00000166863 [Q9UHF0-3]
ENST00000438756; ENSP00000408131; ENSG00000166863 [Q9UHF0-2]
ENST00000441881; ENSP00000408208; ENSG00000166863 [Q9UHF0-3]
ENST00000458521; ENSP00000404056; ENSG00000166863 [Q9UHF0-1]
ENST00000615887; ENSP00000483110; ENSG00000166863 [Q9UHF0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6866

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6866

UCSC genome browser

More...
UCSCi
uc001smo.4 human [Q9UHF0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186112 mRNA Translation: AAF01430.1
AF216586 mRNA Translation: AAF76980.1
AF537113 mRNA Translation: AAQ10783.1
AF537114 mRNA Translation: AAQ10784.1
AF537115 mRNA Translation: AAQ10785.1
AF537116 mRNA Translation: AAQ10786.1
AF537117 mRNA Translation: AAQ10787.1
AF537118 mRNA Translation: AAQ10788.1
AF537119 mRNA Translation: AAQ10789.1
AF537120 mRNA Translation: AAQ10790.1
AF537121 mRNA Translation: AAQ10791.1
AY358679 mRNA Translation: AAQ89042.1
CR457193 mRNA Translation: CAG33474.1
BC032145 mRNA Translation: AAH32145.1
CCDSiCCDS53803.1 [Q9UHF0-3]
CCDS8928.1 [Q9UHF0-1]
RefSeqiNP_001171525.1, NM_001178054.1 [Q9UHF0-3]
NP_037383.1, NM_013251.3 [Q9UHF0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P9FNMR-A81-90[»]
SMRiQ9UHF0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112729, 10 interactors
IntActiQ9UHF0, 9 interactors
STRINGi9606.ENSP00000483110

Chemistry databases

BindingDBiQ9UHF0
ChEMBLiCHEMBL3707470
DrugBankiDB09130 Copper

PTM databases

iPTMnetiQ9UHF0
PhosphoSitePlusiQ9UHF0

Polymorphism and mutation databases

BioMutaiTAC3
DMDMi18203501

Proteomic databases

MassIVEiQ9UHF0
PaxDbiQ9UHF0
PeptideAtlasiQ9UHF0
PRIDEiQ9UHF0
ProteomicsDBi84336 [Q9UHF0-1]
84337 [Q9UHF0-2]
84338 [Q9UHF0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28422 263 antibodies

The DNASU plasmid repository

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DNASUi
6866

Genome annotation databases

EnsembliENST00000300108; ENSP00000300108; ENSG00000166863 [Q9UHF0-1]
ENST00000357616; ENSP00000350236; ENSG00000166863 [Q9UHF0-2]
ENST00000379411; ENSP00000368721; ENSG00000166863 [Q9UHF0-3]
ENST00000393867; ENSP00000377445; ENSG00000166863 [Q9UHF0-2]
ENST00000415231; ENSP00000402995; ENSG00000166863 [Q9UHF0-1]
ENST00000423597; ENSP00000416292; ENSG00000166863 [Q9UHF0-3]
ENST00000438756; ENSP00000408131; ENSG00000166863 [Q9UHF0-2]
ENST00000441881; ENSP00000408208; ENSG00000166863 [Q9UHF0-3]
ENST00000458521; ENSP00000404056; ENSG00000166863 [Q9UHF0-1]
ENST00000615887; ENSP00000483110; ENSG00000166863 [Q9UHF0-1]
GeneIDi6866
KEGGihsa:6866
UCSCiuc001smo.4 human [Q9UHF0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6866
DisGeNETi6866

GeneCards: human genes, protein and diseases

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GeneCardsi
TAC3
GeneReviewsiTAC3
HGNCiHGNC:11521 TAC3
HPAiENSG00000166863 Tissue enriched (placenta)
MalaCardsiTAC3
MIMi162330 gene
614839 phenotype
neXtProtiNX_Q9UHF0
OpenTargetsiENSG00000166863
Orphaneti432 Normosmic congenital hypogonadotropic hypogonadism
PharmGKBiPA36298

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J2QH Eukaryota
ENOG4111D7S LUCA
GeneTreeiENSGT00390000000335
HOGENOMiCLU_138627_1_0_1
InParanoidiQ9UHF0
KOiK05240
OMAiAVCEESQ
PhylomeDBiQ9UHF0
TreeFamiTF337038

Enzyme and pathway databases

ReactomeiR-HSA-380095 Tachykinin receptors bind tachykinins
R-HSA-416476 G alpha (q) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TAC3 human
EvolutionaryTraceiQ9UHF0

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TAC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6866
PharosiQ9UHF0 Tchem

Protein Ontology

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PROi
PR:Q9UHF0
RNActiQ9UHF0 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166863 Expressed in placenta and 119 other tissues
ExpressionAtlasiQ9UHF0 baseline and differential
GenevisibleiQ9UHF0 HS

Family and domain databases

InterProiView protein in InterPro
IPR003635 Neurokinin-B/TAC3
IPR013055 Tachy_Neuro_lke_CS
PANTHERiPTHR15536 PTHR15536, 1 hit
PfamiView protein in Pfam
PF03823 Neurokinin_B, 1 hit
PIRSFiPIRSF001843 Neurokinin, 1 hit
PRINTSiPR01828 NEUROKININB
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTKNK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHF0
Secondary accession number(s): Q6IAG2, Q71BC6, Q71BC9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: April 22, 2020
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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