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Entry version 126 (08 May 2019)
Sequence version 1 (01 May 2000)
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Protein

Nucleolar protein 12

Gene

NOL12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May bind to 28S rRNA.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding, rRNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar protein 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOL12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28585 NOL12

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UGY1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000273899

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145148362

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NOL12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761951

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002712071 – 213Nucleolar protein 12Add BLAST213

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UGY1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UGY1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UGY1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UGY1

PeptideAtlas

More...
PeptideAtlasi
Q9UGY1

PRoteomics IDEntifications database

More...
PRIDEi
Q9UGY1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84270

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UGY1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UGY1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000273899 Expressed in 152 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UGY1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UGY1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003547

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KIAA1191.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122577, 94 interactors

Protein interaction database and analysis system

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IntActi
Q9UGY1, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352021

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UGY1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili33 – 96Sequence analysisAdd BLAST64

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRP17 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4709 Eukaryota
ENOG410XZ47 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015973

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082448

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UGY1

KEGG Orthology (KO)

More...
KOi
K14851

Identification of Orthologs from Complete Genome Data

More...
OMAi
SMEKPTK

Database of Orthologous Groups

More...
OrthoDBi
1635966at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UGY1

TreeFam database of animal gene trees

More...
TreeFami
TF323855

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019186 Nucleolar_protein_12

The PANTHER Classification System

More...
PANTHERi
PTHR14577 PTHR14577, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09805 Nop25, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UGY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRNKKKKRD GDDRRPRLVL SFDEEKRREY LTGFHKRKVE RKKAAIEEIK
60 70 80 90 100
QRLKEEQRKL REERHQEYLK MLAEREEALE EADELDRLVT AKTESVQYDH
110 120 130 140 150
PNHTVTVTTI SDLDLSGARL LGLTPPEGGA GDRSEEEASS TEKPTKALPR
160 170 180 190 200
KSRDPLLSQR ISSLTASLHA HSRKKVKRKH PRRAQDSKKP PRAPRTSKAQ
210
RRRLTGKARH SGE
Length:213
Mass (Da):24,663
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86A4DFBD363179CA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL160132 mRNA Translation: CAB77148.1
CR456463 mRNA Translation: CAG30349.1
Z83844 Genomic DNA No translation available.
BC002808 mRNA Translation: AAH02808.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13955.1

NCBI Reference Sequences

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RefSeqi
NP_077289.1, NM_024313.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359114; ENSP00000352021; ENSG00000273899
ENST00000438329; ENSP00000403059; ENSG00000273899
ENST00000611699; ENSP00000482349; ENSG00000273899

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79159

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79159

UCSC genome browser

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UCSCi
uc003ato.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160132 mRNA Translation: CAB77148.1
CR456463 mRNA Translation: CAG30349.1
Z83844 Genomic DNA No translation available.
BC002808 mRNA Translation: AAH02808.1
CCDSiCCDS13955.1
RefSeqiNP_077289.1, NM_024313.2

3D structure databases

SMRiQ9UGY1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122577, 94 interactors
IntActiQ9UGY1, 19 interactors
STRINGi9606.ENSP00000352021

PTM databases

iPTMnetiQ9UGY1
PhosphoSitePlusiQ9UGY1

Polymorphism and mutation databases

BioMutaiNOL12
DMDMi74761951

Proteomic databases

EPDiQ9UGY1
jPOSTiQ9UGY1
MaxQBiQ9UGY1
PaxDbiQ9UGY1
PeptideAtlasiQ9UGY1
PRIDEiQ9UGY1
ProteomicsDBi84270

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79159
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359114; ENSP00000352021; ENSG00000273899
ENST00000438329; ENSP00000403059; ENSG00000273899
ENST00000611699; ENSP00000482349; ENSG00000273899
GeneIDi79159
KEGGihsa:79159
UCSCiuc003ato.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79159

GeneCards: human genes, protein and diseases

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GeneCardsi
NOL12

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0041259
HIX0080291
HGNCiHGNC:28585 NOL12
HPAiHPA003547
neXtProtiNX_Q9UGY1
OpenTargetsiENSG00000273899
PharmGKBiPA145148362

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4709 Eukaryota
ENOG410XZ47 LUCA
GeneTreeiENSGT00390000015973
HOGENOMiHOG000082448
InParanoidiQ9UGY1
KOiK14851
OMAiSMEKPTK
OrthoDBi1635966at2759
PhylomeDBiQ9UGY1
TreeFamiTF323855

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NOL12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79159

Protein Ontology

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PROi
PR:Q9UGY1

Gene expression databases

BgeeiENSG00000273899 Expressed in 152 organ(s), highest expression level in right testis
ExpressionAtlasiQ9UGY1 baseline and differential
GenevisibleiQ9UGY1 HS

Family and domain databases

InterProiView protein in InterPro
IPR019186 Nucleolar_protein_12
PANTHERiPTHR14577 PTHR14577, 1 hit
PfamiView protein in Pfam
PF09805 Nop25, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOL12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGY1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 1, 2000
Last modified: May 8, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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