Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q9UGU5 (HMGX4_HUMAN)

Entry version 169 (25 May 2022)
Sequence version 2 (15 Mar 2005)
Previous versions | rss
Add a publicationFeedback
Protein

HMG domain-containing protein 4

Gene

HMGXB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively regulates Wnt/beta-catenin signaling during development.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi407 – 475HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UGU5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UGU5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HMG domain-containing protein 4
Alternative name(s):
HMG box-containing protein 4
High mobility group protein 2-like 1
Protein HMGBCG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HMGXB4
Synonyms:HMG2L1, HMGBCG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5003, HMGXB4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604702, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UGU5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100281

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10042

Open Targets

More...OpenTargetsi		ENSG00000100281

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164720673

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UGU5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HMGXB4

Domain mapping of disease mutations (DMDM)

More...DMDMi		61252700

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000485421 – 601HMG domain-containing protein 4Add BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102PhosphoserineCombined sources1
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei197PhosphoserineCombined sources1
Modified residuei497PhosphoserineCombined sources1
Modified residuei502PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UGU5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UGU5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UGU5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UGU5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UGU5

PeptideAtlas

More...PeptideAtlasi		Q9UGU5

PRoteomics IDEntifications database

More...PRIDEi		Q9UGU5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84266

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UGU5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UGU5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100281, Expressed in oocyte and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UGU5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UGU5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100281, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115353, 105 interactors

Database of interacting proteins

More...DIPi		DIP-60550N

Protein interaction database and analysis system

More...IntActi		Q9UGU5, 43 interactors

Molecular INTeraction database

More...MINTi		Q9UGU5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216106

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UGU5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9UGU5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UGU5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni51 – 410DisorderedSequence analysisAdd BLAST360
Regioni473 – 514DisorderedSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 83Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi138 – 156Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi207 – 222Polar residuesSequence analysisAdd BLAST16
Compositional biasi244 – 258Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi318 – 344Basic residuesSequence analysisAdd BLAST27
Compositional biasi383 – 409Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi473 – 488Polar residuesSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSH9, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012436

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032486_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UGU5

Identification of Orthologs from Complete Genome Data

More...OMAi		XGMVAVS

Database of Orthologous Groups

More...OrthoDBi		1641977at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UGU5

TreeFam database of animal gene trees

More...TreeFami		TF106404

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025228, DUF4171
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR042477, HMGXB4

The PANTHER Classification System

More...PANTHERi		PTHR46584, PTHR46584, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13775, DUF4171, 1 hit
PF00505, HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00398, HMG, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47095, SSF47095, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9UGU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYDDSVKKE DCFDGDHTFE DIGLAAGRSQ REKKRSYKDF LREEEEIAAQ 
        60         70         80         90        100
VRNSSKKKLK DSELYFLGTD THKKKRKHSS DDYYYGDISS LESSQKKKKK 
       110        120        130        140        150
SSPQSTDTAM DLLKAITSPL AAGSKPSKKT GEKSSGSSSH SESKKEHHRK 
       160        170        180        190        200
KVSGSSGELP LEDGGSHKSK KMKPLYVNTE TLTLREPDGL KMKLILSPKE 
       210        220        230        240        250
KGSSSVDEES FQYPSQQATV KKSSKKSARD EQGALLLGHE LQSFLKTARK 
       260        270        280        290        300
KHKSSSDAHS SPGPEGCGSD ASQFAESHSA NLDLSGLEPI LVESDSSSGG 
       310        320        330        340        350
ELEAGELVID DSYREIKKKK KSKKSKKKKD KEKHKEKRHS KSKRSLGLSA 
       360        370        380        390        400
VPVGEVTVTS GPPPSIPYAG AAAPPLPLPG LHTDGHSEKK KKKEEKDKER 
       410        420        430        440        450
ERGEKPKKKN MSAYQVFCKE YRVTIVADHP GIDFGELSKK LAEVWKQLPE 
       460        470        480        490        500
KDKLIWKQKA QYLQHKQNKA EATTVKRKAS SSEGSMKVKA SSVGVLSPQK 
       510        520        530        540        550
KSPPTTMLLP ASPAKAPETE PIDVAAHLQL LGESLSLIGH RLQETEGMVA 
       560        570        580        590        600
VSGSLSVLLD SIICALGPLA CLTTQLPELN GCPKQVLSNT LDNIAYIMPG 

L
Length:601
Mass (Da):65,712
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i819527F6081FBD86
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QXZ8B0QXZ8_HUMAN
HMG domain-containing protein 4
HMGXB4
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QXZ9B0QXZ9_HUMAN
HMG domain-containing protein 4
HMGXB4
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDU7F8WDU7_HUMAN
HMG domain-containing protein 4
HMGXB4
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti201K → R in CAA08992 (PubMed:10329004).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049559165G → V. Corresponds to variant dbSNP:rs1053593Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL079310 mRNA Translation: CAB45240.1 Sequence problems.
CR456504 mRNA Translation: CAG30390.1
AL008635 Genomic DNA No translation available.
AJ010070 mRNA Translation: CAA08992.1
AJ010069 mRNA Translation: CAA08991.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33641.1

NCBI Reference Sequences

More...RefSeqi		NP_001003681.1, NM_001003681.2
XP_006724165.1, XM_006724102.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216106.6; ENSP00000216106.5; ENSG00000100281.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10042

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10042

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000216106.6; ENSP00000216106.5; NM_001003681.3; NP_001003681.1

UCSC genome browser

More...UCSCi		uc003anl.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL079310 mRNA Translation: CAB45240.1 Sequence problems.
CR456504 mRNA Translation: CAG30390.1
AL008635 Genomic DNA No translation available.
AJ010070 mRNA Translation: CAA08992.1
AJ010069 mRNA Translation: CAA08991.1
CCDSiCCDS33641.1
RefSeqiNP_001003681.1, NM_001003681.2
XP_006724165.1, XM_006724102.1

3D structure databases

AlphaFoldDBiQ9UGU5
SMRiQ9UGU5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115353, 105 interactors
DIPiDIP-60550N
IntActiQ9UGU5, 43 interactors
MINTiQ9UGU5
STRINGi9606.ENSP00000216106

PTM databases

iPTMnetiQ9UGU5
PhosphoSitePlusiQ9UGU5

Genetic variation databases

BioMutaiHMGXB4
DMDMi61252700

Proteomic databases

EPDiQ9UGU5
jPOSTiQ9UGU5
MassIVEiQ9UGU5
MaxQBiQ9UGU5
PaxDbiQ9UGU5
PeptideAtlasiQ9UGU5
PRIDEiQ9UGU5
ProteomicsDBi84266

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		247, 181 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		10042

Genome annotation databases

EnsembliENST00000216106.6; ENSP00000216106.5; ENSG00000100281.14
GeneIDi10042
KEGGihsa:10042
MANE-SelectiENST00000216106.6; ENSP00000216106.5; NM_001003681.3; NP_001003681.1
UCSCiuc003anl.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10042
DisGeNETi10042

GeneCards: human genes, protein and diseases

More...GeneCardsi		HMGXB4
HGNCiHGNC:5003, HMGXB4
HPAiENSG00000100281, Low tissue specificity
MIMi604702, gene
neXtProtiNX_Q9UGU5
OpenTargetsiENSG00000100281
PharmGKBiPA164720673
VEuPathDBiHostDB:ENSG00000100281

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSH9, Eukaryota
GeneTreeiENSGT00390000012436
HOGENOMiCLU_032486_0_0_1
InParanoidiQ9UGU5
OMAiXGMVAVS
OrthoDBi1641977at2759
PhylomeDBiQ9UGU5
TreeFamiTF106404

Enzyme and pathway databases

PathwayCommonsiQ9UGU5
SignaLinkiQ9UGU5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10042, 18 hits in 1095 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HMGXB4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10042
PharosiQ9UGU5, Tbio

Protein Ontology

More...PROi		PR:Q9UGU5
RNActiQ9UGU5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100281, Expressed in oocyte and 246 other tissues
ExpressionAtlasiQ9UGU5, baseline and differential
GenevisibleiQ9UGU5, HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR025228, DUF4171
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR042477, HMGXB4
PANTHERiPTHR46584, PTHR46584, 1 hit
PfamiView protein in Pfam
PF13775, DUF4171, 1 hit
PF00505, HMG_box, 1 hit
SMARTiView protein in SMART
SM00398, HMG, 1 hit
SUPFAMiSSF47095, SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMGX4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGU5
Secondary accession number(s): O75672, O75673, Q9UMT5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 15, 2005
Last modified: May 25, 2022
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again