UniProtKB - Q9UH62 (ARMX3_HUMAN)
Protein
Armadillo repeat-containing X-linked protein 3
Gene
ARMCX3
Organism
Homo sapiens (Human)
Status
Functioni
Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.By similarity
GO - Biological processi
- cellular protein localization Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9UH62 |
Names & Taxonomyi
Protein namesi | Recommended name: Armadillo repeat-containing X-linked protein 3Alternative name(s): ARM protein lost in epithelial cancers on chromosome X 3 Short name: Protein ALEX3 |
Gene namesi | Name:ARMCX3 Synonyms:ALEX3 ORF Names:BM-017, UNQ2517/PRO6007 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000102401.19 |
HGNCi | HGNC:24065, ARMCX3 |
MIMi | 300364, gene |
neXtProti | NX_Q9UH62 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Mitochondrion
- Mitochondrion outer membrane By similarity; Single-pass membrane protein Sequence analysis
Other locations
- Cytoplasm By similarity
Mitochondrion
- integral component of mitochondrial outer membrane Source: Ensembl
Nucleus
- nucleus Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | Mitochondrial intermembraneBy similarity | 6 | |
Transmembranei | 7 – 29 | Helical; Signal-anchorSequence analysisAdd BLAST | 23 | |
Topological domaini | 30 – 379 | CytoplasmicBy similarityAdd BLAST | 350 |
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51566 |
OpenTargetsi | ENSG00000102401 |
PharmGKBi | PA134977725 |
Miscellaneous databases
Pharosi | Q9UH62, Tdark |
Polymorphism and mutation databases
BioMutai | ARMCX3 |
DMDMi | 74753322 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191366 | 1 – 379 | Armadillo repeat-containing X-linked protein 3Add BLAST | 379 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 61 | PhosphoserineCombined sources | 1 | |
Modified residuei | 67 | PhosphoserineCombined sources | 1 | |
Modified residuei | 72 | PhosphoserineCombined sources | 1 | |
Modified residuei | 110 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UH62 |
jPOSTi | Q9UH62 |
MassIVEi | Q9UH62 |
MaxQBi | Q9UH62 |
PaxDbi | Q9UH62 |
PeptideAtlasi | Q9UH62 |
PRIDEi | Q9UH62 |
ProteomicsDBi | 84277 |
PTM databases
iPTMneti | Q9UH62 |
MetOSitei | Q9UH62 |
PhosphoSitePlusi | Q9UH62 |
Expressioni
Gene expression databases
Bgeei | ENSG00000102401, Expressed in amniotic fluid and 246 other tissues |
ExpressionAtlasi | Q9UH62, baseline and differential |
Genevisiblei | Q9UH62, HS |
Organism-specific databases
HPAi | ENSG00000102401, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via ARM domain) with MIRO1, MIRO2 and TRAK2. The interaction with Miro is calcium-dependent.
Interacts with SOX10.
By similarityBinary interactionsi
Hide detailsQ9UH62
With | #Exp. | IntAct |
---|---|---|
EHHADH [Q08426] | 3 | EBI-717832,EBI-2339219 |
FAM25C [B3EWG5] | 3 | EBI-717832,EBI-14240149 |
MAF1 [Q9H063] | 3 | EBI-717832,EBI-720354 |
Protein-protein interaction databases
BioGRIDi | 119614, 91 interactors |
IntActi | Q9UH62, 23 interactors |
MINTi | Q9UH62 |
STRINGi | 9606.ENSP00000340672 |
Miscellaneous databases
RNActi | Q9UH62, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 111 – 151 | ARM 1Sequence analysisAdd BLAST | 41 | |
Repeati | 153 – 192 | ARM 2Sequence analysisAdd BLAST | 40 | |
Repeati | 233 – 272 | ARM 3Sequence analysisAdd BLAST | 40 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 6 | Mitochondrion outer membrane (MOM)-targeting sequenceCurated | 6 | |
Regioni | 26 – 37 | Mitochondrion outer membrane (MOM)-targeting sequenceCuratedAdd BLAST | 12 | |
Regioni | 89 – 98 | Nuclear localization signalBy similarity | 10 |
Sequence similaritiesi
Belongs to the eutherian X-chromosome-specific Armcx family.Curated
Keywords - Domaini
Repeat, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502TCDI, Eukaryota |
GeneTreei | ENSGT00940000162753 |
HOGENOMi | CLU_037187_0_0_1 |
InParanoidi | Q9UH62 |
OMAi | NEYQHIL |
OrthoDBi | 860703at2759 |
PhylomeDBi | Q9UH62 |
TreeFami | TF335652 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR006911, ARM-rpt_dom IPR016024, ARM-type_fold IPR000225, Armadillo |
Pfami | View protein in Pfam PF04826, Arm_2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9UH62-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGSGDVDDAG
60 70 80 90 100
DCSGARYNDW SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR
110 120 130 140 150
ARRAVQKRAS PNSDDTVLSP QELQKVLCLV EMSEKPYILE AALIALGNNA
160 170 180 190 200
AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK EKALIVLNNL SVNAENQRRL
210 220 230 240 250
KVYMNQVCDD TITSRLNSSV QLAGLRLLTN MTVTNEYQHM LANSISDFFR
260 270 280 290 300
LFSAGNEETK LQVLKLLLNL AENPAMTREL LRAQVPSSLG SLFNKKENKE
310 320 330 340 350
VILKLLVIFE NINDNFKWEE NEPTQNQFGE GSLFFFLKEF QVCADKVLGI
360 370
ESHHDFLVKV KVGKFMAKLA EHMFPKSQE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BV87 | H3BV87_HUMAN | Armadillo repeat-containing X-linke... | ARMCX3 | 94 | Annotation score: | ||
H3BM63 | H3BM63_HUMAN | Armadillo repeat-containing X-linke... | ARMCX3 | 63 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 310 | E → V in BAD96375 (Ref. 5) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB039669 mRNA Translation: BAA94602.1 AF211175 mRNA Translation: AAF24487.1 AF208859 mRNA Translation: AAF64273.1 AY359079 mRNA Translation: AAQ89438.1 AK222655 mRNA Translation: BAD96375.1 CR933656 mRNA Translation: CAI45955.1 AL121883 Genomic DNA Translation: CAI42939.1 BC005194 mRNA Translation: AAH05194.1 |
CCDSi | CCDS14489.1 |
RefSeqi | NP_057691.1, NM_016607.3 NP_808816.1, NM_177947.2 NP_808817.1, NM_177948.2 XP_005262198.1, XM_005262141.2 |
Genome annotation databases
Ensembli | ENST00000341189; ENSP00000340672; ENSG00000102401 ENST00000471229; ENSP00000454483; ENSG00000102401 ENST00000537169; ENSP00000439032; ENSG00000102401 |
GeneIDi | 51566 |
KEGGi | hsa:51566 |
UCSCi | uc004ehz.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB039669 mRNA Translation: BAA94602.1 AF211175 mRNA Translation: AAF24487.1 AF208859 mRNA Translation: AAF64273.1 AY359079 mRNA Translation: AAQ89438.1 AK222655 mRNA Translation: BAD96375.1 CR933656 mRNA Translation: CAI45955.1 AL121883 Genomic DNA Translation: CAI42939.1 BC005194 mRNA Translation: AAH05194.1 |
CCDSi | CCDS14489.1 |
RefSeqi | NP_057691.1, NM_016607.3 NP_808816.1, NM_177947.2 NP_808817.1, NM_177948.2 XP_005262198.1, XM_005262141.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119614, 91 interactors |
IntActi | Q9UH62, 23 interactors |
MINTi | Q9UH62 |
STRINGi | 9606.ENSP00000340672 |
PTM databases
iPTMneti | Q9UH62 |
MetOSitei | Q9UH62 |
PhosphoSitePlusi | Q9UH62 |
Polymorphism and mutation databases
BioMutai | ARMCX3 |
DMDMi | 74753322 |
Proteomic databases
EPDi | Q9UH62 |
jPOSTi | Q9UH62 |
MassIVEi | Q9UH62 |
MaxQBi | Q9UH62 |
PaxDbi | Q9UH62 |
PeptideAtlasi | Q9UH62 |
PRIDEi | Q9UH62 |
ProteomicsDBi | 84277 |
Protocols and materials databases
Antibodypediai | 378, 234 antibodies |
DNASUi | 51566 |
Genome annotation databases
Ensembli | ENST00000341189; ENSP00000340672; ENSG00000102401 ENST00000471229; ENSP00000454483; ENSG00000102401 ENST00000537169; ENSP00000439032; ENSG00000102401 |
GeneIDi | 51566 |
KEGGi | hsa:51566 |
UCSCi | uc004ehz.2, human |
Organism-specific databases
CTDi | 51566 |
DisGeNETi | 51566 |
EuPathDBi | HostDB:ENSG00000102401.19 |
GeneCardsi | ARMCX3 |
HGNCi | HGNC:24065, ARMCX3 |
HPAi | ENSG00000102401, Low tissue specificity |
MIMi | 300364, gene |
neXtProti | NX_Q9UH62 |
OpenTargetsi | ENSG00000102401 |
PharmGKBi | PA134977725 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TCDI, Eukaryota |
GeneTreei | ENSGT00940000162753 |
HOGENOMi | CLU_037187_0_0_1 |
InParanoidi | Q9UH62 |
OMAi | NEYQHIL |
OrthoDBi | 860703at2759 |
PhylomeDBi | Q9UH62 |
TreeFami | TF335652 |
Enzyme and pathway databases
PathwayCommonsi | Q9UH62 |
Miscellaneous databases
BioGRID-ORCSi | 51566, 3 hits in 472 CRISPR screens |
ChiTaRSi | ARMCX3, human |
GeneWikii | ARMCX3 |
GenomeRNAii | 51566 |
Pharosi | Q9UH62, Tdark |
PROi | PR:Q9UH62 |
RNActi | Q9UH62, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102401, Expressed in amniotic fluid and 246 other tissues |
ExpressionAtlasi | Q9UH62, baseline and differential |
Genevisiblei | Q9UH62, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR006911, ARM-rpt_dom IPR016024, ARM-type_fold IPR000225, Armadillo |
Pfami | View protein in Pfam PF04826, Arm_2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARMX3_HUMAN | |
Accessioni | Q9UH62Primary (citable) accession number: Q9UH62 Secondary accession number(s): Q53HC6, Q7LCF5, Q9NPE4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM