Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-36 alpha

Gene

IL36A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.4 Publications

Miscellaneous

Initial experiments using non-processed full-length protein found in vitro activity only in the µg range.1 Publication

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-1 receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-9014826 Interleukin-36 pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-36 alpha
Alternative name(s):
FIL1 epsilon
Interleukin-1 epsilon
Short name:
IL-1 epsilon
Interleukin-1 family member 6
Short name:
IL-1F6
Gene namesi
Name:IL36A
Synonyms:FIL1E, IL1E, IL1F6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000136694.8
HGNCiHGNC:15562 IL36A
MIMi605509 gene
neXtProtiNX_Q9UHA7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi27179
OpenTargetsiENSG00000136694
PharmGKBiPA38389

Polymorphism and mutation databases

BioMutaiIL36A
DMDMi25008601

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00004305451 – 51 Publication5
ChainiPRO_00001536446 – 158Interleukin-36 alphaAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96Nitrated tyrosineCombined sources1

Post-translational modificationi

N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).1 Publication

Keywords - PTMi

Nitration

Proteomic databases

PaxDbiQ9UHA7
PeptideAtlasiQ9UHA7
PRIDEiQ9UHA7
ProteomicsDBi84293

PTM databases

iPTMnetiQ9UHA7
PhosphoSitePlusiQ9UHA7

Expressioni

Tissue specificityi

Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin.1 Publication

Inductioni

By Il-1 and TNF-alpha.1 Publication

Gene expression databases

BgeeiENSG00000136694 Expressed in 54 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_IL1F6
GenevisibleiQ9UHA7 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118055, 12 interactors
IntActiQ9UHA7, 1 interactor
STRINGi9606.ENSP00000259211

Structurei

3D structure databases

ProteinModelPortaliQ9UHA7
SMRiQ9UHA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JBMR Eukaryota
ENOG41118FS LUCA
GeneTreeiENSGT00900000141014
HOVERGENiHBG052100
InParanoidiQ9UHA7
KOiK05484
OMAiPFLFYHN
OrthoDBiEOG091G0V8E
PhylomeDBiQ9UHA7
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR000975 IL-1_fam
IPR027163 IL-36_alpha
IPR008996 IL1/FGF
PANTHERiPTHR10078:SF25 PTHR10078:SF25, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
SUPFAMiSSF50353 SSF50353, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UHA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR
60 70 80 90 100
HVETLEKDRG NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE
110 120 130 140 150
PVKSFLFYHS QSGRNSTFES VAFPGWFIAV SSEGGCPLIL TQELGKANTT

DFGLTMLF
Length:158
Mass (Da):17,684
Last modified:May 1, 2000 - v1
Checksum:i469AC84306B0E280
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02450412Q → R2 PublicationsCorresponds to variant dbSNP:rs895497Ensembl.1
Natural variantiVAR_02505563I → T1 PublicationCorresponds to variant dbSNP:rs28938798Ensembl.1
Natural variantiVAR_025056134G → R1 PublicationCorresponds to variant dbSNP:rs28947175Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201831 mRNA Translation: AAF25211.1
BN000002 Genomic DNA Translation: CAD29875.1
AK314149 mRNA Translation: BAG36836.1
AY944686 Genomic DNA Translation: AAX20113.1
AC016724 Genomic DNA Translation: AAY14988.1
BC107042 mRNA Translation: AAI07043.1
BC107043 mRNA Translation: AAI07044.1
CCDSiCCDS42734.1
RefSeqiNP_055255.1, NM_014440.2
XP_005263696.1, XM_005263639.2
XP_011509267.1, XM_011510965.1
XP_016859295.1, XM_017003806.1
UniGeneiHs.278910

Genome annotation databases

EnsembliENST00000259211; ENSP00000259211; ENSG00000136694
GeneIDi27179
KEGGihsa:27179
UCSCiuc010yxr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-1 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201831 mRNA Translation: AAF25211.1
BN000002 Genomic DNA Translation: CAD29875.1
AK314149 mRNA Translation: BAG36836.1
AY944686 Genomic DNA Translation: AAX20113.1
AC016724 Genomic DNA Translation: AAY14988.1
BC107042 mRNA Translation: AAI07043.1
BC107043 mRNA Translation: AAI07044.1
CCDSiCCDS42734.1
RefSeqiNP_055255.1, NM_014440.2
XP_005263696.1, XM_005263639.2
XP_011509267.1, XM_011510965.1
XP_016859295.1, XM_017003806.1
UniGeneiHs.278910

3D structure databases

ProteinModelPortaliQ9UHA7
SMRiQ9UHA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118055, 12 interactors
IntActiQ9UHA7, 1 interactor
STRINGi9606.ENSP00000259211

PTM databases

iPTMnetiQ9UHA7
PhosphoSitePlusiQ9UHA7

Polymorphism and mutation databases

BioMutaiIL36A
DMDMi25008601

Proteomic databases

PaxDbiQ9UHA7
PeptideAtlasiQ9UHA7
PRIDEiQ9UHA7
ProteomicsDBi84293

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259211; ENSP00000259211; ENSG00000136694
GeneIDi27179
KEGGihsa:27179
UCSCiuc010yxr.3 human

Organism-specific databases

CTDi27179
DisGeNETi27179
EuPathDBiHostDB:ENSG00000136694.8
GeneCardsiIL36A
HGNCiHGNC:15562 IL36A
MIMi605509 gene
neXtProtiNX_Q9UHA7
OpenTargetsiENSG00000136694
PharmGKBiPA38389
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBMR Eukaryota
ENOG41118FS LUCA
GeneTreeiENSGT00900000141014
HOVERGENiHBG052100
InParanoidiQ9UHA7
KOiK05484
OMAiPFLFYHN
OrthoDBiEOG091G0V8E
PhylomeDBiQ9UHA7
TreeFamiTF300203

Enzyme and pathway databases

ReactomeiR-HSA-9014826 Interleukin-36 pathway

Miscellaneous databases

GeneWikiiIL1F6
GenomeRNAii27179
PROiPR:Q9UHA7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136694 Expressed in 54 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_IL1F6
GenevisibleiQ9UHA7 HS

Family and domain databases

InterProiView protein in InterPro
IPR000975 IL-1_fam
IPR027163 IL-36_alpha
IPR008996 IL1/FGF
PANTHERiPTHR10078:SF25 PTHR10078:SF25, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
SUPFAMiSSF50353 SSF50353, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL36A_HUMAN
AccessioniPrimary (citable) accession number: Q9UHA7
Secondary accession number(s): B2RAD9
, Q53SR7, Q5BLR4, Q7RTZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again