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UniProtKB - Q9UGP8 (SEC63_HUMAN)

Entry version 185 (02 Jun 2021)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Translocation protein SEC63 homolog

Gene

SEC63

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251).

Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251).

Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UGP8

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.5.9.1, the general secretory pathway (sec) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translocation protein SEC63 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC631 PublicationImported
Synonyms:SEC63L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21082, SEC63

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608648, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UGP8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000025796.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14LumenalSequence analysisAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 69CytoplasmicSequence analysisAdd BLAST34
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 188LumenalSequence analysisAdd BLAST98
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 760CytoplasmicSequence analysisAdd BLAST551

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Polycystic liver disease 2 with or without kidney cysts (PCLD2)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. A subset of patients may develop kidney cysts that usually do not result in clinically significant renal disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0809447 – 760Missing in PCLD2. 1 PublicationAdd BLAST754
Natural variantiVAR_08094558 – 760Missing in PCLD2. 1 PublicationAdd BLAST703
Natural variantiVAR_08094698 – 760Missing in PCLD2. 1 PublicationAdd BLAST663
Natural variantiVAR_080947233 – 760Missing in PCLD2. 1 PublicationAdd BLAST528
Natural variantiVAR_080948239 – 760Missing in PCLD2. 1 PublicationAdd BLAST522
Natural variantiVAR_080949297 – 760Missing in PCLD2. 1 PublicationAdd BLAST464
Natural variantiVAR_080950417 – 760Missing in PCLD2. 1 PublicationAdd BLAST344
Natural variantiVAR_080951550 – 760Missing in PCLD2. 1 PublicationAdd BLAST211
Natural variantiVAR_019645568Missing in PCLD2. 1 Publication1
Natural variantiVAR_080952601 – 760Missing in PCLD2. 1 PublicationAdd BLAST160

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi132H → Q: Reduces cotranslational translocation of APLN precursor/preproapelin. 1 Publication1
Mutagenesisi735 – 760Missing : Reduces cotranslational translocation of APLN precursor/preproapelin. 1 PublicationAdd BLAST26

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		11231

MalaCards human disease database

More...MalaCardsi		SEC63
MIMi617004, phenotype

Open Targets

More...OpenTargetsi		ENSG00000025796

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2924, Isolated polycystic liver disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134936990

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UGP8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SEC63

Domain mapping of disease mutations (DMDM)

More...DMDMi		18203500

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000710971 – 760Translocation protein SEC63 homologAdd BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei537PhosphothreonineCombined sources1
Modified residuei742PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UGP8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UGP8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UGP8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UGP8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UGP8

PeptideAtlas

More...PeptideAtlasi		Q9UGP8

PRoteomics IDEntifications database

More...PRIDEi		Q9UGP8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84254

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q9UGP8

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UGP8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UGP8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9UGP8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with high levels in the liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000025796, Expressed in testis and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UGP8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UGP8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000025796, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116397, 101 interactors

Protein interaction database and analysis system

More...IntActi		Q9UGP8, 36 interactors

Molecular INTeraction database

More...MINTi		Q9UGP8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357998

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UGP8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UGP8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 165JPROSITE-ProRule annotationAdd BLAST62
Domaini197 – 541SEC63 1Add BLAST345
Domaini637 – 714SEC63 2Add BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni492 – 617DisorderedSequence analysisAdd BLAST126
Regioni720 – 760DisorderedSequence analysisAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili597 – 635Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi520 – 535Basic residuesSequence analysisAdd BLAST16
Compositional biasi540 – 554Polar residuesSequence analysisAdd BLAST15
Compositional biasi576 – 617Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi734 – 760Acidic residuesSequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001965

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014210_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UGP8

Identification of Orthologs from Complete Genome Data

More...OMAi		YTFTVCL

Database of Orthologous Groups

More...OrthoDBi		686427at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UGP8

TreeFam database of animal gene trees

More...TreeFami		TF105904

Family and domain databases

Conserved Domains Database

More...CDDi		cd06257, DnaJ, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.287.110, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035892, C2_domain_sf
IPR001623, DnaJ_domain
IPR014756, Ig_E-set
IPR036869, J_dom_sf
IPR027137, Sec63
IPR004179, Sec63-dom

The PANTHER Classification System

More...PANTHERi		PTHR24075:SF0, PTHR24075:SF0, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00226, DnaJ, 1 hit
PF02889, Sec63, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00625, JDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00271, DnaJ, 1 hit
SM00973, Sec63, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46565, SSF46565, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50076, DNAJ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UGP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGQQFQYDD SGNTFFYFLT SFVGLIVIPA TYYLWPRDQN AEQIRLKNIR 
        60         70         80         90        100
KVYGRCMWYR LRLLKPQPNI IPTVKKIVLL AGWALFLFLA YKVSKTDREY 
       110        120        130        140        150
QEYNPYEVLN LDPGATVAEI KKQYRLLSLK YHPDKGGDEV MFMRIAKAYA 
       160        170        180        190        200
ALTDEESRKN WEEFGNPDGP QATSFGIALP AWIVDQKNSI LVLLVYGLAF 
       210        220        230        240        250
MVILPVVVGS WWYRSIRYSG DQILIRTTQI YTYFVYKTRN MDMKRLIMVL 
       260        270        280        290        300
AGASEFDPQY NKDATSRPTD NILIPQLIRE IGSINLKKNE PPLTCPYSLK 
       310        320        330        340        350
ARVLLLSHLA RMKIPETLEE DQQFMLKKCP ALLQEMVNVI CQLIVMARNR 
       360        370        380        390        400
EEREFRAPTL ASLENCMKLS QMAVQGLQQF KSPLLQLPHI EEDNLRRVSN 
       410        420        430        440        450
HKKYKIKTIQ DLVSLKESDR HTLLHFLEDE KYEEVMAVLG SFPYVTMDIK 
       460        470        480        490        500
SQVLDDEDSN NITVGSLVTV LVKLTRQTMA EVFEKEQSIC AAEEQPAEDG 
       510        520        530        540        550
QGETNKNRTK GGWQQKSKGP KKTAKSKKKK PLKKKPTPVL LPQSKQQKQK 
       560        570        580        590        600
QANGVVGNEA AVKEDEEEVS DKGSDSEEEE TNRDSQSEKD DGSDRDSDRE 
       610        620        630        640        650
QDEKQNKDDE AEWQELQQSI QRKERALLET KSKITHPVYS LYFPEEKQEW 
       660        670        680        690        700
WWLYIADRKE QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS 
       710        720        730        740        750
DSYMGLDQIK PLKLEVHEAK PVPENHPQWD TAIEGDEDQE DSEGFEDSFE 
       760
EEEEEEEDDD
Length:760
Mass (Da):87,997
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81BBF269A3FCCF0D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PVC9A6PVC9_HUMAN
Translocation protein SEC63 homolog
SEC63
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB27F8WB27_HUMAN
Translocation protein SEC63 homolog
SEC63
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH23598 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti115A → V in AAH23598 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0809447 – 760Missing in PCLD2. 1 PublicationAdd BLAST754
Natural variantiVAR_08094558 – 760Missing in PCLD2. 1 PublicationAdd BLAST703
Natural variantiVAR_08094698 – 760Missing in PCLD2. 1 PublicationAdd BLAST663
Natural variantiVAR_080947233 – 760Missing in PCLD2. 1 PublicationAdd BLAST528
Natural variantiVAR_080948239 – 760Missing in PCLD2. 1 PublicationAdd BLAST522
Natural variantiVAR_080949297 – 760Missing in PCLD2. 1 PublicationAdd BLAST464
Natural variantiVAR_080950417 – 760Missing in PCLD2. 1 PublicationAdd BLAST344
Natural variantiVAR_080951550 – 760Missing in PCLD2. 1 PublicationAdd BLAST211
Natural variantiVAR_061146556V → I1 PublicationCorresponds to variant dbSNP:rs17854547EnsemblClinVar.1
Natural variantiVAR_019645568Missing in PCLD2. 1 Publication1
Natural variantiVAR_080952601 – 760Missing in PCLD2. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ011779 mRNA Translation: CAB46275.1
AF100141 mRNA Translation: AAC83375.1
AL024507 Genomic DNA No translation available.
BC023598 mRNA Translation: AAH23598.1 Sequence problems.
BC047221 mRNA Translation: AAH47221.1
BC048287 mRNA Translation: AAH48287.1
AL137338 mRNA Translation: CAB70701.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5061.1

Protein sequence database of the Protein Information Resource

More...PIRi		T46504

NCBI Reference Sequences

More...RefSeqi		NP_009145.1, NM_007214.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369002; ENSP00000357998; ENSG00000025796

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11231

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11231

UCSC genome browser

More...UCSCi		uc003psc.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011779 mRNA Translation: CAB46275.1
AF100141 mRNA Translation: AAC83375.1
AL024507 Genomic DNA No translation available.
BC023598 mRNA Translation: AAH23598.1 Sequence problems.
BC047221 mRNA Translation: AAH47221.1
BC048287 mRNA Translation: AAH48287.1
AL137338 mRNA Translation: CAB70701.1
CCDSiCCDS5061.1
PIRiT46504
RefSeqiNP_009145.1, NM_007214.4

3D structure databases

SMRiQ9UGP8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116397, 101 interactors
IntActiQ9UGP8, 36 interactors
MINTiQ9UGP8
STRINGi9606.ENSP00000357998

Protein family/group databases

TCDBi3.A.5.9.1, the general secretory pathway (sec) family

PTM databases

CarbonylDBiQ9UGP8
iPTMnetiQ9UGP8
PhosphoSitePlusiQ9UGP8
SwissPalmiQ9UGP8

Genetic variation databases

BioMutaiSEC63
DMDMi18203500

Proteomic databases

EPDiQ9UGP8
jPOSTiQ9UGP8
MassIVEiQ9UGP8
MaxQBiQ9UGP8
PaxDbiQ9UGP8
PeptideAtlasiQ9UGP8
PRIDEiQ9UGP8
ProteomicsDBi84254

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32190, 128 antibodies

The DNASU plasmid repository

More...DNASUi		11231

Genome annotation databases

EnsembliENST00000369002; ENSP00000357998; ENSG00000025796
GeneIDi11231
KEGGihsa:11231
UCSCiuc003psc.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11231
DisGeNETi11231

GeneCards: human genes, protein and diseases

More...GeneCardsi		SEC63
HGNCiHGNC:21082, SEC63
HPAiENSG00000025796, Low tissue specificity
MalaCardsiSEC63
MIMi608648, gene
617004, phenotype
neXtProtiNX_Q9UGP8
OpenTargetsiENSG00000025796
Orphaneti2924, Isolated polycystic liver disease
PharmGKBiPA134936990
VEuPathDBiHostDB:ENSG00000025796.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0721, Eukaryota
GeneTreeiENSGT00390000001965
HOGENOMiCLU_014210_1_0_1
InParanoidiQ9UGP8
OMAiYTFTVCL
OrthoDBi686427at2759
PhylomeDBiQ9UGP8
TreeFamiTF105904

Enzyme and pathway databases

PathwayCommonsiQ9UGP8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11231, 400 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SEC63, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SEC63

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11231
PharosiQ9UGP8, Tbio

Protein Ontology

More...PROi		PR:Q9UGP8
RNActiQ9UGP8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000025796, Expressed in testis and 250 other tissues
ExpressionAtlasiQ9UGP8, baseline and differential
GenevisibleiQ9UGP8, HS

Family and domain databases

CDDicd06257, DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892, C2_domain_sf
IPR001623, DnaJ_domain
IPR014756, Ig_E-set
IPR036869, J_dom_sf
IPR027137, Sec63
IPR004179, Sec63-dom
PANTHERiPTHR24075:SF0, PTHR24075:SF0, 1 hit
PfamiView protein in Pfam
PF00226, DnaJ, 1 hit
PF02889, Sec63, 2 hits
PRINTSiPR00625, JDOMAIN
SMARTiView protein in SMART
SM00271, DnaJ, 1 hit
SM00973, Sec63, 1 hit
SUPFAMiSSF46565, SSF46565, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50076, DNAJ_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEC63_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UGP8
Secondary accession number(s): O95380
, Q5THN4, Q86VS9, Q8IWL0, Q9NTE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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