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UniProtKB - Q9UGV2 (NDRG3_HUMAN)

Entry version 158 (10 Feb 2021)
Sequence version 2 (23 Jan 2002)
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Protein

Protein NDRG3

Gene

NDRG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UGV2

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-NDRG3, Ndr_family

MEROPS protease database

More...MEROPSi		S33.987

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein NDRG3
Alternative name(s):
N-myc downstream-regulated gene 3 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDRG3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14462, NDRG3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605273, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UGV2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000101079.20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57446

Open Targets

More...OpenTargetsi		ENSG00000101079

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31484

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UGV2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NDRG3

Domain mapping of disease mutations (DMDM)

More...DMDMi		20141613

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001595771 – 375Protein NDRG3Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei322PhosphothreonineCombined sources1
Modified residuei329PhosphothreonineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei332PhosphothreonineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei355PhosphothreonineCombined sources1
Modified residuei361PhosphoserineBy similarity1
Modified residuei374PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UGV2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UGV2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UGV2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UGV2

PeptideAtlas

More...PeptideAtlasi		Q9UGV2

PRoteomics IDEntifications database

More...PRIDEi		Q9UGV2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84267 [Q9UGV2-1]
84268 [Q9UGV2-2]
84269 [Q9UGV2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UGV2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UGV2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000101079, Expressed in cerebellar vermis and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UGV2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UGV2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000101079, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121519, 19 interactors

Protein interaction database and analysis system

More...IntActi		Q9UGV2, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000345292

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UGV2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UGV2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NDRG family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2931, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182872

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035361_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UGV2

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UGV2

TreeFam database of animal gene trees

More...TreeFami		TF313168

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR004142, NDRG
IPR030692, NDRG3

The PANTHER Classification System

More...PANTHERi		PTHR11034, PTHR11034, 1 hit
PTHR11034:SF20, PTHR11034:SF20, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03096, Ndr, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETTHG VVHVTIRGLP 
        60         70         80         90        100
KGNRPVILTY HDIGLNHKSC FNAFFNFEDM QEITQHFAVC HVDAPGQQEG 
       110        120        130        140        150
APSFPTGYQY PTMDELAEML PPVLTHLSLK SIIGIGVGAG AYILSRFALN 
       160        170        180        190        200
HPELVEGLVL INVDPCAKGW IDWAASKLSG LTTNVVDIIL AHHFGQEELQ 
       210        220        230        240        250
ANLDLIQTYR MHIAQDINQD NLQLFLNSYN GRRDLEIERP ILGQNDNKSK 
       260        270        280        290        300
TLKCSTLLVV GDNSPAVEAV VECNSRLNPI NTTLLKMADC GGLPQVVQPG 
       310        320        330        340        350
KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSLGSGE SPFSRSVTSN 
       360        370 
QSDGTQESCE SPDVLDRHQT MEVSC
Length:375
Mass (Da):41,409
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i237B6DF43AAB7F1E
GO
Isoform 2 (identifier: Q9UGV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-31: Missing.

Show »
Length:363
Mass (Da):39,982
Checksum:i55B7390D327B78CE
GO
Isoform 3 (identifier: Q9UGV2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-135: Missing.

Show »
Length:286
Mass (Da):31,484
Checksum:i76B0EC7BE14E7409
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TH30Q5TH30_HUMAN
N-myc downstream-regulated gene 3 p...
NDRG3 hCG_1785125
388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBF9F8WBF9_HUMAN
N-myc downstream-regulated gene 3 p...
NDRG3
280Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TH29Q5TH29_HUMAN
N-myc downstream-regulated gene 3 p...
NDRG3
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32E → G in AAL08807 (PubMed:11936845).Curated1
Sequence conflicti71F → S in BAB55277 (PubMed:14702039).Curated1
Sequence conflicti122P → S in AAK34944 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00341920 – 31Missing in isoform 2. 3 PublicationsAdd BLAST12
Alternative sequenceiVSP_00342047 – 135Missing in isoform 3. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB044943 mRNA Translation: BAB20067.1
AF251054 mRNA Translation: AAK34944.1
AF308609 mRNA Translation: AAL08807.1
AK023618 mRNA Translation: BAB14620.1
AK027665 mRNA Translation: BAB55277.1
AL031662 Genomic DNA No translation available.
AL132768 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76112.1
CH471077 Genomic DNA Translation: EAW76109.1
CH471077 Genomic DNA Translation: EAW76114.1
CH471077 Genomic DNA Translation: EAW76115.1
BC136489 mRNA Translation: AAI36490.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13284.1 [Q9UGV2-2]
CCDS13285.1 [Q9UGV2-1]

NCBI Reference Sequences

More...RefSeqi		NP_071922.2, NM_022477.3 [Q9UGV2-2]
NP_114402.1, NM_032013.3 [Q9UGV2-1]
XP_016883468.1, XM_017027979.1 [Q9UGV2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000349004; ENSP00000345292; ENSG00000101079 [Q9UGV2-1]
ENST00000359675; ENSP00000352703; ENSG00000101079 [Q9UGV2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57446

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57446

UCSC genome browser

More...UCSCi		uc002xfw.4, human [Q9UGV2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044943 mRNA Translation: BAB20067.1
AF251054 mRNA Translation: AAK34944.1
AF308609 mRNA Translation: AAL08807.1
AK023618 mRNA Translation: BAB14620.1
AK027665 mRNA Translation: BAB55277.1
AL031662 Genomic DNA No translation available.
AL132768 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76112.1
CH471077 Genomic DNA Translation: EAW76109.1
CH471077 Genomic DNA Translation: EAW76114.1
CH471077 Genomic DNA Translation: EAW76115.1
BC136489 mRNA Translation: AAI36490.1
CCDSiCCDS13284.1 [Q9UGV2-2]
CCDS13285.1 [Q9UGV2-1]
RefSeqiNP_071922.2, NM_022477.3 [Q9UGV2-2]
NP_114402.1, NM_032013.3 [Q9UGV2-1]
XP_016883468.1, XM_017027979.1 [Q9UGV2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6L4BX-ray2.20A/B/C/D/E/F1-375[»]
6L4GX-ray3.30A/B1-375[»]
6L4HX-ray3.40A/B/C/D1-375[»]
SMRiQ9UGV2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121519, 19 interactors
IntActiQ9UGV2, 4 interactors
STRINGi9606.ENSP00000345292

Protein family/group databases

ESTHERihuman-NDRG3, Ndr_family
MEROPSiS33.987

PTM databases

iPTMnetiQ9UGV2
PhosphoSitePlusiQ9UGV2

Genetic variation databases

BioMutaiNDRG3
DMDMi20141613

Proteomic databases

EPDiQ9UGV2
jPOSTiQ9UGV2
MassIVEiQ9UGV2
PaxDbiQ9UGV2
PeptideAtlasiQ9UGV2
PRIDEiQ9UGV2
ProteomicsDBi84267 [Q9UGV2-1]
84268 [Q9UGV2-2]
84269 [Q9UGV2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11784, 130 antibodies

Genome annotation databases

EnsembliENST00000349004; ENSP00000345292; ENSG00000101079 [Q9UGV2-1]
ENST00000359675; ENSP00000352703; ENSG00000101079 [Q9UGV2-2]
GeneIDi57446
KEGGihsa:57446
UCSCiuc002xfw.4, human [Q9UGV2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57446
DisGeNETi57446

GeneCards: human genes, protein and diseases

More...GeneCardsi		NDRG3
HGNCiHGNC:14462, NDRG3
HPAiENSG00000101079, Tissue enhanced (brain)
MIMi605273, gene
neXtProtiNX_Q9UGV2
OpenTargetsiENSG00000101079
PharmGKBiPA31484
VEuPathDBiHostDB:ENSG00000101079.20

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2931, Eukaryota
GeneTreeiENSGT00950000182872
HOGENOMiCLU_035361_1_0_1
InParanoidiQ9UGV2
PhylomeDBiQ9UGV2
TreeFamiTF313168

Enzyme and pathway databases

PathwayCommonsiQ9UGV2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57446, 30 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NDRG3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57446
PharosiQ9UGV2, Tbio

Protein Ontology

More...PROi		PR:Q9UGV2
RNActiQ9UGV2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000101079, Expressed in cerebellar vermis and 249 other tissues
ExpressionAtlasiQ9UGV2, baseline and differential
GenevisibleiQ9UGV2, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR004142, NDRG
IPR030692, NDRG3
PANTHERiPTHR11034, PTHR11034, 1 hit
PTHR11034:SF20, PTHR11034:SF20, 1 hit
PfamiView protein in Pfam
PF03096, Ndr, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDRG3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGV2
Secondary accession number(s): A2A2S8
, E1P5U7, E1P5U8, Q5TH32, Q96PL8, Q96SM2, Q9BXY7, Q9H3N7, Q9H411, Q9H8J6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2002
Last modified: February 10, 2021
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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