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Entry version 174 (22 Apr 2020)
Sequence version 2 (23 Jan 2007)
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Protein

Ubiquilin-2

Gene

UBQLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q9UHD9 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquilin-2
Alternative name(s):
Chap1
DSK2 homolog
Protein linking IAP with cytoskeleton 2
Short name:
PLIC-2
Short name:
hPLIC-2
Ubiquitin-like product Chap1/Dsk2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBQLN2
Synonyms:N4BP4, PLIC2
ORF Names:HRIHFB2157
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:12509 UBQLN2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300264 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9UHD9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amyotrophic lateral sclerosis 15, with or without frontotemporal dementia (ALS15)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS15 may develop frontotemporal dementia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068892155S → N in ALS15; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs374522677Ensembl.1
Natural variantiVAR_068893189P → T in ALS15; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1490021329Ensembl.1
Natural variantiVAR_068895283A → T in ALS15. 1 PublicationCorresponds to variant dbSNP:rs749463696Ensembl.1
Natural variantiVAR_068896425Q → R in ALS15. 1 PublicationCorresponds to variant dbSNP:rs1243726473Ensembl.1
Natural variantiVAR_068897487T → I in ALS15. 1 Publication1
Natural variantiVAR_066562497P → H in ALS15; leads to defective ubiquitin-mediated proteasomal degradation; reduces binding to HNRNPA1 and FAF2; increases translocation of HNRNPA1 to the cytoplasm; adversely affects ERAD. 3 PublicationsCorresponds to variant dbSNP:rs387906709EnsemblClinVar.1
Natural variantiVAR_066563497P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906710EnsemblClinVar.1
Natural variantiVAR_066564506P → T in ALS15; leads to defective ubiquitin-mediated proteasomal degradation; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906711EnsemblClinVar.1
Natural variantiVAR_066565509P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906712EnsemblClinVar.1
Natural variantiVAR_066566525P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs369947678EnsemblClinVar.1

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

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DisGeNETi
29978

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
UBQLN2

MalaCards human disease database

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MalaCardsi
UBQLN2
MIMi300857 phenotype

Open Targets

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OpenTargetsi
ENSG00000188021

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
803 Amyotrophic lateral sclerosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37156

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9UHD9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
UBQLN2

Domain mapping of disease mutations (DMDM)

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DMDMi
124056593

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002110112 – 624Ubiquilin-2Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Degraded during macroautophagy.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UHD9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UHD9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UHD9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9UHD9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UHD9

PeptideAtlas

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PeptideAtlasi
Q9UHD9

PRoteomics IDEntifications database

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PRIDEi
Q9UHD9

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
84333

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UHD9

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q9UHD9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UHD9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Highly expressed in mitotic cells from metaphase to telophase. Expression in non-mitotic cells is very low.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000188021 Expressed in cerebellar vermis and 244 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UHD9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188021 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Forms heterodimer with UBQLN1. Binds UBE3A and BTRC.

Interacts with the 19S proteasome subunit.

Interacts with C9orf72.

Interacts with HNRNPA1 and HNRNPU.

Found in a complex with UBQLN1 and MAP1LC3A/B/C.

Interacts with EPS15, EPN1 and EPN2.

Interacts with HERPUD1.

Interacts with RAD23A.

Interacts with TARDBP.

Interacts (via C-terminus) with FAF2 (via N-terminus).

Interacts with UBQLN4. Binds CD47 (By similarity).

By similarity12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9UHD9
With#Exp.IntAct
A0A1U9X8X86EBI-947187,EBI-17234977
Q96FB23EBI-947187,EBI-2857623
itself3EBI-947187,EBI-947187
ABI2 - isoform 2 [Q9NYB9-2]3EBI-947187,EBI-11096309
ACOT7 - isoform 4 [O00154-4]3EBI-947187,EBI-12007918
ADAMTS3 [O15072]3EBI-947187,EBI-12200127
ADRM1 [Q16186]5EBI-947187,EBI-954387
AGR2 [O95994]5EBI-947187,EBI-712648
AGR3 [Q8TD06]6EBI-947187,EBI-3925742
AMBN [Q9NP70]3EBI-947187,EBI-11893530
ANKRD33 - isoform 1 [Q7Z3H0-1]3EBI-947187,EBI-16746154
APOC4 [P55056]3EBI-947187,EBI-18302142
ARRDC3 [Q96B67]3EBI-947187,EBI-2875665
ASCL1 [P50553]3EBI-947187,EBI-957042
AZGP1 [P25311]3EBI-947187,EBI-2513837
BAG6 - isoform 2 [P46379-2]3EBI-947187,EBI-10988864
BCL2L11 [O43521]3EBI-947187,EBI-526406
BPIFA1 [Q9NP55]3EBI-947187,EBI-953896
C1orf94 [Q6P1W5]3EBI-947187,EBI-946029
C1QA [P02745]6EBI-947187,EBI-1220209
C1QB [P02746]3EBI-947187,EBI-2813376
C1QC [P02747]5EBI-947187,EBI-1220222
C1QL4 [Q86Z23]3EBI-947187,EBI-12062109
C1QTNF2 [Q9BXJ5]3EBI-947187,EBI-2817707
C1QTNF4 [Q9BXJ3]3EBI-947187,EBI-11955105
C6orf15 [Q6UXA7]8EBI-947187,EBI-11990870
C8G [P07360]3EBI-947187,EBI-9021652
CAPN15 [O75808]3EBI-947187,EBI-6149008
CCK [P06307]3EBI-947187,EBI-6624398
CCL16 [O15467]3EBI-947187,EBI-12204739
CCL3 [P10147]3EBI-947187,EBI-8459634
CCL7 [P80098]3EBI-947187,EBI-718759
CCN1 [O00622]3EBI-947187,EBI-1237454
CD99L2 [Q8TCZ2]3EBI-947187,EBI-2824782
CDH15 [P55291]3EBI-947187,EBI-10215061
CDH17 [Q12864]3EBI-947187,EBI-12278850
CDIP1 [Q9H305]3EBI-947187,EBI-2876678
CEACAM6 [P40199]5EBI-947187,EBI-4314501
CLEC11A [Q9Y240]3EBI-947187,EBI-3957044
CLPSL2 [Q6UWE3]6EBI-947187,EBI-12183429
CNNM3 [Q8NE01]3EBI-947187,EBI-741032
COL10A1 [Q03692]3EBI-947187,EBI-2528309
COL17A1 [Q9UMD9]3EBI-947187,EBI-2528742
COL1A2 [P08123]5EBI-947187,EBI-983038
COL8A1 [P27658]3EBI-947187,EBI-747133
COL9A2 [Q14055]3EBI-947187,EBI-714971
COLGALT2 [Q8IYK4]3EBI-947187,EBI-10263496
CSN1S1 [P47710]3EBI-947187,EBI-2433045
CSN2 [P05814]6EBI-947187,EBI-1642112
CSN3 [P07498]3EBI-947187,EBI-2602175
CST1 [P01037]3EBI-947187,EBI-1056240
CST4 [P01036]3EBI-947187,EBI-1049999
CSTF2 [P33240]5EBI-947187,EBI-711360
CSTF2T [Q9H0L4]5EBI-947187,EBI-747012
CTAG1B [P78358]3EBI-947187,EBI-1188472
CTDNEP1 [O95476]3EBI-947187,EBI-5323433
DAZAP2 [Q15038]3EBI-947187,EBI-724310
DDR1 - isoform 2 [Q08345-2]5EBI-947187,EBI-711903
DEFA1B [P59665]3EBI-947187,EBI-726336
DEFA6 [Q01524]6EBI-947187,EBI-10222451
DEFB115 [Q30KQ5]3EBI-947187,EBI-12253292
DESI1 [Q6ICB0]5EBI-947187,EBI-2806959
DMKN [Q6E0U4]3EBI-947187,EBI-7943171
DUSP21 [Q9H596]5EBI-947187,EBI-7357329
ECM1 [Q16610]3EBI-947187,EBI-947964
ECRG4 [Q9H1Z8]3EBI-947187,EBI-12208839
EFEMP1 [Q12805]3EBI-947187,EBI-536772
EGFL6 [Q8IUX8]3EBI-947187,EBI-715208
ERP27 [Q96DN0]3EBI-947187,EBI-953772
ERP29 [P30040]3EBI-947187,EBI-946830
ETNK1 [Q9HBU6]3EBI-947187,EBI-2834493
F10 [P00742]3EBI-947187,EBI-719750
FAM168A - isoform 2 [Q92567-2]3EBI-947187,EBI-11978259
FAM222B [Q8WU58]3EBI-947187,EBI-2807642
FDCSP [Q8NFU4]3EBI-947187,EBI-12210457
FGF17 [O60258]3EBI-947187,EBI-12184083
FKBP2 [P26885]3EBI-947187,EBI-719873
FNDC11 [Q9BVV2]3EBI-947187,EBI-744935
FUCA1 [P04066]5EBI-947187,EBI-2512153
FZD7 [O75084]3EBI-947187,EBI-746917
GAL [P22466]3EBI-947187,EBI-6624768
GALP [Q9UBC7]6EBI-947187,EBI-12244186
GHRL [Q9UBU3]3EBI-947187,EBI-10319458
GPR162 [Q16538]3EBI-947187,EBI-22387200
GPX7 [Q96SL4]3EBI-947187,EBI-749411
GUCA2A [Q02747]3EBI-947187,EBI-12244272
GUCA2B [Q16661]3EBI-947187,EBI-12349759
hCG_1987119 [A0A024R8L2]3EBI-947187,EBI-14103818
HEMK1 [Q9Y5R4]3EBI-947187,EBI-10329202
HGS [O14964]3EBI-947187,EBI-740220
HNRNPA1 [P09651]2EBI-947187,EBI-352662
HNRNPA1 - isoform A1-A [P09651-2]4EBI-947187,EBI-352677
HNRNPU [Q00839]3EBI-947187,EBI-351126
HSD17B12 [Q53GQ0]3EBI-947187,EBI-2963255
HSPA13 [P48723]5EBI-947187,EBI-750892
ICAM1 [P05362]5EBI-947187,EBI-1035358
IFNA1 [P01562]3EBI-947187,EBI-11478589
IGFBP6 [P24592]3EBI-947187,EBI-947015
IGLL1 [P15814]3EBI-947187,EBI-1222221
IL11 [P20809]3EBI-947187,EBI-751694
IQCF3 [P0C7M6]3EBI-947187,EBI-11953784
IST1 - isoform 3 [P53990-3]3EBI-947187,EBI-12188567
ITPKB [P27987]5EBI-947187,EBI-751388
ITPRIPL1 - isoform 2 [Q6GPH6-2]3EBI-947187,EBI-12337095
JPH4 [Q96JJ6]3EBI-947187,EBI-2847044
KISS1 [Q15726]3EBI-947187,EBI-23759979
KLHL11 [Q9NVR0]3EBI-947187,EBI-2691832
KLHL42 [Q9P2K6]5EBI-947187,EBI-739890
KRT6A [P02538]3EBI-947187,EBI-702198
KRTAP12-1 [P59990]3EBI-947187,EBI-10210845
KRTAP19-3 [Q7Z4W3]3EBI-947187,EBI-12020132
KRTAP19-5 [Q3LI72]3EBI-947187,EBI-1048945
LAIR2 [Q6ISS4]3EBI-947187,EBI-10250491
LASP1 - isoform 2 [Q14847-2]3EBI-947187,EBI-9088686
LATS1 - isoform 2 [O95835-2]3EBI-947187,EBI-17978514
LCN1 [P31025]3EBI-947187,EBI-1052433
LCN2 [P80188]5EBI-947187,EBI-11911016
LITAF [Q99732]3EBI-947187,EBI-725647
LMO4 [P61968]3EBI-947187,EBI-2798728
LY6G6D [O95868]3EBI-947187,EBI-12382527
MAGED1 [Q9Y5V3]3EBI-947187,EBI-716006
MBL2 [P11226]5EBI-947187,EBI-5325353
MDK [P21741]3EBI-947187,EBI-722444
MIEF1 [Q9NQG6]3EBI-947187,EBI-740987
MIEF2 - isoform 3 [Q96C03-3]3EBI-947187,EBI-11988931
MINPP1 [Q9UNW1]3EBI-947187,EBI-4290963
MOAP1 [Q96BY2]3EBI-947187,EBI-739825
MTX2 [O75431]3EBI-947187,EBI-7415268
MYDGF [Q969H8]3EBI-947187,EBI-718622
NAXD [Q8IW45]3EBI-947187,EBI-8650724
NBL1 - isoform 2 [P41271-2]3EBI-947187,EBI-12135485
NDOR1 [Q9UHB4]3EBI-947187,EBI-10249760
NME3 [Q13232]3EBI-947187,EBI-713684
NOC4L [Q9BVI4]3EBI-947187,EBI-395927
NOL3 [O60936]3EBI-947187,EBI-740992
NPBWR1 [P48145]3EBI-947187,EBI-13061492
NPPA [P01160]3EBI-947187,EBI-953859
NPVF [Q9HCQ7]3EBI-947187,EBI-1753111
NPY [P01303]3EBI-947187,EBI-3905877
NRN1L [Q496H8]3EBI-947187,EBI-13079132
NT5C3A [Q9H0P0]3EBI-947187,EBI-3918356
NUP58 [Q9BVL2]3EBI-947187,EBI-2811583
ODAPH [Q17RF5]3EBI-947187,EBI-10239029
OPN4 [Q9UHM6]3EBI-947187,EBI-18058356
OR7D4 [Q8NG98]3EBI-947187,EBI-18164026
OSMR [Q99650]3EBI-947187,EBI-2804080
PARM1 [Q6UWI2]3EBI-947187,EBI-12350959
PCDHGA9 - isoform 2 [Q9Y5G4-2]3EBI-947187,EBI-12202741
PIANP [Q8IYJ0]3EBI-947187,EBI-12204277
PIK3IP1 [Q96FE7]3EBI-947187,EBI-10285708
PIN1 [Q13526]5EBI-947187,EBI-714158
PLAAT2 [Q9NWW9]3EBI-947187,EBI-12253270
PLAAT3 [P53816]3EBI-947187,EBI-746318
PLEKHB2 [Q96CS7]3EBI-947187,EBI-373552
PMEPA1 - isoform 2 [Q969W9-2]3EBI-947187,EBI-13318883
PNMA3 [Q9UL41]3EBI-947187,EBI-11278955
PODXL - isoform 2 [O00592-2]5EBI-947187,EBI-12407415
POLE2 [P56282]3EBI-947187,EBI-713847
POM121 - isoform 2 [Q96HA1-2]3EBI-947187,EBI-11956563
PPIB [P23284]5EBI-947187,EBI-359252
PPIC [P45877]5EBI-947187,EBI-953909
PPIH [O43447]3EBI-947187,EBI-1055615
PRAP1 [Q96NZ9]6EBI-947187,EBI-2116102
PRR4 [Q16378]6EBI-947187,EBI-738624
PSMD2 [Q13200]3EBI-947187,EBI-357648
PSORS1C2 [Q9UIG4]3EBI-947187,EBI-11974061
PTGDS [P41222]6EBI-947187,EBI-948821
QPCT [Q16769]3EBI-947187,EBI-2856807
RAD23A [P54725]6EBI-947187,EBI-746453
RAD23B [P54727]3EBI-947187,EBI-954531
RBFOX2 - isoform 10 [O43251-10]3EBI-947187,EBI-11963050
RBM24 - isoform 2 [Q9BX46-2]3EBI-947187,EBI-12224445
RNF128 [Q8TEB7]3EBI-947187,EBI-2341619
RNF208 [Q9H0X6]6EBI-947187,EBI-751555
RNF4 [P78317]3EBI-947187,EBI-2340927
RPN13 [O48726] from Arabidopsis thaliana.4EBI-947187,EBI-7710745
RPS27A [P62979]3EBI-947187,EBI-357375
RSRC2 [Q7L4I2]3EBI-947187,EBI-953753
RTL8A [Q9BWD3]3EBI-947187,EBI-741643
RTL8B [Q17RB0]3EBI-947187,EBI-10238588
RTL8C [A6ZKI3]5EBI-947187,EBI-10174072
SCG5 [P05408]3EBI-947187,EBI-722635
SCGB2B2 [Q4G0G5]3EBI-947187,EBI-12019232
SEMG1 - isoform 2 [P04279-2]3EBI-947187,EBI-12272118
SERPINE1 [P05121]3EBI-947187,EBI-953978
SERPINI2 [O75830]3EBI-947187,EBI-750144
SEZ6 [Q53EL9]3EBI-947187,EBI-723710
SEZ6L - isoform 5 [Q9BYH1-5]3EBI-947187,EBI-12012146
SFTPA2 [Q8IWL1]6EBI-947187,EBI-12350685
SGTA [O43765]3EBI-947187,EBI-347996
SLC16A3 [O15427]3EBI-947187,EBI-7600166
SLITRK1 [Q96PX8]3EBI-947187,EBI-7137880
SLPI [P03973]3EBI-947187,EBI-355293
SMIM11A [P58511]3EBI-947187,EBI-1051936
SMIM19 [Q96E16]3EBI-947187,EBI-17657124
SMIM2 [Q9BVW6]3EBI-947187,EBI-10300146
SMR3B [P02814]3EBI-947187,EBI-738612
SNRPB - isoform SM-B [P14678-2]3EBI-947187,EBI-372475
SOD3 [P08294]3EBI-947187,EBI-10195782
SPAG11B - isoform EP2D [Q08648-4]3EBI-947187,EBI-14835966
SPINT1 - isoform 2 [O43278-2]3EBI-947187,EBI-12078338
SPN [P16150]3EBI-947187,EBI-10049055
SRGN [P10124]3EBI-947187,EBI-744915
SRP68 - isoform 2 [Q9UHB9-2]3EBI-947187,EBI-12210563
STAM2 [O75886]3EBI-947187,EBI-373258
SUOX [P51687]3EBI-947187,EBI-3921347
SUSD4 - isoform 3 [Q5VX71-3]3EBI-947187,EBI-12017810
TENT5B [Q96A09]3EBI-947187,EBI-752030
TFF3 [Q07654]3EBI-947187,EBI-10224676
TIMM21 [Q9BVV7]3EBI-947187,EBI-6570759
TIMP2 [P16035]3EBI-947187,EBI-1033507
TMEM123 [Q8N131]3EBI-947187,EBI-749248
TNFRSF18 - isoform 2 [Q9Y5U5-2]3EBI-947187,EBI-12197205
TOMM20L [Q6UXN7]3EBI-947187,EBI-11954062
TRAF4 [Q9BUZ4]3EBI-947187,EBI-3650647
TRIM32 [Q13049]3EBI-947187,EBI-742790
TXNDC12 [O95881]3EBI-947187,EBI-2564581
TXNDC5 [Q8NBS9]3EBI-947187,EBI-2510815
UACA [Q9BZF9]3EBI-947187,EBI-350510
UBA52 [P62987]3EBI-947187,EBI-357304
UBAC1 [Q9BSL1]3EBI-947187,EBI-749370
UBB [P0CG47]3EBI-947187,EBI-413034
UBC [P0CG48]3EBI-947187,EBI-3390054
UBE2I [Q7KZS0]3EBI-947187,EBI-10180829
UBE2V1 [Q13404]3EBI-947187,EBI-1050671
UBQLN1 [Q9UMX0]3EBI-947187,EBI-741480
UBXN1 - isoform 2 [Q04323-2]3EBI-947187,EBI-11530712
UBXN7 [O94888]3EBI-947187,EBI-1993627
UFSP1 [Q6NVU6]3EBI-947187,EBI-12068150
VENTX [O95231]3EBI-947187,EBI-10191303
VIP - isoform 2 [P01282-2]3EBI-947187,EBI-12320391
VTN [P04004]3EBI-947187,EBI-1036653
VWC2 [Q2TAL6]3EBI-947187,EBI-11957238
WFDC10B [Q8IUB3]3EBI-947187,EBI-10261124
WFDC12 [Q8WWY7]6EBI-947187,EBI-11958577
ZFAND2A [Q8N6M9]3EBI-947187,EBI-3921109
ZFAND2B [Q8WV99]3EBI-947187,EBI-747823
ZG16 [O60844]3EBI-947187,EBI-746479
ZG16B [Q96DA0]6EBI-947187,EBI-953824
ZNF205 [O95201]3EBI-947187,EBI-747343

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119006, 347 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UHD9

Database of interacting proteins

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DIPi
DIP-42116N

Protein interaction database and analysis system

More...
IntActi
Q9UHD9, 255 interactors

Molecular INTeraction database

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MINTi
Q9UHD9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345195

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UHD9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1624
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UHD9

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UHD9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 107Ubiquitin-likePROSITE-ProRule annotationAdd BLAST75
Domaini178 – 206STI1 1Sequence analysisAdd BLAST29
Domaini208 – 247STI1 2Sequence analysisAdd BLAST40
Domaini379 – 426STI1 3Sequence analysisAdd BLAST48
Domaini430 – 462STI1 4Sequence analysisAdd BLAST33
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati491 – 49313
Repeati494 – 49623
Repeati497 – 49933
Repeati500 – 50243
Repeati503 – 50553
Repeati506 – 50863
Repeati509 – 51173
Repeati512 – 51483
Repeati515 – 51793
Repeati518 – 520103
Repeati521 – 523113
Repeati524 – 526123
Domaini581 – 621UBAPROSITE-ProRule annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni491 – 52612 X 3 AA tandem repeats of P-X-XAdd BLAST36

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ubiquitin-like domain is essential for its inhibitory effect on GPCR endocytosis. Mediates its association with the subunits of the proteasome.1 Publication1 Publication
The UBA domain is essential for its association with microtubule-associated protein 1 light chain 3 (MAP1LC3). Mediates its association with ubiquitinated substrates.1 Publication1 Publication
Dimerization is dependent upon the central region of the protein containing the STI1 domains and is independent of its ubiquitin-like and UBA domains.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0010 Eukaryota
COG5272 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162603

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024293_4_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UHD9

KEGG Orthology (KO)

More...
KOi
K04523

Identification of Orthologs from Complete Genome Data

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OMAi
PQQGTEN

Database of Orthologous Groups

More...
OrthoDBi
1553668at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UHD9

TreeFam database of animal gene trees

More...
TreeFami
TF314412

Family and domain databases

Database of protein disorder

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DisProti
DP01110

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR041243 STI1
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR015496 Ubiquilin
IPR028430 Ubiquilin-2
IPR000626 Ubiquitin-like_dom
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR10677 PTHR10677, 1 hit
PTHR10677:SF5 PTHR10677:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17830 STI1, 1 hit
PF00627 UBA, 1 hit
PF00240 ubiquitin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00727 STI1, 4 hits
SM00165 UBA, 1 hit
SM00213 UBQ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit
SSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50030 UBA, 1 hit
PS50053 UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UHD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENGESSGP PRPSRGPAAA QGSAAAPAEP KIIKVTVKTP KEKEEFAVPE
60 70 80 90 100
NSSVQQFKEA ISKRFKSQTD QLVLIFAGKI LKDQDTLIQH GIHDGLTVHL
110 120 130 140 150
VIKSQNRPQG QSTQPSNAAG TNTTSASTPR SNSTPISTNS NPFGLGSLGG
160 170 180 190 200
LAGLSSLGLS STNFSELQSQ MQQQLMASPE MMIQIMENPF VQSMLSNPDL
210 220 230 240 250
MRQLIMANPQ MQQLIQRNPE ISHLLNNPDI MRQTLEIARN PAMMQEMMRN
260 270 280 290 300
QDLALSNLES IPGGYNALRR MYTDIQEPML NAAQEQFGGN PFASVGSSSS
310 320 330 340 350
SGEGTQPSRT ENRDPLPNPW APPPATQSSA TTSTTTSTGS GSGNSSSNAT
360 370 380 390 400
GNTVAAANYV ASIFSTPGMQ SLLQQITENP QLIQNMLSAP YMRSMMQSLS
410 420 430 440 450
QNPDLAAQMM LNSPLFTANP QLQEQMRPQL PAFLQQMQNP DTLSAMSNPR
460 470 480 490 500
AMQALMQIQQ GLQTLATEAP GLIPSFTPGV GVGVLGTAIG PVGPVTPIGP
510 520 530 540 550
IGPIVPFTPI GPIGPIGPTG PAAPPGSTGS GGPTGPTVSS AAPSETTSPT
560 570 580 590 600
SESGPNQQFI QQMVQALAGA NAPQLPNPEV RFQQQLEQLN AMGFLNREAN
610 620
LQALIATGGD INAAIERLLG SQPS
Length:624
Mass (Da):65,696
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF7DF8C4D7B71AC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti544S → R in AAF17237 (PubMed:10675567).Curated1
Sequence conflicti544S → R in BAA34801 (PubMed:9853615).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068892155S → N in ALS15; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs374522677Ensembl.1
Natural variantiVAR_068893189P → T in ALS15; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1490021329Ensembl.1
Natural variantiVAR_052680235L → H. Corresponds to variant dbSNP:rs17002693Ensembl.1
Natural variantiVAR_068894282A → V Probable disease-associated mutation found in a patient with frontotemporal dementia. 1 PublicationCorresponds to variant dbSNP:rs1001930696Ensembl.1
Natural variantiVAR_068895283A → T in ALS15. 1 PublicationCorresponds to variant dbSNP:rs749463696Ensembl.1
Natural variantiVAR_068896425Q → R in ALS15. 1 PublicationCorresponds to variant dbSNP:rs1243726473Ensembl.1
Natural variantiVAR_068897487T → I in ALS15. 1 Publication1
Natural variantiVAR_066562497P → H in ALS15; leads to defective ubiquitin-mediated proteasomal degradation; reduces binding to HNRNPA1 and FAF2; increases translocation of HNRNPA1 to the cytoplasm; adversely affects ERAD. 3 PublicationsCorresponds to variant dbSNP:rs387906709EnsemblClinVar.1
Natural variantiVAR_066563497P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906710EnsemblClinVar.1
Natural variantiVAR_066564506P → T in ALS15; leads to defective ubiquitin-mediated proteasomal degradation; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906711EnsemblClinVar.1
Natural variantiVAR_066565509P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906712EnsemblClinVar.1
Natural variantiVAR_066566525P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs369947678EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF189009 mRNA Translation: AAF17237.1
AF293385 mRNA Translation: AAG02474.1
AL354793 Genomic DNA No translation available.
CH471154 Genomic DNA Translation: EAW93233.1
BC069237 mRNA Translation: AAH69237.1
AL442081 mRNA Translation: CAC09446.1
AB015344 mRNA Translation: BAA34801.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14374.1

NCBI Reference Sequences

More...
RefSeqi
NP_038472.2, NM_013444.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338222; ENSP00000345195; ENSG00000188021

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29978

UCSC genome browser

More...
UCSCi
uc004dus.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189009 mRNA Translation: AAF17237.1
AF293385 mRNA Translation: AAG02474.1
AL354793 Genomic DNA No translation available.
CH471154 Genomic DNA Translation: EAW93233.1
BC069237 mRNA Translation: AAH69237.1
AL442081 mRNA Translation: CAC09446.1
AB015344 mRNA Translation: BAA34801.1
CCDSiCCDS14374.1
RefSeqiNP_038472.2, NM_013444.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J8CNMR-A1-103[»]
2NBVNMR-B26-103[»]
6MUNNMR-B/C26-103[»]
SMRiQ9UHD9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119006, 347 interactors
CORUMiQ9UHD9
DIPiDIP-42116N
IntActiQ9UHD9, 255 interactors
MINTiQ9UHD9
STRINGi9606.ENSP00000345195

Protein family/group databases

MoonDBiQ9UHD9 Predicted

PTM databases

iPTMnetiQ9UHD9
MetOSiteiQ9UHD9
PhosphoSitePlusiQ9UHD9

Polymorphism and mutation databases

BioMutaiUBQLN2
DMDMi124056593

Proteomic databases

EPDiQ9UHD9
jPOSTiQ9UHD9
MassIVEiQ9UHD9
MaxQBiQ9UHD9
PaxDbiQ9UHD9
PeptideAtlasiQ9UHD9
PRIDEiQ9UHD9
ProteomicsDBi84333

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
570 273 antibodies

Genome annotation databases

EnsembliENST00000338222; ENSP00000345195; ENSG00000188021
GeneIDi29978
KEGGihsa:29978
UCSCiuc004dus.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29978
DisGeNETi29978

GeneCards: human genes, protein and diseases

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GeneCardsi
UBQLN2
GeneReviewsiUBQLN2
HGNCiHGNC:12509 UBQLN2
HPAiENSG00000188021 Low tissue specificity
MalaCardsiUBQLN2
MIMi300264 gene
300857 phenotype
neXtProtiNX_Q9UHD9
OpenTargetsiENSG00000188021
Orphaneti803 Amyotrophic lateral sclerosis
PharmGKBiPA37156

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0010 Eukaryota
COG5272 LUCA
GeneTreeiENSGT00940000162603
HOGENOMiCLU_024293_4_0_1
InParanoidiQ9UHD9
KOiK04523
OMAiPQQGTEN
OrthoDBi1553668at2759
PhylomeDBiQ9UHD9
TreeFamiTF314412

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UBQLN2 human
EvolutionaryTraceiQ9UHD9

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
UBQLN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29978
PharosiQ9UHD9 Tbio

Protein Ontology

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PROi
PR:Q9UHD9
RNActiQ9UHD9 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000188021 Expressed in cerebellar vermis and 244 other tissues
GenevisibleiQ9UHD9 HS

Family and domain databases

DisProtiDP01110
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR041243 STI1
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR015496 Ubiquilin
IPR028430 Ubiquilin-2
IPR000626 Ubiquitin-like_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10677 PTHR10677, 1 hit
PTHR10677:SF5 PTHR10677:SF5, 1 hit
PfamiView protein in Pfam
PF17830 STI1, 1 hit
PF00627 UBA, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00727 STI1, 4 hits
SM00165 UBA, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit
PS50053 UBIQUITIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBQL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHD9
Secondary accession number(s): O94798
, Q5D027, Q9H3W6, Q9HAZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: April 22, 2020
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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