UniProtKB - Q9UHD4 (CIDEB_HUMAN)
Protein
Cell death activator CIDE-B
Gene
CIDEB
Organism
Homo sapiens (Human)
Status
Functioni
Activates apoptosis.
(Microbial infection) Involved in Hepatatis C virus (HCV) assembly and required for HCV entry into hepatocytes.1 Publication
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- activation of cysteine-type endopeptidase activity Source: AgBase
- apoptotic process Source: MGI
- bile acid signaling pathway Source: Ensembl
- execution phase of apoptosis Source: BHF-UCL
- intrinsic apoptotic signaling pathway in response to DNA damage Source: ProtInc
- positive regulation of cell death Source: AgBase
- positive regulation of release of cytochrome c from mitochondria Source: AgBase
- regulation of apoptotic process Source: GO_Central
- response to nutrient levels Source: Ensembl
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis, Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q9UHD4 |
SignaLinki | Q9UHD4 |
Names & Taxonomyi
Protein namesi | Recommended name: Cell death activator CIDE-BAlternative name(s): Cell death-inducing DFFA-like effector B |
Gene namesi | Name:CIDEB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1977, CIDEB |
MIMi | 604441, gene |
neXtProti | NX_Q9UHD4 |
VEuPathDBi | HostDB:ENSG00000136305.11 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Other locations
- perinuclear region of cytoplasm Source: AgBase
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 27141 |
OpenTargetsi | ENSG00000136305 |
PharmGKBi | PA26515 |
Miscellaneous databases
Pharosi | Q9UHD4, Tbio |
Genetic variation databases
BioMutai | CIDEB |
DMDMi | 20141283 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144720 | 1 – 219 | Cell death activator CIDE-BAdd BLAST | 219 |
Proteomic databases
MassIVEi | Q9UHD4 |
PaxDbi | Q9UHD4 |
PeptideAtlasi | Q9UHD4 |
PRIDEi | Q9UHD4 |
ProteomicsDBi | 84324 |
PTM databases
iPTMneti | Q9UHD4 |
PhosphoSitePlusi | Q9UHD4 |
Expressioni
Tissue specificityi
Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen.1 Publication
Gene expression databases
Bgeei | ENSG00000136305, Expressed in jejunal mucosa and 194 other tissues |
ExpressionAtlasi | Q9UHD4, baseline and differential |
Genevisiblei | Q9UHD4, HS |
Organism-specific databases
HPAi | ENSG00000136305, Group enriched (intestine, liver) |
Interactioni
Subunit structurei
Inhibited by DFFB.
Interacts with DFFA and DFFB.
1 Publication(Microbial infection) Interacts (via N-terminus) with HCV non-structural protein 5A (via N-terminus); this interaction seems to regulate the association of HCV particles with ApoE.
1 PublicationBinary interactionsi
Q9UHD4
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 118027, 75 interactors |
IntActi | Q9UHD4, 69 interactors |
STRINGi | 9606.ENSP00000337731 |
Miscellaneous databases
RNActi | Q9UHD4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9UHD4 |
SMRi | Q9UHD4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UHD4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 110 | CIDE-NPROSITE-ProRule annotationAdd BLAST | 77 |
Phylogenomic databases
eggNOGi | ENOG502RUS7, Eukaryota |
GeneTreei | ENSGT00390000018596 |
HOGENOMi | CLU_090011_0_0_1 |
InParanoidi | Q9UHD4 |
OMAi | RVWNSAP |
OrthoDBi | 1421916at2759 |
PhylomeDBi | Q9UHD4 |
TreeFami | TF334321 |
Family and domain databases
InterProi | View protein in InterPro IPR003508, CIDE-N_dom |
Pfami | View protein in Pfam PF02017, CIDE-N, 1 hit |
SMARTi | View protein in SMART SM00266, CAD, 1 hit |
PROSITEi | View protein in PROSITE PS51135, CIDE_N, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9UHD4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEYLSALNPS DLLRSVSNIS SEFGRRVWTS APPPQRPFRV CDHKRTIRKG
60 70 80 90 100
LTAATRQELL AKALETLLLN GVLTLVLEED GTAVDSEDFF QLLEDDTCLM
110 120 130 140 150
VLQSGQSWSP TRSGVLSYGL GRERPKHSKD IARFTFDVYK QNPRDLFGSL
160 170 180 190 200
NVKATFYGLY SMSCDFQGLG PKKVLRELLR WTSTLLQGLG HMLLGISSTL
210
RHAVEGAEQW QQKGRLHSY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V4E2 | G3V4E2_HUMAN | Cell death activator CIDE-B | CIDEB | 61 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 120 | L → P in AAF23324 (PubMed:10619428).Curated | 1 | |
Sequence conflicti | 124 | R → S in AAF23324 (PubMed:10619428).Curated | 1 | |
Sequence conflicti | 132 | A → G in AAF23324 (PubMed:10619428).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF190901 mRNA Translation: AAF23324.1 AF218586 mRNA Translation: AAF27658.1 AF544398 mRNA Translation: AAN37907.1 AK000387 mRNA Translation: BAA91132.1 CH471078 Genomic DNA Translation: EAW66031.1 CH471078 Genomic DNA Translation: EAW66032.1 CH471078 Genomic DNA Translation: EAW66033.1 BC035970 mRNA Translation: AAH35970.1 |
CCDSi | CCDS32056.1 |
RefSeqi | NP_001305736.1, NM_001318807.1 NP_055245.2, NM_014430.2 XP_011534961.1, XM_011536659.2 XP_016876710.1, XM_017021221.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF190901 mRNA Translation: AAF23324.1 AF218586 mRNA Translation: AAF27658.1 AF544398 mRNA Translation: AAN37907.1 AK000387 mRNA Translation: BAA91132.1 CH471078 Genomic DNA Translation: EAW66031.1 CH471078 Genomic DNA Translation: EAW66032.1 CH471078 Genomic DNA Translation: EAW66033.1 BC035970 mRNA Translation: AAH35970.1 |
CCDSi | CCDS32056.1 |
RefSeqi | NP_001305736.1, NM_001318807.1 NP_055245.2, NM_014430.2 XP_011534961.1, XM_011536659.2 XP_016876710.1, XM_017021221.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1D4B | NMR | - | A | 1-116 | [»] | |
BMRBi | Q9UHD4 | |||||
SMRi | Q9UHD4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118027, 75 interactors |
IntActi | Q9UHD4, 69 interactors |
STRINGi | 9606.ENSP00000337731 |
PTM databases
iPTMneti | Q9UHD4 |
PhosphoSitePlusi | Q9UHD4 |
Genetic variation databases
BioMutai | CIDEB |
DMDMi | 20141283 |
Proteomic databases
MassIVEi | Q9UHD4 |
PaxDbi | Q9UHD4 |
PeptideAtlasi | Q9UHD4 |
PRIDEi | Q9UHD4 |
ProteomicsDBi | 84324 |
Protocols and materials databases
Antibodypediai | 9150, 333 antibodies |
DNASUi | 27141 |
Genome annotation databases
Organism-specific databases
CTDi | 27141 |
DisGeNETi | 27141 |
GeneCardsi | CIDEB |
HGNCi | HGNC:1977, CIDEB |
HPAi | ENSG00000136305, Group enriched (intestine, liver) |
MIMi | 604441, gene |
neXtProti | NX_Q9UHD4 |
OpenTargetsi | ENSG00000136305 |
PharmGKBi | PA26515 |
VEuPathDBi | HostDB:ENSG00000136305.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RUS7, Eukaryota |
GeneTreei | ENSGT00390000018596 |
HOGENOMi | CLU_090011_0_0_1 |
InParanoidi | Q9UHD4 |
OMAi | RVWNSAP |
OrthoDBi | 1421916at2759 |
PhylomeDBi | Q9UHD4 |
TreeFami | TF334321 |
Enzyme and pathway databases
PathwayCommonsi | Q9UHD4 |
SignaLinki | Q9UHD4 |
Miscellaneous databases
BioGRID-ORCSi | 27141, 8 hits in 933 CRISPR screens |
ChiTaRSi | CIDEB, human |
EvolutionaryTracei | Q9UHD4 |
GenomeRNAii | 27141 |
Pharosi | Q9UHD4, Tbio |
PROi | PR:Q9UHD4 |
RNActi | Q9UHD4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136305, Expressed in jejunal mucosa and 194 other tissues |
ExpressionAtlasi | Q9UHD4, baseline and differential |
Genevisiblei | Q9UHD4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003508, CIDE-N_dom |
Pfami | View protein in Pfam PF02017, CIDE-N, 1 hit |
SMARTi | View protein in SMART SM00266, CAD, 1 hit |
PROSITEi | View protein in PROSITE PS51135, CIDE_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CIDEB_HUMAN | |
Accessioni | Q9UHD4Primary (citable) accession number: Q9UHD4 Secondary accession number(s): D3DS73, Q546V8, Q9NNW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | March 27, 2002 | |
Last modified: | April 7, 2021 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references