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Protein

Signal recognition particle subunit SRP68

Gene

SRP68

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

GO - Molecular functioni

  • 7S RNA binding Source: CAFA
  • endoplasmic reticulum signal peptide binding Source: InterPro
  • protein domain specific binding Source: CAFA
  • RNA binding Source: UniProtKB
  • signal recognition particle binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane

Protein family/group databases

TCDBi3.A.5.9.1 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle subunit SRP68
Short name:
SRP68
Alternative name(s):
Signal recognition particle 68 kDa protein
Gene namesi
Name:SRP68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167881.14
HGNCiHGNC:11302 SRP68
MIMi604858 gene
neXtProtiNX_Q9UHB9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signal recognition particle

Pathology & Biotechi

Organism-specific databases

DisGeNETi6730
OpenTargetsiENSG00000167881
PharmGKBiPA36126

Polymorphism and mutation databases

BioMutaiSRP68
DMDMi37154869

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352271 – 627Signal recognition particle subunit SRP68Add BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei452N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UHB9
PaxDbiQ9UHB9
PeptideAtlasiQ9UHB9
PRIDEiQ9UHB9
ProteomicsDBi84303
84304 [Q9UHB9-2]

PTM databases

iPTMnetiQ9UHB9
PhosphoSitePlusiQ9UHB9
SwissPalmiQ9UHB9

Expressioni

Gene expression databases

BgeeiENSG00000167881 Expressed in 198 organ(s), highest expression level in cerebellum
CleanExiHS_SRP68
ExpressionAtlasiQ9UHB9 baseline and differential
GenevisibleiQ9UHB9 HS

Organism-specific databases

HPAiHPA023303
HPA055617

Interactioni

Subunit structurei

Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

Binary interactionsi

WithEntry#Exp.IntActNotes
SRP19P091322EBI-1048560,EBI-2680090

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112608, 76 interactors
DIPiDIP-50905N
IntActiQ9UHB9, 24 interactors
MINTiQ9UHB9
STRINGi9606.ENSP00000312066

Structurei

Secondary structure

1627
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UHB9
SMRiQ9UHB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 24Poly-GlyAdd BLAST16

Domaini

The RNA-binding domain is located near the N-terminus.

Sequence similaritiesi

Belongs to the SRP68 family.Curated

Phylogenomic databases

eggNOGiKOG2460 Eukaryota
ENOG410XPW1 LUCA
GeneTreeiENSGT00390000011856
HOGENOMiHOG000231195
HOVERGENiHBG059793
InParanoidiQ9UHB9
KOiK03107
OMAiFRCYYIA
OrthoDBiEOG091G0ARE
PhylomeDBiQ9UHB9
TreeFamiTF105779

Family and domain databases

CDDicd15481 SRP68-RBD, 1 hit
Gene3Di1.10.3450.40, 1 hit
InterProiView protein in InterPro
IPR026258 SRP68
IPR034652 SRP68-RBD
IPR038253 SRP68_N_sf
PANTHERiPTHR12860 PTHR12860, 1 hit
PfamiView protein in Pfam
PF16969 SRP68, 1 hit
PIRSFiPIRSF038995 SRP68, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UHB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEKQVPGG GGGGGSGGGG GSGGGGSGGG RGAGGEENKE NERPSAGSKA
60 70 80 90 100
NKEFGDSLSL EILQIIKESQ QQHGLRHGDF QRYRGYCSRR QRRLRKTLNF
110 120 130 140 150
KMGNRHKFTG KKVTEELLTD NRYLLLVLMD AERAWSYAMQ LKQEANTEPR
160 170 180 190 200
KRFHLLSRLR KAVKHAEELE RLCESNRVDA KTKLEAQAYT AYLSGMLRFE
210 220 230 240 250
HQEWKAAIEA FNKCKTIYEK LASAFTEEQA VLYNQRVEEI SPNIRYCAYN
260 270 280 290 300
IGDQSAINEL MQMRLRSGGT EGLLAEKLEA LITQTRAKQA ATMSEVEWRG
310 320 330 340 350
RTVPVKIDKV RIFLLGLADN EAAIVQAESE ETKERLFESM LSECRDAIQV
360 370 380 390 400
VREELKPDQK QRDYILEGEP GKVSNLQYLH SYLTYIKLST AIKRNENMAK
410 420 430 440 450
GLQRALLQQQ PEDDSKRSPR PQDLIRLYDI ILQNLVELLQ LPGLEEDKAF
460 470 480 490 500
QKEIGLKTLV FKAYRCFFIA QSYVLVKKWS EALVLYDRVL KYANEVNSDA
510 520 530 540 550
GAFKNSLKDL PDVQELITQV RSEKCSLQAA AILDANDAHQ TETSSSQVKD
560 570 580 590 600
NKPLVERFET FCLDPSLVTK QANLVHFPPG FQPIPCKPLF FDLALNHVAF
610 620
PPLEDKLEQK TKSGLTGYIK GIFGFRS
Length:627
Mass (Da):70,730
Last modified:September 26, 2003 - v2
Checksum:i6EF582892D300B2D
GO
Isoform 2 (identifier: Q9UHB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-286: Missing.

Note: No experimental confirmation available.
Show »
Length:596
Mass (Da):67,304
Checksum:i025BF536B2452299
GO
Isoform 3 (identifier: Q9UHB9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-339: Missing.

Show »
Length:288
Mass (Da):32,851
Checksum:iFF3915ED8952AE0D
GO
Isoform 4 (identifier: Q9UHB9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-121: Missing.

Note: No experimental confirmation available.
Show »
Length:589
Mass (Da):66,108
Checksum:iC8F8D0CB68D9C34D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQC2K7EQC2_HUMAN
Signal recognition particle subunit...
SRP68
63Annotation score:
K7EN53K7EN53_HUMAN
Signal recognition particle subunit...
SRP68
54Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 19Missing in AAF24308 (PubMed:10618370).Curated5
Sequence conflicti27 – 29Missing in AAF24308 (PubMed:10618370).Curated3
Sequence conflicti174E → K in AAF24308 (PubMed:10618370).Curated1
Sequence conflicti534 – 535DA → ES in AAF24308 (PubMed:10618370).Curated2
Sequence conflicti606K → E in BAG54299 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451321 – 339Missing in isoform 3. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_04694484 – 121Missing in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_008347256 – 286Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195951 mRNA Translation: AAF24308.1
AK074698 mRNA Translation: BAC11145.1
AK097962 mRNA Translation: BAG53557.1
AK126258 mRNA Translation: BAG54299.1
AC040980 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89360.1
CH471099 Genomic DNA Translation: EAW89362.1
BC020238 mRNA Translation: AAH20238.1
CCDSiCCDS11738.1 [Q9UHB9-1]
CCDS58600.1 [Q9UHB9-3]
CCDS58601.1 [Q9UHB9-4]
RefSeqiNP_001247431.1, NM_001260502.1 [Q9UHB9-4]
NP_001247432.1, NM_001260503.1 [Q9UHB9-3]
NP_055045.2, NM_014230.3 [Q9UHB9-1]
UniGeneiHs.514495

Genome annotation databases

EnsembliENST00000307877; ENSP00000312066; ENSG00000167881 [Q9UHB9-1]
ENST00000539137; ENSP00000446136; ENSG00000167881 [Q9UHB9-4]
ENST00000602720; ENSP00000473613; ENSG00000167881 [Q9UHB9-3]
GeneIDi6730
KEGGihsa:6730
UCSCiuc002jqj.3 human [Q9UHB9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Signal recognition particle entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195951 mRNA Translation: AAF24308.1
AK074698 mRNA Translation: BAC11145.1
AK097962 mRNA Translation: BAG53557.1
AK126258 mRNA Translation: BAG54299.1
AC040980 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89360.1
CH471099 Genomic DNA Translation: EAW89362.1
BC020238 mRNA Translation: AAH20238.1
CCDSiCCDS11738.1 [Q9UHB9-1]
CCDS58600.1 [Q9UHB9-3]
CCDS58601.1 [Q9UHB9-4]
RefSeqiNP_001247431.1, NM_001260502.1 [Q9UHB9-4]
NP_001247432.1, NM_001260503.1 [Q9UHB9-3]
NP_055045.2, NM_014230.3 [Q9UHB9-1]
UniGeneiHs.514495

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P3EX-ray3.50C47-254[»]
4P3FX-ray1.70A/B47-254[»]
5M72X-ray1.60B546-614[»]
5M73X-ray3.40C/G60-254[»]
5WRVX-ray1.70A509-614[»]
ProteinModelPortaliQ9UHB9
SMRiQ9UHB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112608, 76 interactors
DIPiDIP-50905N
IntActiQ9UHB9, 24 interactors
MINTiQ9UHB9
STRINGi9606.ENSP00000312066

Protein family/group databases

TCDBi3.A.5.9.1 the general secretory pathway (sec) family

PTM databases

iPTMnetiQ9UHB9
PhosphoSitePlusiQ9UHB9
SwissPalmiQ9UHB9

Polymorphism and mutation databases

BioMutaiSRP68
DMDMi37154869

Proteomic databases

EPDiQ9UHB9
PaxDbiQ9UHB9
PeptideAtlasiQ9UHB9
PRIDEiQ9UHB9
ProteomicsDBi84303
84304 [Q9UHB9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307877; ENSP00000312066; ENSG00000167881 [Q9UHB9-1]
ENST00000539137; ENSP00000446136; ENSG00000167881 [Q9UHB9-4]
ENST00000602720; ENSP00000473613; ENSG00000167881 [Q9UHB9-3]
GeneIDi6730
KEGGihsa:6730
UCSCiuc002jqj.3 human [Q9UHB9-1]

Organism-specific databases

CTDi6730
DisGeNETi6730
EuPathDBiHostDB:ENSG00000167881.14
GeneCardsiSRP68
HGNCiHGNC:11302 SRP68
HPAiHPA023303
HPA055617
MIMi604858 gene
neXtProtiNX_Q9UHB9
OpenTargetsiENSG00000167881
PharmGKBiPA36126
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2460 Eukaryota
ENOG410XPW1 LUCA
GeneTreeiENSGT00390000011856
HOGENOMiHOG000231195
HOVERGENiHBG059793
InParanoidiQ9UHB9
KOiK03107
OMAiFRCYYIA
OrthoDBiEOG091G0ARE
PhylomeDBiQ9UHB9
TreeFamiTF105779

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane

Miscellaneous databases

ChiTaRSiSRP68 human
GenomeRNAii6730
PROiPR:Q9UHB9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167881 Expressed in 198 organ(s), highest expression level in cerebellum
CleanExiHS_SRP68
ExpressionAtlasiQ9UHB9 baseline and differential
GenevisibleiQ9UHB9 HS

Family and domain databases

CDDicd15481 SRP68-RBD, 1 hit
Gene3Di1.10.3450.40, 1 hit
InterProiView protein in InterPro
IPR026258 SRP68
IPR034652 SRP68-RBD
IPR038253 SRP68_N_sf
PANTHERiPTHR12860 PTHR12860, 1 hit
PfamiView protein in Pfam
PF16969 SRP68, 1 hit
PIRSFiPIRSF038995 SRP68, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRP68_HUMAN
AccessioniPrimary (citable) accession number: Q9UHB9
Secondary accession number(s): B3KUU5
, B3KWY7, G3V1U4, Q8NCJ4, Q8WUK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: September 26, 2003
Last modified: September 12, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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