HMGXB4

Functionⁱ

Negatively regulates Wnt/beta-catenin signaling during development.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	407 – 475	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endosome to lysosome transport
Source: UniProtKB
Non-traceable author statementⁱ
- 10329004
negative regulation of Wnt signaling pathway Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Wnt signaling pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HMG domain-containing protein 4 Alternative name(s): HMG box-containing protein 4 High mobility group protein 2-like 1 Protein HMGBCG
Gene namesⁱ	Name:HMGXB4 Synonyms:HMG2L1, HMGBCG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100281.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5003 HMGXB4
MIMⁱ	604702 gene
neXtProtⁱ	NX_Q9UGU5

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10042
Open Targets More...OpenTargetsⁱ	ENSG00000100281
PharmGKBⁱ	PA164720673

Polymorphism and mutation databases

BioMutaⁱ	HMGXB4
DMDMⁱ	61252700

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048542	1 – 601	HMG domain-containing protein 4Add BLAST		601

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	8	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	102	PhosphoserineCombined sources	1
Cross-linkⁱ	191	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	197	PhosphoserineCombined sources	1
Modified residueⁱ	497	PhosphoserineCombined sources	1
Modified residueⁱ	502	PhosphoserineCombined sources	1
Modified residueⁱ	512	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9UGU5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UGU5
PaxDbⁱ	Q9UGU5
PeptideAtlas More...PeptideAtlasⁱ	Q9UGU5
PRIDEⁱ	Q9UGU5
ProteomicsDBⁱ	84266

PTM databases

iPTMnetⁱ	Q9UGU5
PhosphoSitePlusⁱ	Q9UGU5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100281
ExpressionAtlasⁱ	Q9UGU5 baseline and differential
Genevisibleⁱ	Q9UGU5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000725

HPAⁱ

HPA000725

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115353, 33 interactors
Database of interacting proteins More...DIPⁱ	DIP-60550N
IntActⁱ	Q9UGU5, 32 interactors
Molecular INTeraction database More...MINTⁱ	Q9UGU5
STRINGⁱ	9606.ENSP00000216106

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UGU5
SMRⁱ	Q9UGU5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410IE16 Eukaryota ENOG41101FA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012436
HOGENOMⁱ	HOG000112916
InParanoidⁱ	Q9UGU5
KEGG Orthology (KO) More...KOⁱ	K11298
OMAⁱ	FDGDHSF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14II
PhylomeDBⁱ	Q9UGU5
TreeFamⁱ	TF106404

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR025228 DUF4171 IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13775 DUF4171, 1 hit PF00505 HMG_box, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9UGU5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAYDDSVKKE DCFDGDHTFE DIGLAAGRSQ REKKRSYKDF LREEEEIAAQ 
        60         70         80         90        100
VRNSSKKKLK DSELYFLGTD THKKKRKHSS DDYYYGDISS LESSQKKKKK 
       110        120        130        140        150
SSPQSTDTAM DLLKAITSPL AAGSKPSKKT GEKSSGSSSH SESKKEHHRK 
       160        170        180        190        200
KVSGSSGELP LEDGGSHKSK KMKPLYVNTE TLTLREPDGL KMKLILSPKE 
       210        220        230        240        250
KGSSSVDEES FQYPSQQATV KKSSKKSARD EQGALLLGHE LQSFLKTARK 
       260        270        280        290        300
KHKSSSDAHS SPGPEGCGSD ASQFAESHSA NLDLSGLEPI LVESDSSSGG 
       310        320        330        340        350
ELEAGELVID DSYREIKKKK KSKKSKKKKD KEKHKEKRHS KSKRSLGLSA 
       360        370        380        390        400
VPVGEVTVTS GPPPSIPYAG AAAPPLPLPG LHTDGHSEKK KKKEEKDKER 
       410        420        430        440        450
ERGEKPKKKN MSAYQVFCKE YRVTIVADHP GIDFGELSKK LAEVWKQLPE 
       460        470        480        490        500
KDKLIWKQKA QYLQHKQNKA EATTVKRKAS SSEGSMKVKA SSVGVLSPQK 
       510        520        530        540        550
KSPPTTMLLP ASPAKAPETE PIDVAAHLQL LGESLSLIGH RLQETEGMVA 
       560        570        580        590        600
VSGSLSVLLD SIICALGPLA CLTTQLPELN GCPKQVLSNT LDNIAYIMPG 

L

Length:601

Mass (Da):65,712

Last modified:March 15, 2005 - v2

Checksum:ⁱ819527F6081FBD86

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	201	K → R in CAA08992 (PubMed:10329004).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049559	165	G → V. Corresponds to variant dbSNP:rs1053593Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL079310 mRNA Translation: CAB45240.1 Sequence problems. CR456504 mRNA Translation: CAG30390.1 AL008635 Genomic DNA No translation available. AJ010070 mRNA Translation: CAA08992.1 AJ010069 mRNA Translation: CAA08991.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33641.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001003681.1, NM_001003681.2 XP_006724165.1, XM_006724102.1
UniGeneⁱ	Hs.588815

Genome annotation databases

Ensemblⁱ	ENST00000216106; ENSP00000216106; ENSG00000100281
GeneIDⁱ	10042
KEGGⁱ	hsa:10042
UCSC genome browser More...UCSCⁱ	uc003anl.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9UGU5	HMGXB4 protein (Fragment)		HUMAN		393
HMG-box containing 4		PIG		674
HMG-box containing 4		FELCA		644
HMG-box containing 4		PAPAN		644
HMG-box containing 4		MACFA		644
+197

Protein	Similar proteins		Species	Score	Length
Q9UGU5	HMG box-containing protein 4		XENLA		554
UPI0009E400BE		central bearded dragon		612
HMG domain-containing protein 4		wild yak		602
HMG-box containing 4		PIG		674
UPI00042BE7C4		PANTA		644
+223

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL079310 mRNA Translation: CAB45240.1 Sequence problems. CR456504 mRNA Translation: CAG30390.1 AL008635 Genomic DNA No translation available. AJ010070 mRNA Translation: CAA08992.1 AJ010069 mRNA Translation: CAA08991.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33641.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001003681.1, NM_001003681.2 XP_006724165.1, XM_006724102.1
UniGeneⁱ	Hs.588815

3D structure databases

ProteinModelPortalⁱ	Q9UGU5
SMRⁱ	Q9UGU5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115353, 33 interactors
Database of interacting proteins More...DIPⁱ	DIP-60550N
IntActⁱ	Q9UGU5, 32 interactors
Molecular INTeraction database More...MINTⁱ	Q9UGU5
STRINGⁱ	9606.ENSP00000216106

PTM databases

iPTMnetⁱ	Q9UGU5
PhosphoSitePlusⁱ	Q9UGU5

Polymorphism and mutation databases

BioMutaⁱ	HMGXB4
DMDMⁱ	61252700

Proteomic databases

EPDⁱ	Q9UGU5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UGU5
PaxDbⁱ	Q9UGU5
PeptideAtlas More...PeptideAtlasⁱ	Q9UGU5
PRIDEⁱ	Q9UGU5
ProteomicsDBⁱ	84266

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10042
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000216106; ENSP00000216106; ENSG00000100281
GeneIDⁱ	10042
KEGGⁱ	hsa:10042
UCSC genome browser More...UCSCⁱ	uc003anl.4 human

Organism-specific databases

CTDⁱ	10042
DisGeNET More...DisGeNETⁱ	10042
EuPathDBⁱ	HostDB:ENSG00000100281.13
GeneCardsⁱ	HMGXB4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5003 HMGXB4
Human Protein Atlas More...HPAⁱ	HPA000725
MIMⁱ	604702 gene
neXtProtⁱ	NX_Q9UGU5
Open Targets More...OpenTargetsⁱ	ENSG00000100281
PharmGKBⁱ	PA164720673
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IE16 Eukaryota ENOG41101FA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012436
HOGENOMⁱ	HOG000112916
InParanoidⁱ	Q9UGU5
KEGG Orthology (KO) More...KOⁱ	K11298
OMAⁱ	FDGDHSF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14II
PhylomeDBⁱ	Q9UGU5
TreeFamⁱ	TF106404

Miscellaneous databases

ChiTaRSⁱ	HMGXB4 human
GenomeRNAiⁱ	10042
Protein Ontology More...PROⁱ	PR:Q9UGU5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100281
ExpressionAtlasⁱ	Q9UGU5 baseline and differential
Genevisibleⁱ	Q9UGU5 HS

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR025228 DUF4171 IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13775 DUF4171, 1 hit PF00505 HMG_box, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HMGX4_HUMAN
Accessionⁱ	Q9UGU5Primary (citable) accession number: Q9UGU5 Secondary accession number(s): O75672, O75673, Q9UMT5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	March 15, 2005
	Last modified:	June 20, 2018
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q9UGU5 (HMGX4_HUMAN)

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HMG domain-containing protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ