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Protein

Transcription factor COE1

Gene

EBF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 170C5-typeSequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SIGNORiQ9UH73

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor COE1
Short name:
O/E-1
Short name:
OE-1
Alternative name(s):
Early B-cell factor
Gene namesi
Name:EBF1
Synonyms:COE1, EBF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164330.16
HGNCiHGNC:3126 EBF1
MIMi164343 gene
neXtProtiNX_Q9UH73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1879
OpenTargetsiENSG00000164330
PharmGKBiPA162384225

Polymorphism and mutation databases

BioMutaiEBF1
DMDMi47117917

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001078251 – 591Transcription factor COE1Add BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki16Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki16Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9UH73
PeptideAtlasiQ9UH73
PRIDEiQ9UH73
ProteomicsDBi84280
84281 [Q9UH73-2]

PTM databases

iPTMnetiQ9UH73
PhosphoSitePlusiQ9UH73
SwissPalmiQ9UH73

Expressioni

Gene expression databases

BgeeiENSG00000164330 Expressed in 205 organ(s), highest expression level in forebrain
CleanExiHS_EBF1
ExpressionAtlasiQ9UH73 baseline and differential
GenevisibleiQ9UH73 HS

Organism-specific databases

HPAiHPA061169

Interactioni

Subunit structurei

Forms either a homodimer or a heterodimer with a related family member (By similarity). Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei163Interaction with DNABy similarity1
Sitei172Interaction with DNABy similarity1

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108211, 10 interactors
IntActiQ9UH73, 7 interactors
STRINGi9606.ENSP00000322898

Structurei

Secondary structure

1591
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UH73
SMRiQ9UH73
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UH73

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini262 – 345IPT/TIGAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 66Interaction with DNABy similarity4
Regioni197 – 204Interaction with DNABy similarity8
Regioni236 – 239Interaction with DNABy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi462 – 550Pro/Ser/Thr-richAdd BLAST89

Sequence similaritiesi

Belongs to the COE family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 170C5-typeSequence analysisAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3836 Eukaryota
ENOG410XQ9Z LUCA
GeneTreeiENSGT00390000014051
HOGENOMiHOG000092311
HOVERGENiHBG005108
InParanoidiQ9UH73
KOiK09103
OMAiCKVLFTE
OrthoDBiEOG091G0A9D
PhylomeDBiQ9UH73
TreeFamiTF313391

Family and domain databases

CDDicd11606 COE_DBD, 1 hit
cd01175 IPT_COE, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.3180, 1 hit
4.10.280.10, 2 hits
InterProiView protein in InterPro
IPR032200 COE_DBD
IPR038173 COE_DBD_sf
IPR032201 COE_HLH
IPR038006 COE_IPT
IPR036638 HLH_DNA-bd_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR003523 Transcription_factor_COE
IPR018350 Transcription_factor_COE_CS
PANTHERiPTHR10747 PTHR10747, 1 hit
PfamiView protein in Pfam
PF16422 COE1_DBD, 1 hit
PF16423 COE1_HLH, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01345 COE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UH73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGIQESIQR SGSSMKEEPL GSGMNAVRTW MQGAGVLDAN TAAQSGVGLA
60 70 80 90 100
RAHFEKQPPS NLRKSNFFHF VLALYDRQGQ PVEIERTAFV GFVEKEKEAN
110 120 130 140 150
SEKTNNGIHY RLQLLYSNGI RTEQDFYVRL IDSMTKQAIV YEGQDKNPEM
160 170 180 190 200
CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK
210 220 230 240 250
NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS
260 270 280 290 300
EGTPSYLEHA TPCIKAISPS EGWTTGGATV IIIGDNFFDG LQVIFGTMLV
310 320 330 340 350
WSELITPHAI RVQTPPRHIP GVVEVTLSYK SKQFCKGTPG RFIYTALNEP
360 370 380 390 400
TIDYGFQRLQ KVIPRHPGDP ERLPKEVILK RAADLVEALY GMPHNNQEII
410 420 430 440 450
LKRAADIAEA LYSVPRNHNQ LPALANTSVH AGMMGVNSFS GQLAVNVSEA
460 470 480 490 500
SQATNQGFTR NSSSVSPHGY VPSTTPQQTN YNSVTTSMNG YGSAAMSNLG
510 520 530 540 550
GSPTFLNGSA ANSPYAIVPS SPTMASSTSL PSNCSSSSGI FSFSPANMVS
560 570 580 590
AVKQKSAFAP VVRPQTSPPP TCTSTNGNSL QAISGMIVPP M
Length:591
Mass (Da):64,464
Last modified:May 10, 2004 - v2
Checksum:iE47797B6FC1E5071
GO
Isoform 2 (identifier: Q9UH73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-184: Missing.
     252-259: Missing.

Note: No experimental confirmation available.
Show »
Length:560
Mass (Da):61,059
Checksum:i5D199E23BDD2E2F6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFQ1E5RFQ1_HUMAN
Transcription factor COE1
EBF1
523Annotation score:
A0A087WTE5A0A087WTE5_HUMAN
Transcription factor COE1
EBF1
407Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112L → I in AAF19643 (PubMed:10942392).Curated1
Sequence conflicti147N → S in AAF19643 (PubMed:10942392).Curated1
Sequence conflicti228 – 229VS → AP in AAF19643 (PubMed:10942392).Curated2
Sequence conflicti305 – 306IT → TG in AAF19643 (PubMed:10942392).Curated2
Sequence conflicti309A → S in AAF19643 (PubMed:10942392).Curated1
Sequence conflicti347L → R in AAF19643 (PubMed:10942392).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012304162 – 184Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_012305252 – 259Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC038805 mRNA Translation: AAH38805.1
BC041178 mRNA Translation: AAH41178.1
AF208502 mRNA Translation: AAF19643.1
CCDSiCCDS4343.1 [Q9UH73-1]
CCDS78081.1 [Q9UH73-2]
RefSeqiNP_076870.1, NM_024007.4 [Q9UH73-1]
NP_874367.1, NM_182708.2 [Q9UH73-2]
UniGeneiHs.573143
Hs.733761

Genome annotation databases

EnsembliENST00000313708; ENSP00000322898; ENSG00000164330 [Q9UH73-1]
ENST00000380654; ENSP00000370029; ENSG00000164330 [Q9UH73-2]
GeneIDi1879
KEGGihsa:1879
UCSCiuc003lxl.7 human [Q9UH73-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC038805 mRNA Translation: AAH38805.1
BC041178 mRNA Translation: AAH41178.1
AF208502 mRNA Translation: AAF19643.1
CCDSiCCDS4343.1 [Q9UH73-1]
CCDS78081.1 [Q9UH73-2]
RefSeqiNP_076870.1, NM_024007.4 [Q9UH73-1]
NP_874367.1, NM_182708.2 [Q9UH73-2]
UniGeneiHs.573143
Hs.733761

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LYRX-ray2.51A10-250[»]
3MQIX-ray2.30A/B/C258-351[»]
ProteinModelPortaliQ9UH73
SMRiQ9UH73
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108211, 10 interactors
IntActiQ9UH73, 7 interactors
STRINGi9606.ENSP00000322898

PTM databases

iPTMnetiQ9UH73
PhosphoSitePlusiQ9UH73
SwissPalmiQ9UH73

Polymorphism and mutation databases

BioMutaiEBF1
DMDMi47117917

Proteomic databases

PaxDbiQ9UH73
PeptideAtlasiQ9UH73
PRIDEiQ9UH73
ProteomicsDBi84280
84281 [Q9UH73-2]

Protocols and materials databases

DNASUi1879
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313708; ENSP00000322898; ENSG00000164330 [Q9UH73-1]
ENST00000380654; ENSP00000370029; ENSG00000164330 [Q9UH73-2]
GeneIDi1879
KEGGihsa:1879
UCSCiuc003lxl.7 human [Q9UH73-1]

Organism-specific databases

CTDi1879
DisGeNETi1879
EuPathDBiHostDB:ENSG00000164330.16
GeneCardsiEBF1
HGNCiHGNC:3126 EBF1
HPAiHPA061169
MIMi164343 gene
neXtProtiNX_Q9UH73
OpenTargetsiENSG00000164330
PharmGKBiPA162384225
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3836 Eukaryota
ENOG410XQ9Z LUCA
GeneTreeiENSGT00390000014051
HOGENOMiHOG000092311
HOVERGENiHBG005108
InParanoidiQ9UH73
KOiK09103
OMAiCKVLFTE
OrthoDBiEOG091G0A9D
PhylomeDBiQ9UH73
TreeFamiTF313391

Enzyme and pathway databases

ReactomeiR-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SIGNORiQ9UH73

Miscellaneous databases

ChiTaRSiEBF1 human
EvolutionaryTraceiQ9UH73
GeneWikiiEBF1
GenomeRNAii1879
PROiPR:Q9UH73
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164330 Expressed in 205 organ(s), highest expression level in forebrain
CleanExiHS_EBF1
ExpressionAtlasiQ9UH73 baseline and differential
GenevisibleiQ9UH73 HS

Family and domain databases

CDDicd11606 COE_DBD, 1 hit
cd01175 IPT_COE, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.3180, 1 hit
4.10.280.10, 2 hits
InterProiView protein in InterPro
IPR032200 COE_DBD
IPR038173 COE_DBD_sf
IPR032201 COE_HLH
IPR038006 COE_IPT
IPR036638 HLH_DNA-bd_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR003523 Transcription_factor_COE
IPR018350 Transcription_factor_COE_CS
PANTHERiPTHR10747 PTHR10747, 1 hit
PfamiView protein in Pfam
PF16422 COE1_DBD, 1 hit
PF16423 COE1_HLH, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01345 COE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOE1_HUMAN
AccessioniPrimary (citable) accession number: Q9UH73
Secondary accession number(s): Q8IW11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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