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Protein

Solute carrier family 2, facilitated glucose transporter member 6

Gene

SLC2A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter; binds cytochalasin B with low affinity.

Caution

Has been described as GLUT9 in literature, but this gene name has already been used for SLC2A9.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei418MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Protein family/group databases

TCDBi2.A.1.1.88 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 6
Alternative name(s):
Glucose transporter type 6
Short name:
GLUT-6
Glucose transporter type 9
Short name:
GLUT-9
Gene namesi
Name:SLC2A6
Synonyms:GLUT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000160326.13
HGNCiHGNC:11011 SLC2A6
MIMi606813 gene
neXtProtiNX_Q9UGQ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini59 – 81ExtracellularSequence analysisAdd BLAST23
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini103 – 111CytoplasmicSequence analysis9
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 140ExtracellularSequence analysis8
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 168CytoplasmicSequence analysis7
Transmembranei169 – 189Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini190 – 194ExtracellularSequence analysis5
Transmembranei195 – 215Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini216 – 289CytoplasmicSequence analysisAdd BLAST74
Transmembranei290 – 310Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini311 – 314ExtracellularSequence analysis4
Transmembranei315 – 335Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini336 – 339CytoplasmicSequence analysis4
Transmembranei340 – 360Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini361 – 395ExtracellularSequence analysisAdd BLAST35
Transmembranei396 – 416Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini417 – 435CytoplasmicSequence analysisAdd BLAST19
Transmembranei436 – 456Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini457 – 462ExtracellularSequence analysis6
Transmembranei463 – 483Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini484 – 507CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11182
OpenTargetsiENSG00000160326
PharmGKBiPA35881

Chemistry databases

DrugBankiDB09502 Fludeoxyglucose F-18

Polymorphism and mutation databases

BioMutaiSLC2A6
DMDMi150421565

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503731 – 507Solute carrier family 2, facilitated glucose transporter member 6Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UGQ3
PaxDbiQ9UGQ3
PeptideAtlasiQ9UGQ3
PRIDEiQ9UGQ3
ProteomicsDBi84259
84260 [Q9UGQ3-2]

PTM databases

iPTMnetiQ9UGQ3
PhosphoSitePlusiQ9UGQ3
SwissPalmiQ9UGQ3

Expressioni

Tissue specificityi

Highly expressed in brain, spleen and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000160326
CleanExiHS_SLC2A6
ExpressionAtlasiQ9UGQ3 baseline and differential
GenevisibleiQ9UGQ3 HS

Organism-specific databases

HPAiCAB046014
HPA042272

Interactioni

Protein-protein interaction databases

BioGridi116352, 3 interactors
IntActiQ9UGQ3, 1 interactor
STRINGi9606.ENSP00000360966

Structurei

3D structure databases

ProteinModelPortaliQ9UGQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni286 – 292Monosaccharide bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 6Dileucine internalization motifSequence analysis2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254 Eukaryota
ENOG410XNQK LUCA
GeneTreeiENSGT00920000149002
HOGENOMiHOG000202868
HOVERGENiHBG104335
InParanoidiQ9UGQ3
KOiK08144
OMAiCIPVYVS
OrthoDBiEOG091G1600
PhylomeDBiQ9UGQ3
TreeFamiTF325324

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UGQ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQEPLLGAEG PDYDTFPEKP PPSPGDRARV GTLQNKRVFL ATFAAVLGNF
60 70 80 90 100
SFGYALVYTS PVIPALERSL DPDLHLTKSQ ASWFGSVFTL GAAAGGLSAM
110 120 130 140 150
ILNDLLGRKL SIMFSAVPSA AGYALMAGAH GLWMLLLGRT LTGFAGGLTA
160 170 180 190 200
ACIPVYVSEI APPGVRGALG ATPQLMAVFG SLSLYALGLL LPWRWLAVAG
210 220 230 240 250
EAPVLIMILL LSFMPNSPRF LLSRGRDEEA LRALAWLRGT DVDVHWEFEQ
260 270 280 290 300
IQDNVRRQSS RVSWAEARAP HVCRPITVAL LMRLLQQLTG ITPILVYLQS
310 320 330 340 350
IFDSTAVLLP PKDDAAIVGA VRLLSVLIAA LTMDLAGRKV LLFVSAAIMF
360 370 380 390 400
AANLTLGLYI HFGPRPLSPN STAGLESESW GDLAQPLAAP AGYLTLVPLL
410 420 430 440 450
ATMLFIMGYA VGWGPITWLL MSEVLPLRAR GVASGLCVLA SWLTAFVLTK
460 470 480 490 500
SFLPVVSTFG LQVPFFFFAA ICLVSLVFTG CCVPETKGRS LEQIESFFRT

GRRSFLR
Length:507
Mass (Da):54,539
Last modified:June 26, 2007 - v2
Checksum:i32C6E2EB11588477
GO
Isoform 2 (identifier: Q9UGQ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-407: Missing.

Show »
Length:445
Mass (Da):48,041
Checksum:iBF37DC0C313A32CE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025426500T → M2 PublicationsCorresponds to variant dbSNP:rs3094378Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041402346 – 407Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17803 mRNA Translation: CAB96996.1
AJ011372 mRNA Translation: CAB66155.1
AK074927 mRNA Translation: BAC11297.1
AK222919 mRNA Translation: BAD96639.1
AK074836 mRNA Translation: BAC11235.1
AL593848 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88093.1
CH471090 Genomic DNA Translation: EAW88094.1
BC013740 mRNA Translation: AAH13740.1
CCDSiCCDS48052.1 [Q9UGQ3-2]
CCDS6975.1 [Q9UGQ3-1]
RefSeqiNP_001138571.1, NM_001145099.1 [Q9UGQ3-2]
NP_060055.2, NM_017585.3 [Q9UGQ3-1]
UniGeneiHs.244378

Genome annotation databases

EnsembliENST00000371897; ENSP00000360964; ENSG00000160326 [Q9UGQ3-2]
ENST00000371899; ENSP00000360966; ENSG00000160326 [Q9UGQ3-1]
ENST00000625425; ENSP00000486637; ENSG00000281165 [Q9UGQ3-2]
ENST00000626271; ENSP00000487067; ENSG00000281165 [Q9UGQ3-1]
GeneIDi11182
KEGGihsa:11182
UCSCiuc004cee.4 human [Q9UGQ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGTR6_HUMAN
AccessioniPrimary (citable) accession number: Q9UGQ3
Secondary accession number(s): A6NNU6, Q5SXD7, Q8NCC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 26, 2007
Last modified: July 18, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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