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UniProtKB - Q9UHA3 (RLP24_HUMAN)
Protein
Probable ribosome biogenesis protein RLP24
Gene
RSL24D1
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).
By similarityGO - Molecular functioni
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- ribosomal large subunit biogenesis Source: GO_Central
- translation Source: InterPro
Keywordsi
Biological process | Ribosome biogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9UHA3 |
SignaLinki | Q9UHA3 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable ribosome biogenesis protein RLP24Alternative name(s): Ribosomal L24 domain-containing protein 1 Ribosomal protein L24-like |
Gene namesi | Name:RSL24D1 Synonyms:C15orf15, RPL24L ORF Names:My024 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18479, RSL24D1 |
MIMi | 613262, gene |
neXtProti | NX_Q9UHA3 |
VEuPathDBi | HostDB:ENSG00000137876 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Other locations
- ribosome Source: InterPro
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000137876 |
PharmGKBi | PA164725551 |
Miscellaneous databases
Pharosi | Q9UHA3, Tbio |
Chemistry databases
DrugBanki | DB02494, (S)-3-phenyllactic acid DB07374, Anisomycin DB08437, Puromycin |
Genetic variation databases
BioMutai | RSL24D1 |
DMDMi | 52783333 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000136896 | 1 – 163 | Probable ribosome biogenesis protein RLP24Add BLAST | 163 |
Proteomic databases
EPDi | Q9UHA3 |
jPOSTi | Q9UHA3 |
MassIVEi | Q9UHA3 |
MaxQBi | Q9UHA3 |
PaxDbi | Q9UHA3 |
PeptideAtlasi | Q9UHA3 |
PRIDEi | Q9UHA3 |
ProteomicsDBi | 84291 |
2D gel databases
SWISS-2DPAGEi | Q9UHA3 |
PTM databases
iPTMneti | Q9UHA3 |
PhosphoSitePlusi | Q9UHA3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137876, Expressed in endometrium and 244 other tissues |
ExpressionAtlasi | Q9UHA3, baseline and differential |
Genevisiblei | Q9UHA3, HS |
Organism-specific databases
HPAi | ENSG00000137876, Low tissue specificity |
Interactioni
Subunit structurei
Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 (By similarity).
By similarityBinary interactionsi
Q9UHA3
With | #Exp. | IntAct |
---|---|---|
CDC23 [Q9UJX2] | 3 | EBI-749321,EBI-396137 |
DNMT3L [Q9UJW3] | 7 | EBI-749321,EBI-740967 |
FAM9B [Q8IZU0] | 3 | EBI-749321,EBI-10175124 |
Protein-protein interaction databases
BioGRIDi | 119362, 107 interactors |
CORUMi | Q9UHA3 |
IntActi | Q9UHA3, 21 interactors |
MINTi | Q9UHA3 |
STRINGi | 9606.ENSP00000260443 |
Miscellaneous databases
RNActi | Q9UHA3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the eukaryotic ribosomal protein eL24 family.Curated
Phylogenomic databases
eggNOGi | KOG1723, Eukaryota |
GeneTreei | ENSGT00950000183105 |
HOGENOMi | CLU_089419_2_2_1 |
InParanoidi | Q9UHA3 |
OMAi | RERQFYK |
OrthoDBi | 1502432at2759 |
PhylomeDBi | Q9UHA3 |
TreeFami | TF314926 |
Family and domain databases
CDDi | cd00472, Ribosomal_L24e_L24, 1 hit |
Gene3Di | 2.30.170.20, 1 hit |
HAMAPi | MF_00773, Ribosomal_L24e, 1 hit |
InterProi | View protein in InterPro IPR038630, L24e/L24_sf IPR023438, Ribosomal_L24e IPR000988, Ribosomal_L24e-rel IPR023442, Ribosomal_L24e_CS IPR011017, TRASH_dom |
PANTHERi | PTHR10792, PTHR10792, 1 hit |
Pfami | View protein in Pfam PF01246, Ribosomal_L24e, 1 hit |
SMARTi | View protein in SMART SM00746, TRASH, 1 hit |
PROSITEi | View protein in PROSITE PS01073, RIBOSOMAL_L24E, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9UHA3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR
60 70 80 90 100
WTKAFRKAAG KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK
110 120 130 140 150
QKRQAKFIMN RLKKNKELQK VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV
160
QQLQEDVDME DAP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BMQ2 | H3BMQ2_HUMAN | Probable ribosome biogenesis protei... | RSL24D1 | 146 | Annotation score: | ||
H3BPF2 | H3BPF2_HUMAN | Probable ribosome biogenesis protei... | RSL24D1 | 83 | Annotation score: | ||
A0A7I2V359 | A0A7I2V359_HUMAN | Probable ribosome biogenesis protei... | RSL24D1 | 166 | Annotation score: | ||
A0A7I2V3F2 | A0A7I2V3F2_HUMAN | Probable ribosome biogenesis protei... | RSL24D1 | 174 | Annotation score: | ||
A0A7I2V2C6 | A0A7I2V2C6_HUMAN | Probable ribosome biogenesis protei... | RSL24D1 | 71 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 29 | F → I in AAH08499 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 30 | R → G in AAH14576 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 45 | N → D in AAH28672 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 86 | W → R in AAH16312 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 146 | E → G in AAH28672 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF201949 mRNA Translation: AAF17241.1 AF060926 mRNA Translation: AAG43138.1 AF165521 mRNA Translation: AAF86651.1 AF212226 mRNA Translation: AAK26249.1 CR457179 mRNA Translation: CAG33460.1 AK315431 mRNA Translation: BAG37819.1 CH471082 Genomic DNA Translation: EAW77473.1 BC008409 mRNA Translation: AAH08409.1 BC008422 mRNA Translation: AAH08422.1 BC008449 mRNA Translation: AAH08449.1 BC008499 mRNA Translation: AAH08499.1 BC009593 mRNA Translation: AAH09593.1 BC009604 mRNA Translation: AAH09604.1 BC012913 mRNA Translation: AAH12913.1 BC014576 mRNA Translation: AAH14576.1 BC016312 mRNA Translation: AAH16312.1 BC016331 mRNA Translation: AAH16331.1 BC016725 mRNA Translation: AAH16725.1 BC016777 mRNA Translation: AAH16777.1 BC026266 mRNA Translation: AAH26266.1 BC026267 mRNA Translation: AAH26267.1 BC028672 mRNA Translation: AAH28672.1 BC035995 mRNA Translation: AAH35995.1 BC093067 mRNA Translation: AAH93067.1 |
CCDSi | CCDS10152.1 |
RefSeqi | NP_057388.1, NM_016304.2 |
Genome annotation databases
Ensembli | ENST00000260443.9; ENSP00000260443.4; ENSG00000137876.11 |
GeneIDi | 51187 |
KEGGi | hsa:51187 |
MANE-Selecti | ENST00000260443.9; ENSP00000260443.4; NM_016304.3; NP_057388.1 |
UCSCi | uc002acn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF201949 mRNA Translation: AAF17241.1 AF060926 mRNA Translation: AAG43138.1 AF165521 mRNA Translation: AAF86651.1 AF212226 mRNA Translation: AAK26249.1 CR457179 mRNA Translation: CAG33460.1 AK315431 mRNA Translation: BAG37819.1 CH471082 Genomic DNA Translation: EAW77473.1 BC008409 mRNA Translation: AAH08409.1 BC008422 mRNA Translation: AAH08422.1 BC008449 mRNA Translation: AAH08449.1 BC008499 mRNA Translation: AAH08499.1 BC009593 mRNA Translation: AAH09593.1 BC009604 mRNA Translation: AAH09604.1 BC012913 mRNA Translation: AAH12913.1 BC014576 mRNA Translation: AAH14576.1 BC016312 mRNA Translation: AAH16312.1 BC016331 mRNA Translation: AAH16331.1 BC016725 mRNA Translation: AAH16725.1 BC016777 mRNA Translation: AAH16777.1 BC026266 mRNA Translation: AAH26266.1 BC026267 mRNA Translation: AAH26267.1 BC028672 mRNA Translation: AAH28672.1 BC035995 mRNA Translation: AAH35995.1 BC093067 mRNA Translation: AAH93067.1 |
CCDSi | CCDS10152.1 |
RefSeqi | NP_057388.1, NM_016304.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6LSS | electron microscopy | 3.23 | 7 | 1-163 | [»] | |
6LU8 | electron microscopy | 3.13 | 7 | 1-163 | [»] | |
AlphaFoldDBi | Q9UHA3 | |||||
SMRi | Q9UHA3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119362, 107 interactors |
CORUMi | Q9UHA3 |
IntActi | Q9UHA3, 21 interactors |
MINTi | Q9UHA3 |
STRINGi | 9606.ENSP00000260443 |
Chemistry databases
DrugBanki | DB02494, (S)-3-phenyllactic acid DB07374, Anisomycin DB08437, Puromycin |
PTM databases
iPTMneti | Q9UHA3 |
PhosphoSitePlusi | Q9UHA3 |
Genetic variation databases
BioMutai | RSL24D1 |
DMDMi | 52783333 |
2D gel databases
SWISS-2DPAGEi | Q9UHA3 |
Proteomic databases
EPDi | Q9UHA3 |
jPOSTi | Q9UHA3 |
MassIVEi | Q9UHA3 |
MaxQBi | Q9UHA3 |
PaxDbi | Q9UHA3 |
PeptideAtlasi | Q9UHA3 |
PRIDEi | Q9UHA3 |
ProteomicsDBi | 84291 |
Protocols and materials databases
Antibodypediai | 25045, 77 antibodies from 18 providers |
DNASUi | 51187 |
Genome annotation databases
Ensembli | ENST00000260443.9; ENSP00000260443.4; ENSG00000137876.11 |
GeneIDi | 51187 |
KEGGi | hsa:51187 |
MANE-Selecti | ENST00000260443.9; ENSP00000260443.4; NM_016304.3; NP_057388.1 |
UCSCi | uc002acn.4, human |
Organism-specific databases
CTDi | 51187 |
GeneCardsi | RSL24D1 |
HGNCi | HGNC:18479, RSL24D1 |
HPAi | ENSG00000137876, Low tissue specificity |
MIMi | 613262, gene |
neXtProti | NX_Q9UHA3 |
OpenTargetsi | ENSG00000137876 |
PharmGKBi | PA164725551 |
VEuPathDBi | HostDB:ENSG00000137876 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1723, Eukaryota |
GeneTreei | ENSGT00950000183105 |
HOGENOMi | CLU_089419_2_2_1 |
InParanoidi | Q9UHA3 |
OMAi | RERQFYK |
OrthoDBi | 1502432at2759 |
PhylomeDBi | Q9UHA3 |
TreeFami | TF314926 |
Enzyme and pathway databases
PathwayCommonsi | Q9UHA3 |
SignaLinki | Q9UHA3 |
Miscellaneous databases
BioGRID-ORCSi | 51187, 747 hits in 1010 CRISPR screens |
ChiTaRSi | RSL24D1, human |
GeneWikii | C15orf15 |
GenomeRNAii | 51187 |
Pharosi | Q9UHA3, Tbio |
PROi | PR:Q9UHA3 |
RNActi | Q9UHA3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137876, Expressed in endometrium and 244 other tissues |
ExpressionAtlasi | Q9UHA3, baseline and differential |
Genevisiblei | Q9UHA3, HS |
Family and domain databases
CDDi | cd00472, Ribosomal_L24e_L24, 1 hit |
Gene3Di | 2.30.170.20, 1 hit |
HAMAPi | MF_00773, Ribosomal_L24e, 1 hit |
InterProi | View protein in InterPro IPR038630, L24e/L24_sf IPR023438, Ribosomal_L24e IPR000988, Ribosomal_L24e-rel IPR023442, Ribosomal_L24e_CS IPR011017, TRASH_dom |
PANTHERi | PTHR10792, PTHR10792, 1 hit |
Pfami | View protein in Pfam PF01246, Ribosomal_L24e, 1 hit |
SMARTi | View protein in SMART SM00746, TRASH, 1 hit |
PROSITEi | View protein in PROSITE PS01073, RIBOSOMAL_L24E, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RLP24_HUMAN | |
Accessioni | Q9UHA3Primary (citable) accession number: Q9UHA3 Secondary accession number(s): B2RD72 Q96HJ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families