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Protein

Protein NDRG3

Gene

NDRG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • signal transduction Source: GO_Central
  • spermatogenesis Source: UniProtKB

Protein family/group databases

ESTHERihuman-NDRG3 Ndr_family
MEROPSiS33.987

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NDRG3
Alternative name(s):
N-myc downstream-regulated gene 3 protein
Gene namesi
Name:NDRG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101079.20
HGNCiHGNC:14462 NDRG3
MIMi605273 gene
neXtProtiNX_Q9UGV2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi57446
OpenTargetsiENSG00000101079
PharmGKBiPA31484

Polymorphism and mutation databases

BioMutaiNDRG3
DMDMi20141613

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595771 – 375Protein NDRG3Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei322PhosphothreonineCombined sources1
Modified residuei329PhosphothreonineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei332PhosphothreonineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei355PhosphothreonineCombined sources1
Modified residuei361PhosphoserineBy similarity1
Modified residuei374PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UGV2
PaxDbiQ9UGV2
PeptideAtlasiQ9UGV2
PRIDEiQ9UGV2
ProteomicsDBi84267
84268 [Q9UGV2-2]
84269 [Q9UGV2-3]

PTM databases

iPTMnetiQ9UGV2
PhosphoSitePlusiQ9UGV2

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000101079 Expressed in 239 organ(s), highest expression level in cerebellar vermis
CleanExiHS_NDRG3
ExpressionAtlasiQ9UGV2 baseline and differential
GenevisibleiQ9UGV2 HS

Organism-specific databases

HPAiHPA017851
HPA018256

Interactioni

Protein-protein interaction databases

BioGridi121519, 14 interactors
IntActiQ9UGV2, 1 interactor
STRINGi9606.ENSP00000345292

Structurei

3D structure databases

ProteinModelPortaliQ9UGV2
SMRiQ9UGV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDRG family.Curated

Phylogenomic databases

eggNOGiKOG2931 Eukaryota
ENOG410XSPF LUCA
GeneTreeiENSGT00390000001874
HOVERGENiHBG052591
InParanoidiQ9UGV2
PhylomeDBiQ9UGV2
TreeFamiTF313168

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR004142 NDRG
IPR030692 NDRG3
PANTHERiPTHR11034 PTHR11034, 1 hit
PTHR11034:SF20 PTHR11034:SF20, 1 hit
PfamiView protein in Pfam
PF03096 Ndr, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETTHG VVHVTIRGLP
60 70 80 90 100
KGNRPVILTY HDIGLNHKSC FNAFFNFEDM QEITQHFAVC HVDAPGQQEG
110 120 130 140 150
APSFPTGYQY PTMDELAEML PPVLTHLSLK SIIGIGVGAG AYILSRFALN
160 170 180 190 200
HPELVEGLVL INVDPCAKGW IDWAASKLSG LTTNVVDIIL AHHFGQEELQ
210 220 230 240 250
ANLDLIQTYR MHIAQDINQD NLQLFLNSYN GRRDLEIERP ILGQNDNKSK
260 270 280 290 300
TLKCSTLLVV GDNSPAVEAV VECNSRLNPI NTTLLKMADC GGLPQVVQPG
310 320 330 340 350
KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSLGSGE SPFSRSVTSN
360 370
QSDGTQESCE SPDVLDRHQT MEVSC
Length:375
Mass (Da):41,409
Last modified:January 23, 2002 - v2
Checksum:i237B6DF43AAB7F1E
GO
Isoform 2 (identifier: Q9UGV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-31: Missing.

Show »
Length:363
Mass (Da):39,982
Checksum:i55B7390D327B78CE
GO
Isoform 3 (identifier: Q9UGV2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-135: Missing.

Show »
Length:286
Mass (Da):31,484
Checksum:i76B0EC7BE14E7409
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TH30Q5TH30_HUMAN
NDRG family member 3, isoform CRA_c
NDRG3 hCG_1785125
388Annotation score:
Q5TH29Q5TH29_HUMAN
Protein NDRG3
NDRG3
187Annotation score:
F8WBF9F8WBF9_HUMAN
Protein NDRG3
NDRG3
280Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32E → G in AAL08807 (PubMed:11936845).Curated1
Sequence conflicti71F → S in BAB55277 (PubMed:14702039).Curated1
Sequence conflicti122P → S in AAK34944 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00341920 – 31Missing in isoform 2. 3 PublicationsAdd BLAST12
Alternative sequenceiVSP_00342047 – 135Missing in isoform 3. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044943 mRNA Translation: BAB20067.1
AF251054 mRNA Translation: AAK34944.1
AF308609 mRNA Translation: AAL08807.1
AK023618 mRNA Translation: BAB14620.1
AK027665 mRNA Translation: BAB55277.1
AL031662 Genomic DNA No translation available.
AL132768 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76112.1
CH471077 Genomic DNA Translation: EAW76109.1
CH471077 Genomic DNA Translation: EAW76114.1
CH471077 Genomic DNA Translation: EAW76115.1
BC136489 mRNA Translation: AAI36490.1
CCDSiCCDS13284.1 [Q9UGV2-2]
CCDS13285.1 [Q9UGV2-1]
RefSeqiNP_071922.2, NM_022477.3 [Q9UGV2-2]
NP_114402.1, NM_032013.3 [Q9UGV2-1]
XP_016883468.1, XM_017027979.1 [Q9UGV2-1]
UniGeneiHs.437338

Genome annotation databases

EnsembliENST00000349004; ENSP00000345292; ENSG00000101079 [Q9UGV2-1]
ENST00000359675; ENSP00000352703; ENSG00000101079 [Q9UGV2-2]
GeneIDi57446
KEGGihsa:57446
UCSCiuc002xfw.4 human [Q9UGV2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044943 mRNA Translation: BAB20067.1
AF251054 mRNA Translation: AAK34944.1
AF308609 mRNA Translation: AAL08807.1
AK023618 mRNA Translation: BAB14620.1
AK027665 mRNA Translation: BAB55277.1
AL031662 Genomic DNA No translation available.
AL132768 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76112.1
CH471077 Genomic DNA Translation: EAW76109.1
CH471077 Genomic DNA Translation: EAW76114.1
CH471077 Genomic DNA Translation: EAW76115.1
BC136489 mRNA Translation: AAI36490.1
CCDSiCCDS13284.1 [Q9UGV2-2]
CCDS13285.1 [Q9UGV2-1]
RefSeqiNP_071922.2, NM_022477.3 [Q9UGV2-2]
NP_114402.1, NM_032013.3 [Q9UGV2-1]
XP_016883468.1, XM_017027979.1 [Q9UGV2-1]
UniGeneiHs.437338

3D structure databases

ProteinModelPortaliQ9UGV2
SMRiQ9UGV2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121519, 14 interactors
IntActiQ9UGV2, 1 interactor
STRINGi9606.ENSP00000345292

Protein family/group databases

ESTHERihuman-NDRG3 Ndr_family
MEROPSiS33.987

PTM databases

iPTMnetiQ9UGV2
PhosphoSitePlusiQ9UGV2

Polymorphism and mutation databases

BioMutaiNDRG3
DMDMi20141613

Proteomic databases

EPDiQ9UGV2
PaxDbiQ9UGV2
PeptideAtlasiQ9UGV2
PRIDEiQ9UGV2
ProteomicsDBi84267
84268 [Q9UGV2-2]
84269 [Q9UGV2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349004; ENSP00000345292; ENSG00000101079 [Q9UGV2-1]
ENST00000359675; ENSP00000352703; ENSG00000101079 [Q9UGV2-2]
GeneIDi57446
KEGGihsa:57446
UCSCiuc002xfw.4 human [Q9UGV2-1]

Organism-specific databases

CTDi57446
DisGeNETi57446
EuPathDBiHostDB:ENSG00000101079.20
GeneCardsiNDRG3
H-InvDBiHIX0174711
HGNCiHGNC:14462 NDRG3
HPAiHPA017851
HPA018256
MIMi605273 gene
neXtProtiNX_Q9UGV2
OpenTargetsiENSG00000101079
PharmGKBiPA31484
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2931 Eukaryota
ENOG410XSPF LUCA
GeneTreeiENSGT00390000001874
HOVERGENiHBG052591
InParanoidiQ9UGV2
PhylomeDBiQ9UGV2
TreeFamiTF313168

Miscellaneous databases

ChiTaRSiNDRG3 human
GenomeRNAii57446
PROiPR:Q9UGV2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101079 Expressed in 239 organ(s), highest expression level in cerebellar vermis
CleanExiHS_NDRG3
ExpressionAtlasiQ9UGV2 baseline and differential
GenevisibleiQ9UGV2 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR004142 NDRG
IPR030692 NDRG3
PANTHERiPTHR11034 PTHR11034, 1 hit
PTHR11034:SF20 PTHR11034:SF20, 1 hit
PfamiView protein in Pfam
PF03096 Ndr, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDRG3_HUMAN
AccessioniPrimary (citable) accession number: Q9UGV2
Secondary accession number(s): A2A2S8
, E1P5U7, E1P5U8, Q5TH32, Q96PL8, Q96SM2, Q9BXY7, Q9H3N7, Q9H411, Q9H8J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2002
Last modified: October 10, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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