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Protein

Neuronal-specific septin-3

Gene

SEPT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102GTP1
Binding sitei265GTP; via amide nitrogen and carbonyl oxygen1
Binding sitei280GTP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 75GTP8
Nucleotide bindingi208 – 216GTP9

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • protein-containing complex scaffold activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal-specific septin-3
Gene namesi
Name:SEPT3
Synonyms:SEP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100167.19
HGNCiHGNC:10750 SEPT3
MIMi608314 gene
neXtProtiNX_Q9UH03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi55964
OpenTargetsiENSG00000100167
PharmGKBiPA24355

Polymorphism and mutation databases

BioMutaiSEPT3
DMDMi147744590

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735171 – 358Neuronal-specific septin-3Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UH03
PaxDbiQ9UH03
PeptideAtlasiQ9UH03
PRIDEiQ9UH03
ProteomicsDBi84271
84272 [Q9UH03-2]
84273 [Q9UH03-3]

PTM databases

iPTMnetiQ9UH03
PhosphoSitePlusiQ9UH03
SwissPalmiQ9UH03

Expressioni

Tissue specificityi

Brain-specific.2 Publications

Inductioni

Up-regulated during neuronal differentiation.1 Publication

Gene expression databases

BgeeiENSG00000100167 Expressed in 118 organ(s), highest expression level in cerebellar vermis
CleanExiHS_SEPT3
ExpressionAtlasiQ9UH03 baseline and differential
GenevisibleiQ9UH03 HS

Organism-specific databases

HPAiCAB017633
HPA003548

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121011, 33 interactors
IntActiQ9UH03, 17 interactors
MINTiQ9UH03
STRINGi9606.ENSP00000379704

Structurei

Secondary structure

1358
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UH03
SMRiQ9UH03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 331Septin-type GPROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 75G1 motifPROSITE-ProRule annotation8
Regioni125 – 128G3 motifPROSITE-ProRule annotation4
Regioni207 – 210G4 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1547 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
HOVERGENiHBG065093
InParanoidiQ9UH03
KOiK16938
OMAiNRWGVVN
OrthoDBiEOG091G08V5
PhylomeDBiQ9UH03
TreeFamiTF101078

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
IPR008114 Septin3
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
PRINTSiPR01741 SEPTIN3
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UH03-1) [UniParc]FASTAAdd to basket
Also known as: A, SEP3A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKGLPETRT DAAMSELVPE PRPKPAVPMK PMSINSNLLG YIGIDTIIEQ
60 70 80 90 100
MRKKTMKTGF DFNIMVVGQS GLGKSTLVNT LFKSQVSRKA SSWNREEKIP
110 120 130 140 150
KTVEIKAIGH VIEEGGVKMK LTVIDTPGFG DQINNENCWE PIEKYINEQY
160 170 180 190 200
EKFLKEEVNI ARKKRIPDTR VHCCLYFISP TGHSLRPLDL EFMKHLSKVV
210 220 230 240 250
NIIPVIAKAD TMTLEEKSEF KQRVRKELEV NGIEFYPQKE FDEDLEDKTE
260 270 280 290 300
NDKIRQESMP FAVVGSDKEY QVNGKRVLGR KTPWGIIEVE NLNHCEFALL
310 320 330 340 350
RDFVIRTHLQ DLKEVTHNIH YETYRAKRLN DNGGLPPGEG LLGTVLPPVP

ATPCPTAE
Length:358
Mass (Da):40,704
Last modified:May 15, 2007 - v3
Checksum:iB49B0D1FBD9DE43B
GO
Isoform 2 (identifier: Q9UH03-2) [UniParc]FASTAAdd to basket
Also known as: B, SEP3B

The sequence of this isoform differs from the canonical sequence as follows:
     338-358: GEGLLGTVLPPVPATPCPTAE → VSVDTEESHDSNP

Show »
Length:350
Mass (Da):40,100
Checksum:i71D66D57E04D6C93
GO
Isoform 3 (identifier: Q9UH03-3) [UniParc]FASTAAdd to basket
Also known as: C, SEP3C

The sequence of this isoform differs from the canonical sequence as follows:
     68-83: GQSGLGKSTLVNTLFK → AGSPLRSTSMSSTRSS
     84-358: Missing.

Show »
Length:83
Mass (Da):9,061
Checksum:iA1008153DB5F8F76
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AHR1B1AHR1_HUMAN
Neuronal-specific septin-3
SEPT3
294Annotation score:
B1AHR2B1AHR2_HUMAN
Neuronal-specific septin-3
SEPT3
178Annotation score:
A0A2R8Y4H2A0A2R8Y4H2_HUMAN
Neuronal-specific septin-3
SEPT3
856Annotation score:

Sequence cautioni

The sequence AAG00517 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG00518 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG00519 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI11780 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD38797 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAG30458 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02539868 – 83GQSGL…NTLFK → AGSPLRSTSMSSTRSS in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_02539984 – 358Missing in isoform 3. 1 PublicationAdd BLAST275
Alternative sequenceiVSP_006049338 – 358GEGLL…CPTAE → VSVDTEESHDSNP in isoform 2. 4 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285107 mRNA Translation: AAG00517.1 Different initiation.
AF285108 mRNA Translation: AAG00518.1 Different initiation.
AF285109 mRNA Translation: AAG00519.1 Different initiation.
CR456572 mRNA Translation: CAG30458.1 Different initiation.
AL833942 mRNA Translation: CAD38797.1 Different initiation.
Z99716 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60480.1
BC111779 mRNA Translation: AAI11780.2 Different initiation.
AB209152 mRNA Translation: BAD92389.1
CCDSiCCDS14026.2 [Q9UH03-1]
CCDS14027.2 [Q9UH03-2]
PIRiJC7681
RefSeqiNP_061979.3, NM_019106.5 [Q9UH03-2]
NP_663786.2, NM_145733.2 [Q9UH03-1]
UniGeneiHs.120483

Genome annotation databases

EnsembliENST00000396417; ENSP00000379695; ENSG00000100167 [Q9UH03-3]
ENST00000396425; ENSP00000379703; ENSG00000100167 [Q9UH03-2]
ENST00000396426; ENSP00000379704; ENSG00000100167 [Q9UH03-1]
GeneIDi55964
KEGGihsa:55964
UCSCiuc003bbr.5 human [Q9UH03-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285107 mRNA Translation: AAG00517.1 Different initiation.
AF285108 mRNA Translation: AAG00518.1 Different initiation.
AF285109 mRNA Translation: AAG00519.1 Different initiation.
CR456572 mRNA Translation: CAG30458.1 Different initiation.
AL833942 mRNA Translation: CAD38797.1 Different initiation.
Z99716 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60480.1
BC111779 mRNA Translation: AAI11780.2 Different initiation.
AB209152 mRNA Translation: BAD92389.1
CCDSiCCDS14026.2 [Q9UH03-1]
CCDS14027.2 [Q9UH03-2]
PIRiJC7681
RefSeqiNP_061979.3, NM_019106.5 [Q9UH03-2]
NP_663786.2, NM_145733.2 [Q9UH03-1]
UniGeneiHs.120483

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SOPX-ray2.88A/B60-329[»]
4Z51X-ray1.86A60-330[»]
4Z54X-ray1.83A/B43-329[»]
ProteinModelPortaliQ9UH03
SMRiQ9UH03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121011, 33 interactors
IntActiQ9UH03, 17 interactors
MINTiQ9UH03
STRINGi9606.ENSP00000379704

PTM databases

iPTMnetiQ9UH03
PhosphoSitePlusiQ9UH03
SwissPalmiQ9UH03

Polymorphism and mutation databases

BioMutaiSEPT3
DMDMi147744590

Proteomic databases

EPDiQ9UH03
PaxDbiQ9UH03
PeptideAtlasiQ9UH03
PRIDEiQ9UH03
ProteomicsDBi84271
84272 [Q9UH03-2]
84273 [Q9UH03-3]

Protocols and materials databases

DNASUi55964
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396417; ENSP00000379695; ENSG00000100167 [Q9UH03-3]
ENST00000396425; ENSP00000379703; ENSG00000100167 [Q9UH03-2]
ENST00000396426; ENSP00000379704; ENSG00000100167 [Q9UH03-1]
GeneIDi55964
KEGGihsa:55964
UCSCiuc003bbr.5 human [Q9UH03-1]

Organism-specific databases

CTDi55964
DisGeNETi55964
EuPathDBiHostDB:ENSG00000100167.19
GeneCardsiSEPT3
HGNCiHGNC:10750 SEPT3
HPAiCAB017633
HPA003548
MIMi608314 gene
neXtProtiNX_Q9UH03
OpenTargetsiENSG00000100167
PharmGKBiPA24355
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1547 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144020
HOVERGENiHBG065093
InParanoidiQ9UH03
KOiK16938
OMAiNRWGVVN
OrthoDBiEOG091G08V5
PhylomeDBiQ9UH03
TreeFamiTF101078

Miscellaneous databases

ChiTaRSiSEPT3 human
GeneWikiiSEPT3
GenomeRNAii55964
PROiPR:Q9UH03
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100167 Expressed in 118 organ(s), highest expression level in cerebellar vermis
CleanExiHS_SEPT3
ExpressionAtlasiQ9UH03 baseline and differential
GenevisibleiQ9UH03 HS

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
IPR008114 Septin3
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
PRINTSiPR01741 SEPTIN3
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT3_HUMAN
AccessioniPrimary (citable) accession number: Q9UH03
Secondary accession number(s): B1AHR0
, Q2NKJ7, Q59GF7, Q6IBZ6, Q8N3P3, Q9HD35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 15, 2007
Last modified: November 7, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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