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UniProtKB - Q9UHD9 (UBQL2_HUMAN)
Protein
Ubiquilin-2
Gene
UBQLN2
Organism
Homo sapiens (Human)
Status
Functioni
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987).
Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982).
Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957).
Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).
6 PublicationsGO - Molecular functioni
- identical protein binding Source: IntAct
- polyubiquitin modification-dependent protein binding Source: GO_Central
GO - Biological processi
- autophagosome assembly Source: GO_Central
- negative regulation of clathrin-dependent endocytosis Source: UniProtKB
- negative regulation of G protein-coupled receptor internalization Source: UniProtKB
- positive regulation of ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
- regulation of autophagosome assembly Source: UniProtKB
- regulation of macroautophagy Source: UniProtKB
- ubiquitin-dependent ERAD pathway Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
| Biological process | Autophagy |
Enzyme and pathway databases
| PathwayCommonsi | Q9UHD9 |
| Reactomei | R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis |
| SIGNORi | Q9UHD9 |
Protein family/group databases
| MoonDBi | Q9UHD9, Predicted |
Names & Taxonomyi
| Protein namesi | Recommended name: Ubiquilin-2Alternative name(s): Chap1 DSK2 homolog Protein linking IAP with cytoskeleton 2 Short name: PLIC-2 Short name: hPLIC-2 Ubiquitin-like product Chap1/Dsk2 |
| Gene namesi | Name:UBQLN2 Synonyms:N4BP4, PLIC2 ORF Names:HRIHFB2157 |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| HGNCi | HGNC:12509, UBQLN2 |
| MIMi | 300264, gene |
| neXtProti | NX_Q9UHD9 |
| VEuPathDBi | HostDB:ENSG00000188021 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- Membrane By similarity
- autophagosome 1 Publication
Note: Colocalizes with a subset of proteasomes, namely those that are cytoskeleton associated or free in the cytosol. Associated with fibers in mitotic cells.1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- autophagosome Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Amyotrophic lateral sclerosis 15, with or without frontotemporal dementia (ALS15)6 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS15 may develop frontotemporal dementia.
Related information in OMIM| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_068892 | 155 | S → N in ALS15; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs374522677Ensembl. | 1 | |
| Natural variantiVAR_068893 | 189 | P → T in ALS15; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1490021329Ensembl. | 1 | |
| Natural variantiVAR_068895 | 283 | A → T in ALS15. 1 PublicationCorresponds to variant dbSNP:rs749463696Ensembl. | 1 | |
| Natural variantiVAR_068896 | 425 | Q → R in ALS15. 1 PublicationCorresponds to variant dbSNP:rs1243726473Ensembl. | 1 | |
| Natural variantiVAR_068897 | 487 | T → I in ALS15. 1 PublicationCorresponds to variant dbSNP:rs1569254459Ensembl. | 1 | |
| Natural variantiVAR_066562 | 497 | P → H in ALS15; leads to defective ubiquitin-mediated proteasomal degradation; reduces binding to HNRNPA1 and FAF2; increases translocation of HNRNPA1 to the cytoplasm; adversely affects ERAD. 3 PublicationsCorresponds to variant dbSNP:rs387906709EnsemblClinVar. | 1 | |
| Natural variantiVAR_066563 | 497 | P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906710EnsemblClinVar. | 1 | |
| Natural variantiVAR_066564 | 506 | P → T in ALS15; leads to defective ubiquitin-mediated proteasomal degradation; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906711EnsemblClinVar. | 1 | |
| Natural variantiVAR_066565 | 509 | P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906712EnsemblClinVar. | 1 | |
| Natural variantiVAR_066566 | 525 | P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs369947678EnsemblClinVar. | 1 |
Keywords - Diseasei
Amyotrophic lateral sclerosis, Disease variant, NeurodegenerationOrganism-specific databases
| DisGeNETi | 29978 |
| GeneReviewsi | UBQLN2 |
| MalaCardsi | UBQLN2 |
| MIMi | 300857, phenotype |
| OpenTargetsi | ENSG00000188021 |
| Orphaneti | 803, Amyotrophic lateral sclerosis |
| PharmGKBi | PA37156 |
Miscellaneous databases
| Pharosi | Q9UHD9, Tbio |
Genetic variation databases
| BioMutai | UBQLN2 |
| DMDMi | 124056593 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Initiator methioninei | RemovedCombined sources | |||
| ChainiPRO_0000211011 | 2 – 624 | Ubiquilin-2Add BLAST | 623 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Post-translational modificationi
Degraded during macroautophagy.1 Publication
Keywords - PTMi
AcetylationProteomic databases
| EPDi | Q9UHD9 |
| jPOSTi | Q9UHD9 |
| MassIVEi | Q9UHD9 |
| MaxQBi | Q9UHD9 |
| PaxDbi | Q9UHD9 |
| PeptideAtlasi | Q9UHD9 |
| PRIDEi | Q9UHD9 |
| ProteomicsDBi | 84333 |
PTM databases
| GlyGeni | Q9UHD9, 20 sites, 2 O-linked glycans (20 sites) |
| iPTMneti | Q9UHD9 |
| MetOSitei | Q9UHD9 |
| PhosphoSitePlusi | Q9UHD9 |
Expressioni
Inductioni
Highly expressed in mitotic cells from metaphase to telophase. Expression in non-mitotic cells is very low.
Gene expression databases
| Bgeei | ENSG00000188021, Expressed in cerebellar vermis and 258 other tissues |
| Genevisiblei | Q9UHD9, HS |
Organism-specific databases
| HPAi | ENSG00000188021, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer. Forms heterodimer with UBQLN1. Binds UBE3A and BTRC.
Interacts with the 19S proteasome subunit.
Interacts with C9orf72.
Interacts with HNRNPA1 and HNRNPU.
Found in a complex with UBQLN1 and MAP1LC3A/B/C.
Interacts with EPS15, EPN1 and EPN2.
Interacts with HERPUD1.
Interacts with RAD23A.
Interacts with TARDBP.
Interacts (via C-terminus) with FAF2 (via N-terminus).
Interacts with UBQLN4. Binds CD47 (By similarity).
By similarity12 PublicationsBinary interactionsi
Q9UHD9
GO - Molecular functioni
- identical protein binding Source: IntAct
- polyubiquitin modification-dependent protein binding Source: GO_Central
Protein-protein interaction databases
| BioGRIDi | 119006, 586 interactors |
| CORUMi | Q9UHD9 |
| DIPi | DIP-42116N |
| IntActi | Q9UHD9, 268 interactors |
| MINTi | Q9UHD9 |
| STRINGi | 9606.ENSP00000345195 |
Miscellaneous databases
| RNActi | Q9UHD9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
| SMRi | Q9UHD9 |
| ModBasei | Search... |
| PDBe-KBi | Search... |
Miscellaneous databases
| EvolutionaryTracei | Q9UHD9 |
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Domaini | 33 – 107 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 75 | |
| Domaini | 178 – 206 | STI1 1Sequence analysisAdd BLAST | 29 | |
| Domaini | 208 – 247 | STI1 2Sequence analysisAdd BLAST | 40 | |
| Domaini | 379 – 426 | STI1 3Sequence analysisAdd BLAST | 48 | |
| Domaini | 430 – 462 | STI1 4Sequence analysisAdd BLAST | 33 | |
| Repeati | 491 – 493 | 1 | 3 | |
| Repeati | 494 – 496 | 2 | 3 | |
| Repeati | 497 – 499 | 3 | 3 | |
| Repeati | 500 – 502 | 4 | 3 | |
| Repeati | 503 – 505 | 5 | 3 | |
| Repeati | 506 – 508 | 6 | 3 | |
| Repeati | 509 – 511 | 7 | 3 | |
| Repeati | 512 – 514 | 8 | 3 | |
| Repeati | 515 – 517 | 9 | 3 | |
| Repeati | 518 – 520 | 10 | 3 | |
| Repeati | 521 – 523 | 11 | 3 | |
| Repeati | 524 – 526 | 12 | 3 | |
| Domaini | 581 – 621 | UBAPROSITE-ProRule annotationAdd BLAST | 41 |
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 | |
| Regioni | 106 – 141 | DisorderedSequence analysisAdd BLAST | 36 | |
| Regioni | 287 – 349 | DisorderedSequence analysisAdd BLAST | 63 | |
| Regioni | 491 – 526 | 12 X 3 AA tandem repeats of P-X-XAdd BLAST | 36 | |
| Regioni | 512 – 556 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Compositional biasi | 287 – 313 | Polar residuesSequence analysisAdd BLAST | 27 | |
| Compositional biasi | 325 – 349 | Polar residuesSequence analysisAdd BLAST | 25 | |
| Compositional biasi | 530 – 556 | Polar residuesSequence analysisAdd BLAST | 27 |
Domaini
The ubiquitin-like domain is essential for its inhibitory effect on GPCR endocytosis. Mediates its association with the subunits of the proteasome.1 Publication1 Publication
The UBA domain is essential for its association with microtubule-associated protein 1 light chain 3 (MAP1LC3). Mediates its association with ubiquitinated substrates.1 Publication1 Publication
Dimerization is dependent upon the central region of the protein containing the STI1 domains and is independent of its ubiquitin-like and UBA domains.1 Publication
Keywords - Domaini
RepeatPhylogenomic databases
| eggNOGi | KOG0010, Eukaryota |
| GeneTreei | ENSGT00940000162603 |
| HOGENOMi | CLU_024293_4_0_1 |
| InParanoidi | Q9UHD9 |
| OMAi | QMMNNPD |
| OrthoDBi | 1553668at2759 |
| PhylomeDBi | Q9UHD9 |
| TreeFami | TF314412 |
Family and domain databases
| DisProti | DP01110 |
| InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR006636, STI1_HS-bd IPR015940, UBA IPR009060, UBA-like_sf IPR028430, Ubiquilin-1/2 IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
| PANTHERi | PTHR10677:SF5, PTHR10677:SF5, 1 hit |
| Pfami | View protein in Pfam PF00627, UBA, 1 hit PF00240, ubiquitin, 1 hit |
| SMARTi | View protein in SMART SM00727, STI1, 4 hits SM00165, UBA, 1 hit SM00213, UBQ, 1 hit |
| SUPFAMi | SSF46934, SSF46934, 1 hit SSF48371, SSF48371, 1 hit SSF54236, SSF54236, 1 hit |
| PROSITEi | View protein in PROSITE PS50030, UBA, 1 hit PS50053, UBIQUITIN_2, 1 hit |
Sequencei
Sequence statusi: Complete.
Sequence processingi: The displayed sequence is further processed into a mature form.
Q9UHD9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAENGESSGP PRPSRGPAAA QGSAAAPAEP KIIKVTVKTP KEKEEFAVPE
60 70 80 90 100
NSSVQQFKEA ISKRFKSQTD QLVLIFAGKI LKDQDTLIQH GIHDGLTVHL
110 120 130 140 150
VIKSQNRPQG QSTQPSNAAG TNTTSASTPR SNSTPISTNS NPFGLGSLGG
160 170 180 190 200
LAGLSSLGLS STNFSELQSQ MQQQLMASPE MMIQIMENPF VQSMLSNPDL
210 220 230 240 250
MRQLIMANPQ MQQLIQRNPE ISHLLNNPDI MRQTLEIARN PAMMQEMMRN
260 270 280 290 300
QDLALSNLES IPGGYNALRR MYTDIQEPML NAAQEQFGGN PFASVGSSSS
310 320 330 340 350
SGEGTQPSRT ENRDPLPNPW APPPATQSSA TTSTTTSTGS GSGNSSSNAT
360 370 380 390 400
GNTVAAANYV ASIFSTPGMQ SLLQQITENP QLIQNMLSAP YMRSMMQSLS
410 420 430 440 450
QNPDLAAQMM LNSPLFTANP QLQEQMRPQL PAFLQQMQNP DTLSAMSNPR
460 470 480 490 500
AMQALMQIQQ GLQTLATEAP GLIPSFTPGV GVGVLGTAIG PVGPVTPIGP
510 520 530 540 550
IGPIVPFTPI GPIGPIGPTG PAAPPGSTGS GGPTGPTVSS AAPSETTSPT
560 570 580 590 600
SESGPNQQFI QQMVQALAGA NAPQLPNPEV RFQQQLEQLN AMGFLNREAN
610 620
LQALIATGGD INAAIERLLG SQPS
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sequence conflicti | 544 | S → R in AAF17237 (PubMed:10675567).Curated | 1 | |
| Sequence conflicti | 544 | S → R in BAA34801 (PubMed:9853615).Curated | 1 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_068892 | 155 | S → N in ALS15; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs374522677Ensembl. | 1 | |
| Natural variantiVAR_068893 | 189 | P → T in ALS15; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1490021329Ensembl. | 1 | |
| Natural variantiVAR_052680 | 235 | L → H. Corresponds to variant dbSNP:rs17002693Ensembl. | 1 | |
| Natural variantiVAR_068894 | 282 | A → V Probable disease-associated variant found in a patient with frontotemporal dementia. 1 PublicationCorresponds to variant dbSNP:rs1001930696Ensembl. | 1 | |
| Natural variantiVAR_068895 | 283 | A → T in ALS15. 1 PublicationCorresponds to variant dbSNP:rs749463696Ensembl. | 1 | |
| Natural variantiVAR_068896 | 425 | Q → R in ALS15. 1 PublicationCorresponds to variant dbSNP:rs1243726473Ensembl. | 1 | |
| Natural variantiVAR_068897 | 487 | T → I in ALS15. 1 PublicationCorresponds to variant dbSNP:rs1569254459Ensembl. | 1 | |
| Natural variantiVAR_066562 | 497 | P → H in ALS15; leads to defective ubiquitin-mediated proteasomal degradation; reduces binding to HNRNPA1 and FAF2; increases translocation of HNRNPA1 to the cytoplasm; adversely affects ERAD. 3 PublicationsCorresponds to variant dbSNP:rs387906709EnsemblClinVar. | 1 | |
| Natural variantiVAR_066563 | 497 | P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906710EnsemblClinVar. | 1 | |
| Natural variantiVAR_066564 | 506 | P → T in ALS15; leads to defective ubiquitin-mediated proteasomal degradation; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906711EnsemblClinVar. | 1 | |
| Natural variantiVAR_066565 | 509 | P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906712EnsemblClinVar. | 1 | |
| Natural variantiVAR_066566 | 525 | P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs369947678EnsemblClinVar. | 1 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF189009 mRNA Translation: AAF17237.1 AF293385 mRNA Translation: AAG02474.1 AL354793 Genomic DNA No translation available. CH471154 Genomic DNA Translation: EAW93233.1 BC069237 mRNA Translation: AAH69237.1 AL442081 mRNA Translation: CAC09446.1 AB015344 mRNA Translation: BAA34801.1 |
| CCDSi | CCDS14374.1 |
| RefSeqi | NP_038472.2, NM_013444.3 |
Genome annotation databases
| Ensembli | ENST00000338222; ENSP00000345195; ENSG00000188021 |
| GeneIDi | 29978 |
| KEGGi | hsa:29978 |
| UCSCi | uc004dus.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF189009 mRNA Translation: AAF17237.1 AF293385 mRNA Translation: AAG02474.1 AL354793 Genomic DNA No translation available. CH471154 Genomic DNA Translation: EAW93233.1 BC069237 mRNA Translation: AAH69237.1 AL442081 mRNA Translation: CAC09446.1 AB015344 mRNA Translation: BAA34801.1 |
| CCDSi | CCDS14374.1 |
| RefSeqi | NP_038472.2, NM_013444.3 |
3D structure databases
| Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 1J8C | NMR | - | A | 1-103 | [»] | |
| 2NBV | NMR | - | B | 26-103 | [»] | |
| 6MUN | NMR | - | B/C | 26-103 | [»] | |
| SMRi | Q9UHD9 | |||||
| ModBasei | Search... | |||||
| PDBe-KBi | Search... | |||||
Protein-protein interaction databases
| BioGRIDi | 119006, 586 interactors |
| CORUMi | Q9UHD9 |
| DIPi | DIP-42116N |
| IntActi | Q9UHD9, 268 interactors |
| MINTi | Q9UHD9 |
| STRINGi | 9606.ENSP00000345195 |
Protein family/group databases
| MoonDBi | Q9UHD9, Predicted |
PTM databases
| GlyGeni | Q9UHD9, 20 sites, 2 O-linked glycans (20 sites) |
| iPTMneti | Q9UHD9 |
| MetOSitei | Q9UHD9 |
| PhosphoSitePlusi | Q9UHD9 |
Genetic variation databases
| BioMutai | UBQLN2 |
| DMDMi | 124056593 |
Proteomic databases
| EPDi | Q9UHD9 |
| jPOSTi | Q9UHD9 |
| MassIVEi | Q9UHD9 |
| MaxQBi | Q9UHD9 |
| PaxDbi | Q9UHD9 |
| PeptideAtlasi | Q9UHD9 |
| PRIDEi | Q9UHD9 |
| ProteomicsDBi | 84333 |
Protocols and materials databases
| Antibodypediai | 570, 295 antibodies |
| DNASUi | 29978 |
Genome annotation databases
| Ensembli | ENST00000338222; ENSP00000345195; ENSG00000188021 |
| GeneIDi | 29978 |
| KEGGi | hsa:29978 |
| UCSCi | uc004dus.4, human |
Organism-specific databases
| CTDi | 29978 |
| DisGeNETi | 29978 |
| GeneCardsi | UBQLN2 |
| GeneReviewsi | UBQLN2 |
| HGNCi | HGNC:12509, UBQLN2 |
| HPAi | ENSG00000188021, Low tissue specificity |
| MalaCardsi | UBQLN2 |
| MIMi | 300264, gene 300857, phenotype |
| neXtProti | NX_Q9UHD9 |
| OpenTargetsi | ENSG00000188021 |
| Orphaneti | 803, Amyotrophic lateral sclerosis |
| PharmGKBi | PA37156 |
| VEuPathDBi | HostDB:ENSG00000188021 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | KOG0010, Eukaryota |
| GeneTreei | ENSGT00940000162603 |
| HOGENOMi | CLU_024293_4_0_1 |
| InParanoidi | Q9UHD9 |
| OMAi | QMMNNPD |
| OrthoDBi | 1553668at2759 |
| PhylomeDBi | Q9UHD9 |
| TreeFami | TF314412 |
Enzyme and pathway databases
| PathwayCommonsi | Q9UHD9 |
| Reactomei | R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis |
| SIGNORi | Q9UHD9 |
Miscellaneous databases
| BioGRID-ORCSi | 29978, 5 hits in 645 CRISPR screens |
| ChiTaRSi | UBQLN2, human |
| EvolutionaryTracei | Q9UHD9 |
| GeneWikii | UBQLN2 |
| GenomeRNAii | 29978 |
| Pharosi | Q9UHD9, Tbio |
| PROi | PR:Q9UHD9 |
| RNActi | Q9UHD9, protein |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000188021, Expressed in cerebellar vermis and 258 other tissues |
| Genevisiblei | Q9UHD9, HS |
Family and domain databases
| DisProti | DP01110 |
| InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR006636, STI1_HS-bd IPR015940, UBA IPR009060, UBA-like_sf IPR028430, Ubiquilin-1/2 IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
| PANTHERi | PTHR10677:SF5, PTHR10677:SF5, 1 hit |
| Pfami | View protein in Pfam PF00627, UBA, 1 hit PF00240, ubiquitin, 1 hit |
| SMARTi | View protein in SMART SM00727, STI1, 4 hits SM00165, UBA, 1 hit SM00213, UBQ, 1 hit |
| SUPFAMi | SSF46934, SSF46934, 1 hit SSF48371, SSF48371, 1 hit SSF54236, SSF54236, 1 hit |
| PROSITEi | View protein in PROSITE PS50030, UBA, 1 hit PS50053, UBIQUITIN_2, 1 hit |
| MobiDBi | Search... |
Entry informationi
| Entry namei | UBQL2_HUMAN | |
| Accessioni | Q9UHD9Primary (citable) accession number: Q9UHD9 Secondary accession number(s): O94798 Q9HAZ4 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2004 |
| Last sequence update: | January 23, 2007 | |
| Last modified: | September 29, 2021 | |
| This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references
