UBQLN2

Functionⁱ

Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).6 Publications

GO - Biological processⁱ

autophagy Source: UniProtKB-KW
negative regulation of clathrin-dependent endocytosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18199683
negative regulation of G-protein coupled receptor internalization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18199683
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18307982
regulation of autophagosome assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20529957
regulation of macroautophagy
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20529957
ubiquitin-dependent ERAD pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24215460

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Autophagy

Biological process

Autophagy

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis

Reactomeⁱ

R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis

Protein family/group databases

MoonDBⁱ	Q9UHD9 Predicted

MoonDBⁱ

Q9UHD9 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ubiquilin-2 Alternative name(s): Chap1 DSK2 homolog Protein linking IAP with cytoskeleton 2 Short name: PLIC-2 Short name: hPLIC-2 Ubiquitin-like product Chap1/Dsk2
Gene namesⁱ	Name:UBQLN2 Synonyms:N4BP4, PLIC2 ORF Names:HRIHFB2157
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188021.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12509 UBQLN2
MIMⁱ	300264 gene
neXtProtⁱ	NX_Q9UHD9

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Amyotrophic lateral sclerosis 15, with or without frontotemporal dementia (ALS15)6 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS15 may develop frontotemporal dementia.

Keywords - Diseaseⁱ

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	29978
GeneReviewsⁱ	UBQLN2
MalaCards human disease database More...MalaCardsⁱ	UBQLN2
MIMⁱ	300857 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000188021
Orphanetⁱ	803 Amyotrophic lateral sclerosis
PharmGKBⁱ	PA37156

Polymorphism and mutation databases

BioMutaⁱ	UBQLN2
DMDMⁱ	124056593

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000211011	2 – 624	Ubiquilin-2Add BLAST		623

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Post-translational modificationⁱ

Degraded during macroautophagy.1 Publication

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9UHD9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UHD9
PaxDbⁱ	Q9UHD9
PeptideAtlas More...PeptideAtlasⁱ	Q9UHD9
PRIDEⁱ	Q9UHD9
ProteomicsDBⁱ	84333

PTM databases

iPTMnetⁱ	Q9UHD9
PhosphoSitePlusⁱ	Q9UHD9

Expressionⁱ

Inductionⁱ

Highly expressed in mitotic cells from metaphase to telophase. Expression in non-mitotic cells is very low.

Gene expression databases

Bgeeⁱ	ENSG00000188021 Expressed in 245 organ(s), highest expression level in cerebellar vermis
CleanExⁱ	HS_UBQLN2
Genevisibleⁱ	Q9UHD9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB013481 HPA006431

HPAⁱ

CAB013481
HPA006431

Interactionⁱ

Subunit structureⁱ

Homodimer. Forms heterodimer with UBQLN1. Binds UBE3A and BTRC. Interacts with the 19S proteasome subunit. Interacts with C9orf72. Interacts with HNRNPA1 and HNRNPU. Found in a complex with UBQLN1 and MAP1LC3A/B/C. Interacts with EPS15, EPN1 and EPN2. Interacts with HERPUD1. Interacts with RAD23A. Interacts with TARDBP. Interacts (via C-terminus) with FAF2 (via N-terminus). Interacts with UBQLN4. Binds CD47 (By similarity).By similarity12 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	A0A1U9X8X8	4	EBI-947187,EBI-17234977
ADRM1	Q16186	5	EBI-947187,EBI-954387
AGR2	O95994	4	EBI-947187,EBI-712648
AGR3	Q8TD06	4	EBI-947187,EBI-3925742
C1QA	P02745	3	EBI-947187,EBI-1220209
CEACAM6	P40199	4	EBI-947187,EBI-4314501
CLPSL2	Q6UWE3	4	EBI-947187,EBI-12183429
DAZAP2	Q15038	4	EBI-947187,EBI-724310
DEFA6	Q01524	4	EBI-947187,EBI-10222451
EFEMP1	Q12805	4	EBI-947187,EBI-536772
HGS	O14964	4	EBI-947187,EBI-740220
HNRNPA1	P09651	2	EBI-947187,EBI-352662
HNRNPA1	P09651-2	4	EBI-947187,EBI-352677
HNRNPU	Q00839	3	EBI-947187,EBI-351126
HSPA13	P48723	4	EBI-947187,EBI-750892
PRAP1	Q96NZ9	4	EBI-947187,EBI-2116102
PRR4	Q16378	4	EBI-947187,EBI-738624
PTGDS	P41222	4	EBI-947187,EBI-948821
RAD23A	P54725	5	EBI-947187,EBI-746453
RPN13	O48726	4	EBI-947187,EBI-7710745	From Arabidopsis thaliana.
RTL8C	A6ZKI3	4	EBI-947187,EBI-10174072
TRIM32	Q13049	4	EBI-947187,EBI-742790
WFDC12	Q8WWY7	4	EBI-947187,EBI-11958577
ZG16B	Q96DA0	4	EBI-947187,EBI-953824

Protein-protein interaction databases

BioGridⁱ	119006, 89 interactors
CORUMⁱ	Q9UHD9
Database of interacting proteins More...DIPⁱ	DIP-42116N
IntActⁱ	Q9UHD9, 252 interactors
Molecular INTeraction database More...MINTⁱ	Q9UHD9
STRINGⁱ	9606.ENSP00000345195

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	23 – 25	Combined sources	3
Beta strandⁱ	33 – 38	Combined sources	6
Beta strandⁱ	43 – 48	Combined sources	6
Helixⁱ	54 – 65	Combined sources	12
Beta strandⁱ	69 – 76	Combined sources	8
Beta strandⁱ	79 – 82	Combined sources	4
Helixⁱ	87 – 91	Combined sources	5
Beta strandⁱ	93 – 102	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UHD9
SMRⁱ	Q9UHD9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UHD9

EvolutionaryTraceⁱ

Q9UHD9

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	33 – 107	Ubiquitin-likePROSITE-ProRule annotationAdd BLAST	75
Domainⁱ	178 – 206	STI1 1Sequence analysisAdd BLAST	29
Domainⁱ	208 – 247	STI1 2Sequence analysisAdd BLAST	40
Domainⁱ	379 – 426	STI1 3Sequence analysisAdd BLAST	48
Domainⁱ	430 – 462	STI1 4Sequence analysisAdd BLAST	33
Repeatⁱ	491 – 493	1	3
Repeatⁱ	494 – 496	2	3
Repeatⁱ	497 – 499	3	3
Repeatⁱ	500 – 502	4	3
Repeatⁱ	503 – 505	5	3
Repeatⁱ	506 – 508	6	3
Repeatⁱ	509 – 511	7	3
Repeatⁱ	512 – 514	8	3
Repeatⁱ	515 – 517	9	3
Repeatⁱ	518 – 520	10	3
Repeatⁱ	521 – 523	11	3
Repeatⁱ	524 – 526	12	3
Domainⁱ	581 – 621	UBAPROSITE-ProRule annotationAdd BLAST	41

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	491 – 526	12 X 3 AA tandem repeats of P-X-XAdd BLAST		36

Domainⁱ

The ubiquitin-like domain is essential for its inhibitory effect on GPCR endocytosis. Mediates its association with the subunits of the proteasome.1 Publication1 Publication

The UBA domain is essential for its association with microtubule-associated protein 1 light chain 3 (MAP1LC3). Mediates its association with ubiquitinated substrates.1 Publication1 Publication

Dimerization is dependent upon the central region of the protein containing the STI1 domains and is independent of its ubiquitin-like and UBA domains.1 Publication

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0010 Eukaryota COG5272 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005720
HOGENOMⁱ	HOG000234878
HOVERGENⁱ	HBG064537
InParanoidⁱ	Q9UHD9
KEGG Orthology (KO) More...KOⁱ	K04523
OMAⁱ	PQQGTEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08WB
PhylomeDBⁱ	Q9UHD9
TreeFamⁱ	TF314412

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR006636 STI1_HS-bd IPR015940 UBA IPR009060 UBA-like_sf IPR015496 Ubiquilin IPR028430 Ubiquilin-2 IPR029071 Ubiquitin-like_domsf IPR000626 Ubiquitin_dom
PANTHERⁱ	PTHR10677 PTHR10677, 1 hit PTHR10677:SF5 PTHR10677:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00627 UBA, 1 hit PF00240 ubiquitin, 1 hit
SMARTⁱ	View protein in SMART SM00727 STI1, 4 hits SM00165 UBA, 1 hit SM00213 UBQ, 1 hit
SUPFAMⁱ	SSF46934 SSF46934, 1 hit SSF48371 SSF48371, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50030 UBA, 1 hit PS50053 UBIQUITIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9UHD9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAENGESSGP PRPSRGPAAA QGSAAAPAEP KIIKVTVKTP KEKEEFAVPE 
        60         70         80         90        100
NSSVQQFKEA ISKRFKSQTD QLVLIFAGKI LKDQDTLIQH GIHDGLTVHL 
       110        120        130        140        150
VIKSQNRPQG QSTQPSNAAG TNTTSASTPR SNSTPISTNS NPFGLGSLGG 
       160        170        180        190        200
LAGLSSLGLS STNFSELQSQ MQQQLMASPE MMIQIMENPF VQSMLSNPDL 
       210        220        230        240        250
MRQLIMANPQ MQQLIQRNPE ISHLLNNPDI MRQTLEIARN PAMMQEMMRN 
       260        270        280        290        300
QDLALSNLES IPGGYNALRR MYTDIQEPML NAAQEQFGGN PFASVGSSSS 
       310        320        330        340        350
SGEGTQPSRT ENRDPLPNPW APPPATQSSA TTSTTTSTGS GSGNSSSNAT 
       360        370        380        390        400
GNTVAAANYV ASIFSTPGMQ SLLQQITENP QLIQNMLSAP YMRSMMQSLS 
       410        420        430        440        450
QNPDLAAQMM LNSPLFTANP QLQEQMRPQL PAFLQQMQNP DTLSAMSNPR 
       460        470        480        490        500
AMQALMQIQQ GLQTLATEAP GLIPSFTPGV GVGVLGTAIG PVGPVTPIGP 
       510        520        530        540        550
IGPIVPFTPI GPIGPIGPTG PAAPPGSTGS GGPTGPTVSS AAPSETTSPT 
       560        570        580        590        600
SESGPNQQFI QQMVQALAGA NAPQLPNPEV RFQQQLEQLN AMGFLNREAN 
       610        620 
LQALIATGGD INAAIERLLG SQPS

Length:624

Mass (Da):65,696

Last modified:January 23, 2007 - v2

Checksum:ⁱDF7DF8C4D7B71AC3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	544	S → R in AAF17237 (PubMed:10675567).Curated		1
Sequence conflictⁱ	544	S → R in BAA34801 (PubMed:9853615).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_068892	155	S → N in ALS15; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs374522677Ensembl.	1
Natural variantⁱVAR_068893	189	P → T in ALS15; uncertain pathological significance. 1 Publication	1
Natural variantⁱVAR_052680	235	L → H. Corresponds to variant dbSNP:rs17002693Ensembl.	1
Natural variantⁱVAR_068894	282	A → V Probable disease-associated mutation found in a patient with frontotemporal dementia. 1 PublicationCorresponds to variant dbSNP:rs1001930696Ensembl.	1
Natural variantⁱVAR_068895	283	A → T in ALS15. 1 PublicationCorresponds to variant dbSNP:rs749463696Ensembl.	1
Natural variantⁱVAR_068896	425	Q → R in ALS15. 1 Publication	1
Natural variantⁱVAR_068897	487	T → I in ALS15. 1 Publication	1
Natural variantⁱVAR_066562	497	P → H in ALS15; leads to defective ubiquitin-mediated proteasomal degradation; reduces binding to HNRNPA1 and FAF2; increases translocation of HNRNPA1 to the cytoplasm; adversely affects ERAD. 3 PublicationsCorresponds to variant dbSNP:rs387906709EnsemblClinVar.	1
Natural variantⁱVAR_066563	497	P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906710EnsemblClinVar.	1
Natural variantⁱVAR_066564	506	P → T in ALS15; leads to defective ubiquitin-mediated proteasomal degradation; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906711EnsemblClinVar.	1
Natural variantⁱVAR_066565	509	P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs387906712EnsemblClinVar.	1
Natural variantⁱVAR_066566	525	P → S in ALS15; reduces binding to HNRNPA1; increases translocation of HNRNPA1 to the cytoplasm. 2 PublicationsCorresponds to variant dbSNP:rs369947678EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF189009 mRNA Translation: AAF17237.1 AF293385 mRNA Translation: AAG02474.1 AL354793 Genomic DNA No translation available. CH471154 Genomic DNA Translation: EAW93233.1 BC069237 mRNA Translation: AAH69237.1 AL442081 mRNA Translation: CAC09446.1 AB015344 mRNA Translation: BAA34801.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14374.1
NCBI Reference Sequences More...RefSeqⁱ	NP_038472.2, NM_013444.3
UniGeneⁱ	Hs.179309

Genome annotation databases

Ensemblⁱ	ENST00000338222; ENSP00000345195; ENSG00000188021
GeneIDⁱ	29978
KEGGⁱ	hsa:29978
UCSC genome browser More...UCSCⁱ	uc004dus.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UHD9	ubiquilin-2 isoform X1		Florida manatee		630	UniRef90_Q9UHD9
ubiquilin-2		DIPOR		629
Ubiquilin-2		HETGA		625
Ubiquilin 2		MYOLU		625
Ubiquilin-2		MYOBR		453
+80

Protein	Similar proteins		Species	Score	Length	Source
Q9UHD9	Ubiquilin-2		MOUSE		638	UniRef50_Q9UHD9
Ubiquilin-1		PONAB		589
Ubiquilin-1	)	RAT		582
ubiquilin-2 isoform X1		Florida manatee		630
ubiquilin-2		DIPOR		629
+499

Entry informationⁱ

Entry nameⁱ	UBQL2_HUMAN
Accessionⁱ	Q9UHD9Primary (citable) accession number: Q9UHD9 Secondary accession number(s): O94798 , Q5D027, Q9H3W6, Q9HAZ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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UniProtKB - Q9UHD9 (UBQL2_HUMAN)

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Ubiquilin-2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ