UniProtKB - Q9UHD2 (TBK1_HUMAN)
Serine/threonine-protein kinase TBK1
TBK1
Functioni
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:10581243, PubMed:11839743, PubMed:15485837, PubMed:21138416, PubMed:25636800, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:26611359, PubMed:32404352).
Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:25636800).
This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995).
In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807).
Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653).
Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800).
Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631).
Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227).
Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041).
Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069).
Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703).
Phosphorylates and activates AKT1 (PubMed:21464307).
Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity (By similarity).
Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402).
Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125).
Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595).
By similarity26 PublicationsMiscellaneous
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 38 | ATPCurated | 1 | |
Active sitei | 135 | Proton acceptor3 Publications | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 15 – 23 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- nucleic acid binding Source: Ensembl
- phosphoprotein binding Source: UniProtKB
- protein kinase activity Source: ProtInc
- protein phosphatase binding Source: ARUK-UCL
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- activation of innate immune response Source: Ensembl
- defense response to Gram-positive bacterium Source: Ensembl
- defense response to virus Source: UniProtKB-KW
- dendritic cell proliferation Source: Ensembl
- I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- inflammatory response Source: UniProtKB
- innate immune response Source: UniProtKB
- negative regulation of gene expression Source: Ensembl
- peptidyl-serine phosphorylation Source: UniProtKB
- peptidyl-threonine phosphorylation Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of interferon-alpha production Source: BHF-UCL
- positive regulation of interferon-beta production Source: BHF-UCL
- positive regulation of macroautophagy Source: HGNC
- positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
- positive regulation of type I interferon production Source: UniProtKB
- positive regulation of xenophagy Source: Ensembl
- protein phosphorylation Source: UniProtKB
- regulation of neuron death Source: ParkinsonsUK-UCL
- regulation of type I interferon production Source: UniProtKB
- response to virus Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Antiviral defense, Host-virus interaction, Immunity, Innate immunity |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UHD2 |
Reactomei | R-HSA-1606341, IRF3 mediated activation of type 1 IFN R-HSA-168928, DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-3134975, Regulation of innate immune responses to cytosolic DNA R-HSA-3249367, STAT6-mediated induction of chemokines R-HSA-3270619, IRF3-mediated induction of type I IFN R-HSA-9008059, Interleukin-37 signaling R-HSA-9013973, TICAM1-dependent activation of IRF3/IRF7 R-HSA-918233, TRAF3-dependent IRF activation pathway R-HSA-933541, TRAF6 mediated IRF7 activation R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling R-HSA-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-9679191, Potential therapeutics for SARS |
SABIO-RKi | Q9UHD2 |
SignaLinki | Q9UHD2 |
SIGNORi | Q9UHD2 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase TBK1Curated (EC:2.7.11.17 Publications)Alternative name(s): NF-kappa-B-activating kinase1 Publication T2K TANK-binding kinase 11 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11584, TBK1 |
MIMi | 604834, gene |
neXtProti | NX_Q9UHD2 |
VEuPathDBi | HostDB:ENSG00000183735 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 3 Publications
Note: Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2.1 Publication
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Glaucoma 1, open angle, P (GLC1P)2 Publications
Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 (FTDALS4)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073938 | 47 | R → H in FTDALS4; loss of kinase activity. 1 Publication | 1 | |
Natural variantiVAR_073939 | 105 | Y → C in FTDALS4. 1 PublicationCorresponds to variant dbSNP:rs1366668789EnsemblClinVar. | 1 | |
Natural variantiVAR_073940 | 305 | I → T in FTDALS4. 1 PublicationCorresponds to variant dbSNP:rs770942184Ensembl. | 1 | |
Natural variantiVAR_069755 | 306 | L → I in FTDALS4; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs201970436EnsemblClinVar. | 1 | |
Natural variantiVAR_073941 | 308 | R → Q in FTDALS4; reduced kinase activity. 1 Publication | 1 | |
Natural variantiVAR_073942 | 357 | R → Q in FTDALS4; reduced kinase activity. 1 PublicationCorresponds to variant dbSNP:rs758357594Ensembl. | 1 | |
Natural variantiVAR_073943 | 401 | K → E in FTDALS4. 1 PublicationCorresponds to variant dbSNP:rs756751089EnsemblClinVar. | 1 | |
Natural variantiVAR_073944 | 559 | M → R in FTDALS4; loss of kinase activity. 1 Publication | 1 | |
Natural variantiVAR_073945 | 571 | A → V in FTDALS4. 1 PublicationCorresponds to variant dbSNP:rs765035140Ensembl. | 1 | |
Natural variantiVAR_073946 | 598 | M → V in FTDALS4. 1 PublicationCorresponds to variant dbSNP:rs899858451EnsemblClinVar. | 1 | |
Natural variantiVAR_073947 | 643 | Missing in FTDALS4. 1 Publication | 1 | |
Natural variantiVAR_073948 | 696 | E → K in FTDALS4; loss of kinase activity; impairs binding to OPTN. 2 PublicationsCorresponds to variant dbSNP:rs748112833EnsemblClinVar. | 1 |
Encephalopathy, acute, infection-induced, 8, herpes-specific (IIAE8)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080517 | 50 | D → A in IIAE8; decreased expression levels. 1 PublicationCorresponds to variant dbSNP:rs1010930015EnsemblClinVar. | 1 | |
Natural variantiVAR_080518 | 159 | G → A in IIAE8; loss of kinase activity; loss of autophosphorylation at S-172; loss of IFNB induction. 2 PublicationsCorresponds to variant dbSNP:rs1555202947EnsemblClinVar. | 1 | |
Natural variantiVAR_080519 | 207 | I → V in IIAE8; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1555203557EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 30 | K → R: Decreases ubiquitination. Abolishes ubiquitination, phosphorylation and kinase activity; when associated with R-401. 1 Publication | 1 | |
Mutagenesisi | 33 | D → A: Decreases phosphorylation and kinase activity. 1 Publication | 1 | |
Mutagenesisi | 38 | K → A: Loss of kinase activity. 5 Publications | 1 | |
Mutagenesisi | 135 | D → N: Loss of kinase activity. 4 Publications | 1 | |
Mutagenesisi | 172 | S → A: Loss of kinase activity. No effect on dimerization. 2 Publications | 1 | |
Mutagenesisi | 172 | S → E: Decreased kinase activity. 2 Publications | 1 | |
Mutagenesisi | 316 | L → E: Decreases kinase activity. No effect on phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 325 | Y → E: Abolishes phosphorylation and kinase activity. 1 Publication | 1 | |
Mutagenesisi | 355 | E → R: Decreases phosphorylation and kinase activity. Abolishes dimerization; when associated with A-357 or R-448. 2 Publications | 1 | |
Mutagenesisi | 357 | R → A: Decreases phosphorylation and kinase activity. Abolishes dimerization; when associated with R-355. 1 Publication | 1 | |
Mutagenesisi | 401 | K → R: Decreases ubiquitination. Abolishes ubiquitination, phosphorylation and kinase activity; when associated with R-30. 1 Publication | 1 | |
Mutagenesisi | 448 | E → R: Decreases phosphorylation and kinase activity. Abolishes dimerization; when associated with R-355. 1 Publication | 1 | |
Mutagenesisi | 459 | H → E: Abolishes dimerization and decreases kinase activity but no effect on phosphorylation; when associated with E-466 and E-470. 1 Publication | 1 | |
Mutagenesisi | 466 | I → E: Abolishes dimerization and decreases kinase activity but no effect on phosphorylation; when associated with E-459 and E-470. 1 Publication | 1 | |
Mutagenesisi | 470 | F → E: Abolishes dimerization and decreases kinase activity but no effect on phosphorylation; when associated with E-459 and E-466. 1 Publication | 1 | |
Mutagenesisi | 547 | R → D: Decreases phosphorylation and kinase activity. Abolishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 577 | Y → A: Decreases kinase activity. Reduced phosphorylation of STING1. 2 Publications | 1 | |
Mutagenesisi | 578 | N → A: Reduced phosphorylation of STING1. 1 Publication | 1 | |
Mutagenesisi | 580 | E → A: Decreases kinase activity. 1 Publication | 1 | |
Mutagenesisi | 581 | Q → A: Reduced phosphorylation of STING1. 1 Publication | 1 | |
Mutagenesisi | 582 | I → A: Decreases kinase activity. 1 Publication | 1 | |
Mutagenesisi | 589 | K → D: Decreases phosphorylation and kinase activity. 1 Publication | 1 | |
Mutagenesisi | 690 | M → A: Decreases interaction with TANK. 1 Publication | 1 | |
Mutagenesisi | 693 | L → A: Almost abolishes interaction with TANK. 1 Publication | 1 | |
Mutagenesisi | 694 | K → E: Strongly decreases interaction with TANK and TBKBP1. No effect on phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 704 | L → A: Strongly decreases interaction with AZI2, TANK and TBKBP1. No effect on phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 708 | N → A: Decreases interaction with TANK. 1 Publication | 1 | |
Mutagenesisi | 711 | L → A: Almost abolishes interaction with TANK. 1 Publication | 1 |
Keywords - Diseasei
Amyotrophic lateral sclerosis, Disease variant, Glaucoma, NeurodegenerationOrganism-specific databases
DisGeNETi | 29110 |
MalaCardsi | TBK1 |
MIMi | 177700, phenotype 616439, phenotype 617900, phenotype |
OpenTargetsi | ENSG00000183735 |
Orphaneti | 803, Amyotrophic lateral sclerosis 275872, Frontotemporal dementia with motor neuron disease 1930, Herpes simplex virus encephalitis |
PharmGKBi | PA36348 |
Miscellaneous databases
Pharosi | Q9UHD2, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5408 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9UHD2 |
GuidetoPHARMACOLOGYi | 2237 |
Genetic variation databases
BioMutai | TBK1 |
DMDMi | 74761953 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086743 | 1 – 729 | Serine/threonine-protein kinase TBK1Add BLAST | 729 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 30 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 172 | Phosphoserine; by autocatalysis and IKKB3 Publications | 1 | |
Cross-linki | 401 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Cross-linki | 670 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 716 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-910 CPTAC-911 |
EPDi | Q9UHD2 |
jPOSTi | Q9UHD2 |
MassIVEi | Q9UHD2 |
MaxQBi | Q9UHD2 |
PaxDbi | Q9UHD2 |
PeptideAtlasi | Q9UHD2 |
PRIDEi | Q9UHD2 |
ProteomicsDBi | 84323 |
PTM databases
iPTMneti | Q9UHD2 |
MetOSitei | Q9UHD2 |
PhosphoSitePlusi | Q9UHD2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000183735, Expressed in lateral nuclear group of thalamus and 244 other tissues |
ExpressionAtlasi | Q9UHD2, baseline and differential |
Genevisiblei | Q9UHD2, HS |
Organism-specific databases
HPAi | ENSG00000183735, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (PubMed:21145761).
Interacts with DDX3X, TIRAP and TRAF2 (PubMed:10581243, PubMed:14530355).
Part of a ternary complex consisting of TANK, TRAF2 and TBK1 (PubMed:10581243).
Interacts with AZI2, TANK and TBKBP1; these interactions are mutually exclusive and mediate TBK1 activation (PubMed:14560022, PubMed:21931631, PubMed:23453972, PubMed:10581243, PubMed:29251827).
Interacts with GSK3B; this interaction promotes TBK1 self-association and autophosphorylation (PubMed:21145761).
Interacts with SIKE1; SIKE1 is associated with TBK1 under physiological condition and dissociated from TBK1 upon viral infection or TLR3 stimulation (PubMed:16281057).
Interacts with IRF3, leading to IRF3 phosphorylation (PubMed:14703513, PubMed:25636800).
Interacts with DDX58/RIG-I (PubMed:16281057).
Interacts with CYLD (PubMed:18636086, PubMed:32185393).
Interacts with OPTN and TRAF3 (PubMed:20174559).
Interacts with SRC (PubMed:19419966).
Interacts with the exocyst complex subunit SEC5/EXOC2; this interaction is sufficient to trigger TBK1 activity (PubMed:17018283).
Interacts with STING1, leading to STING1 phosphorylation (PubMed:19416887, PubMed:25636800, PubMed:30842653).
Interacts with IFIT3 (via N-terminus) (PubMed:21813773).
Interacts with MAVS; interaction only takes place in the presence of IFIT3 and leads to MAVS phosphorylation (PubMed:21813773, PubMed:25636800, PubMed:28011935).
Interacts (via protein kinase domain) with TTLL12 (via TTL domain); the interaction prevents MAVS binding to TBK1 (PubMed:28011935).
Interacts with TICAM1; this interaction is enhanced in the presence of WDFY1 and leads to TICAM1 phosphorylation (PubMed:14530355, PubMed:14739303, PubMed:25736436, PubMed:25636800).
Interacts with TRIM26 (PubMed:26611359).
Interacts with TRIM23 (PubMed:28871090).
Interacts with TTC4 and IKBKE (PubMed:29251827).
Interacts with HNRNPA2B1 (PubMed:31320558).
Interacts with DDX3X (PubMed:20375222).
Interacts with TRIM14 (PubMed:32404352).
Interacts with CEP170; efficient complex formation may be dependent on the presence of CCDC61 (PubMed:30354798).
Interacts with TRAF3IP3 (PubMed:32366851).
Interacts with HSP90AA1; the interaction mediates TBK1 association with TOMM70 (PubMed:20628368).
29 Publications(Microbial infection) Interacts with Borna disease virus (BDV) P protein leading to its phosphorylation.
1 Publication(Microbial infection) Interacts with Ebola virus protein VP35.
1 Publication(Microbial infection) Interacts with HCV NS3; this interaction leads to inhibition of cellular antiviral response by blocking necessary interactions between the TBK1 and its substrates IRF3 and IRF7.
1 Publication(Microbial infection) Interacts with herpes simplex virus 1 protein ICP34.5.
1 Publication(Microbial infection) Interacts with Zika virus non-structural protein 1/NS1 and non-structural protein 4B/NS4B.
1 Publication(Microbial infection) Interacts with SARS-CoV-2 non-structural protein 6; this interaction decreases IRF3 phosphorylation by 57%, which leads to reduced IFN-beta (IFNB) production (PubMed:32979938).
Interacts with SARS-CoV-2 helicase; this interaction inhibits TBK1 phosphorylation and decreases IRF3 phosphorylation by 75%, which leads to reduced IFN-beta production (PubMed:32979938).
Interacts with SARS-CoV-2 M protein; the interaction promotes TBK1 degradation via 'Lys-48'-linked ubiquitination (PubMed:34084167).
2 Publications(Microbial infection) Interacts with human cytomegalovirus protein UL35; this interaction inhibits type I interferon production.
1 PublicationBinary interactionsi
Q9UHD2
GO - Molecular functioni
- identical protein binding Source: Ensembl
- phosphoprotein binding Source: UniProtKB
- protein phosphatase binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 118878, 259 interactors |
ComplexPortali | CPX-6018, STING-TRAF3-TBK1 complex CPX-6038, TBK1-IKKepsilon-NAP1 complex CPX-6089, TBK1-IKKepsilon-TANK complex CPX-6090, TBK1-IKKepsilon-SINTBAD complex |
CORUMi | Q9UHD2 |
DIPi | DIP-27529N |
IntActi | Q9UHD2, 119 interactors |
MINTi | Q9UHD2 |
STRINGi | 9606.ENSP00000329967 |
Chemistry databases
BindingDBi | Q9UHD2 |
Miscellaneous databases
RNActi | Q9UHD2, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9UHD2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 310 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 302 | |
Domaini | 309 – 385 | Ubiquitin-likeAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 621 – 729 | Interaction with AZI2, TANK and TBKBP11 PublicationAdd BLAST | 109 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 407 – 657 | By similarityAdd BLAST | 251 | |
Coiled coili | 658 – 713 | Sequence analysisAdd BLAST | 56 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4250, Eukaryota |
GeneTreei | ENSGT00950000182937 |
HOGENOMi | CLU_000288_101_1_1 |
InParanoidi | Q9UHD2 |
OMAi | ILHRMIV |
OrthoDBi | 563981at2759 |
PhylomeDBi | Q9UHD2 |
TreeFami | TF324269 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR041309, TBK1_CCD1 IPR041087, TBK1_ULD |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF18394, TBK1_CCD1, 1 hit PF18396, TBK1_ULD, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 45 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD
60 70 80 90 100
VQMREFEVLK KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE
110 120 130 140 150
PSNAYGLPES EFLIVLRDVV GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ
160 170 180 190 200
SVYKLTDFGA ARELEDDEQF VSLYGTEEYL HPDMYERAVL RKDHQKKYGA
210 220 230 240 250
TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITG KPSGAISGVQ
260 270 280 290 300
KAENGPIDWS GDMPVSCSLS RGLQVLLTPV LANILEADQE KCWGFDQFFA
310 320 330 340 350
ETSDILHRMV IHVFSLQQMT AHKIYIHSYN TATIFHELVY KQTKIISSNQ
360 370 380 390 400
ELIYEGRRLV LEPGRLAQHF PKTTEENPIF VVSREPLNTI GLIYEKISLP
410 420 430 440 450
KVHPRYDLDG DASMAKAITG VVCYACRIAS TLLLYQELMR KGIRWLIELI
460 470 480 490 500
KDDYNETVHK KTEVVITLDF CIRNIEKTVK VYEKLMKINL EAAELGEISD
510 520 530 540 550
IHTKLLRLSS SQGTIETSLQ DIDSRLSPGG SLADAWAHQE GTHPKDRNVE
560 570 580 590 600
KLQVLLNCMT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMTH
610 620 630 640 650
FTDECVKKYE AFLNKSEEWI RKMLHLRKQL LSLTNQCFDI EEEVSKYQEY
660 670 680 690 700
TNELQETLPQ KMFTASSGIK HTMTPIYPSS NTLVEMTLGM KKLKEEMEGV
710 720
VKELAENNHI LERFGSLTMD GGLRNVDCL
Computationally mapped potential isoform sequencesi
There are 45 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494C045 | A0A494C045_HUMAN | Serine/threonine-protein kinase TBK... | TBK1 | 731 | Annotation score: | ||
A0A494C148 | A0A494C148_HUMAN | Serine/threonine-protein kinase TBK... | TBK1 | 705 | Annotation score: | ||
A0A494C079 | A0A494C079_HUMAN | Serine/threonine-protein kinase TBK... | TBK1 | 519 | Annotation score: | ||
A0A494C0A8 | A0A494C0A8_HUMAN | Serine/threonine-protein kinase TBK... | TBK1 | 551 | Annotation score: | ||
A0A494C1M6 | A0A494C1M6_HUMAN | Serine/threonine-protein kinase TBK... | TBK1 | 575 | Annotation score: | ||
A0A7I2V2F4 | A0A7I2V2F4_HUMAN | Serine/threonine-protein kinase TBK... | TBK1 | 613 | Annotation score: | ||
A0A7I2V463 | A0A7I2V463_HUMAN | Serine/threonine-protein kinase TBK... | TBK1 | 541 | Annotation score: | ||
A0A7I2V4W4 | A0A7I2V4W4_HUMAN | Serine/threonine-protein kinase TBK... | TBK1 | 695 | Annotation score: | ||
A0A7I2V4Z2 | A0A7I2V4Z2_HUMAN | Serine/threonine-protein kinase TBK... | TBK1 | 511 | Annotation score: | ||
A0A7I2V643 | A0A7I2V643_HUMAN | Serine/threonine-protein kinase TBK... | TBK1 | 724 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_084111 | 24 | F → S Loss of IFNB induction. 1 Publication | 1 | |
Natural variantiVAR_073938 | 47 | R → H in FTDALS4; loss of kinase activity. 1 Publication | 1 | |
Natural variantiVAR_080517 | 50 | D → A in IIAE8; decreased expression levels. 1 PublicationCorresponds to variant dbSNP:rs1010930015EnsemblClinVar. | 1 | |
Natural variantiVAR_073939 | 105 | Y → C in FTDALS4. 1 PublicationCorresponds to variant dbSNP:rs1366668789EnsemblClinVar. | 1 | |
Natural variantiVAR_069754 | 151 | S → F1 PublicationCorresponds to variant dbSNP:rs55824172EnsemblClinVar. | 1 | |
Natural variantiVAR_084112 | 152 | V → L No effect on IFNB induction. 1 Publication | 1 | |
Natural variantiVAR_080518 | 159 | G → A in IIAE8; loss of kinase activity; loss of autophosphorylation at S-172; loss of IFNB induction. 2 PublicationsCorresponds to variant dbSNP:rs1555202947EnsemblClinVar. | 1 | |
Natural variantiVAR_080519 | 207 | I → V in IIAE8; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1555203557EnsemblClinVar. | 1 | |
Natural variantiVAR_041208 | 271 | R → Q1 PublicationCorresponds to variant dbSNP:rs56196591EnsemblClinVar. | 1 | |
Natural variantiVAR_041209 | 291 | K → E1 PublicationCorresponds to variant dbSNP:rs34774243EnsemblClinVar. | 1 | |
Natural variantiVAR_041210 | 296 | D → H in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_073940 | 305 | I → T in FTDALS4. 1 PublicationCorresponds to variant dbSNP:rs770942184Ensembl. | 1 | |
Natural variantiVAR_069755 | 306 | L → I in FTDALS4; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs201970436EnsemblClinVar. | 1 | |
Natural variantiVAR_084113 | 308 – 729 | Missing Loss of IFNB induction. 1 PublicationAdd BLAST | 422 | |
Natural variantiVAR_073941 | 308 | R → Q in FTDALS4; reduced kinase activity. 1 Publication | 1 | |
Natural variantiVAR_073942 | 357 | R → Q in FTDALS4; reduced kinase activity. 1 PublicationCorresponds to variant dbSNP:rs758357594Ensembl. | 1 | |
Natural variantiVAR_084114 | 384 | R → Q No effect on IFNB induction. 1 Publication | 1 | |
Natural variantiVAR_024746 | 388 | N → D1 PublicationCorresponds to variant dbSNP:rs17857028Ensembl. | 1 | |
Natural variantiVAR_084115 | 388 | N → S No effect on IFNB induction. 1 Publication | 1 | |
Natural variantiVAR_084116 | 397 | I → T No effect on IFNB induction. 1 Publication | 1 | |
Natural variantiVAR_073943 | 401 | K → E in FTDALS4. 1 PublicationCorresponds to variant dbSNP:rs756751089EnsemblClinVar. | 1 | |
Natural variantiVAR_041211 | 410 | G → R in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1262765773Ensembl. | 1 | |
Natural variantiVAR_041212 | 464 | V → A2 Publications |