UniProtKB - Q9UHE8 (STEA1_HUMAN)
Protein
Metalloreductase STEAP1
Gene
STEAP1
Organism
Homo sapiens (Human)
Status
Functioni
Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor.By similarity
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 140 | FADBy similarity | 1 | |
Binding sitei | 161 | FADBy similarity | 1 | |
Metal bindingi | 175 | Iron (heme axial ligand)By similarity | 1 | |
Binding sitei | 237 | FADBy similarity | 1 | |
Binding sitei | 254 | FADBy similarity | 1 | |
Metal bindingi | 268 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- channel activity Source: ProtInc
- metal ion binding Source: UniProtKB-KW
- oxidoreductase activity Source: UniProtKB-KW
- transporter activity Source: ProtInc
GO - Biological processi
- ion transport Source: UniProtKB-KW
- iron ion homeostasis Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Electron transport, Ion transport, Iron transport, Transport |
Ligand | Copper, FAD, Flavoprotein, Heme, Iron, Metal-binding, NAD |
Enzyme and pathway databases
PathwayCommonsi | Q9UHE8 |
Protein family/group databases
TCDBi | 5.B.6.1.4, the transmembrane epithelial antigen protein-3 ferric reductase (steap) family |
Names & Taxonomyi
Protein namesi | Recommended name: Metalloreductase STEAP1 (EC:1.16.1.-)Alternative name(s): Six-transmembrane epithelial antigen of prostate 1 |
Gene namesi | Name:STEAP1 Synonyms:PRSS24, STEAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11378, STEAP1 |
MIMi | 604415, gene |
neXtProti | NX_Q9UHE8 |
VEuPathDBi | HostDB:ENSG00000164647.8 |
Subcellular locationi
Endosome
- Endosome membrane By similarity; Multi-pass membrane protein By similarity
Endosome
- endosome Source: GO_Central
- endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- cell-cell junction Source: ProtInc
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 71 – 91 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 218 – 238 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 258 – 278 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 291 – 311 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 26872 |
OpenTargetsi | ENSG00000164647 |
PharmGKBi | PA36193 |
Miscellaneous databases
Pharosi | Q9UHE8, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3712956 |
Genetic variation databases
BioMutai | STEAP1 |
DMDMi | 12643440 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191694 | 1 – 339 | Metalloreductase STEAP1Add BLAST | 339 |
Proteomic databases
EPDi | Q9UHE8 |
jPOSTi | Q9UHE8 |
MassIVEi | Q9UHE8 |
MaxQBi | Q9UHE8 |
PaxDbi | Q9UHE8 |
PeptideAtlasi | Q9UHE8 |
PRIDEi | Q9UHE8 |
ProteomicsDBi | 84335 |
PTM databases
iPTMneti | Q9UHE8 |
PhosphoSitePlusi | Q9UHE8 |
SwissPalmi | Q9UHE8 |
Expressioni
Tissue specificityi
Ubiquitously expressed. Highly expressed in prostate tumors.1 Publication
Gene expression databases
Bgeei | ENSG00000164647, Expressed in prostate gland and 190 other tissues |
ExpressionAtlasi | Q9UHE8, baseline and differential |
Genevisiblei | Q9UHE8, HS |
Organism-specific databases
HPAi | ENSG00000164647, Tissue enhanced (prostate) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 117921, 8 interactors |
IntActi | Q9UHE8, 3 interactors |
STRINGi | 9606.ENSP00000297205 |
Miscellaneous databases
RNActi | Q9UHE8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UHE8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 265 | Ferric oxidoreductaseAdd BLAST | 148 |
Sequence similaritiesi
Belongs to the STEAP family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWI9, Eukaryota |
GeneTreei | ENSGT00390000008042 |
HOGENOMi | CLU_034618_0_0_1 |
InParanoidi | Q9UHE8 |
OMAi | MLARKQF |
OrthoDBi | 638341at2759 |
PhylomeDBi | Q9UHE8 |
TreeFami | TF332031 |
Family and domain databases
InterProi | View protein in InterPro IPR013130, Fe3_Rdtase_TM_dom |
Pfami | View protein in Pfam PF01794, Ferric_reduct, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9UHE8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESRKDITNQ EELWKMKPRR NLEEDDYLHK DTGETSMLKR PVLLHLHQTA
60 70 80 90 100
HADEFDCPSE LQHTQELFPQ WHLPIKIAAI IASLTFLYTL LREVIHPLAT
110 120 130 140 150
SHQQYFYKIP ILVINKVLPM VSITLLALVY LPGVIAAIVQ LHNGTKYKKF
160 170 180 190 200
PHWLDKWMLT RKQFGLLSFF FAVLHAIYSL SYPMRRSYRY KLLNWAYQQV
210 220 230 240 250
QQNKEDAWIE HDVWRMEIYV SLGIVGLAIL ALLAVTSIPS VSDSLTWREF
260 270 280 290 300
HYIQSKLGIV SLLLGTIHAL IFAWNKWIDI KQFVWYTPPT FMIAVFLPIV
310 320 330
VLIFKSILFL PCLRKKILKI RHGWEDVTKI NKTEICSQL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C0D8 | H7C0D8_HUMAN | Metalloreductase STEAP1 | STEAP1 | 101 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053696 | 47 | H → Q1 PublicationCorresponds to variant dbSNP:rs4015375Ensembl. | 1 | |
Natural variantiVAR_053697 | 169 | F → L. Corresponds to variant dbSNP:rs2888782Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF186249 mRNA Translation: AAF17479.1 AC005053 Genomic DNA No translation available. AC004969 Genomic DNA Translation: AAD15620.2 CH236949 Genomic DNA Translation: EAL24167.1 BC011802 mRNA Translation: AAH11802.1 |
CCDSi | CCDS5614.1 |
RefSeqi | NP_036581.1, NM_012449.2 |
Genome annotation databases
Ensembli | ENST00000297205; ENSP00000297205; ENSG00000164647 |
GeneIDi | 26872 |
KEGGi | hsa:26872 |
UCSCi | uc003ujx.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF186249 mRNA Translation: AAF17479.1 AC005053 Genomic DNA No translation available. AC004969 Genomic DNA Translation: AAD15620.2 CH236949 Genomic DNA Translation: EAL24167.1 BC011802 mRNA Translation: AAH11802.1 |
CCDSi | CCDS5614.1 |
RefSeqi | NP_036581.1, NM_012449.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6Y9B | electron microscopy | 2.97 | A/B/C | 2-339 | [»] | |
SMRi | Q9UHE8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117921, 8 interactors |
IntActi | Q9UHE8, 3 interactors |
STRINGi | 9606.ENSP00000297205 |
Chemistry databases
ChEMBLi | CHEMBL3712956 |
Protein family/group databases
TCDBi | 5.B.6.1.4, the transmembrane epithelial antigen protein-3 ferric reductase (steap) family |
PTM databases
iPTMneti | Q9UHE8 |
PhosphoSitePlusi | Q9UHE8 |
SwissPalmi | Q9UHE8 |
Genetic variation databases
BioMutai | STEAP1 |
DMDMi | 12643440 |
Proteomic databases
EPDi | Q9UHE8 |
jPOSTi | Q9UHE8 |
MassIVEi | Q9UHE8 |
MaxQBi | Q9UHE8 |
PaxDbi | Q9UHE8 |
PeptideAtlasi | Q9UHE8 |
PRIDEi | Q9UHE8 |
ProteomicsDBi | 84335 |
Protocols and materials databases
ABCDi | Q9UHE8, 1 sequenced antibody |
Antibodypediai | 4048, 398 antibodies |
DNASUi | 26872 |
Genome annotation databases
Ensembli | ENST00000297205; ENSP00000297205; ENSG00000164647 |
GeneIDi | 26872 |
KEGGi | hsa:26872 |
UCSCi | uc003ujx.3, human |
Organism-specific databases
CTDi | 26872 |
DisGeNETi | 26872 |
GeneCardsi | STEAP1 |
HGNCi | HGNC:11378, STEAP1 |
HPAi | ENSG00000164647, Tissue enhanced (prostate) |
MIMi | 604415, gene |
neXtProti | NX_Q9UHE8 |
OpenTargetsi | ENSG00000164647 |
PharmGKBi | PA36193 |
VEuPathDBi | HostDB:ENSG00000164647.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWI9, Eukaryota |
GeneTreei | ENSGT00390000008042 |
HOGENOMi | CLU_034618_0_0_1 |
InParanoidi | Q9UHE8 |
OMAi | MLARKQF |
OrthoDBi | 638341at2759 |
PhylomeDBi | Q9UHE8 |
TreeFami | TF332031 |
Enzyme and pathway databases
PathwayCommonsi | Q9UHE8 |
Miscellaneous databases
BioGRID-ORCSi | 26872, 10 hits in 850 CRISPR screens |
ChiTaRSi | STEAP1, human |
GeneWikii | STEAP1 |
GenomeRNAii | 26872 |
Pharosi | Q9UHE8, Tbio |
PROi | PR:Q9UHE8 |
RNActi | Q9UHE8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164647, Expressed in prostate gland and 190 other tissues |
ExpressionAtlasi | Q9UHE8, baseline and differential |
Genevisiblei | Q9UHE8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013130, Fe3_Rdtase_TM_dom |
Pfami | View protein in Pfam PF01794, Ferric_reduct, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STEA1_HUMAN | |
Accessioni | Q9UHE8Primary (citable) accession number: Q9UHE8 Secondary accession number(s): A4D1E0, O95034 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM