UniProtKB - Q9UH62 (ARMX3_HUMAN)
Armadillo repeat-containing X-linked protein 3
ARMCX3
Functioni
Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.
By similarityGO - Biological processi
- axonal transport of mitochondrion Source: Ensembl
- cellular protein localization Source: GO_Central
- mitochondrion organization Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9UH62 |
Reactomei | R-HSA-9013404, RAC2 GTPase cycle |
SignaLinki | Q9UH62 |
Names & Taxonomyi
Protein namesi | Recommended name: Armadillo repeat-containing X-linked protein 3Alternative name(s): ARM protein lost in epithelial cancers on chromosome X 3 Short name: Protein ALEX3 |
Gene namesi | Name:ARMCX3 Synonyms:ALEX3 ORF Names:BM-017, UNQ2517/PRO6007 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24065, ARMCX3 |
MIMi | 300364, gene |
neXtProti | NX_Q9UH62 |
VEuPathDBi | HostDB:ENSG00000102401 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane By similarity; Single-pass membrane protein Sequence analysis
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: Ensembl
Mitochondrion
- integral component of mitochondrial outer membrane Source: Ensembl
- mitochondrion Source: GO_Central
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- axon cytoplasm Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | Mitochondrial intermembraneBy similarity | 6 | |
Transmembranei | 7 – 29 | Helical; Signal-anchorSequence analysisAdd BLAST | 23 | |
Topological domaini | 30 – 379 | CytoplasmicBy similarityAdd BLAST | 350 |
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51566 |
OpenTargetsi | ENSG00000102401 |
PharmGKBi | PA134977725 |
Miscellaneous databases
Pharosi | Q9UH62, Tdark |
Genetic variation databases
BioMutai | ARMCX3 |
DMDMi | 74753322 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191366 | 1 – 379 | Armadillo repeat-containing X-linked protein 3Add BLAST | 379 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 61 | PhosphoserineCombined sources | 1 | |
Modified residuei | 67 | PhosphoserineCombined sources | 1 | |
Modified residuei | 72 | PhosphoserineCombined sources | 1 | |
Modified residuei | 110 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UH62 |
jPOSTi | Q9UH62 |
MassIVEi | Q9UH62 |
MaxQBi | Q9UH62 |
PaxDbi | Q9UH62 |
PeptideAtlasi | Q9UH62 |
PRIDEi | Q9UH62 |
ProteomicsDBi | 84277 |
PTM databases
iPTMneti | Q9UH62 |
MetOSitei | Q9UH62 |
PhosphoSitePlusi | Q9UH62 |
Expressioni
Gene expression databases
Bgeei | ENSG00000102401, Expressed in amniotic fluid and 247 other tissues |
ExpressionAtlasi | Q9UH62, baseline and differential |
Genevisiblei | Q9UH62, HS |
Organism-specific databases
HPAi | ENSG00000102401, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via ARM domain) with MIRO1, MIRO2 and TRAK2. The interaction with Miro is calcium-dependent.
Interacts with SOX10.
By similarityBinary interactionsi
Q9UH62
With | #Exp. | IntAct |
---|---|---|
EHHADH [Q08426] | 3 | EBI-717832,EBI-2339219 |
FAM25C [B3EWG5] | 3 | EBI-717832,EBI-14240149 |
MAF1 [Q9H063] | 3 | EBI-717832,EBI-720354 |
Protein-protein interaction databases
BioGRIDi | 119614, 122 interactors |
IntActi | Q9UH62, 28 interactors |
MINTi | Q9UH62 |
STRINGi | 9606.ENSP00000340672 |
Miscellaneous databases
RNActi | Q9UH62, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 111 – 151 | ARM 1Sequence analysisAdd BLAST | 41 | |
Repeati | 153 – 192 | ARM 2Sequence analysisAdd BLAST | 40 | |
Repeati | 233 – 272 | ARM 3Sequence analysisAdd BLAST | 40 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 6 | Mitochondrion outer membrane (MOM)-targeting sequenceCurated | 6 | |
Regioni | 26 – 37 | Mitochondrion outer membrane (MOM)-targeting sequenceCuratedAdd BLAST | 12 | |
Regioni | 89 – 98 | Nuclear localization signalBy similarity | 10 | |
Regioni | 95 – 116 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502TCDI, Eukaryota |
GeneTreei | ENSGT00940000162753 |
HOGENOMi | CLU_037187_0_0_1 |
InParanoidi | Q9UH62 |
OMAi | DSKSIVW |
OrthoDBi | 860703at2759 |
PhylomeDBi | Q9UH62 |
TreeFami | TF335652 |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR006911, ARM-rpt_dom IPR016024, ARM-type_fold IPR000225, Armadillo |
Pfami | View protein in Pfam PF04826, Arm_2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGSGDVDDAG
60 70 80 90 100
DCSGARYNDW SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR
110 120 130 140 150
ARRAVQKRAS PNSDDTVLSP QELQKVLCLV EMSEKPYILE AALIALGNNA
160 170 180 190 200
AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK EKALIVLNNL SVNAENQRRL
210 220 230 240 250
KVYMNQVCDD TITSRLNSSV QLAGLRLLTN MTVTNEYQHM LANSISDFFR
260 270 280 290 300
LFSAGNEETK LQVLKLLLNL AENPAMTREL LRAQVPSSLG SLFNKKENKE
310 320 330 340 350
VILKLLVIFE NINDNFKWEE NEPTQNQFGE GSLFFFLKEF QVCADKVLGI
360 370
ESHHDFLVKV KVGKFMAKLA EHMFPKSQE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BV87 | H3BV87_HUMAN | Armadillo repeat-containing X-linke... | ARMCX3 | 94 | Annotation score: | ||
H3BM63 | H3BM63_HUMAN | Armadillo repeat-containing X-linke... | ARMCX3 | 63 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 310 | E → V in BAD96375 (Ref. 5) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB039669 mRNA Translation: BAA94602.1 AF211175 mRNA Translation: AAF24487.1 AF208859 mRNA Translation: AAF64273.1 AY359079 mRNA Translation: AAQ89438.1 AK222655 mRNA Translation: BAD96375.1 CR933656 mRNA Translation: CAI45955.1 AL121883 Genomic DNA Translation: CAI42939.1 BC005194 mRNA Translation: AAH05194.1 |
CCDSi | CCDS14489.1 |
RefSeqi | NP_057691.1, NM_016607.3 NP_808816.1, NM_177947.2 NP_808817.1, NM_177948.2 XP_005262198.1, XM_005262141.2 |
Genome annotation databases
Ensembli | ENST00000341189.8; ENSP00000340672.4; ENSG00000102401.20 ENST00000471229.7; ENSP00000454483.1; ENSG00000102401.20 ENST00000537169.1; ENSP00000439032.1; ENSG00000102401.20 |
GeneIDi | 51566 |
KEGGi | hsa:51566 |
MANE-Selecti | ENST00000471229.7; ENSP00000454483.1; NM_177947.3; NP_808816.1 |
UCSCi | uc004ehz.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB039669 mRNA Translation: BAA94602.1 AF211175 mRNA Translation: AAF24487.1 AF208859 mRNA Translation: AAF64273.1 AY359079 mRNA Translation: AAQ89438.1 AK222655 mRNA Translation: BAD96375.1 CR933656 mRNA Translation: CAI45955.1 AL121883 Genomic DNA Translation: CAI42939.1 BC005194 mRNA Translation: AAH05194.1 |
CCDSi | CCDS14489.1 |
RefSeqi | NP_057691.1, NM_016607.3 NP_808816.1, NM_177947.2 NP_808817.1, NM_177948.2 XP_005262198.1, XM_005262141.2 |
3D structure databases
AlphaFoldDBi | Q9UH62 |
SMRi | Q9UH62 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119614, 122 interactors |
IntActi | Q9UH62, 28 interactors |
MINTi | Q9UH62 |
STRINGi | 9606.ENSP00000340672 |
PTM databases
iPTMneti | Q9UH62 |
MetOSitei | Q9UH62 |
PhosphoSitePlusi | Q9UH62 |
Genetic variation databases
BioMutai | ARMCX3 |
DMDMi | 74753322 |
Proteomic databases
EPDi | Q9UH62 |
jPOSTi | Q9UH62 |
MassIVEi | Q9UH62 |
MaxQBi | Q9UH62 |
PaxDbi | Q9UH62 |
PeptideAtlasi | Q9UH62 |
PRIDEi | Q9UH62 |
ProteomicsDBi | 84277 |
Protocols and materials databases
Antibodypediai | 378, 244 antibodies from 29 providers |
DNASUi | 51566 |
Genome annotation databases
Ensembli | ENST00000341189.8; ENSP00000340672.4; ENSG00000102401.20 ENST00000471229.7; ENSP00000454483.1; ENSG00000102401.20 ENST00000537169.1; ENSP00000439032.1; ENSG00000102401.20 |
GeneIDi | 51566 |
KEGGi | hsa:51566 |
MANE-Selecti | ENST00000471229.7; ENSP00000454483.1; NM_177947.3; NP_808816.1 |
UCSCi | uc004ehz.2, human |
Organism-specific databases
CTDi | 51566 |
DisGeNETi | 51566 |
GeneCardsi | ARMCX3 |
HGNCi | HGNC:24065, ARMCX3 |
HPAi | ENSG00000102401, Low tissue specificity |
MIMi | 300364, gene |
neXtProti | NX_Q9UH62 |
OpenTargetsi | ENSG00000102401 |
PharmGKBi | PA134977725 |
VEuPathDBi | HostDB:ENSG00000102401 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TCDI, Eukaryota |
GeneTreei | ENSGT00940000162753 |
HOGENOMi | CLU_037187_0_0_1 |
InParanoidi | Q9UH62 |
OMAi | DSKSIVW |
OrthoDBi | 860703at2759 |
PhylomeDBi | Q9UH62 |
TreeFami | TF335652 |
Enzyme and pathway databases
PathwayCommonsi | Q9UH62 |
Reactomei | R-HSA-9013404, RAC2 GTPase cycle |
SignaLinki | Q9UH62 |
Miscellaneous databases
BioGRID-ORCSi | 51566, 11 hits in 702 CRISPR screens |
ChiTaRSi | ARMCX3, human |
GeneWikii | ARMCX3 |
GenomeRNAii | 51566 |
Pharosi | Q9UH62, Tdark |
PROi | PR:Q9UH62 |
RNActi | Q9UH62, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102401, Expressed in amniotic fluid and 247 other tissues |
ExpressionAtlasi | Q9UH62, baseline and differential |
Genevisiblei | Q9UH62, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR006911, ARM-rpt_dom IPR016024, ARM-type_fold IPR000225, Armadillo |
Pfami | View protein in Pfam PF04826, Arm_2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARMX3_HUMAN | |
Accessioni | Q9UH62Primary (citable) accession number: Q9UH62 Secondary accession number(s): Q53HC6, Q7LCF5, Q9NPE4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families