UniProtKB - Q9UGP8 (SEC63_HUMAN)

BLAST

>sp|Q9UGP8|SEC63_HUMAN Translocation protein SEC63 homolog OS=Homo sapiens OX=9606 GN=SEC63 PE=1 SV=2
MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYR
LRLLKPQPNIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEI
KKQYRLLSLKYHPDKGGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALP
AWIVDQKNSILVLLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRN
MDMKRLIMVLAGASEFDPQYNKDATSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLK
ARVLLLSHLARMKIPETLEEDQQFMLKKCPALLQEMVNVICQLIVMARNREEREFRAPTL
ASLENCMKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDR
HTLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITVGSLVTVLVKLTRQTMA
EVFEKEQSICAAEEQPAEDGQGETNKNRTKGGWQQKSKGPKKTAKSKKKKPLKKKPTPVL
LPQSKQQKQKQANGVVGNEAAVKEDEEEVSDKGSDSEEEETNRDSQSEKDDGSDRDSDRE
QDEKQNKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKE
QTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAK
PVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEDDD

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History
Entry version 168 (07 Nov 2018)
Sequence version 2 (23 Jan 2007)
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Protein

Translocation protein SEC63 homolog

Gene

SEC63

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

protein transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 10799540

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

liver development Source: Ensembl
multicellular organism aging Source: Ensembl
nitrogen compound metabolic process Source: Ensembl
posttranslational protein targeting to endoplasmic reticulum membrane
Source: MGI
Inferred from mutant phenotypeⁱ
- 22375059
posttranslational protein targeting to membrane, translocation Source: InterPro
protein targeting to membrane
Source: ProtInc
Traceable author statementⁱ
- 10799540
renal system development Source: Ensembl
SRP-dependent cotranslational protein targeting to membrane
Source: MGI
Inferred from mutant phenotypeⁱ
- 22375059

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Biological process	Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381038 XBP1(S) activates chaperone genes

Reactomeⁱ

R-HSA-381038 XBP1(S) activates chaperone genes

Protein family/group databases

TCDBⁱ	3.A.5.9.1 the general secretory pathway (sec) family

TCDBⁱ

3.A.5.9.1 the general secretory pathway (sec) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Translocation protein SEC63 homolog
Gene namesⁱ	Name:SEC631 PublicationImported Synonyms:SEC63L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000025796.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21082 SEC63
MIMⁱ	608648 gene
neXtProtⁱ	NX_Q9UGP8

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 14	LumenalSequence analysisAdd BLAST	14
Transmembraneⁱ	15 – 35	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	36 – 69	CytoplasmicSequence analysisAdd BLAST	34
Transmembraneⁱ	70 – 90	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	91 – 188	LumenalSequence analysisAdd BLAST	98
Transmembraneⁱ	189 – 209	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	210 – 760	CytoplasmicSequence analysisAdd BLAST	551

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Polycystic liver disease 2 with or without kidney cysts (PCLD2)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. A subset of patients may develop kidney cysts that usually do not result in clinically significant renal disease.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	132	H → Q: Reduces cotranslational translocation of APLN precursor/preproapelin. 1 Publication		1
Mutagenesisⁱ	735 – 760	Missing : Reduces cotranslational translocation of APLN precursor/preproapelin. 1 PublicationAdd BLAST		26

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11231
MalaCards human disease database More...MalaCardsⁱ	SEC63
MIMⁱ	617004 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000025796
Orphanetⁱ	2924 Isolated polycystic liver disease
PharmGKBⁱ	PA134936990

Polymorphism and mutation databases

BioMutaⁱ	SEC63
DMDMⁱ	18203500

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000071097	1 – 760	Translocation protein SEC63 homologAdd BLAST		760

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	537	PhosphothreonineCombined sources	1
Modified residueⁱ	742	PhosphoserineCombined sources	1
Modified residueⁱ	748	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UGP8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UGP8
PaxDbⁱ	Q9UGP8
PeptideAtlas More...PeptideAtlasⁱ	Q9UGP8
PRIDEⁱ	Q9UGP8
ProteomicsDBⁱ	84254

PTM databases

CarbonylDBⁱ	Q9UGP8
iPTMnetⁱ	Q9UGP8
PhosphoSitePlusⁱ	Q9UGP8
SwissPalmⁱ	Q9UGP8

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000025796 Expressed in 239 organ(s), highest expression level in testis
CleanExⁱ	HS_SEC63
ExpressionAtlasⁱ	Q9UGP8 baseline and differential
Genevisibleⁱ	Q9UGP8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053295 HPA060535

HPAⁱ

HPA053295
HPA060535

Interactionⁱ

Subunit structureⁱ

The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MEOX2	Q6FHY5	3	EBI-1045560,EBI-16439278
Nxn	P97346	6	EBI-1045560,EBI-309684	From Mus musculus.

Protein-protein interaction databases

BioGridⁱ	116397, 44 interactors
CORUMⁱ	Q9UGP8
IntActⁱ	Q9UGP8, 28 interactors
Molecular INTeraction database More...MINTⁱ	Q9UGP8
STRINGⁱ	9606.ENSP00000357998

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UGP8
SMRⁱ	Q9UGP8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	104 – 165	JPROSITE-ProRule annotationAdd BLAST	62
Domainⁱ	197 – 541	SEC63 1Add BLAST	345
Domainⁱ	637 – 714	SEC63 2Add BLAST	78

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	597 – 635	Sequence analysisAdd BLAST		39

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	734 – 760	Asp/Glu-rich (highly acidic)Add BLAST		27

Keywords - Domainⁱ

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0721 Eukaryota KOG4434 Eukaryota COG5407 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001965
HOGENOMⁱ	HOG000037933
HOVERGENⁱ	HBG057075
InParanoidⁱ	Q9UGP8
KEGG Orthology (KO) More...KOⁱ	K09540
OMAⁱ	SQFDYEM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03YI
PhylomeDBⁱ	Q9UGP8
TreeFamⁱ	TF105904

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257 DnaJ, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit 2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR035892 C2_domain_sf IPR001623 DnaJ_domain IPR014756 Ig_E-set IPR036869 J_dom_sf IPR027137 Sec63 IPR004179 Sec63-dom
PANTHERⁱ	PTHR24075:SF0 PTHR24075:SF0, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF02889 Sec63, 2 hits
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit SM00973 Sec63, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF81296 SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS50076 DNAJ_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9UGP8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGQQFQYDD SGNTFFYFLT SFVGLIVIPA TYYLWPRDQN AEQIRLKNIR 
        60         70         80         90        100
KVYGRCMWYR LRLLKPQPNI IPTVKKIVLL AGWALFLFLA YKVSKTDREY 
       110        120        130        140        150
QEYNPYEVLN LDPGATVAEI KKQYRLLSLK YHPDKGGDEV MFMRIAKAYA 
       160        170        180        190        200
ALTDEESRKN WEEFGNPDGP QATSFGIALP AWIVDQKNSI LVLLVYGLAF 
       210        220        230        240        250
MVILPVVVGS WWYRSIRYSG DQILIRTTQI YTYFVYKTRN MDMKRLIMVL 
       260        270        280        290        300
AGASEFDPQY NKDATSRPTD NILIPQLIRE IGSINLKKNE PPLTCPYSLK 
       310        320        330        340        350
ARVLLLSHLA RMKIPETLEE DQQFMLKKCP ALLQEMVNVI CQLIVMARNR 
       360        370        380        390        400
EEREFRAPTL ASLENCMKLS QMAVQGLQQF KSPLLQLPHI EEDNLRRVSN 
       410        420        430        440        450
HKKYKIKTIQ DLVSLKESDR HTLLHFLEDE KYEEVMAVLG SFPYVTMDIK 
       460        470        480        490        500
SQVLDDEDSN NITVGSLVTV LVKLTRQTMA EVFEKEQSIC AAEEQPAEDG 
       510        520        530        540        550
QGETNKNRTK GGWQQKSKGP KKTAKSKKKK PLKKKPTPVL LPQSKQQKQK 
       560        570        580        590        600
QANGVVGNEA AVKEDEEEVS DKGSDSEEEE TNRDSQSEKD DGSDRDSDRE 
       610        620        630        640        650
QDEKQNKDDE AEWQELQQSI QRKERALLET KSKITHPVYS LYFPEEKQEW 
       660        670        680        690        700
WWLYIADRKE QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS 
       710        720        730        740        750
DSYMGLDQIK PLKLEVHEAK PVPENHPQWD TAIEGDEDQE DSEGFEDSFE 
       760
EEEEEEEDDD

Length:760

Mass (Da):87,997

Last modified:January 23, 2007 - v2

Checksum:ⁱ81BBF269A3FCCF0D

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A6PVC9	A6PVC9_HUMAN	Translocation protein SEC63 homolog Translocation protein SEC63 homolog	SEC63	161	Annotation score:
F8WB27	F8WB27_HUMAN	Translocation protein SEC63 homolog Translocation protein SEC63 homolog	SEC63	80	Annotation score:

Sequence cautionⁱ

The sequence AAH23598 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	115	A → V in AAH23598 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_080944	7 – 760	Missing in PCLD2. 1 PublicationAdd BLAST	754
Natural variantⁱVAR_080945	58 – 760	Missing in PCLD2. 1 PublicationAdd BLAST	703
Natural variantⁱVAR_080946	98 – 760	Missing in PCLD2. 1 PublicationAdd BLAST	663
Natural variantⁱVAR_080947	233 – 760	Missing in PCLD2. 1 PublicationAdd BLAST	528
Natural variantⁱVAR_080948	239 – 760	Missing in PCLD2. 1 PublicationAdd BLAST	522
Natural variantⁱVAR_080949	297 – 760	Missing in PCLD2. 1 PublicationAdd BLAST	464
Natural variantⁱVAR_080950	417 – 760	Missing in PCLD2. 1 PublicationAdd BLAST	344
Natural variantⁱVAR_080951	550 – 760	Missing in PCLD2. 1 PublicationAdd BLAST	211
Natural variantⁱVAR_061146	556	V → I1 PublicationCorresponds to variant dbSNP:rs17854547EnsemblClinVar.	1
Natural variantⁱVAR_019645	568	Missing in PCLD2. 1 Publication	1
Natural variantⁱVAR_080952	601 – 760	Missing in PCLD2. 1 PublicationAdd BLAST	160

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ011779 mRNA Translation: CAB46275.1 AF100141 mRNA Translation: AAC83375.1 AL024507 Genomic DNA No translation available. BC023598 mRNA Translation: AAH23598.1 Sequence problems. BC047221 mRNA Translation: AAH47221.1 BC048287 mRNA Translation: AAH48287.1 AL137338 mRNA Translation: CAB70701.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5061.1
PIRⁱ	T46504
NCBI Reference Sequences More...RefSeqⁱ	NP_009145.1, NM_007214.4
UniGeneⁱ	Hs.26904

Genome annotation databases

Ensemblⁱ	ENST00000369002; ENSP00000357998; ENSG00000025796
GeneIDⁱ	11231
KEGGⁱ	hsa:11231
UCSC genome browser More...UCSCⁱ	uc003psc.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UGP8	SEC63-like (S. cerevisiae) (Fragment)		HUMAN		760	UniRef100_Q9UGP8
SEC63 isoform 1		PONAB		760
Translocation protein SEC63 homolog		MACMU		760
Uncharacterized protein		PAPAN		760
Uncharacterized protein		MACFA		760
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9UGP8	Translocation protein SEC63 homolog		PONAB		761	UniRef90_Q9UGP8
Translocation protein SEC63 homolog		MOUSE		760
SEC63-like (S. cerevisiae) (Fragment)		HUMAN		760
Translocation protein SEC63 homolog		MACMU		760
Uncharacterized protein		PAPAN		760
+231

Protein	Similar proteins		Species	Score	Length	Source
Q9UGP8	Translocation protein SEC63 homolog		PONAB		761	UniRef50_Q9UGP8
Translocation protein SEC63 homolog		MOUSE		760
SEC63-like (S. cerevisiae) (Fragment)		HUMAN		760
Translocation protein SEC63 homolog		MACMU		760
Uncharacterized protein		PAPAN		760
+325

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ011779 mRNA Translation: CAB46275.1 AF100141 mRNA Translation: AAC83375.1 AL024507 Genomic DNA No translation available. BC023598 mRNA Translation: AAH23598.1 Sequence problems. BC047221 mRNA Translation: AAH47221.1 BC048287 mRNA Translation: AAH48287.1 AL137338 mRNA Translation: CAB70701.1
CCDSⁱ	CCDS5061.1
PIRⁱ	T46504
RefSeqⁱ	NP_009145.1, NM_007214.4
UniGeneⁱ	Hs.26904

3D structure databases

ProteinModelPortalⁱ	Q9UGP8
SMRⁱ	Q9UGP8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116397, 44 interactors
CORUMⁱ	Q9UGP8
IntActⁱ	Q9UGP8, 28 interactors
MINTⁱ	Q9UGP8
STRINGⁱ	9606.ENSP00000357998

Protein family/group databases

TCDBⁱ	3.A.5.9.1 the general secretory pathway (sec) family

TCDBⁱ

3.A.5.9.1 the general secretory pathway (sec) family

PTM databases

CarbonylDBⁱ	Q9UGP8
iPTMnetⁱ	Q9UGP8
PhosphoSitePlusⁱ	Q9UGP8
SwissPalmⁱ	Q9UGP8

Polymorphism and mutation databases

BioMutaⁱ	SEC63
DMDMⁱ	18203500

Proteomic databases

EPDⁱ	Q9UGP8
MaxQBⁱ	Q9UGP8
PaxDbⁱ	Q9UGP8
PeptideAtlasⁱ	Q9UGP8
PRIDEⁱ	Q9UGP8
ProteomicsDBⁱ	84254

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11231
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369002; ENSP00000357998; ENSG00000025796
GeneIDⁱ	11231
KEGGⁱ	hsa:11231
UCSCⁱ	uc003psc.5 human

Organism-specific databases

CTDⁱ	11231
DisGeNETⁱ	11231
EuPathDBⁱ	HostDB:ENSG00000025796.13
GeneCardsⁱ	SEC63
HGNCⁱ	HGNC:21082 SEC63
HPAⁱ	HPA053295 HPA060535
MalaCardsⁱ	SEC63
MIMⁱ	608648 gene 617004 phenotype
neXtProtⁱ	NX_Q9UGP8
OpenTargetsⁱ	ENSG00000025796
Orphanetⁱ	2924 Isolated polycystic liver disease
PharmGKBⁱ	PA134936990
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0721 Eukaryota KOG4434 Eukaryota COG5407 LUCA
GeneTreeⁱ	ENSGT00390000001965
HOGENOMⁱ	HOG000037933
HOVERGENⁱ	HBG057075
InParanoidⁱ	Q9UGP8
KOⁱ	K09540
OMAⁱ	SQFDYEM
OrthoDBⁱ	EOG091G03YI
PhylomeDBⁱ	Q9UGP8
TreeFamⁱ	TF105904

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381038 XBP1(S) activates chaperone genes

Reactomeⁱ

R-HSA-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSⁱ	SEC63 human
GeneWikiⁱ	SEC63
GenomeRNAiⁱ	11231
Protein Ontology More...PROⁱ	PR:Q9UGP8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000025796 Expressed in 239 organ(s), highest expression level in testis
CleanExⁱ	HS_SEC63
ExpressionAtlasⁱ	Q9UGP8 baseline and differential
Genevisibleⁱ	Q9UGP8 HS

Family and domain databases

CDDⁱ	cd06257 DnaJ, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit 2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR035892 C2_domain_sf IPR001623 DnaJ_domain IPR014756 Ig_E-set IPR036869 J_dom_sf IPR027137 Sec63 IPR004179 Sec63-dom
PANTHERⁱ	PTHR24075:SF0 PTHR24075:SF0, 1 hit
Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF02889 Sec63, 2 hits
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit SM00973 Sec63, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF81296 SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS50076 DNAJ_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SEC63_HUMAN
Accessionⁱ	Q9UGP8Primary (citable) accession number: Q9UGP8 Secondary accession number(s): O95380 , Q5THN4, Q86VS9, Q8IWL0, Q9NTE0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UGP8 (SEC63_HUMAN)

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Translocation protein SEC63 homolog

SEC63

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Cytosol

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ