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Protein

HMG domain-containing protein 4

Gene

HMGXB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates Wnt/beta-catenin signaling during development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi407 – 475HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
HMG domain-containing protein 4
Alternative name(s):
HMG box-containing protein 4
High mobility group protein 2-like 1
Protein HMGBCG
Gene namesi
Name:HMGXB4
Synonyms:HMG2L1, HMGBCG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100281.13
HGNCiHGNC:5003 HMGXB4
MIMi604702 gene
neXtProtiNX_Q9UGU5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10042
OpenTargetsiENSG00000100281
PharmGKBiPA164720673

Polymorphism and mutation databases

BioMutaiHMGXB4
DMDMi61252700

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485421 – 601HMG domain-containing protein 4Add BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei102PhosphoserineCombined sources1
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei197PhosphoserineCombined sources1
Modified residuei497PhosphoserineCombined sources1
Modified residuei502PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UGU5
MaxQBiQ9UGU5
PaxDbiQ9UGU5
PeptideAtlasiQ9UGU5
PRIDEiQ9UGU5
ProteomicsDBi84266

PTM databases

iPTMnetiQ9UGU5
PhosphoSitePlusiQ9UGU5

Expressioni

Gene expression databases

BgeeiENSG00000100281
ExpressionAtlasiQ9UGU5 baseline and differential
GenevisibleiQ9UGU5 HS

Organism-specific databases

HPAiHPA000725

Interactioni

Protein-protein interaction databases

BioGridi115353, 33 interactors
DIPiDIP-60550N
IntActiQ9UGU5, 32 interactors
MINTiQ9UGU5
STRINGi9606.ENSP00000216106

Structurei

3D structure databases

ProteinModelPortaliQ9UGU5
SMRiQ9UGU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IE16 Eukaryota
ENOG41101FA LUCA
GeneTreeiENSGT00390000012436
HOGENOMiHOG000112916
InParanoidiQ9UGU5
KOiK11298
OMAiFDGDHSF
OrthoDBiEOG091G14II
PhylomeDBiQ9UGU5
TreeFamiTF106404

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR025228 DUF4171
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF13775 DUF4171, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UGU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYDDSVKKE DCFDGDHTFE DIGLAAGRSQ REKKRSYKDF LREEEEIAAQ
60 70 80 90 100
VRNSSKKKLK DSELYFLGTD THKKKRKHSS DDYYYGDISS LESSQKKKKK
110 120 130 140 150
SSPQSTDTAM DLLKAITSPL AAGSKPSKKT GEKSSGSSSH SESKKEHHRK
160 170 180 190 200
KVSGSSGELP LEDGGSHKSK KMKPLYVNTE TLTLREPDGL KMKLILSPKE
210 220 230 240 250
KGSSSVDEES FQYPSQQATV KKSSKKSARD EQGALLLGHE LQSFLKTARK
260 270 280 290 300
KHKSSSDAHS SPGPEGCGSD ASQFAESHSA NLDLSGLEPI LVESDSSSGG
310 320 330 340 350
ELEAGELVID DSYREIKKKK KSKKSKKKKD KEKHKEKRHS KSKRSLGLSA
360 370 380 390 400
VPVGEVTVTS GPPPSIPYAG AAAPPLPLPG LHTDGHSEKK KKKEEKDKER
410 420 430 440 450
ERGEKPKKKN MSAYQVFCKE YRVTIVADHP GIDFGELSKK LAEVWKQLPE
460 470 480 490 500
KDKLIWKQKA QYLQHKQNKA EATTVKRKAS SSEGSMKVKA SSVGVLSPQK
510 520 530 540 550
KSPPTTMLLP ASPAKAPETE PIDVAAHLQL LGESLSLIGH RLQETEGMVA
560 570 580 590 600
VSGSLSVLLD SIICALGPLA CLTTQLPELN GCPKQVLSNT LDNIAYIMPG

L
Length:601
Mass (Da):65,712
Last modified:March 15, 2005 - v2
Checksum:i819527F6081FBD86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201K → R in CAA08992 (PubMed:10329004).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049559165G → V. Corresponds to variant dbSNP:rs1053593Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL079310 mRNA Translation: CAB45240.1 Sequence problems.
CR456504 mRNA Translation: CAG30390.1
AL008635 Genomic DNA No translation available.
AJ010070 mRNA Translation: CAA08992.1
AJ010069 mRNA Translation: CAA08991.1
CCDSiCCDS33641.1
RefSeqiNP_001003681.1, NM_001003681.2
XP_006724165.1, XM_006724102.1
UniGeneiHs.588815

Genome annotation databases

EnsembliENST00000216106; ENSP00000216106; ENSG00000100281
GeneIDi10042
KEGGihsa:10042
UCSCiuc003anl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHMGX4_HUMAN
AccessioniPrimary (citable) accession number: Q9UGU5
Secondary accession number(s): O75672, O75673, Q9UMT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 15, 2005
Last modified: June 20, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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