UniProtKB - Q9UGV2 (NDRG3_HUMAN)
Protein
Protein NDRG3
Gene
NDRG3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- cell differentiation Source: UniProtKB
- negative regulation of cell growth Source: UniProtKB
- signal transduction Source: GO_Central
- spermatogenesis Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9UGV2 |
Protein family/group databases
ESTHERi | human-NDRG3, Ndr_family |
MEROPSi | S33.987 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein NDRG3Alternative name(s): N-myc downstream-regulated gene 3 protein |
Gene namesi | Name:NDRG3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14462, NDRG3 |
MIMi | 605273, gene |
neXtProti | NX_Q9UGV2 |
VEuPathDBi | HostDB:ENSG00000101079.20 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 57446 |
OpenTargetsi | ENSG00000101079 |
PharmGKBi | PA31484 |
Miscellaneous databases
Pharosi | Q9UGV2, Tbio |
Genetic variation databases
BioMutai | NDRG3 |
DMDMi | 20141613 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000159577 | 1 – 375 | Protein NDRG3Add BLAST | 375 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 322 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 329 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 331 | PhosphoserineCombined sources | 1 | |
Modified residuei | 332 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 334 | PhosphoserineCombined sources | 1 | |
Modified residuei | 335 | PhosphoserineCombined sources | 1 | |
Modified residuei | 338 | PhosphoserineCombined sources | 1 | |
Modified residuei | 341 | PhosphoserineCombined sources | 1 | |
Modified residuei | 352 | PhosphoserineCombined sources | 1 | |
Modified residuei | 355 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 361 | PhosphoserineBy similarity | 1 | |
Modified residuei | 374 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9UGV2 |
jPOSTi | Q9UGV2 |
MassIVEi | Q9UGV2 |
PaxDbi | Q9UGV2 |
PeptideAtlasi | Q9UGV2 |
PRIDEi | Q9UGV2 |
ProteomicsDBi | 84267 [Q9UGV2-1] 84268 [Q9UGV2-2] 84269 [Q9UGV2-3] |
PTM databases
iPTMneti | Q9UGV2 |
PhosphoSitePlusi | Q9UGV2 |
Expressioni
Tissue specificityi
Ubiquitous. Highly expressed in brain.1 Publication
Gene expression databases
Bgeei | ENSG00000101079, Expressed in cerebellar vermis and 249 other tissues |
ExpressionAtlasi | Q9UGV2, baseline and differential |
Genevisiblei | Q9UGV2, HS |
Organism-specific databases
HPAi | ENSG00000101079, Tissue enhanced (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121519, 19 interactors |
IntActi | Q9UGV2, 4 interactors |
STRINGi | 9606.ENSP00000345292 |
Miscellaneous databases
RNActi | Q9UGV2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the NDRG family.Curated
Phylogenomic databases
eggNOGi | KOG2931, Eukaryota |
GeneTreei | ENSGT00950000182872 |
HOGENOMi | CLU_035361_1_0_1 |
InParanoidi | Q9UGV2 |
PhylomeDBi | Q9UGV2 |
TreeFami | TF313168 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR004142, NDRG IPR030692, NDRG3 |
PANTHERi | PTHR11034, PTHR11034, 1 hit PTHR11034:SF20, PTHR11034:SF20, 1 hit |
Pfami | View protein in Pfam PF03096, Ndr, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UGV2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETTHG VVHVTIRGLP
60 70 80 90 100
KGNRPVILTY HDIGLNHKSC FNAFFNFEDM QEITQHFAVC HVDAPGQQEG
110 120 130 140 150
APSFPTGYQY PTMDELAEML PPVLTHLSLK SIIGIGVGAG AYILSRFALN
160 170 180 190 200
HPELVEGLVL INVDPCAKGW IDWAASKLSG LTTNVVDIIL AHHFGQEELQ
210 220 230 240 250
ANLDLIQTYR MHIAQDINQD NLQLFLNSYN GRRDLEIERP ILGQNDNKSK
260 270 280 290 300
TLKCSTLLVV GDNSPAVEAV VECNSRLNPI NTTLLKMADC GGLPQVVQPG
310 320 330 340 350
KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSLGSGE SPFSRSVTSN
360 370
QSDGTQESCE SPDVLDRHQT MEVSC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5TH30 | Q5TH30_HUMAN | N-myc downstream-regulated gene 3 p... | NDRG3 hCG_1785125 | 388 | Annotation score: | ||
F8WBF9 | F8WBF9_HUMAN | N-myc downstream-regulated gene 3 p... | NDRG3 | 280 | Annotation score: | ||
Q5TH29 | Q5TH29_HUMAN | N-myc downstream-regulated gene 3 p... | NDRG3 | 187 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | E → G in AAL08807 (PubMed:11936845).Curated | 1 | |
Sequence conflicti | 71 | F → S in BAB55277 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 122 | P → S in AAK34944 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003419 | 20 – 31 | Missing in isoform 2. 3 PublicationsAdd BLAST | 12 | |
Alternative sequenceiVSP_003420 | 47 – 135 | Missing in isoform 3. 1 PublicationAdd BLAST | 89 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB044943 mRNA Translation: BAB20067.1 AF251054 mRNA Translation: AAK34944.1 AF308609 mRNA Translation: AAL08807.1 AK023618 mRNA Translation: BAB14620.1 AK027665 mRNA Translation: BAB55277.1 AL031662 Genomic DNA No translation available. AL132768 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76112.1 CH471077 Genomic DNA Translation: EAW76109.1 CH471077 Genomic DNA Translation: EAW76114.1 CH471077 Genomic DNA Translation: EAW76115.1 BC136489 mRNA Translation: AAI36490.1 |
CCDSi | CCDS13284.1 [Q9UGV2-2] CCDS13285.1 [Q9UGV2-1] |
RefSeqi | NP_071922.2, NM_022477.3 [Q9UGV2-2] NP_114402.1, NM_032013.3 [Q9UGV2-1] XP_016883468.1, XM_017027979.1 [Q9UGV2-1] |
Genome annotation databases
Ensembli | ENST00000349004; ENSP00000345292; ENSG00000101079 [Q9UGV2-1] ENST00000359675; ENSP00000352703; ENSG00000101079 [Q9UGV2-2] |
GeneIDi | 57446 |
KEGGi | hsa:57446 |
UCSCi | uc002xfw.4, human [Q9UGV2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB044943 mRNA Translation: BAB20067.1 AF251054 mRNA Translation: AAK34944.1 AF308609 mRNA Translation: AAL08807.1 AK023618 mRNA Translation: BAB14620.1 AK027665 mRNA Translation: BAB55277.1 AL031662 Genomic DNA No translation available. AL132768 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76112.1 CH471077 Genomic DNA Translation: EAW76109.1 CH471077 Genomic DNA Translation: EAW76114.1 CH471077 Genomic DNA Translation: EAW76115.1 BC136489 mRNA Translation: AAI36490.1 |
CCDSi | CCDS13284.1 [Q9UGV2-2] CCDS13285.1 [Q9UGV2-1] |
RefSeqi | NP_071922.2, NM_022477.3 [Q9UGV2-2] NP_114402.1, NM_032013.3 [Q9UGV2-1] XP_016883468.1, XM_017027979.1 [Q9UGV2-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6L4B | X-ray | 2.20 | A/B/C/D/E/F | 1-375 | [»] | |
6L4G | X-ray | 3.30 | A/B | 1-375 | [»] | |
6L4H | X-ray | 3.40 | A/B/C/D | 1-375 | [»] | |
SMRi | Q9UGV2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121519, 19 interactors |
IntActi | Q9UGV2, 4 interactors |
STRINGi | 9606.ENSP00000345292 |
Protein family/group databases
ESTHERi | human-NDRG3, Ndr_family |
MEROPSi | S33.987 |
PTM databases
iPTMneti | Q9UGV2 |
PhosphoSitePlusi | Q9UGV2 |
Genetic variation databases
BioMutai | NDRG3 |
DMDMi | 20141613 |
Proteomic databases
EPDi | Q9UGV2 |
jPOSTi | Q9UGV2 |
MassIVEi | Q9UGV2 |
PaxDbi | Q9UGV2 |
PeptideAtlasi | Q9UGV2 |
PRIDEi | Q9UGV2 |
ProteomicsDBi | 84267 [Q9UGV2-1] 84268 [Q9UGV2-2] 84269 [Q9UGV2-3] |
Protocols and materials databases
Antibodypediai | 11784, 130 antibodies |
Genome annotation databases
Ensembli | ENST00000349004; ENSP00000345292; ENSG00000101079 [Q9UGV2-1] ENST00000359675; ENSP00000352703; ENSG00000101079 [Q9UGV2-2] |
GeneIDi | 57446 |
KEGGi | hsa:57446 |
UCSCi | uc002xfw.4, human [Q9UGV2-1] |
Organism-specific databases
CTDi | 57446 |
DisGeNETi | 57446 |
GeneCardsi | NDRG3 |
HGNCi | HGNC:14462, NDRG3 |
HPAi | ENSG00000101079, Tissue enhanced (brain) |
MIMi | 605273, gene |
neXtProti | NX_Q9UGV2 |
OpenTargetsi | ENSG00000101079 |
PharmGKBi | PA31484 |
VEuPathDBi | HostDB:ENSG00000101079.20 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2931, Eukaryota |
GeneTreei | ENSGT00950000182872 |
HOGENOMi | CLU_035361_1_0_1 |
InParanoidi | Q9UGV2 |
PhylomeDBi | Q9UGV2 |
TreeFami | TF313168 |
Enzyme and pathway databases
PathwayCommonsi | Q9UGV2 |
Miscellaneous databases
BioGRID-ORCSi | 57446, 30 hits in 875 CRISPR screens |
ChiTaRSi | NDRG3, human |
GenomeRNAii | 57446 |
Pharosi | Q9UGV2, Tbio |
PROi | PR:Q9UGV2 |
RNActi | Q9UGV2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101079, Expressed in cerebellar vermis and 249 other tissues |
ExpressionAtlasi | Q9UGV2, baseline and differential |
Genevisiblei | Q9UGV2, HS |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR004142, NDRG IPR030692, NDRG3 |
PANTHERi | PTHR11034, PTHR11034, 1 hit PTHR11034:SF20, PTHR11034:SF20, 1 hit |
Pfami | View protein in Pfam PF03096, Ndr, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NDRG3_HUMAN | |
Accessioni | Q9UGV2Primary (citable) accession number: Q9UGV2 Secondary accession number(s): A2A2S8 Q9H8J6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | January 23, 2002 | |
Last modified: | February 10, 2021 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM