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Entry version 136 (16 Oct 2019)
Sequence version 2 (05 Feb 2008)
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Protein

Cysteine and histidine-rich domain-containing protein 1

Gene

CHORDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi5Zinc 1Combined sources1 Publication1
Metal bindingi10Zinc 1Combined sources1 Publication1
Metal bindingi24Zinc 1Combined sources1 Publication1
Metal bindingi27Zinc 2Combined sources1 Publication1
Metal bindingi42Zinc 2Combined sources1 Publication1
Metal bindingi43Zinc 2Combined sources1 Publication1
Metal bindingi59Zinc 2Combined sources1 Publication1
Metal bindingi64Zinc 1Combined sources1 Publication1
Metal bindingi157Zinc 3PROSITE-ProRule annotation1
Metal bindingi162Zinc 3PROSITE-ProRule annotation1
Metal bindingi176Zinc 3PROSITE-ProRule annotation1
Metal bindingi179Zinc 4PROSITE-ProRule annotation1
Metal bindingi194Zinc 4PROSITE-ProRule annotation1
Metal bindingi195Zinc 4PROSITE-ProRule annotation1
Metal bindingi211Zinc 4PROSITE-ProRule annotation1
Metal bindingi216Zinc 3PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ADP binding Source: Ensembl
  • ATP binding Source: Ensembl
  • Hsp90 protein binding Source: UniProtKB
  • zinc ion binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processStress response
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine and histidine-rich domain-containing protein 1
Alternative name(s):
CHORD domain-containing protein 1
Short name:
CHORD-containing protein 1
Short name:
CHP-1
Protein morgana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHORDC1
Synonyms:CHP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14525 CHORDC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604353 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UHD1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26973

Open Targets

More...
OpenTargetsi
ENSG00000110172

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26476

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UHD1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHORDC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
167008724

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003177702 – 332Cysteine and histidine-rich domain-containing protein 1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei47PhosphothreonineCombined sources1
Modified residuei51PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UHD1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UHD1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UHD1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UHD1

PeptideAtlas

More...
PeptideAtlasi
Q9UHD1

PRoteomics IDEntifications database

More...
PRIDEi
Q9UHD1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84321 [Q9UHD1-1]
84322 [Q9UHD1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UHD1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UHD1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UHD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Underexpressed in many breast and lung cancers.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110172 Expressed in 104 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UHD1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UHD1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041040

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HSP90AA1, ROCK1 and ROCK2.

Interacts with HSP90AB1 and PPP5C (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117929, 75 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UHD1, 45 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319255

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1332
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UHD1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UHD1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 64CHORD 1PROSITE-ProRule annotationAdd BLAST60
Domaini157 – 216CHORD 2PROSITE-ProRule annotationAdd BLAST60
Domaini227 – 316CSPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 77Interaction with PPP5CBy similarityAdd BLAST76
Regioni65 – 316Interaction with HSP90AA1 and HSP90AB1By similarityAdd BLAST252

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1667 Eukaryota
ENOG410XPV6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154174

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000207093

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UHD1

KEGG Orthology (KO)

More...
KOi
K16729

Identification of Orthologs from Complete Genome Data

More...
OMAi
QCRYDWH

Database of Orthologous Groups

More...
OrthoDBi
1163528at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UHD1

TreeFam database of animal gene trees

More...
TreeFami
TF105394

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.790, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007051 CHORD_dom
IPR039790 CHORD_protein
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone

The PANTHER Classification System

More...
PANTHERi
PTHR12621 PTHR12621, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04968 CHORD, 2 hits
PF04969 CS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49764 SSF49764, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51401 CHORD, 2 hits
PS51203 CS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UHD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALLCYNRGC GQRFDPETNS DDACTYHPGV PVFHDALKGW SCCKRRTTDF
60 70 80 90 100
SDFLSIVGCT KGRHNSEKPP EPVKPEVKTT EKKELCELKP KFQEHIIQAP
110 120 130 140 150
KPVEAIKRPS PDEPMTNLEL KISASLKQAL DKLKLSSGNE ENKKEEDNDE
160 170 180 190 200
IKIGTSCKNG GCSKTYQGLE SLEEVCVYHS GVPIFHEGMK YWSCCRRKTS
210 220 230 240 250
DFNTFLAQEG CTKGKHMWTK KDAGKKVVPC RHDWHQTGGE VTISVYAKNS
260 270 280 290 300
LPELSRVEAN STLLNVHIVF EGEKEFDQNV KLWGVIDVKR SYVTMTATKI
310 320 330
EITMRKAEPM QWASLELPAA KKQEKQKDAT TD
Length:332
Mass (Da):37,490
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3142D8EC8A879155
GO
Isoform 2 (identifier: Q9UHD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-57: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):35,286
Checksum:i3347F35622425A90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PPQ5E9PPQ5_HUMAN
Cysteine and histidine-rich domain-...
CHORDC1
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSD5E9PSD5_HUMAN
Cysteine and histidine-rich domain-...
CHORDC1
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIF7E9PIF7_HUMAN
Cysteine and histidine-rich domain-...
CHORDC1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHZ2E9PHZ2_HUMAN
Cysteine and histidine-rich domain-...
CHORDC1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIZ4E9PIZ4_HUMAN
Cysteine and histidine-rich domain-...
CHORDC1
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL00E9PL00_HUMAN
Cysteine and histidine-rich domain-...
CHORDC1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17789 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti234W → L in AAF18437 (PubMed:10571178).Curated1
Sequence conflicti267H → I in AAF18437 (PubMed:10571178).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038676329A → D4 PublicationsCorresponds to variant dbSNP:rs1045861Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03115039 – 57Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF192466 mRNA Translation: AAF18437.1
AF123249 mRNA Translation: AAG43237.1
AK290231 mRNA Translation: BAF82920.1
AK312663 mRNA Translation: BAG35545.1
AP002364 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66868.1
CH471065 Genomic DNA Translation: EAW66870.1
BC017789 mRNA Translation: AAH17789.1 Different initiation.
BC072461 mRNA Translation: AAH72461.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44705.1 [Q9UHD1-2]
CCDS8289.1 [Q9UHD1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001137545.1, NM_001144073.1 [Q9UHD1-2]
NP_036256.2, NM_012124.2 [Q9UHD1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000320585; ENSP00000319255; ENSG00000110172 [Q9UHD1-1]
ENST00000457199; ENSP00000401080; ENSG00000110172 [Q9UHD1-2]
ENST00000646618; ENSP00000496744; ENSG00000285023 [Q9UHD1-1]
ENST00000647220; ENSP00000494044; ENSG00000285023 [Q9UHD1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26973

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:26973

UCSC genome browser

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UCSCi
uc001pdg.4 human [Q9UHD1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192466 mRNA Translation: AAF18437.1
AF123249 mRNA Translation: AAG43237.1
AK290231 mRNA Translation: BAF82920.1
AK312663 mRNA Translation: BAG35545.1
AP002364 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66868.1
CH471065 Genomic DNA Translation: EAW66870.1
BC017789 mRNA Translation: AAH17789.1 Different initiation.
BC072461 mRNA Translation: AAH72461.1
CCDSiCCDS44705.1 [Q9UHD1-2]
CCDS8289.1 [Q9UHD1-1]
RefSeqiNP_001137545.1, NM_001144073.1 [Q9UHD1-2]
NP_036256.2, NM_012124.2 [Q9UHD1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YRTNMR-A1-68[»]
SMRiQ9UHD1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi117929, 75 interactors
IntActiQ9UHD1, 45 interactors
STRINGi9606.ENSP00000319255

PTM databases

iPTMnetiQ9UHD1
PhosphoSitePlusiQ9UHD1
SwissPalmiQ9UHD1

Polymorphism and mutation databases

BioMutaiCHORDC1
DMDMi167008724

Proteomic databases

EPDiQ9UHD1
jPOSTiQ9UHD1
MassIVEiQ9UHD1
PaxDbiQ9UHD1
PeptideAtlasiQ9UHD1
PRIDEiQ9UHD1
ProteomicsDBi84321 [Q9UHD1-1]
84322 [Q9UHD1-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
26973

Genome annotation databases

EnsembliENST00000320585; ENSP00000319255; ENSG00000110172 [Q9UHD1-1]
ENST00000457199; ENSP00000401080; ENSG00000110172 [Q9UHD1-2]
ENST00000646618; ENSP00000496744; ENSG00000285023 [Q9UHD1-1]
ENST00000647220; ENSP00000494044; ENSG00000285023 [Q9UHD1-2]
GeneIDi26973
KEGGihsa:26973
UCSCiuc001pdg.4 human [Q9UHD1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26973
DisGeNETi26973

GeneCards: human genes, protein and diseases

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GeneCardsi
CHORDC1
HGNCiHGNC:14525 CHORDC1
HPAiHPA041040
MIMi604353 gene
neXtProtiNX_Q9UHD1
OpenTargetsiENSG00000110172
PharmGKBiPA26476

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1667 Eukaryota
ENOG410XPV6 LUCA
GeneTreeiENSGT00940000154174
HOGENOMiHOG000207093
InParanoidiQ9UHD1
KOiK16729
OMAiQCRYDWH
OrthoDBi1163528at2759
PhylomeDBiQ9UHD1
TreeFamiTF105394

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CHORDC1 human
EvolutionaryTraceiQ9UHD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26973
PharosiQ9UHD1

Protein Ontology

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PROi
PR:Q9UHD1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110172 Expressed in 104 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9UHD1 baseline and differential
GenevisibleiQ9UHD1 HS

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007051 CHORD_dom
IPR039790 CHORD_protein
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
PANTHERiPTHR12621 PTHR12621, 1 hit
PfamiView protein in Pfam
PF04968 CHORD, 2 hits
PF04969 CS, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51401 CHORD, 2 hits
PS51203 CS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHRD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHD1
Secondary accession number(s): B2R6P8
, Q6IN49, Q8WVL9, Q9H3D6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 16, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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