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Entry version 120 (17 Jun 2020)
Sequence version 1 (01 May 2000)
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Protein

SS18-like protein 2

Gene

SS18L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SS18-like protein 2
Alternative name(s):
SYT homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SS18L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000008324.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15593 SS18L2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606473 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UHA2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000008324

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37990

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UHA2 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SS18L2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
24418678

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001818261 – 77SS18-like protein 2Add BLAST77

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UHA2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UHA2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UHA2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UHA2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UHA2

PeptideAtlas

More...
PeptideAtlasi
Q9UHA2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UHA2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84290

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UHA2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UHA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000008324 Expressed in prostate gland and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UHA2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UHA2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000008324 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119363, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UHA2, 26 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000401115

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UHA2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UHA2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi50 – 53SH2-bindingSequence analysis4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SS18 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3227 Eukaryota
ENOG41128HA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160407

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_164146_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UHA2

Identification of Orthologs from Complete Genome Data

More...
OMAi
GRAHECV

Database of Orthologous Groups

More...
OrthoDBi
1442230at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UHA2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007726 SS18_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05030 SSXT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UHA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVAFVPDWL RGKAEVNQET IQRLLEENDQ LIRCIVEYQN KGRGNECVQY
60 70
QHVLHRNLIY LATIADASPT STSKAME
Length:77
Mass (Da):8,835
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2204523E5B412BBF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF201950 mRNA Translation: AAF17242.1
AK312225 mRNA Translation: BAG35158.1
CH471055 Genomic DNA Translation: EAW64657.1
BC017804 mRNA Translation: AAH17804.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2701.1

NCBI Reference Sequences

More...
RefSeqi
NP_057389.1, NM_016305.3
XP_016862037.1, XM_017006548.1
XP_016862038.1, XM_017006549.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000011691; ENSP00000011691; ENSG00000008324
ENST00000447630; ENSP00000401115; ENSG00000008324

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51188

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51188

UCSC genome browser

More...
UCSCi
uc003clk.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201950 mRNA Translation: AAF17242.1
AK312225 mRNA Translation: BAG35158.1
CH471055 Genomic DNA Translation: EAW64657.1
BC017804 mRNA Translation: AAH17804.1
CCDSiCCDS2701.1
RefSeqiNP_057389.1, NM_016305.3
XP_016862037.1, XM_017006548.1
XP_016862038.1, XM_017006549.1

3D structure databases

SMRiQ9UHA2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119363, 25 interactors
IntActiQ9UHA2, 26 interactors
STRINGi9606.ENSP00000401115

PTM databases

iPTMnetiQ9UHA2
PhosphoSitePlusiQ9UHA2

Polymorphism and mutation databases

BioMutaiSS18L2
DMDMi24418678

Proteomic databases

EPDiQ9UHA2
jPOSTiQ9UHA2
MassIVEiQ9UHA2
MaxQBiQ9UHA2
PaxDbiQ9UHA2
PeptideAtlasiQ9UHA2
PRIDEiQ9UHA2
ProteomicsDBi84290

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
29253 22 antibodies

The DNASU plasmid repository

More...
DNASUi
51188

Genome annotation databases

EnsembliENST00000011691; ENSP00000011691; ENSG00000008324
ENST00000447630; ENSP00000401115; ENSG00000008324
GeneIDi51188
KEGGihsa:51188
UCSCiuc003clk.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51188
EuPathDBiHostDB:ENSG00000008324.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SS18L2
HGNCiHGNC:15593 SS18L2
HPAiENSG00000008324 Low tissue specificity
MIMi606473 gene
neXtProtiNX_Q9UHA2
OpenTargetsiENSG00000008324
PharmGKBiPA37990

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3227 Eukaryota
ENOG41128HA LUCA
GeneTreeiENSGT00940000160407
HOGENOMiCLU_164146_1_0_1
InParanoidiQ9UHA2
OMAiGRAHECV
OrthoDBi1442230at2759
PhylomeDBiQ9UHA2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
51188 731 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SS18L2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51188
PharosiQ9UHA2 Tdark

Protein Ontology

More...
PROi
PR:Q9UHA2
RNActiQ9UHA2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000008324 Expressed in prostate gland and 226 other tissues
ExpressionAtlasiQ9UHA2 baseline and differential
GenevisibleiQ9UHA2 HS

Family and domain databases

InterProiView protein in InterPro
IPR007726 SS18_fam
PfamiView protein in Pfam
PF05030 SSXT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS18L2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHA2
Secondary accession number(s): B2R5L1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 2000
Last modified: June 17, 2020
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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