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Entry version 159 (11 Dec 2019)
Sequence version 3 (07 Mar 2006)
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Protein

Transcription factor 20

Gene

TCF20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1537 – 1551A.T hookAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1829 – 1865C2HC pre-PHD-type; degeneratePROSITE-ProRule annotationAdd BLAST37
Zinc fingeri1885 – 1933PHD-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor 20
Short name:
TCF-20
Alternative name(s):
Nuclear factor SPBP
Protein AR1
Stromelysin-1 PDGF-responsive element-binding protein
Short name:
SPRE-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCF20
Synonyms:KIAA0292, SPBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100207.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11631 TCF20

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603107 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UGU0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Developmental delay with variable intellectual impairment and behavioral abnormalities (DDVIBA)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by impaired intellectual development with speech difficulties, dysmorphic features, and behavioral abnormalities including autism spectrum disorder, attention deficit and hyperactivity. Additional variable features may include hypotonia, somatic overgrowth, macrocephaly, mild distal skeletal anomalies, sleep disturbances, movement disorders, and gastrointestinal issues, such as constipation.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082678233 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1728
Natural variantiVAR_082679319 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1642
Natural variantiVAR_082681330 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1631
Natural variantiVAR_082682512K → E in DDVIBA; unknown pathological significance. 1 Publication1
Natural variantiVAR_082683654 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1307
Natural variantiVAR_082684719 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1242
Natural variantiVAR_082685742 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1219
Natural variantiVAR_082686754 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1207
Natural variantiVAR_082687865 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1096
Natural variantiVAR_082688961 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1000
Natural variantiVAR_0826891009 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST952
Natural variantiVAR_0826901269 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST692
Natural variantiVAR_0826911557P → L in DDVIBA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0826921592 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST369
Natural variantiVAR_0826931596 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST365
Natural variantiVAR_0826941710K → R in DDVIBA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0826951907 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST54
Natural variantiVAR_0826961909H → Y in DDVIBA. 1 Publication1
Natural variantiVAR_0826971937P → L in DDVIBA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0826981942P → H in DDVIBA; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6942

MalaCards human disease database

More...
MalaCardsi
TCF20
MIMi618430 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000100207

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36386

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UGU0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TCF20

Domain mapping of disease mutations (DMDM)

More...
DMDMi
92090378

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724481 – 1960Transcription factor 20Add BLAST1960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60Omega-N-methylarginineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei419PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei538PhosphoserineCombined sources1
Modified residuei559PhosphoserineCombined sources1
Modified residuei574PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei602N6-acetyllysineBy similarity1
Modified residuei640PhosphoserineCombined sources1
Cross-linki710Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki733Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki748Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki823Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki832Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki844Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei871PhosphoserineCombined sources1
Cross-linki920Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki922Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki929Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki929Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki957Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei966PhosphoserineCombined sources1
Modified residuei1005PhosphoserineCombined sources1
Cross-linki1015Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1024Omega-N-methylarginineCombined sources1
Modified residuei1053PhosphoserineCombined sources1
Cross-linki1086Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1098Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1137Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1183Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1267Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1305PhosphoserineCombined sources1
Cross-linki1309Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1335PhosphoserineCombined sources1
Cross-linki1338Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1361PhosphoserineCombined sources1
Cross-linki1389Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1409Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1428Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1446Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1510Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1522PhosphoserineCombined sources1
Cross-linki1524Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1669PhosphoserineCombined sources1
Modified residuei1671PhosphothreonineCombined sources1
Modified residuei1762PhosphothreonineBy similarity1
Modified residuei1764PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UGU0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UGU0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UGU0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UGU0

PeptideAtlas

More...
PeptideAtlasi
Q9UGU0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UGU0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84264 [Q9UGU0-1]
84265 [Q9UGU0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UGU0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UGU0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100207 Expressed in 246 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UGU0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UGU0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017849
HPA036786

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (Probable).

Interacts with RNF4 and JUN (By similarity).

By similarityCurated

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q925478EBI-3444158,EBI-308302

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112802, 52 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UGU0, 35 interactors

Molecular INTeraction database

More...
MINTi
Q9UGU0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352463

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UGU0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UGU0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1170 – 1191Leucine-zipperAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1254 – 1268Nuclear localization signalBy similarityAdd BLAST15
Motifi1576 – 1600Nuclear localization signalBy similarityAdd BLAST25
Motifi1785 – 1792Nuclear localization signalBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi62 – 70Poly-Ala9
Compositional biasi174 – 182Poly-Gln9
Compositional biasi203 – 262Ser-richAdd BLAST60
Compositional biasi310 – 322Poly-GlnAdd BLAST13
Compositional biasi1556 – 1564Poly-Pro9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The atypical PHD domain functions as a negative modulator of cofactor binding.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1829 – 1865C2HC pre-PHD-type; degeneratePROSITE-ProRule annotationAdd BLAST37
Zinc fingeri1885 – 1933PHD-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPTF Eukaryota
ENOG410ZTQQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157896

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000026801

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UGU0

Identification of Orthologs from Complete Genome Data

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OMAi
PDMKQIN

Database of Orthologous Groups

More...
OrthoDBi
671547at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UGU0

TreeFam database of animal gene trees

More...
TreeFami
TF331317

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15699 ePHD_TCF20, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034732 EPHD
IPR041972 TCF-20_ePHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00249 PHD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805 EPHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UGU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MQSFREQSSY HGNQQSYPQE VHGSSRLEEF SPRQAQMFQN FGGTGGSSGS
60 70 80 90 100
SGSGSGGGRR GAAAAAAAMA SETSGHQGYQ GFRKEAGDFY YMAGNKDPVT
110 120 130 140 150
TGTPQPPQRR PSGPVQSYGP PQGSSFGNQY GSEGHVGQFQ AQHSGLGGVS
160 170 180 190 200
HYQQDYTGPF SPGSAQYQQQ ASSQQQQQQV QQLRQQLYQS HQPLPQATGQ
210 220 230 240 250
PASSSSHLQP MQRPSTLPSS AAGYQLRVGQ FGQHYQSSAS SSSSSSFPSP
260 270 280 290 300
QRFSQSGQSY DGSYNVNAGS QYEGHNVGSN AQAYGTQSNY SYQPQSMKNF
310 320 330 340 350
EQAKIPQGTQ QGQQQQQPQQ QQHPSQHVMQ YTNAATKLPL QSQVGQYNQP
360 370 380 390 400
EVPVRSPMQF HQNFSPISNP SPAASVVQSP SCSSTPSPLM QTGENLQCGQ
410 420 430 440 450
GSVPMGSRNR ILQLMPQLSP TPSMMPSPNS HAAGFKGFGL EGVPEKRLTD
460 470 480 490 500
PGLSSLSALS TQVANLPNTV QHMLLSDALT PQKKTSKRPS SSKKADSCTN
510 520 530 540 550
SEGSSQPEEQ LKSPMAESLD GGCSSSSEDQ GERVRQLSGQ STSSDTTYKG
560 570 580 590 600
GASEKAGSSP AQGAQNEPPR LNASPAAREE ATSPGAKDMP LSSDGNPKVN
610 620 630 640 650
EKTVGVIVSR EAMTGRVEKP GGQDKGSQED DPAATQRPPS NGGAKETSHA
660 670 680 690 700
SLPQPEPPGG GGSKGNKNGD NNSNHNGEGN GQSGHSAAGP GFTSRTEPSK
710 720 730 740 750
SPGSLRYSYK DSFGSAVPRN VSGFPQYPTG QEKGDFTGHG ERKGRNEKFP
760 770 780 790 800
SLLQEVLQGY HHHPDRRYSR STQEHQGMAG SLEGTTRPNV LVSQTNELAS
810 820 830 840 850
RGLLNKSIGS LLENPHWGPW ERKSSSTAPE MKQINLTDYP IPRKFEIEPQ
860 870 880 890 900
SSAHEPGGSL SERRSVICDI SPLRQIVRDP GAHSLGHMSA DTRIGRNDRL
910 920 930 940 950
NPTLSQSVIL PGGLVSMETK LKSQSGQIKE EDFEQSKSQA SFNNKKSGDH
960 970 980 990 1000
CHPPSIKHES YRGNASPGAA THDSLSDYGP QDSRPTPMRR VPGRVGGREG
1010 1020 1030 1040 1050
MRGRSPSQYH DFAEKLKMSP GRSRGPGGDP HHMNPHMTFS ERANRSSLHT
1060 1070 1080 1090 1100
PFSPNSETLA SAYHANTRAH AYGDPNAGLN SQLHYKRQMY QQQPEEYKDW
1110 1120 1130 1140 1150
SSGSAQGVIA AAQHRQEGPR KSPRQQQFLD RVRSPLKNDK DGMMYGPPVG
1160 1170 1180 1190 1200
TYHDPSAQEA GRCLMSSDGL PNKGMELKHG SQKLQESCWD LSRQTSPAKS
1210 1220 1230 1240 1250
SGPPGMSSQK RYGPPHETDG HGLAEATQSS KPGSVMLRLP GQEDHSSQNP
1260 1270 1280 1290 1300
LIMRRRVRSF ISPIPSKRQS QDVKNSSTED KGRLLHSSKE GADKAFNSYA
1310 1320 1330 1340 1350
HLSHSQDIKS IPKRDSSKDL PSPDSRNCPA VTLTSPAKTK ILPPRKGRGL
1360 1370 1380 1390 1400
KLEAIVQKIT SPNIRRSASS NSAEAGGDTV TLDDILSLKS GPPEGGSVAV
1410 1420 1430 1440 1450
QDADIEKRKG EVASDLVSPA NQELHVEKPL PRSSEEWRGS VDDKVKTETH
1460 1470 1480 1490 1500
AETVTAGKEP PGAMTSTTSQ KPGSNQGRPD GSLGGTAPLI FPDSKNVPPV
1510 1520 1530 1540 1550
GILAPEANPK AEEKENDTVT ISPKQEGFPP KGYFPSGKKK GRPIGSVNKQ
1560 1570 1580 1590 1600
KKQQQPPPPP PQPPQIPEGS ADGEPKPKKQ RQRRERRKPG AQPRKRKTKQ
1610 1620 1630 1640 1650
AVPIVEPQEP EIKLKYATQP LDKTDAKNKS FYPYIHVVNK CELGAVCTII
1660 1670 1680 1690 1700
NAEEEEQTKL VRGRKGQRSL TPPPSSTESK ALPASSFMLQ GPVVTESSVM
1710 1720 1730 1740 1750
GHLVCCLCGK WASYRNMGDL FGPFYPQDYA ATLPKNPPPK RATEMQSKVK
1760 1770 1780 1790 1800
VRHKSASNGS KTDTEEEEEQ QQQQKEQRSL AAHPRFKRRH RSEDCGGGPR
1810 1820 1830 1840 1850
SLSRGLPCKK AATEGSSEKT VLDSKPSVPT TSEGGPELEL QIPELPLDSN
1860 1870 1880 1890 1900
EFWVHEGCIL WANGIYLVCG RLYGLQEALE IAREMKCSHC QEAGATLGCY
1910 1920 1930 1940 1950
NKGCSFRYHY PCAIDADCLL HEENFSVRCP KHKPPLPCPL PPLQNKTAKG
1960
SLSTEQSERG
Length:1,960
Mass (Da):211,771
Last modified:March 7, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3E34B1FAA6ED06F
GO
Isoform 2 (identifier: Q9UGU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1934-1938: PPLPC → VRLWR
     1939-1960: Missing.

Show »
Length:1,938
Mass (Da):209,654
Checksum:iDB67ACCB0AE5776C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A9JX13A9JX13_HUMAN
Transcription factor 20
TCF20
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1M7I3L1M7_HUMAN
Transcription factor 20
TCF20
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC36392 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti122Q → R (PubMed:10995766).Curated1
Sequence conflicti200Q → K (PubMed:10995766).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08267716S → T1 Publication1
Natural variantiVAR_082678233 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1728
Natural variantiVAR_082679319 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1642
Natural variantiVAR_082680322Missing 1 Publication1
Natural variantiVAR_082681330 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1631
Natural variantiVAR_051419405M → V1 PublicationCorresponds to variant dbSNP:rs34030679Ensembl.1
Natural variantiVAR_025427485T → N. Corresponds to variant dbSNP:rs6002656Ensembl.1
Natural variantiVAR_082682512K → E in DDVIBA; unknown pathological significance. 1 Publication1
Natural variantiVAR_082683654 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1307
Natural variantiVAR_082684719 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1242
Natural variantiVAR_025428722S → G1 PublicationCorresponds to variant dbSNP:rs5758651Ensembl.1
Natural variantiVAR_082685742 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1219
Natural variantiVAR_082686754 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1207
Natural variantiVAR_082687865 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1096
Natural variantiVAR_082688961 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST1000
Natural variantiVAR_0826891009 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST952
Natural variantiVAR_0254291165M → I1 PublicationCorresponds to variant dbSNP:rs17002890Ensembl.1
Natural variantiVAR_0826901269 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST692
Natural variantiVAR_0254301325S → N. Corresponds to variant dbSNP:rs17002888Ensembl.1
Natural variantiVAR_0826911557P → L in DDVIBA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0826921592 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST369
Natural variantiVAR_0826931596 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST365
Natural variantiVAR_0826941710K → R in DDVIBA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0826951907 – 1960Missing in DDVIBA. 1 PublicationAdd BLAST54
Natural variantiVAR_0826961909H → Y in DDVIBA. 1 Publication1
Natural variantiVAR_0514201910Y → C. Corresponds to variant dbSNP:rs17002865Ensembl.1
Natural variantiVAR_0826971937P → L in DDVIBA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0826981942P → H in DDVIBA; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0039841934 – 1938PPLPC → VRLWR in isoform 2. 1 Publication5
Alternative sequenceiVSP_0039851939 – 1960Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY007595 Genomic DNA Translation: AAG28930.1
AL031346 Genomic DNA No translation available.
BX247885 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60495.1
AB006630 mRNA Translation: BAA22961.1
U19345 mRNA Translation: AAC36392.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14032.1 [Q9UGU0-2]
CCDS14033.1 [Q9UGU0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_005641.1, NM_005650.3 [Q9UGU0-1]
NP_852469.1, NM_181492.2 [Q9UGU0-2]
XP_005261779.1, XM_005261722.3 [Q9UGU0-1]
XP_006724376.1, XM_006724313.3 [Q9UGU0-1]
XP_011528656.1, XM_011530354.2 [Q9UGU0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335626; ENSP00000335561; ENSG00000100207 [Q9UGU0-2]
ENST00000359486; ENSP00000352463; ENSG00000100207 [Q9UGU0-1]
ENST00000574943; ENSP00000460328; ENSG00000262024 [Q9UGU0-1]
ENST00000576946; ENSP00000460587; ENSG00000262024 [Q9UGU0-2]
ENST00000619505; ENSP00000478503; ENSG00000276461 [Q9UGU0-2]
ENST00000621408; ENSP00000483199; ENSG00000276461 [Q9UGU0-1]
ENST00000626486; ENSP00000487465; ENSG00000280467 [Q9UGU0-2]
ENST00000626726; ENSP00000487302; ENSG00000281897 [Q9UGU0-1]
ENST00000628774; ENSP00000487296; ENSG00000280467 [Q9UGU0-1]
ENST00000629538; ENSP00000486940; ENSG00000281897 [Q9UGU0-2]
ENST00000634489; ENSP00000489099; ENSG00000282892 [Q9UGU0-2]
ENST00000634616; ENSP00000489614; ENSG00000283026 [Q9UGU0-1]
ENST00000635146; ENSP00000489215; ENSG00000282892 [Q9UGU0-1]
ENST00000635421; ENSP00000489006; ENSG00000283026 [Q9UGU0-2]
ENST00000636799; ENSP00000490305; ENSG00000283681 [Q9UGU0-1]
ENST00000637355; ENSP00000489734; ENSG00000283681 [Q9UGU0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6942

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6942

UCSC genome browser

More...
UCSCi
uc003bck.3 human [Q9UGU0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007595 Genomic DNA Translation: AAG28930.1
AL031346 Genomic DNA No translation available.
BX247885 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60495.1
AB006630 mRNA Translation: BAA22961.1
U19345 mRNA Translation: AAC36392.1 Frameshift.
CCDSiCCDS14032.1 [Q9UGU0-2]
CCDS14033.1 [Q9UGU0-1]
RefSeqiNP_005641.1, NM_005650.3 [Q9UGU0-1]
NP_852469.1, NM_181492.2 [Q9UGU0-2]
XP_005261779.1, XM_005261722.3 [Q9UGU0-1]
XP_006724376.1, XM_006724313.3 [Q9UGU0-1]
XP_011528656.1, XM_011530354.2 [Q9UGU0-2]

3D structure databases

SMRiQ9UGU0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112802, 52 interactors
IntActiQ9UGU0, 35 interactors
MINTiQ9UGU0
STRINGi9606.ENSP00000352463

PTM databases

iPTMnetiQ9UGU0
PhosphoSitePlusiQ9UGU0

Polymorphism and mutation databases

BioMutaiTCF20
DMDMi92090378

Proteomic databases

EPDiQ9UGU0
jPOSTiQ9UGU0
MassIVEiQ9UGU0
PaxDbiQ9UGU0
PeptideAtlasiQ9UGU0
PRIDEiQ9UGU0
ProteomicsDBi84264 [Q9UGU0-1]
84265 [Q9UGU0-2]

Genome annotation databases

EnsembliENST00000335626; ENSP00000335561; ENSG00000100207 [Q9UGU0-2]
ENST00000359486; ENSP00000352463; ENSG00000100207 [Q9UGU0-1]
ENST00000574943; ENSP00000460328; ENSG00000262024 [Q9UGU0-1]
ENST00000576946; ENSP00000460587; ENSG00000262024 [Q9UGU0-2]
ENST00000619505; ENSP00000478503; ENSG00000276461 [Q9UGU0-2]
ENST00000621408; ENSP00000483199; ENSG00000276461 [Q9UGU0-1]
ENST00000626486; ENSP00000487465; ENSG00000280467 [Q9UGU0-2]
ENST00000626726; ENSP00000487302; ENSG00000281897 [Q9UGU0-1]
ENST00000628774; ENSP00000487296; ENSG00000280467 [Q9UGU0-1]
ENST00000629538; ENSP00000486940; ENSG00000281897 [Q9UGU0-2]
ENST00000634489; ENSP00000489099; ENSG00000282892 [Q9UGU0-2]
ENST00000634616; ENSP00000489614; ENSG00000283026 [Q9UGU0-1]
ENST00000635146; ENSP00000489215; ENSG00000282892 [Q9UGU0-1]
ENST00000635421; ENSP00000489006; ENSG00000283026 [Q9UGU0-2]
ENST00000636799; ENSP00000490305; ENSG00000283681 [Q9UGU0-1]
ENST00000637355; ENSP00000489734; ENSG00000283681 [Q9UGU0-2]
GeneIDi6942
KEGGihsa:6942
UCSCiuc003bck.3 human [Q9UGU0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6942
DisGeNETi6942
EuPathDBiHostDB:ENSG00000100207.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TCF20
HGNCiHGNC:11631 TCF20
HPAiCAB017849
HPA036786
MalaCardsiTCF20
MIMi603107 gene
618430 phenotype
neXtProtiNX_Q9UGU0
OpenTargetsiENSG00000100207
PharmGKBiPA36386

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPTF Eukaryota
ENOG410ZTQQ LUCA
GeneTreeiENSGT00940000157896
HOGENOMiHOG000026801
InParanoidiQ9UGU0
OMAiPDMKQIN
OrthoDBi671547at2759
PhylomeDBiQ9UGU0
TreeFamiTF331317

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TCF20 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TCF20

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6942
PharosiQ9UGU0 Tbio

Protein Ontology

More...
PROi
PR:Q9UGU0
RNActiQ9UGU0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100207 Expressed in 246 organ(s), highest expression level in forebrain
ExpressionAtlasiQ9UGU0 baseline and differential
GenevisibleiQ9UGU0 HS

Family and domain databases

CDDicd15699 ePHD_TCF20, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR034732 EPHD
IPR041972 TCF-20_ePHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00249 PHD, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCF20_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGU0
Secondary accession number(s): A9JX12
, O14528, Q13078, Q4V353, Q9H4M0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: March 7, 2006
Last modified: December 11, 2019
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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