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UniProtKB - Q9UGU5 (HMGX4_HUMAN)
Protein
HMG domain-containing protein 4
Gene
HMGXB4
Organism
Homo sapiens (Human)
Status
Functioni
Negatively regulates Wnt/beta-catenin signaling during development.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 407 – 475 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
GO - Biological processi
- endosome to lysosome transport Source: UniProtKB
- negative regulation of Wnt signaling pathway Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9UGU5 |
SignaLinki | Q9UGU5 |
Names & Taxonomyi
Protein namesi | Recommended name: HMG domain-containing protein 4Alternative name(s): HMG box-containing protein 4 High mobility group protein 2-like 1 Protein HMGBCG |
Gene namesi | Name:HMGXB4 Synonyms:HMG2L1, HMGBCG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5003, HMGXB4 |
MIMi | 604702, gene |
neXtProti | NX_Q9UGU5 |
VEuPathDBi | HostDB:ENSG00000100281 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- NURF complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10042 |
OpenTargetsi | ENSG00000100281 |
PharmGKBi | PA164720673 |
Miscellaneous databases
Pharosi | Q9UGU5, Tbio |
Genetic variation databases
BioMutai | HMGXB4 |
DMDMi | 61252700 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048542 | 1 – 601 | HMG domain-containing protein 4Add BLAST | 601 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 8 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 102 | PhosphoserineCombined sources | 1 | |
Cross-linki | 191 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 197 | PhosphoserineCombined sources | 1 | |
Modified residuei | 497 | PhosphoserineCombined sources | 1 | |
Modified residuei | 502 | PhosphoserineCombined sources | 1 | |
Modified residuei | 512 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9UGU5 |
jPOSTi | Q9UGU5 |
MassIVEi | Q9UGU5 |
MaxQBi | Q9UGU5 |
PaxDbi | Q9UGU5 |
PeptideAtlasi | Q9UGU5 |
PRIDEi | Q9UGU5 |
ProteomicsDBi | 84266 |
PTM databases
iPTMneti | Q9UGU5 |
PhosphoSitePlusi | Q9UGU5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100281, Expressed in oocyte and 246 other tissues |
ExpressionAtlasi | Q9UGU5, baseline and differential |
Genevisiblei | Q9UGU5, HS |
Organism-specific databases
HPAi | ENSG00000100281, Low tissue specificity |
Interactioni
Binary interactionsi
Q9UGU5
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 115353, 105 interactors |
DIPi | DIP-60550N |
IntActi | Q9UGU5, 43 interactors |
MINTi | Q9UGU5 |
STRINGi | 9606.ENSP00000216106 |
Miscellaneous databases
RNActi | Q9UGU5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 51 – 410 | DisorderedSequence analysisAdd BLAST | 360 | |
Regioni | 473 – 514 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 51 – 83 | Basic and acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 138 – 156 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 207 – 222 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 244 – 258 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 318 – 344 | Basic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 383 – 409 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 473 – 488 | Polar residuesSequence analysisAdd BLAST | 16 |
Phylogenomic databases
eggNOGi | ENOG502QSH9, Eukaryota |
GeneTreei | ENSGT00390000012436 |
HOGENOMi | CLU_032486_0_0_1 |
InParanoidi | Q9UGU5 |
OMAi | XGMVAVS |
OrthoDBi | 1641977at2759 |
PhylomeDBi | Q9UGU5 |
TreeFami | TF106404 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR025228, DUF4171 IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR042477, HMGXB4 |
PANTHERi | PTHR46584, PTHR46584, 1 hit |
Pfami | View protein in Pfam PF13775, DUF4171, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9UGU5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAYDDSVKKE DCFDGDHTFE DIGLAAGRSQ REKKRSYKDF LREEEEIAAQ
60 70 80 90 100
VRNSSKKKLK DSELYFLGTD THKKKRKHSS DDYYYGDISS LESSQKKKKK
110 120 130 140 150
SSPQSTDTAM DLLKAITSPL AAGSKPSKKT GEKSSGSSSH SESKKEHHRK
160 170 180 190 200
KVSGSSGELP LEDGGSHKSK KMKPLYVNTE TLTLREPDGL KMKLILSPKE
210 220 230 240 250
KGSSSVDEES FQYPSQQATV KKSSKKSARD EQGALLLGHE LQSFLKTARK
260 270 280 290 300
KHKSSSDAHS SPGPEGCGSD ASQFAESHSA NLDLSGLEPI LVESDSSSGG
310 320 330 340 350
ELEAGELVID DSYREIKKKK KSKKSKKKKD KEKHKEKRHS KSKRSLGLSA
360 370 380 390 400
VPVGEVTVTS GPPPSIPYAG AAAPPLPLPG LHTDGHSEKK KKKEEKDKER
410 420 430 440 450
ERGEKPKKKN MSAYQVFCKE YRVTIVADHP GIDFGELSKK LAEVWKQLPE
460 470 480 490 500
KDKLIWKQKA QYLQHKQNKA EATTVKRKAS SSEGSMKVKA SSVGVLSPQK
510 520 530 540 550
KSPPTTMLLP ASPAKAPETE PIDVAAHLQL LGESLSLIGH RLQETEGMVA
560 570 580 590 600
VSGSLSVLLD SIICALGPLA CLTTQLPELN GCPKQVLSNT LDNIAYIMPG
L
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB0QXZ8 | B0QXZ8_HUMAN | HMG domain-containing protein 4 | HMGXB4 | 284 | Annotation score: | ||
B0QXZ9 | B0QXZ9_HUMAN | HMG domain-containing protein 4 | HMGXB4 | 285 | Annotation score: | ||
F8WDU7 | F8WDU7_HUMAN | HMG domain-containing protein 4 | HMGXB4 | 92 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 201 | K → R in CAA08992 (PubMed:10329004).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049559 | 165 | G → V. Corresponds to variant dbSNP:rs1053593Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL079310 mRNA Translation: CAB45240.1 Sequence problems. CR456504 mRNA Translation: CAG30390.1 AL008635 Genomic DNA No translation available. AJ010070 mRNA Translation: CAA08992.1 AJ010069 mRNA Translation: CAA08991.1 |
CCDSi | CCDS33641.1 |
RefSeqi | NP_001003681.1, NM_001003681.2 XP_006724165.1, XM_006724102.1 |
Genome annotation databases
Ensembli | ENST00000216106.6; ENSP00000216106.5; ENSG00000100281.14 |
GeneIDi | 10042 |
KEGGi | hsa:10042 |
MANE-Selecti | ENST00000216106.6; ENSP00000216106.5; NM_001003681.3; NP_001003681.1 |
UCSCi | uc003anl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL079310 mRNA Translation: CAB45240.1 Sequence problems. CR456504 mRNA Translation: CAG30390.1 AL008635 Genomic DNA No translation available. AJ010070 mRNA Translation: CAA08992.1 AJ010069 mRNA Translation: CAA08991.1 |
CCDSi | CCDS33641.1 |
RefSeqi | NP_001003681.1, NM_001003681.2 XP_006724165.1, XM_006724102.1 |
3D structure databases
AlphaFoldDBi | Q9UGU5 |
SMRi | Q9UGU5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115353, 105 interactors |
DIPi | DIP-60550N |
IntActi | Q9UGU5, 43 interactors |
MINTi | Q9UGU5 |
STRINGi | 9606.ENSP00000216106 |
PTM databases
iPTMneti | Q9UGU5 |
PhosphoSitePlusi | Q9UGU5 |
Genetic variation databases
BioMutai | HMGXB4 |
DMDMi | 61252700 |
Proteomic databases
EPDi | Q9UGU5 |
jPOSTi | Q9UGU5 |
MassIVEi | Q9UGU5 |
MaxQBi | Q9UGU5 |
PaxDbi | Q9UGU5 |
PeptideAtlasi | Q9UGU5 |
PRIDEi | Q9UGU5 |
ProteomicsDBi | 84266 |
Protocols and materials databases
Antibodypediai | 247, 181 antibodies from 19 providers |
DNASUi | 10042 |
Genome annotation databases
Ensembli | ENST00000216106.6; ENSP00000216106.5; ENSG00000100281.14 |
GeneIDi | 10042 |
KEGGi | hsa:10042 |
MANE-Selecti | ENST00000216106.6; ENSP00000216106.5; NM_001003681.3; NP_001003681.1 |
UCSCi | uc003anl.4, human |
Organism-specific databases
CTDi | 10042 |
DisGeNETi | 10042 |
GeneCardsi | HMGXB4 |
HGNCi | HGNC:5003, HMGXB4 |
HPAi | ENSG00000100281, Low tissue specificity |
MIMi | 604702, gene |
neXtProti | NX_Q9UGU5 |
OpenTargetsi | ENSG00000100281 |
PharmGKBi | PA164720673 |
VEuPathDBi | HostDB:ENSG00000100281 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSH9, Eukaryota |
GeneTreei | ENSGT00390000012436 |
HOGENOMi | CLU_032486_0_0_1 |
InParanoidi | Q9UGU5 |
OMAi | XGMVAVS |
OrthoDBi | 1641977at2759 |
PhylomeDBi | Q9UGU5 |
TreeFami | TF106404 |
Enzyme and pathway databases
PathwayCommonsi | Q9UGU5 |
SignaLinki | Q9UGU5 |
Miscellaneous databases
BioGRID-ORCSi | 10042, 18 hits in 1095 CRISPR screens |
ChiTaRSi | HMGXB4, human |
GenomeRNAii | 10042 |
Pharosi | Q9UGU5, Tbio |
PROi | PR:Q9UGU5 |
RNActi | Q9UGU5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100281, Expressed in oocyte and 246 other tissues |
ExpressionAtlasi | Q9UGU5, baseline and differential |
Genevisiblei | Q9UGU5, HS |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR025228, DUF4171 IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR042477, HMGXB4 |
PANTHERi | PTHR46584, PTHR46584, 1 hit |
Pfami | View protein in Pfam PF13775, DUF4171, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HMGX4_HUMAN | |
Accessioni | Q9UGU5Primary (citable) accession number: Q9UGU5 Secondary accession number(s): O75672, O75673, Q9UMT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | March 15, 2005 | |
Last modified: | May 25, 2022 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot