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Protein

Nucleolar protein 12

Gene

NOL12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind to 28S rRNA.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 12
Gene namesi
Name:NOL12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000273899.4
HGNCiHGNC:28585 NOL12
neXtProtiNX_Q9UGY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000273899
PharmGKBiPA145148362

Polymorphism and mutation databases

BioMutaiNOL12
DMDMi74761951

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002712071 – 213Nucleolar protein 12Add BLAST213

Proteomic databases

EPDiQ9UGY1
MaxQBiQ9UGY1
PaxDbiQ9UGY1
PeptideAtlasiQ9UGY1
PRIDEiQ9UGY1
ProteomicsDBi84270

PTM databases

iPTMnetiQ9UGY1
PhosphoSitePlusiQ9UGY1

Expressioni

Gene expression databases

BgeeiENSG00000273899
CleanExiHS_NOL12
ExpressionAtlasiQ9UGY1 baseline and differential
GenevisibleiQ9UGY1 HS

Organism-specific databases

HPAiHPA003547

Interactioni

Subunit structurei

Interacts with KIAA1191.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122577, 94 interactors
IntActiQ9UGY1, 18 interactors
STRINGi9606.ENSP00000352021

Structurei

3D structure databases

ProteinModelPortaliQ9UGY1
SMRiQ9UGY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili33 – 96Sequence analysisAdd BLAST64

Sequence similaritiesi

Belongs to the RRP17 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4709 Eukaryota
ENOG410XZ47 LUCA
GeneTreeiENSGT00390000015973
HOGENOMiHOG000082448
HOVERGENiHBG082042
InParanoidiQ9UGY1
KOiK14851
OMAiRRAQDST
OrthoDBiEOG091G0N95
PhylomeDBiQ9UGY1
TreeFamiTF323855

Family and domain databases

InterProiView protein in InterPro
IPR019186 Nucleolar_protein_12
PANTHERiPTHR14577 PTHR14577, 1 hit
PfamiView protein in Pfam
PF09805 Nop25, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UGY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRNKKKKRD GDDRRPRLVL SFDEEKRREY LTGFHKRKVE RKKAAIEEIK
60 70 80 90 100
QRLKEEQRKL REERHQEYLK MLAEREEALE EADELDRLVT AKTESVQYDH
110 120 130 140 150
PNHTVTVTTI SDLDLSGARL LGLTPPEGGA GDRSEEEASS TEKPTKALPR
160 170 180 190 200
KSRDPLLSQR ISSLTASLHA HSRKKVKRKH PRRAQDSKKP PRAPRTSKAQ
210
RRRLTGKARH SGE
Length:213
Mass (Da):24,663
Last modified:May 1, 2000 - v1
Checksum:i86A4DFBD363179CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160132 mRNA Translation: CAB77148.1
CR456463 mRNA Translation: CAG30349.1
Z83844 Genomic DNA No translation available.
BC002808 mRNA Translation: AAH02808.1
CCDSiCCDS13955.1
RefSeqiNP_077289.1, NM_024313.2
UniGeneiHs.632778

Genome annotation databases

EnsembliENST00000359114; ENSP00000352021; ENSG00000273899
ENST00000438329; ENSP00000403059; ENSG00000273899
ENST00000611699; ENSP00000482349; ENSG00000273899
GeneIDi79159
KEGGihsa:79159
UCSCiuc003ato.2 human

Similar proteinsi

Entry informationi

Entry nameiNOL12_HUMAN
AccessioniPrimary (citable) accession number: Q9UGY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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